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Current DNA Analysis News and Events, DNA Analysis News Articles.
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NUS study: RNA defects linked to multiple myeloma progression in high risk patients
Researchers from the Cancer Institute of Singapore (CSI Singapore) at the National University of Singapore have uncovered an association between RNA abnormalities and MM progression. (2018-10-31)

Biologists discover source for boosting tumor cell drug sensitivity
Biologists at UC San Diego have discovered a new way of re-sensitizing drug-resistant human tumor cells to the potency of DNA-damaging agents, the most widely used group of cancer drugs. In a new study, they describe how a human gene known as Schlafen 11 controls the sensitivity of tumor cells to DDAs. Their research may pave the way to new strategies to overcome chemotherapeutic drug resistance. (2018-10-29)

Novel quantum dots enhance cell imaging
A team of researchers from the University of Illinois at Urbana-Champaign and Mayo Clinic have engineered a new type of molecular probe that can measure and count RNA in cells and tissue without organic dyes. The probe is based on the conventional fluorescence in situ hybridization (FISH) technique, but it relies on compact quantum dots to illuminate molecules and diseased cells rather than fluorescent dyes. (2018-10-29)

Repeated interferon stimulation creates innate immune memory
The innate immune system may be able to be trained to react to viral infections more efficiently by repeated exposure to anti-viral signaling molecules. (2018-10-25)

DNA 'dances' in first explanation of how genetic material flows through a nucleus
DNA flows inside a cell's nucleus in a choreographed line dance, new simulations reveal. The finding is the first large-scale explanation of genetic material moving within a working cell. The dancing DNA may play a role in gene expression, replication and remodeling. (2018-10-25)

Mapping the chromatin landscape of human cancer
By mapping the largely uncharted chromatin landscape of primary human cancers, researchers have revealed new insights into the regulation of different cancer-related genes. (2018-10-25)

Nanocages in the lab and in the computer: how DNA-based dendrimers transport nanoparticles
How to create nanocages, i.e., robust and stable objects with regular voids and tunable properties? Short segments of DNA molecules are perfect candidates for the controllable design of novel complex structures. Physicists investigated methodologies to synthesize DNA-based dendrimers in the lab and to predict their behavior using detailed computer simulations. Their results are published in the high-impact journal Nanoscale. (2018-10-18)

Smallest life forms have smallest working CRISPR system
Bacteria and Archaea have developed many types of CRISPR-Cas systems to protect themselves from viruses. A search through metagenomic databases of microbes, many of them uncultivatable, unearthed the genes of the smallest known working Cas complex, Cas14, from the genome of a DPANN Archaea, a group of microbes with the smallest known geomes. Cas14 is being incorporated into a CRISPR diagnostic called DETECTR. (2018-10-18)

Loss of protein p53 helps cancer cells multiply in 'unfavourable' conditions
Researchers have discovered a novel consequence of loss of the tumour protein p53 that promotes cancer development. (2018-10-17)

Outbreak of multidrug-resistant tuberculosis undetected by standard tests
Amid a plan announced by the United Nations to eradicate tuberculosis by 2030, a new study has revealed the emergence of multidrug-resistant strains of the disease which go undetected by WHO-endorsed tests. These findings, from an international research team co-directed by CNRS researcher Philip Supply are published in the Oct. 17, 2018 edition of The Lancet Infectious Diseases. (2018-10-17)

Immune health maintained by meticulously ordered DNA
Walter and Eliza Hall Institute researchers have revealed how immune health is maintained by the exquisite organisation skills of a protein called Pax5. (2018-10-15)

Parasites from medieval latrines unlock secrets of human history
A radical new approach combining archaeology, genetics and microscopy can reveal long-forgotten secrets of human diet, sanitation and movement from studying parasites in ancient poo, according to new Oxford University research. (2018-10-15)

Clues from a Somalian cavefish about modern mammals' dark past
After millions of years living in darkness, a species of blind cavefish has lost an ancient system of DNA repair. That DNA repair system, found in organisms including bacteria, fungi, plants, and most other animals, harnesses energy from visible light to repair DNA damage induced by ultraviolet (UV) light. The findings reported in journal Current Biology on Oct. 11 are intriguing in part because only placental mammals were previously known to lack this system. (2018-10-11)

How yeast cells detect genetic infections
ETH researchers studying yeast cells have discovered a surprisingly located new mechanism for detecting foreign genetic material -- whether from pathogens or environmental contamination -- and rendering it harmless. (2018-10-11)

Computational model links family members using genealogical and law-enforcement databases
The notion of using genetic ancestry databases to solve crimes recently crossed from hypothetical into credible when police used an online genealogical database to track down the alleged Golden State Killer, a serial criminal who terrorized much of California in the 1970s and 1980s. Now, in a study published Oct. 11 in Cell, researchers are reporting ways in which that type of inquiry could potentially be expanded. (2018-10-11)

New route of acquiring antibiotic resistance in bacteria is the most potent one to date
For the first time in 60 years, researchers at NUS Medicine and the University of Glasgow and colleagues have discovered a new mechanism of genetic transduction, the process by which bacteriophages transfer bacterial DNA between bacteria. As described in Science, this new mechanism (lateral transduction) is the most powerful to date, able to transfer large DNA stretches at high frequencies. It likely plays a major role in bacterial evolution and acquisition of antibiotic resistance. (2018-10-11)

Crime and privacy: Using consumer genomics to identify anonymous individuals
Over 60 percent of individuals in the US with European ancestry -- including those that have not undergone genetic testing themselves -- can be identified through their DNA using data from open genetic genealogy databases, a new study reports. (2018-10-11)

Bacterial DNA gets passed around in viral packages -- in greater amounts than previously
Bacteria's ability to exchange genes amongst each other may occur more frequently and involve the transfer of even more genetic material than previously believed, a new study suggests. (2018-10-11)

Mayo Clinic researchers identify gene types driving racial disparities in myeloma
Researchers at Mayo Clinic have identified three specific gene types that account for a known two-to-three-fold increase in myeloma diagnoses among African-Americans. Researchers also demonstrated the ability to study race and racial admixture more accurately using DNA analysis. The findings were published today in Blood Cancer Journal. (2018-10-10)

There's a better way to decipher DNA's epigenetic code to identify disease
A new method for sequencing the chemical groups attached to the surface of DNA is paving the way for better detection of cancer and other diseases in the blood. These chemical groups mark one of the four DNA 'letters' in the genome, and it is differences in these marks along DNA that control which genes are expressed or silenced. (2018-10-08)

Genes responsible for difference in flower color of snapdragons identified
Snapdragons are tall plants, and flower in a range of colors. In Spain, where snapdragons grow wild, these flower colors show a remarkable pattern: areas of magenta and yellow blooming flowers are separated by just a two kilometer long stretch in which flower colors mix. Writing in today's edition of PNAS, scientists report that they investigate the causes of this pattern and identified the genes responsible for flower color difference from DNA sequence data. (2018-10-08)

Study shows DNA of people with childhood abuse or depression ages faster
DNA from people who suffer from major depression is biologically older than that of healthy people by on average 8 months, suggesting that they are biologically older than their corresponding calendar age. This effect was greater in people who have had childhood trauma, such as violence, neglect or sexual abuse, who show a biological age around a year older than their actual age. This work is presented at the ECNP conference in Barcelona. (2018-10-08)

Nanopore technology with DNA computing easily detects microRNA patterns of lung cancer
Researchers at Tokyo University of Agriculture and Technology (TUAT) have developed a simple technique that allows detection of two independent microRNAs as an early diagnosis marker of Small Cell Lung Cancer (SCLC) , which is very aggressive. In this technique, they combined nanopore and DNA computing technologies as rapid and label-free detection. This method, therefore, could help to identify SCLC in the early stage. (2018-10-05)

UTMB develops a universal vaccine platform that's cheaper and shelf stable
Researchers at The University of Texas Medical Branch at Galveston have developed less expensive way to produce vaccines that cuts the costs of vaccine production and storage by up to 80 percent without decreasing safety or effectiveness. The findings are currently available in EBioMedicine. (2018-10-05)

Scientists use prenatal testing samples to complete the largest genetic study yet in China
Researchers have sequenced the genomes of over 140,000 women in China, the largest-scale genetic analysis of Chinese people to date, using data from non-invasive prenatal testing (NIPT) to assemble a representative sample of the whole population. The proof-of-concept analysis, still underway, could reveal new information about migration patterns, traits under selective pressure, and disease risk in Chinese populations. The work, from BGI-Shenzhen, appears Oct. 4 in the journal Cell. (2018-10-04)

Tales from 141,430 and one genomes
Non-invasive prenatal testing potentially provides a wealth of genetic information, but the quality of the DNA sequencing is poor -- only about 10 percent coverage per genome. Nevertheless, scientists led by Rasmus Nielsen at UC Berkeley now show that with enough genomes -- in this case, 141,431 -- it is possible to find genetic variants linked with human traits, including birth outcomes and susceptibility to infectious disease. Such statistical analyses can even by used to track migration patterns. (2018-10-04)

Why huskies have blue eyes
DNA testing of more than 6,000 dogs has revealed that a duplication on canine chromosome 18 is strongly associated with blue eyes in Siberian Huskies, according to a study published Oct. 4, 2018, in the open-access journal PLOS Genetics by Adam Boyko and Aaron Sams of Embark Veterinary, Inc., and colleagues. (2018-10-04)

Discovery of first genetic variants associated with meaning in life
For the first time, locations on the human genome have been identified that can explain differences in meaning in life between individuals. This is the result of research conducted in over 220,000 individuals by Professor Meike Bartels and PhD student Bart Baselmans from the Vrije Universiteit Amsterdam. The researchers identified two genetic variants for meaning in life and six genetic variants for happiness. The results were published this week in the scientific journal Scientific Reports. (2018-10-03)

Recording device for cell history
ETH researchers are using the CRISPR-Cas system to develop a novel recording mechanism: the snippets of DNA it produces can provide information about certain cellular processes. In future, this cellular memory might even be used in diagnostics. (2018-10-03)

Can we trust digital forensic evidence?
Research carried out at the University of York has suggested that more work is needed to show that digital forensic methods are robust enough to stand-up to interrogation in a court of law. (2018-10-02)

Take my hand and ride with me -- Over the genome
Researchers at the CRG in Barcelona have identified the mechanism by which an important enzyme involved in the differentiation of stem cells is brought to the DNA. Their results describe a new way in which proteins interact with the genome, a novel approach that shakes up our previous knowledge in the field. The work sheds light on fundamental processes such as the formation of pluripotent stem cells and expands our understanding of blood cancer (2018-10-02)

Ciprofloxacin has dramatic effects on the mitochondrial genome
A study carried out at the University of Eastern Finland and published in Nucleic Acids Research investigated the effect of ciprofloxacin on mitochondria, the important cell organelles in our body that produce the energy for cellular function. Ciprofloxacin stopped normal maintenance and transcription of mitochondrial DNA by changing mtDNA topology, causing impaired mitochondrial energy production and blocking cellular growth and differentiation. (2018-10-01)

Unveiling the mechanism protecting replicated DNA from degradation
Researchers from Tokyo Metropolitan University and the FIRC Institute of Molecular Oncology (IFOM) in Italy have succeeded in depleting AND-1, a key protein for DNA replication, by using a recently developed conditional protein degradation system. Consequently, they were able to gain unprecedented access to the mechanism behind how AND-1 works during DNA replication and cell proliferation in vertebrate cells, demonstrating that AND-1 has two different functions during DNA replication mediated by different domains of AND-1. (2018-09-29)

Discovery paves way for improved ovarian cancer care
A new ovarian cancer study could help to better match patients with the appropriate therapy for their cancer. The research identified important epigenetic differences among ovarian cancer patients that could influence their response to treatment. There is no 'one size fits all' approach for treating ovarian cancer so being able to offer personalised care is crucial for patient survival rates which have seen little improvement over 30 years. (2018-09-28)

Mitochondrial diseases could be treated with gene therapy, study suggests
Researchers have developed a genome-editing tool for the potential treatment of mitochondrial diseases: serious and often fatal conditions which affect 1 in 5,000 people. (2018-09-24)

Thousands of DNA changes in the developing brain revealed by machine learning
Scientists at Sanford Burnham Prebys Medical Discovery Institute (SBP) have developed new single-cell approaches wedded to machine learning that allow detection of CNVs below one million base pairs. This has revealed thousands of previously unknown DNA changes arising during prenatal life in the developing mouse brain. The researchers also identified when these changes peaked: evidence that potential regulatory mechanisms -- which remain unknown -- are involved. The study published today in PNAS. (2018-09-24)

New research reveals a mitochondrial gene that protects against Alzheimer's disease
New research from USC has uncovered a previously unknown genetic risk factor for Alzheimer's disease and related dementias. The study provides insights on how these conditions, and other diseases of aging, might one day be treated and prevented. (2018-09-21)

Scientists crack genetic code of cane toad
A group of scientists from UNSW Sydney, the University of Sydney, Deakin University, Portugal and Brazil have unlocked the DNA of the cane toad, a poisonous amphibian that is a threat to many native Australian species. The findings were published in academic journal GigaScience today. (2018-09-19)

Viral RNA sensing
Even tiny amounts of viruses can have disastrous consequences. RNA identification can reveal the type of virus present. A fast and sensitive technique based on optical detection has now been outlined in the journal Angewandte Chemie. Scientists from Germany and Finland have demonstrated the binding of an RNA target to a probe made of gold nanorods and a DNA origami structure. Chirality switches triggered by binding can be measured by circular dichroism spectroscopy. (2018-09-19)

Productive interaction
'ChemLife' research initiative at the University of Konstanz makes an quintessential contribution to study of DNA polymerases. (2018-09-18)

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