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Current Cytokines News and Events, Cytokines News Articles.
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Cell therapy designed to treat inflammatory bowel disease
The UPV/EHU's NanoBioCel research group has for many years been developing systems enabling cells to be used as drugs. Cell therapy raises hopes for treating those diseases for which there are as yet no effective pharmacological solutions. Biomaterials, a leading journal in the field of materials sciences and medicine, has just published the paper 'Multifunctional biomimetic hydrogel systems to boost the immunomodulatory potential of mesenchymal stromal cells'. (2020-09-28)

Study links higher level of exercise to 25% to 32% lower risk of all-cause mortality in people with type 2 diabetes
New research presented at this year's Annual Meeting of the European Association for the Study of Diabetes (EASD), held online this year, shows that having a greater exercise capacity is associated with a significantly decreased all-cause mortality risk of between 25-33% in people with type 2 diabetes (T2D). (2020-09-20)

Potential new drug to mitigate SARS-CoV-2 infection consequences
Researchers at the University of Malaga study how '4-PBA' treatment modulates the inflammatory response in severe cases of COVID-19 (2020-09-18)

A bifidobacterial protein that can reduce inflammation in COVID-19 found by a RUDN geneticist
A geneticist from RUDN University studied the effect of Bifidobacterium (intestinal bacteria) on the inflammatory process and discovered that their surface protein is capable of stopping excessive or uncontrollable inflammation, like the one observed in COVID-19 patients. A fragment of this protein can be used as an anti-inflammatory medication when treating coronavirus and other diseases. (2020-09-14)

New vaccine design reduces inflammation, enhances protection
Researchers have discovered a new way to limit inflammation from adjuvants, a key ingredient of many modern vaccines, by adding a molecule that disrupts certain pathways in cells. (2020-09-09)

Cellular-level interactions that lead to the cytokine storm in COVID-19
Scientists review macrophage activation syndrome -- a feature of the cytokine storm that kills patients with severe cases of COVID-19, as well as possible treatments. (2020-09-08)

Does the COVID-19 cytokine storm exist?
Cytokines play a crucial role in the immune response. If this immune response is too strong, also known as ''cytokine storm'', it can cause harm to the patient. Following the measurement of several important cytokines in patients with COVID-19 and various other severe diseases, researchers at Radboud university medical center show that COVID-19 is not characterized by a cytokine storm. This may have consequences for the treatment of these patients, the researchers write in JAMA. (2020-09-04)

Tiny biological package gets drug right to the 'heart' of transplant rejection
For patients who receive a heart transplant in the near future, the old adage, 'Good things come in small packages,' may become words to live by. In a recent study, researchers at Johns Hopkins Medicine and the National Cancer Institute (NCI) demonstrated in mice that they can easily deliver a promising anti-rejection drug directly to the area surrounding a grafted heart by packaging it within a tiny three-dimensional, protein gel cocoon known as a hydrogel. (2020-09-03)

Overlap between immunology of COVID-19 and obesity could explain the increased risk of death in people living with obesity, and also older patients
Data presented in a special COVID-19 session at the European and International Congress on Obesity (ECOICO 2020) suggests that there are overlaps between the immunological disturbances found in both COVID-19 disease and patients with obesity, which could explain the increased disease severity and mortality risk faced by obese patients, and also elderly patients, who are infected by the SARS-CoV-2 virus that causes COVID-19 disease. (2020-09-02)

Antibody blockade effective in treatment of severe COVID-19
A hyperinflammatory response following infection or trauma can cause the life-threatening condition cytokine release syndrome (CRS). Researchers led by Osaka University found that IL-6 signaling induces the expression of inflammatory cytokines and PAI-1 in CRS patients, causing respiratory distress and multiple organ failure, which are also observed in severe COVID-19 patients. Blockade of IL-6 signaling using a human monoclonal antibody reduced PAI-1 levels and alleviated the clinical manifestations of disease in severe COVID-19 patients. (2020-08-31)

Researchers discover immune predictors of COVID-19 cases that fare the worst
Mount Sinai scientists have identified two markers of inflammation that reliably predict the severity of COVID-19 cases and likelihood of survival, providing a foundation for a diagnostic platform and therapeutic targets, according to a study published in Nature Medicine in August. (2020-08-24)

Inflammatory bowel disease linked to an immune cell run amok
Researchers at UC San Diego School of Medicine report that the lasting nature of inflammatory bowel disease may be due to a type of long-lived immune cell that can provoke persistent, damaging inflammation in the intestinal tract. (2020-08-24)

COVID-19 patients who experience cytokine storms may make few memory B cells
The release of massive amounts of proteins called cytokines can lead to some of the most severe symptoms of COVID-19. An August 19 study in the journal Cell now suggests that high levels of some cytokines may also prevent people who are infected from developing long-term immunity as affected patients were observed to make very few of the type of B cells needed to develop a durable immune response. (2020-08-19)

COVID-19 cytokine storms may prevent a durable immune response
New stud shows high levels of some cytokines seen in COVID-19 patients, as part of a cytokine storm, may prevent the development of long-term immunity to SARS-CoV-2. (2020-08-19)

CHOP researchers identify lab profiles that differentiate MIS-C from COVID-19 in children
Researchers from Children's Hospital of Philadelphia (CHOP) report important data that differentiate MIS-C from severe COVID-19 in children and suggest that MIS-C is a post-infectious syndrome related to COVID-19 but distinct from Kawasaki disease. The findings were published today in The Journal of Clinical Investigation. (2020-07-30)

Elevated levels of a specific protein found to correlate with inflammatory symptom severity in COVID
A new study found raised levels of transforming growth factor beta-induced protein (TGFBIp) in blood sampled from roughly 100 people hospitalized for COVID-19, and further found that elevated levels of (2020-07-24)

Dual role discovered for molecule involved in autoimmune eye disease
The inflammatory molecule interleukin-17A (IL-17A) triggers immune cells that in turn reduce IL-17A's pro-inflammatory activity, according to a study by National Eye Institute (NEI) researchers. (2020-07-23)

Immunotherapy safe for patients with COVID-19, cancer
Preliminary data from researchers at the University of Cincinnati Cancer Center show that immunotherapy doesn't necessarily worsen complications for patients with both COVID-19 and cancer. (2020-07-20)

St18 is a negative regulator of VEGF
A research team led by Kenta Maruyama M.D., Ph.D. from National Institute for Physiological Sciences explored the role of St18 in the regulation of VEGF expression. Mice lacking St18 in myeloid lineages are highly susceptible to septic shock. These mice also exhibit increased retinal vasculature with enhanced serum VEGF concentrations, and pharmacological inhibition of VEGF signaling rescues the high mortality rate of septic shock. These findings suggest that St18 is a negative regulator of VEGF. (2020-07-14)

Contracting COVID-19, lifestyle and social connections may play a role
A new article published in the journal Perspectives on Psychological Science explores how lifestyle, social, and psychological factors may increase the risk of contracting COVID-19. (2020-07-09)

Self-isolation may increase susceptibility to COVID-19
Previous research points to the effect of social stressors on developing upper respiratory infections, holding clues to COVID-19 risk. (2020-07-08)

Researchers propose novel approach to limit organ damage for patients with severe COVID-19
In a paper published in Cancer and Metastasis Reviews, a team of researchers from Beth Israel Deaconess Medical Center and Brigham and Women's Hospital propose that controlling the local and systemic inflammatory response in COVID-19 may be as important as anti-viral and other therapies. (2020-07-08)

"Targeting peptide" discovery offers hope as new, highly effective anti-inflammatory
A collaboration between the University of Toronto's Faculty of Dentistry and the National Jewish Health in Denver -- the top-ranked respiratory research hospital in the US -- has yielded a new drug discovery that could be useful to combat inflammation of all varieties and shows promise in fighting acute respiratory illnesses such as COVID-19. (2020-07-02)

SARS-CoV-2-attacking T cells found in 10 COVID-19 patients and 2 uninfected controls
Patients suffering from severe respiratory symptoms as a result of SARS-CoV-2 infection can rapidly generate virus-attacking T cells, and can increase this production over time, suggests a new study of T cells from 10 COVID-19 patients under intensive care treatment. (2020-06-26)

UConn researchers overcome a vexing problem in vaccine research
Researchers at UConn's Center of Excellence in Vaccine Research (CEVR) have made a breakthrough in vaccine development for a common and difficult to treat pneumonia-causing pathogen. Their research was recently published in the NPJ Vaccines (2020-06-17)

Persistent DNA damage in the placenta affects pregnancy outcomes
Scientists at the Stowers Institute for Medical Research have shown that a dysfunctional placenta can play a previously unrecognized role during the earliest stages of development in mouse models of Cornelia de Lange syndrome. People with this rare genetic disorder often harbor mutations in cohesins, ring-like proteins that help DNA organize and repair itself. (2020-06-16)

Cytokine implicated in HLH treatment resistance
Research sheds light on cytokine storm syndromes and how ruxolitinib may benefit patients with hemophagocytic lymphohistiocytosis. (2020-06-12)

Putting 'super' in natural killer cells
Using induced pluripotent stem cells (iPSCs) and deleting a key gene, researchers at University of California San Diego School of Medicine have created natural killer cells -- a type of immune cell -- with measurably stronger activity against a form of leukemia, both in vivo and in vitro. (2020-06-11)

Type III interferons: Protective or harmful in COVID-19?
Interferons and other cytokines produced by the immune system are important defenses against viral infections, but as we have seen in COVID-19, they can also contribute to damaging, potentially life-threatening lung inflammation. Recent evidence suggests that one type of interferon, known as type III interferon or interferon lambda (λ), can fight viral infection while limiting this inflammatory damage. That has led to clinical trials to test type III interferon as a treatment for COVID-19. (2020-06-11)

Glycolysis involved in immunosuppression by polyphenol; PCB2DG
Researchers at Shinshu University in Japan found that glycolysis is involved in immunosuppression by polyphenols. The functional mechanism of the procyanidin PCB2DG was elucidated for the first time. (2020-06-10)

Study identifies potential approach to treat patients with severe COVID-19
Early data from a clinical study suggest that blocking the Bruton tyrosine kinase (BTK) protein provided clinical benefit to a small group of patients with severe COVID-19. Researchers observed that the off-label use of the cancer drug acalabrutinib, a BTK inhibitor that is approved to treat several blood cancers, was associated with reduced respiratory distress and a reduction in the overactive immune response in most of the treated patients. (2020-06-05)

Cognitive behavior therapy tops other psychotherapies in reducing inflammation
A review of 56 randomized clinical trials finds that psychological and behavioral therapies may be effective non-drug treatments for reducing disease-causing inflammation in the body. (2020-06-03)

Cancer cells cause inflammation to protect themselves from viruses
Researchers at the Francis Crick Institute have uncovered how cancer cells protect themselves from viruses that are harmful to tumors but not to healthy cells. These findings could lead to improved viral treatments for the disease. (2020-06-01)

New effective treatment for inflammatory diseases found
New research conducted by the University of Liverpool and AKL Research and Development Ltd (AKLRD), published in Inflammopharmacology, highlights the potential benefits of a new drug treatment on the human body's immune response in inflammation. (2020-06-01)

New testing system predicts septic shock outcomes
PME professor Savas Tay and his collaborators have developed a new, extremely sensitive method that can quantify bacteria, an antibiotic resistant gene, and immune molecule levels within sepsis patients, far more rapidly than current protocols. (2020-05-26)

Adding a blend of spices to a meal may help lower inflammation
Penn State researchers found that adding six grams of spices to a meal high in fat and carbohydrates resulted in lower inflammation markers hours later. (2020-05-21)

Preventing 'cytokine storm' may ease severe COVID-19 symptoms
A clinical trial in people with the new coronavirus is testing a drug that may halt an overactive immune response before it ramps up. (2020-05-21)

Research Brief: A new approach to averting inflammation caused by COVID-19
U of M Twin Cities student Molly Gilligan studies the body's inflammatory response to the SARS-CoV-2. (2020-05-12)

Vitamin D linked to low virus death rate -- Study
A new study has found an association between low average levels of vitamin D and high numbers of COVID-19 cases and mortality rates across 20 European countries. (2020-05-07)

Cytokine storms and T cell counts may offer clues on how to treat COVID-19
Researchers in China found that patients with COVID-19 had significantly low T cell counts, along with a high concentration of cytokines. This study suggests that coronavirus does not attack T cells directly, but rather triggers a cytokine storm, an excessive inflammatory response that drives the depletion and exhaustion of T cells. The findings offer clues on how to target treatment for COVID-19. (2020-05-01)

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