Current Disease Therapy News and Events | Page 3

Current Disease Therapy News and Events, Disease Therapy News Articles.
Sort By: Most Relevant | Most Viewed
Page 3 of 25 | 1000 Results
Engineered capsids for efficient gene delivery to the eye
A rational design approach created novel variants of adeno-associated viral (AAV) capsids. These have improved transduction properties in the mouse retina and cornea. (2020-08-13)

Age, education, and surgical history affect hormone use after oophorectomy
CLEVELAND, Ohio (August 12, 2020)--Removal of the ovaries before natural menopause (surgical menopause) often exacerbates menopause symptoms and places women at increased risk for heart disease, osteoporosis, and cognitive decline. A new study identified the frequency of hormone therapy (HT) use and factors that determine who is more likely to use hormones after oophorectomy to manage symptoms. Study results are published online today in Menopause, the journal of The North American Menopause Society (NAMS). (2020-08-12)

Gene therapy targets inner retina to combat blindness
Batten disease is a group of fatal, inherited lysosomal storage disorders that predominantly affect children. The most prevalent form is CLN3 disease, for which there is no cure. Retinal degeneration and resulting vision loss is one of the symptoms. (2020-08-10)

COVID-19 may cause deadly blood clots
COVID-19 may increase the risk of blot cots in women who are pregnant or taking estrogen with birth control or hormone replacement therapy, according to a new manuscript published in the Endocrine Society's journal, Endocrinology. (2020-07-29)

Fracture risk associated with bisphosphonate drug holidays
Bisphosphonates have been shown to reduce the risk of osteoporotic fractures. To avoid possible side effects of long-term therapy, many patients take a drug holiday after several years of bisphosphonate therapy. Researchers have examined the implications of such drug holidays on fracture risk. They found that in patients who had previously suffered a vertebral fracture, a longer bisphosphonate drug holiday was associated with an increase in the risk of so-called major osteoporotic fractures. (2020-07-29)

'Good' virus for common infection
Australian researchers have shown how viruses can be used to save lives, developing the potential use of bacteriophages in bandages to treat life-threatening golden staph infections which may not respond to traditional antibiotics. Targeting multidrug-resistant Staphylococcus aureus ('golden staph') in diabetic foot ulcers, Flinders University microbiology researchers have joined infectious diseases and pharmaceutical partners to show the usefulness of a possible 'phage cocktail' therapy on wound infections. (2020-07-29)

Traditional PTSD therapy doesn't trigger drug relapse
Johns Hopkins researchers have now demonstrated that behavior therapy that exposes people to memories of their trauma doesn't cause relapses of opioid or other drug use, and that PTSD severity and emotional problems have decreased after the first therapy session. (2020-07-20)

Researchers identify possible drug target for prostate cancer
Researchers from Boston University School of Medicine (BUSM) have discovered that the protein BRD4 could be an important new target to prevent castration-resistant prostate cancer metastases. (2020-07-20)

Therapy delivered electronically more effective than face to face: Hamilton researchers
In this evidence review, researchers identified 17 randomized control trials comparing therapist-supported cognitive behavioural therapy delivered electronically to face to face cognitive behavioural therapy. The studies were conducted between 2003 and 2018 in the United States, Australia, Netherlands, Switzerland, Sweden and the United Kingdom (2020-07-08)

Diabetic nephropathy: Study results on proteomic analysis do not show benefit
First study on a treatment strategy using a proteomic analysis does not clarify which therapeutic consequence of the test could offer a benefit for people with diabetes and high blood pressure. (2020-07-06)

New Human Gene Therapy editorial: Concern following gene therapy adverse events
Response to the recent report of the deaths of two children receiving high doses of a gene therapy vector (AAV8) in a Phase I trial for X-linked myotubular myopathy (MTM). The news ''is a tragic reminder of how difficult it is to predict outcomes in first-in-human studies (2020-07-02)

Pilot study suggests Parkinson's disease progression can be slowed
Deep Brain Stimulation (DBS) implanted in early stage Parkinson's disease decreases the risk of disease progression and the need to prescribe multiple drugs to patients simultaneously, according to a five-year outcomes study of 30 patients released in the July 2020, issue of Neurology®, the medical journal of the American Academy of Neurology. (2020-06-29)

External ultrasound therapy of calcific aortic stenosis -- First-in-man
Cardiawave (France) has developed a Non-Invasive Ultrasound Therapy (NIUT) for the treatment of cardio-valvular diseases such as aortic stenosis. This is the primary valve disease in adults and one of the leading causes of cardiovascular death worldwide which affects 10 million people in Europe and the USA. (2020-06-25)

Routine revascularization vs. medical therapy: Meta-analysis and review
Revascularization is often performed in patients with stable ischemic heart disease (SIHD). However, whether revascularization reduces death and other cardiovascular outcomes is uncertain. Cumulative evidence from this meta-analysis of randomized trials, including the recently published ISCHEMIA... (2020-06-25)

Existing drugs may limit damage caused by HIV
Yale researchers have identified four drugs that may help minimize the long-term health effects of HIV infection, they report June 23 in the Journal of Clinical Investigation. (2020-06-23)

EULAR: Early and intensive treatment of rheumatoid arthritis reduces fatigue
Disease-related, profound fatigue impairs the quality of life of many people with rheumatic and musculoskeletal diseases. A Belgian study (1) has now concluded that early intensive treatment combining methotrexate with a bridging scheme of prednisone can reduce the onerous fatigue. European League against Rheumatism (EULAR) therefore recommends, that even in so-called low-risk patients, early consideration should be given to whether intensive treatment should be initiated. (2020-06-17)

Off-the-shelf tool for making mouse models of COVID-19
Researchers at the University of Iowa and Medical University, Guangzhou, in China, have created a gene therapy vector that is essentially an off-the-shelf tool that allows labs to create their own COVID-19 mouse model within a matter of days. This simple tool could help overcome a major research hurdle -- the lack of good, widely available animal models for developing and testing new anti-viral therapies and vaccines for COVID-19. (2020-06-16)

First report of systemic delivery of micro-dystrophin gene therapy in children with DMD
Researchers from Nationwide Children's Hospital have published in JAMA Neurology results from the first four patients treated in the first clinical trial of systemic delivery of micro-dystrophin gene therapy in children with Duchenne muscular dystrophy (DMD) -- and initial findings suggest that the therapy can provide functional improvement that is greater than that observed under the standard of care. (2020-06-15)

Case series: Teriflunomide therapy in COVID-19 patients with MS
Co-authors present the cases of five multiple sclerosis patients who developed COVID-19 infection while taking the oral disease-modifying therapy teriflunomide and continued taking the medication. All five patients had favorable outcomes, with their COVID-19 taking a mild course and without experiencing relapse of their MS. (2020-06-12)

Scientists rescue mini retinas from eye disease via new gene therapy approach
Scientists have developed a new gene therapy approach that offers tremendous promise for one day treating an eye disease that leads to blindness and affects thousands of people across the globe. (2020-06-11)

Fewer complications after organ transplantation
A large international study coordinated by University Hospital Regensburg and Charité - Universitätsmedizin Berlin has demonstrated the safety of new cell therapy approaches for use in kidney transplant recipients. Transplant recipients were shown to require lower levels of immunosuppression in order to prevent organ rejection. This reduces the risk of side effects such as viral infections. Results from this study have been published in The Lancet.* (2020-06-10)

Oncotarget: The role of EGFR mutations in predicting recurrence in lung adenocarcinoma
Volume 11, Issue 22 of @Oncotarget reported that while lobectomy can improve mortality in this group, about 30 55% of patients will experience disease recurrence. (2020-06-10)

Serious complication of Crohn's disease may be preventable in young people
For children and young adults with Crohn's disease, steroid-sparing therapies may help reduce the risk of developing a severe and common complication of the inflammatory bowel condition, a new study suggests. (2020-06-09)

Photodynamic therapy used to treat ovarian cancer
Photodynamic therapy (PDT) is one of the most promising methods of treating localized tumors. PDT can be used for treatment in almost all major locations as an independent method or in combination with traditional types of treatment (surgery, radiation, and chemotherapy). (2020-06-08)

Prophylaxis after relapse of ANCA-associated vasculitis
Relapses are not uncommon in ANCA-associated vasculitis (AAV). The disease can cause severe injury to kidneys and other organs, even death. After a relapse, there is an increased risk of further relapses, so there is an urgent need for the most effective relapse prevention strategy. The RITAZAREM study impressively demonstrated that the monoclonal antibody rituximab is superior to conventional therapy with azathioprine following relapse. (2020-06-07)

Systemic lupus erythematosus (SLE)
If renal remission is achieved therapeutically in cases of lupus nephritis (LN), the 10-year survival rate increases significantly. Successful therapy is therefore of great importance. As a recent presentation at the ERA-EDTA Congress showed, this can be achieved by additional administration of belimumab. (2020-06-07)

A Genethon team has succeeded in inhibiting the immune response linked to AAV
A research team from Genethon, in collaboration with teams from CNRS/Inserm and from the biotechnology company Spark Therapeutics, announced today in Nature Medicine that it has succeeded in inhibiting the immune response induced by AAV antibodies present as a result of natural immunity or following gene therapy, thanks to the IdeS enzyme. This result opens up new therapeutic prospects and the possibility of treating more patients. (2020-06-05)

Obstructive sleep apnoea: Mandibular advancement device helps against daytime sleepiness
Obstructive sleep apnoea: mandibular advancement device helps against daytime sleepiness In obstructive sleep apnoea, wearing a plastic splint in the mouth at night to keep the airways open mechanically is about as effective as positive airway pressure therapy with a sleep mask. (2020-06-03)

Thyroid dysfunction in pregnancy being overdiagnosed, overtreated
The current practice of testing most pregnant women for thyroid stimulating hormone (TSH) may be leading to overdiagnosis and overtreatment, according to new research in CMAJ (Canadian Medical Association Journal). http://www.cmaj.ca/lookup/doi/10.1503/cmaj.191664 (2020-06-01)

New study sheds light on IBD patients with COVID
The researchers conclude that increasing age, comorbidities, and corticosteroids are associated with severe COVID-19 among IBD patients. Notably, TNF antagonists do not appear to be associated with severe COVID-19. (2020-05-18)

Cell therapy treatment for cardiac patients with microvascular dysfunction provides enhanced quality
Trial results presented today revealed a promising therapy for patients experiencing angina due to coronary microvascular dysfunction (CMD). The results of the study were presented today as feature clinical research during the SCAI 2020 Scientific Sessions Virtual Conference. (2020-05-14)

EULAR 2020
Breast cancer patients don`t have an increased risk of developing rheumatoid arthritis. (2020-05-13)

Arthritis clinical trial shows support for dextrose injection to alleviate knee pain
A randomized controlled trial conducted by a research team at a primary care clinic at the Chinese University of Hong Kong indicates that intra-articular-only injection therapy with hypertonic dextrose is safe and effective for alleviating symptoms of knee osteoarthritis. (2020-05-12)

Cognitive therapy can help treat anxiety in children with autism
Cognitive behavioural therapy and other psychosocial interventions are effective for treating anxiety in school-aged children with autism spectrum disorder, according to an analysis of all relevant studies published in 2005-2018. The findings are published in Campbell Systematic Reviews. (2020-05-06)

Gas nanomedicine: An emerging cutting-edge field
Several therapeutic gases are quite helpful for treatment of many inflammation-related diseases including cancer, but also exhibit some shortcomings such as limited therapy efficacy. Gas nanomedicine appears as an emerging cutting edge of nanomaterials and gas medicine, raising urgent demand on nanomaterials to address the issues of gas medicine. Scientists based in China propose a series of strategies of engineering advanced gas-releasing nanomedicines, and envisage current trends and future directions of gas-releasing nanomedicines for anticancer. (2020-05-06)

Killing 'sleeper cells' may enhance breast cancer therapy
The anti-cancer medicine venetoclax could improve the current therapy for estrogen receptor-positive (ER+) breast cancer - the most common form of breast cancer in Australia - according to preclinical studies led by Walter and Eliza Hall Institute researchers. The promising preclinical results for this 'triple therapy' have underpinned a phase 1 clinical trial in Melbourne, Australia, that is combining venetoclax with hormone therapy and CDK4/6 inhibitors in patients with ER+ breast cancer. (2020-05-06)

KU Leuven researchers unravel protein mystery of three brain diseases
The accumulation of one particular protein in the brain is at the basis of three very different age-related conditions. Until recently, nobody understood how this was possible. Research by the Laboratory for Neurobiology and Gene Therapy (KU Leuven) now reveals that the shape of the protein determines the clinical picture. (2020-04-29)

Study shows glaucoma could be successfully treated with gene therapy
A new study led by the University of Bristol has shown a common eye condition, glaucoma, could be successfully treated with a single injection using gene therapy, which would improve treatment options, effectiveness and quality of life for many patients. (2020-04-21)

Novel technology aims to improve treatment of neurological diseases
Researchers at Princeton University are developing new ''gene promoters'' - which act like switches to turn genes on - for use with gene therapy, the delivery of new genes to replace ones that are faulty. The new promoters work especially well for brain and other neurological disorders and provide longer-lasting functionality compared to other promoters. (2020-04-17)

A new treatment for liver cancer
In the latest issue of Molecular Therapy, Skoltech and MIT researchers have published a new combinatorial therapy for the treatment of liver cancer. (2020-04-17)

Page 3 of 25 | 1000 Results
   First   Previous   Next      Last   
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.