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Current Cystic Fibrosis News and Events, Cystic Fibrosis News Articles.
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Studies published in NEJM identify promising drug therapies for fatal lung disease
Researchers in separate clinical trials found two drugs slow the progression of idiopathic pulmonary fibrosis, a fatal lung disease with no effective treatment or cure, and for which there is currently no therapy approved by the Food and Drug Administration. Paul W. Noble, M.D., is the senior author of the multicenter study that found that the investigational drug pirfenidone significantly slowed the loss of lung function and reduced the risk of death. (2014-05-18)

Ataluren Phase 3 trial results in nonsense mutation cystic fibrosis
PTC Therapeutics, Inc. today announced that the results of a Phase 3 study of ataluren in patients with nonsense mutation cystic fibrosis were published in Lancet Respiratory Medicine. The results demonstrated positive trends in both the primary endpoint, lung function as measured by relative change in percent predicted FEV1 (forced expiratory volume in one second) and in the secondary outcome measure, rate of pulmonary exacerbations. (2014-05-16)

Protein molecule may improve survival in deadly lung disease
Researchers at the University of Illinois at Chicago College of Medicine have discovered a protein molecule that seems to slow the progression of pulmonary fibrosis, a progressive lung disease that is often fatal three to five years after diagnosis. (2014-05-06)

Weight-loss surgery can reduce liver damage
Bariatric surgery, which is best known for its ability to help patients lose substantial weight, can also result in significant improvement in nonalcoholic fatty liver disease, according to new research presented today at Digestive Disease Week. (2014-05-04)

Drinking poses greater risk for advanced liver disease in HIV/hep C patients
Penn Medicine researchers find much stronger association between alcohol use and advanced liver fibrosis in co-infected patients compared to uninfected. (2014-05-02)

Microfluidic technology reveals potential biomarker for early pancreatic cancer
The findings, published in Gastroenterology, revealed circulating pancreas cells seed the bloodstream before tumors can be detected using current clinical tests. The data suggest that the detection of pancreas cells in the blood may be an early sign of cancer. (2014-04-29)

'Beneficial inflammation' may promote healing in pulmonary fibrosis
Inflammation has long been considered an integral part of the biological process that leads to deadly scarring in idiopathic pulmonary fibrosis. New research at National Jewish Health, however, suggests that a little inflammation may also be crucial to the healing and repair processes in the lungs. (2014-04-25)

Low-dose natural antimicrobial exacerbates chronic lung infection in cystic fibrosis
Respiratory failure caused by chronic lung infection with Pseudomonas aeruginosa bacteria is a common cause of death in patients with cystic fibrosis, a genetic disease that is common in individuals of European descent. A study published on April 24 in PLOS Pathogens demonstrates that an antimicrobial peptide produced by human immune cells can promote mutations in the bacterium that make it more lethal. (2014-04-24)

New clues on tissue scarring in scleroderma
A discovery by scientists could lead to potential new treatments for breaking the cycle of tissue scarring in people with scleroderma. The concept for new therapeutic options centers on findings identifying the role that a specific protein plays in promoting fibrosis. (2014-04-17)

Researcher looks at public perceptions around newborn testing
Public opinion should matter when deciding extent of genetic tests, according to a new study. (2014-04-17)

UNC researchers find genetic trigger for RSV-induced infant hospitalizations
Researchers at UNC School of Medicine have pinpointed a viral protein that plays a major role in making respiratory syncytial virus the most common cause of hospitalization in children under one year of age. (2014-04-08)

Montreal researchers explain how our immune system kills abnormal blood cells
A team of researchers at the IRCM, led by Andre Veillette, M.D., explains how our immune system kills abnormal blood cells. Their discovery, recently published in the Journal of Experimental Medicine, could eventually lead to new treatment avenues for leukemia, lymphoma and certain types of infectious viral diseases. (2014-04-08)

Antibiotic resistance enzyme caught in the act
NpmA is a mobile gene in bacteria that confers resistance to aminoglycoside antibiotics. Structural biologists analyze the threat NpmA poses and reveal targets for drug development. (2014-04-07)

Flipping the switch on scleroderma
Scleroderma is a rare and often fatal disease, causing the thickening of tissue, that currently lacks a cure and any effective treatments. A group of researchers, including a Michigan State University professor, is looking to change that. (2014-04-04)

Quality improvement initiative leads to reduction in unnecessary follow-up imaging
The April issue of the Journal of the American College of Radiology focuses on a variety of issues relating to clinical practice, practice management, health services and policy, and radiology education and training. (2014-04-01)

Can antibiotics cause autoimmunity?
A certain class of antibiotics prompts cells to produce low levels of novel self proteins that could trigger an autoimmune disease. (2014-03-31)

IRCM researchers uncover a new function for an important player in the immune response
Institut de recherches cliniques de Montréal researchers led by Javier M. Di Noia, Ph.D., uncovered a new function of AID, a crucial enzyme for the immune response. The discovery, recently published by the scientific journal Proceedings of the National Academy of Sciences, helps explain a rare genetic disorder that causes an immunodeficiency syndrome. (2014-03-27)

New method can diagnose a feared form of cancer
Pancreatic cancer is often detected at a late stage, which results in poor prognosis and limited treatment options. Researchers at The University of Gothenburg, Sweden, have now developed a method which identifies the cancer's visible precursors with 97 percent certainty. The method, which is expected to aid in the early discovery of the cancer as well as minimize the risk of unnecessary surgery, may be introduced in patient care within five years. (2014-03-21)

CF Foundation and CF care expert partnership yields striking progress for people with cystic fibrosi
A decade of strategic efforts to improve care has had a key role in improving quality of life and added years to predicted survival for people with cystic fibrosis in the United States, according to the editors of a BMJ Quality & Safety supplement dedicated to the disease. (2014-03-17)

New research links body clocks to chronic lung diseases
The body clock's natural rhythm could be utilized to improve current therapies to delay the onset of chronic lung diseases. (2014-03-17)

Hepatitis C remains major problem for HIV patients despite antiretroviral therapy
A new study led by researchers at the Perelman School of Medicine at the University of Pennsylvania has found that the risk of hepatitis C-associated serious liver disease persists in HIV patients otherwise benefiting from antiretroviral therapy to treat HIV. (2014-03-17)

Ben-Gurion U. researchers identify severe genetic disease prevalent in Moroccan Jews
One of every 37 Moroccan Jews carries one of the two mutations and based on the high carrier rate, PCCA2 is the most common severe genetic disease in Moroccan Jews discovered to date. Fifteen percent of Israel's total population (1 million people) is of Moroccan ancestry. Nearly 100,000 Moroccan Jews also live in the United States, largely in New York City, Washington, D.C., Boston and Florida. (2014-03-10)

Research benefits surgeons making decisions on how to help their patients breathe easier
UC researchers use computer simulations developed for aircraft design to improve treatment of human airways. (2014-03-04)

Ancient Chinese medicine put through its paces for pancreatic cancer
The bark of the Amur cork tree has traveled a centuries-long road with the healing arts. Now it is being put through its paces by science in the fight against pancreatic cancer, with the potential to make inroads against several more. (2014-03-03)

Dangerous mistaken identity
Tau proteins, which are responsible for Alzheimer's disease, bind to the folding protein HSP90. The molecular recognition mechanisms that play a role here, have been unveiled by an international team of scientists led by the Technische Universitaet Muenchen and the Helmholtz Zentrum Muenchen. This might open the door for new approaches for the treatment of Alzheimer's disease, as the scientists report in the trade journal Cell. (2014-02-28)

Drinking water linked to infections
Brisbane's water supply has been found to contain disease carrying bugs which can be directly linked to infections in some patients, according to a new study by QUT. (2014-02-27)

Montreal researchers find a link between pollutants and certain complications of obesity
A team of researchers at the IRCM in Montreal led by Remi Rabasa-Lhoret, in collaboration with Jerome Ruzzin from the University of Bergen in Norway, found a link between a type of pollutants and certain metabolic complications of obesity. Their breakthrough, published online this week by the Journal of Clinical Endocrinology & Metabolism, could eventually help improve the prevention, diagnosis, and treatment of cardiometabolic risk associated with obesity, such as diabetes, hypertension and cardiovascular disease. (2014-02-27)

Discovery of a 'conductor' in muscle development
A team led by Jean-Francois Cote, researcher at the IRCM, identified a 'conductor' in the development of muscle tissue. The discovery, published online yesterday by the scientific journal Proceedings of the National Academy of Sciences, could have an important impact on the treatment of muscular diseases such as myopathies and muscular dystrophies. (2014-02-25)

Is a 'buttery' molecule behind cystic fibrosis flare-ups?
Katrine Whiteson and colleagues identified a lung-damaging molecule in higher concentrations in cystic fibrosis patients during symptom flare-ups. (2014-02-21)

Study in fruitflies strengthens connection among protein misfolding, sleep loss, and age
Pathways of aging and sleep intersect at the circuitry of a cellular stress response pathway, and that by tinkering with those connections, it may be possible to alter sleep patterns in the aged for the better -- at least in fruit flies. (2014-02-20)

Garlic counteracts virulent bacteria
Garlic contains a substance that is particularly effective in encounters with even the hardiest bacterial strains. A young researcher at the University of Copenhagen will soon be defending his Ph.D. thesis on the positive properties of the malodorous plant. (2014-02-18)

Scientific racism's long history mandates caution
Racism as a social and scientific concept is reshaped and reborn periodically through the ages and according to a Penn State anthropologist, both medical and scientific researchers need to be careful that the growth of genomics does not bring about another resurgence of scientific racism. (2014-02-14)

New therapy to stop progression of fibrosis
Scientists from the University of Sheffield have developed a novel antibody-based therapy which targets the progression of life threating kidney fibrosis. (2014-02-14)

Game changer: Biomarker identified for noncancerous pancreatic cysts
Researchers at the Indiana University School of Medicine have discovered a highly accurate, noninvasive test to identify benign pancreatic cysts. (2014-02-11)

Director of Women's Guild Lung Institute awarded grant to study treatment for lung disease
A Cedars-Sinai research team led by Paul W. Noble, MD, has been awarded $628,816 by California's stem cell agency to develop a treatment for idiopathic pulmonary fibrosis, a deadly disease that destroys the lungs and damages other vital organs. The illness, which has no cure and few effective treatments, thickens and hardens lung tissue, leaving the organs badly scarred. (2014-02-06)

Study shows potential usefulness of non-invasive measure of heart tissue scarring
Scarring of tissue in the upper chamber of the heart (atrium) was associated with recurrent rhythm disorder after treatment, according to a study in the February 5 issue of JAMA. (2014-02-04)

MRIs help predict which atrial fibrillation patients will benefit from catheter ablation
A new type of contrast MRI can predict which heart patients with atrial fibrillation are most likely to benefit from a treatment called catheter ablation, according to a landmark multi-center study published in the Journal of the American Medical Association. (2014-02-04)

Study supports 3-D MRI heart imaging to improve treatment of atrial fibrillation
A University of Utah-led study for treatment of patients with atrial fibrillation provides strong clinical evidence for the use of 3-D MRI to individualize disease management and improve outcomes. (2014-02-04)

HIV-infected teens delaying treatment until advanced disease, Johns Hopkins study shows
Nearly half of HIV-infected teenagers and young adults forego timely treatment, delaying care until their disease has advanced, which puts them at risk for dangerous infections and long-term complications, according to a study led by the Johns Hopkins Children's Center. (2014-02-03)

Researchers reverse some lung diseases in mice by coaxing production of healthy cells
Introducing proteins that direct lung stem cells to grow the specific cell types needed to repair lung injuries could lead to new ways to treat some lung diseases, according to research from Boston Children's Hospital published in the journal Cell. (2014-01-30)

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