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Current DNA Analysis News and Events, DNA Analysis News Articles.
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DNA origami enables fabricating superconducting nanowires
In AIP Advances, researchers describe how to exploit DNA origami as a platform to build superconducting nanoarchitectures. The structures they built are addressable with nanometric precision that can be used as a template for 3D architectures that are not possible today via conventional fabrication techniques. Inspired by previous works using the DNA molecule as a template for superconducting nanowires, the group took advantage of a recent bioengineering advance known as DNA origami. (2021-01-19)

Coercive collection of DNA is unethical and damaging to the future of medical research
The compulsory collection of DNA being undertaken in some parts of the world is not just unethical, but risks affecting people's willingness to donate biological samples and thus contribute to the advancement of medical knowledge and the development of new treatments, says a paper in the European Journal of Human Genetics. (2021-01-18)

Not as simple as thought: How bacteria form membrane vesicles
Researchers from the University of Tsukuba identified a novel mechanism by which bacteria form membrane vesicles, which bacteria employ to communicate with each other or to defend themselves against antibiotics. By studying mycolic acid-containing bacteria (MCB), which also includes tuberculosis-causing bacteria, the researchers demonstrated that environmental stimuli dictate the route by which the MCB form membrane vesicles. Further, their observations were consistent among various MCB. This study has implications for vaccine development as well as novel therapies. (2021-01-14)

Reverse engineering 3D chromosome models for individual cells
A new computational technique that uses heat map data to reverse engineer highly detailed models of chromosomes and researchers have uncovered new information about the close spatial relationships that chromatin folding creates between genes. (2021-01-14)

New molecular structures associated with ALS
Researchers from the University of Seville and the University of Pavia have identified a link between Amyotrophic Lateral Sclerosis (ALS) and the accumulation of DNA-RNA hybrids in the genome. The accumulation of these hybrids causes increased genomic damage and boosts genetic instability. This finding will make it possible to better understand the molecular basis of the disease, as well as to propose new solutions to curb it. (2021-01-13)

Study finds neglected mutations may play important role in autism spectrum disorder
Mutations that occur in certain DNA regions, called tandem repeats, may play a significant role in autism spectrum disorders, according to research led by Melissa Gymrek, assistant professor in the UC San Diego Department of Computer Science and Engineering and School of Medicine. The study, which was published in Nature on Jan. 14, was co-authored by UCLA professor of human genetics Kirk Lohmueller and highlights the contributions these understudied mutations can make to disease. (2021-01-13)

Ancient DNA reveals secrets of Game of Thrones wolves
Extinct dire wolves split off from other wolves nearly six million years ago and were only a distant relative of today's wolves, according to new research published in Nature. (2021-01-13)

Rare quadruple-helix DNA found in living human cells with glowing probes
New probes allow scientists to see four-stranded DNA interacting with molecules inside living human cells, unravelling its role in cellular processes. (2021-01-13)

A bucket of water can reveal climate change impacts on marine life in the Arctic
We know very little about marine life in the Arctic. Now researchers from the University of Copenhagen, among others, are trying to change that. They have shown that a simple water sample makes it possible to monitor the presence, migration patterns and genetic diversity of bowhead whales in an otherwise hard-to-reach area. The method can be used to understand how climate changes and human activities impact life in the oceans. (2021-01-12)

'Bespoke' analysis of DNA packaging sheds light on intricacies of the fundamental process
Researchers from Skoltech and their colleagues have optimized data analysis for a common method of studying the 3D structure of DNA in single cells of a Drosophila fly. The new approach allows the scientists to peek with greater confidence into individual cells to study the unique ways DNA is packaged there and get closer to understanding this crucial process's underlying mechanisms. (2021-01-12)

New method helps pocket-sized DNA sequencer achieve near-perfect accuracy 
Researchers have found a simple way to eliminate almost all sequencing errors produced by a widely used portable DNA sequencer (Oxford Nanopore Technologies' MinION device). (2021-01-12)

Biomarkers in fathers' sperm linked to offspring autism
Epigenetic biomarkers in human sperm have been identified that can indicate a propensity to father children with autism spectrum disorder. In the study, researchers identified a set of genomic features, called DNA methylation regions, in sperm samples from men who were known to have autistic children. Then in a set of blind tests, they were able to use the presence of these features to determine whether other men had fathered autistic children with 90% accuracy. (2021-01-11)

Antibiotic resistance from random DNA sequences
An important and still unanswered question is how new genes that cause antibiotic resistance arise. In a new study, Swedish and American researchers have shown how new genes that produce resistance can arise from completely random DNA sequences. The results have been published in the journal PLOS Genetics. (2021-01-08)

NIST publishes a beginner's guide to DNA origami
Jacob Majikes and Alex Liddle, researchers at the National Institute of Standards and Technology (NIST) who have studied DNA origami for years, have compiled the first detailed tutorial on the technique. (2021-01-08)

How effective are educational support programs for children with cancer?
As children undergo treatment for cancer, they may miss school and risk falling behind in their education. An analysis published in Pyscho-Oncology has examined the educational support programs provided to children with cancer. (2021-01-06)

Making therapeutic sense of antisense oligonucleotides
In a significant extension of their previous research work, researchers at Tokyo Medical and Dental University (TMDU) and Ionis Pharmaceuticals, USA, have devised a molecular structural modification that boosts the efficacy of antisense oligonucleotide-based drugs by replacing the RNA strand of a heteroduplex oligonucleotide with DNA. This advance expands the scope and clinical applicability of nucleic-acid therapeutics across an ever-widening swathe of intractable diseases including neurological disorders. (2021-01-05)

DeepTFactor predicts transcription factors
A joint research team from KAIST and UCSD has developed a deep neural network named DeepTFactor that predicts transcription factors from protein sequences. DeepTFactor will serve as a useful tool for understanding the regulatory systems of organisms, accelerating the use of deep learning for solving biological problems. (2021-01-05)

UCLA scientists develop high-throughput mitochondria transfer device
Scientists from the UCLA Jonsson Comprehensive Cancer have developed a simple, high-throughput method for transferring isolated mitochondria and their associated mitochondrial DNA into mammalian cells. (2020-12-29)

Switching DNA functions on and off by means of light
Biochemists at Münster University have developed a new strategy for controlling the biological functions of DNA (deoxyribonucleic acid) by means of light and therefore provide a tool to investigate processes which take place in cells. The results have been published in the journal Angewandte Chemie. (2020-12-28)

$3.9M project on self-deleting genes takes aim at mosquito-borne diseases
To control mosquito populations and prevent them from transmitting diseases such as malaria, many researchers are pursuing strategies in mosquito genetic engineering. A new Texas A&M AgriLife Research project aims to enable temporary ''test runs'' of proposed genetic changes in mosquitoes, after which the changes remove themselves from the mosquitoes' genetic code. (2020-12-28)

Discovery boosts theory that life on Earth arose from RNA-DNA mix
Chemists at Scripps Research have made a discovery that supports a surprising new view of how life originated on our planet. In a study published in the chemistry journal Angewandte Chemie, they demonstrated that a simple compound called diamidophosphate (DAP), which was plausibly present on Earth before life arose, could have chemically knitted together tiny DNA building blocks called deoxynucleosides into strands of primordial DNA. (2020-12-27)

Discovery of aging mechanism for hematopoietic stem cells
By transferring mouse aged hematopoietic stem cells (aged HSCs) to the environment of young mice (bone marrow niche), it was demonstrated that the pattern of stem cell gene expression was rejuvenated to that of young hematopoietic stem cells. (2020-12-24)

Ludwig Cancer Research study reveals how ecDNA forms and drives cancer drug resistance
Researchers led by Ludwig San Diego Member Don Cleveland and Peter Campbell of the Sanger Center have solved the mystery of how free-floating circular DNA fragments, which are almost exclusively found in cancer cells, drive gene amplification to generate drug resistance in cancer. (2020-12-23)

Researcher uses machine learning to demonstrate that DNA impacts cancer risk
University of Calgary researcher uses machine learning to demonstrate that DNA impacts cancer risk. Team identifies seven DNA fingerprints or patterns that define cancer risk. One of the seven germlines offers protection from developing cancer, and the other six germlines present a greater risk for cancer. It is the first time scientists have described these highly-specialized biological patterns applicable to cancer risk. Discovery refines the long-held views of why people get cancer. (2020-12-22)

Variety: Spice of life for bumble bees
The yield and quality of many crops benefit from pollination, but it isn't just honey bees that do this work: bumble bees also have a role. A team led by University of Göttingen used innovative molecular biological methods and traditional microscopy to investigate the pollen collecting behaviour of honey bees and bum-ble bees in agricultural landscapes. It turns out bumble bees take much more pollen from different plant species than honey bees to satisfy their need for protein. (2020-12-21)

The far-reaching effects of mutagens on human health
Mutagenic threats to a cell's subtle machinery may be far more widespread than previously appreciated. In a new study, Michael Lynch and his colleagues demonstrate that DNA mutation itself may represent only a fraction the health-related havoc caused by mutagens. The study highlights the ability of mutagenic compounds to also affect the process of transcription, during which a DNA sequence is converted (or transcribed) to mRNA, an intermediary stage preceding translation into protein. (2020-12-21)

Study tracks elephant tusks from 16th century shipwreck
In 1533, the Bom Jesus - a Portuguese trading vessel carrying 40 tons of cargo including gold, silver, copper and more than 100 elephant tusks - sank off the coast of Africa near present-day Namibia. The wreck was found in 2008, and scientists say they now have determined the source of much of the ivory recovered from the ship. (2020-12-17)

Researchers discover protein function that could improve chemotherapy in the future
A protein responsible for orchestrating DNA key signaling and repair pathways could play a role in future chemotherapy treatment for cancer patients. The protein's function has been described by researchers at University of Copenhagen. (2020-12-17)

HSE researchers use neural networks to study DNA
HSE scientists have proposed a way to improve the accuracy of finding Z-DNA, or DNA regions that are twisted to the left instead of to the right. To do this, they used neural networks and a dataset of more than 30,000 experiments conducted by different laboratories around the world. Details of the study are published in Scientific Reports. (2020-12-17)

Blocking DNA repair enzyme could help treat certain cancers
Researchers at the Francis Crick Institute have found a new way to prevent some tumours from repairing their own DNA, a function that is essential for cancer cell survival. This discovery could lead to much needed new treatments for certain types of the disease. (2020-12-16)

Rapid lateral flow immunoassay developed for fluorescence detection of SARS-CoV-2 RNA
Scientists from the Suzhou Institute of Biomedical Engineering and Technology have developed a novel amplification-free rapid SARS-CoV-2 nucleic acid detection platform based on hybrid capture fluorescence immunoassay (HC-FIA). (2020-12-10)

Within a hair's breadth--forensic identification of single dyed hair strand now possible
A single strand of hair in a crime scene contains many clues that can help identify a perpetrator. In a recent study, scientists at Tokyo University of Science, Japan, have combined two modern techniques, called surface-enhanced Raman spectroscopy and X-ray fluorescence, to distinguish between different colors in individual hair strands. Both these techniques are almost non-destructive and can be conducted with portable devices, making this a promising way to get supportive evidence in forensic investigations. (2020-12-09)

Bacterial nanopores open the future of data storage
Bioengineers at EPFL have developed a nanopore-based system that can read data encoded into synthetic macromolecules with higher accuracy and resolution than similar methods on the market. The system is also potentially cheaper and longer-lasting, and overcomes limitations that prevent us from moving away from conventional data storage devices that are rapidly maxing out in capacity and endurance. (2020-12-09)

New and unexplored dimension in the study of protein-protein interactions
Cells accumulate glutamate and related molecules under stress, and so formation of high-order protein assemblies under these conditions has important biological implications. Specifically, this would represent a mechanism by which the presence of stressor compounds in the cell could control DNA replication. (2020-12-09)

New findings shed light on the repair of UV-induced DNA damage
A repair system in our cells fixes DNA damage caused by exposure to ultraviolet (UV) light from the sun, however the detailed process behind this is not fully understood. An international research team led by Professor Sugasawa at Kobe University's Biosignal Research Center has clarified the regulatory mechanism of the ubiquitin-proteasome system in recognizing and repairing UV-damaged DNA. This new discovery will contribute towards illuminating the onset mechanisms of diseases such as skin cancer. (2020-12-08)

Research sheds new light on cause of deadly lung disease
New research could shed light on the mystery cause of a lung disease that is a major killer, and potentially unlock new treatments (2020-12-08)

New cost-effective technique facilitates study of non-bacterial plant microbiomes
Thanks to a new technique developed by plant pathologists in Connecticut, scientists now have access to an affordable and effective tool to facilitate the study of the entire non-bacterial microbiomes of any plant species. (2020-12-08)

The world's first DNA 'tricorder' in your pocket
Cold Spring Harbor Laboratory scientists have built the first mobile genome sequence analyzer, making DNA analysis portable and accessible anywhere in the world. (2020-12-07)

Circulating tumor DNA indicates risk of relapse after transplant in DLBCL patients
Many patients with diffuse large B-cell lymphoma (DLBCL) can be cured by a transplant using their own blood-forming stem cells, but as many as half eventually relapse. New research led by Dana-Farber Cancer Institute scientists suggests that patients whose blood or stem cell samples harbor tumor DNA are likely to relapse. (2020-12-07)

How to use antibodies to control chemical reactions
In a collaborative effort a group of international scientists has recently demonstrated a way to control different synthetic chemical reactions with specific antibodies. Their work has been now published in Nature Communications. (2020-12-07)

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