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Current Dopamine News and Events, Dopamine News Articles.
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Some "inactive" drug ingredients may not be inert
The inactive ingredients that make up a major component of drug formulations may not be as inactive as previously thought, researchers report. (2020-07-23)

The immune system facilitates alcohol addiction
The activation of the immune system could eventually perpetuate some of the deleterious effects of alcohol, like addiction. It is the conclusion of a research carried out by an international team led by Dr. Santiago Canals, from the Institute of Neurosciences in Alicante (Spain), a joint center of the Spanish National Research Council and the University Miguel Hernández in Elche, and Dr. Wolfgang Sommer, from the Central Institute of Mental Health of the University of Heidelberg (Germany). (2020-07-21)

Making balanced decisions
How decisions are made and how behavior is controlled is one of the most important questions in neuroscience. The neurotransmitter dopamine plays a central role in all of this. Scientists at the Technical University of Munich (TUM), together with researchers at the Max Planck Institute of Neurobiology, looked into the role that dopamine plays in the decision-making process and in controlling movement. (2020-07-15)

Study funded by ADDF finds dopamine therapy improves cognitive function in Alzheimer's
A study supported by the Alzheimer's Drug Discovery Foundation and published today in JAMA Network Open provides the first evidence that rotigotine, a drug that acts on dopamine transmission in the brain, improves cognitive function in patients with mild-to-moderate Alzheimer's disease. (2020-07-15)

A complex gene program initiates brain changes in response to cocaine
Researchers used single-nucleus RNA sequencing to compare transcriptional responses to acute cocaine in 16 unique cell populations from the brain nucleus accumbens. The atlas is part of a major study that used multiple cutting-edge technologies to describe a dopamine-induced gene expression signature that regulates the brain's response to cocaine. The study shows neurobiological processes that control drug-related adaptations and reveals new information about how transcriptional mechanisms regulate activity-dependent processes within the central nervous system. (2020-07-09)

Dopamine neurons mull over your options
Researchers at the University of Tsukuba have found that dopamine neurons in the brain can represent the decision-making process when making economic choices. As monkeys contemplated whether or not to choose an item, a subset of dopamine neurons transitioned from indicating the item's value to indicating the monkey's ultimate decision. Encoding of the decision into these dopamine neurons happened earlier than it did in other parts of the brain related to economic decision-making. (2020-07-07)

Molecular simulations show how drugs block key receptors
Many pharmaceuticals work by targeting what are known as ''G-protein-coupled receptors''. In a new study, scientists from Uppsala University describe how they have been able to predict how special molecules that can be used in new immunotherapy against cancer bind to these receptors. The researchers' calculation methods, presented in the journal Angewandte Chemie are a vital contribution to future structure-based drug design. (2020-06-24)

One-time treatment generates new neurons, eliminates Parkinson's disease in mice
UC San Diego researchers have discovered that a single treatment to inhibit a gene called PTB in mice converts native astrocytes, brain support cells, into neurons that produce the neurotransmitter dopamine. As a result, the mice's Parkinson's disease symptoms disappear. (2020-06-24)

Faulty brain processing of new information underlies psychotic delusions, finds new research
Problems in how the brain recognizes and processes novel information lie at the root of psychosis, researchers have found. Their discovery that defective brain signals in patients with psychosis could be altered with medication paves the way for new treatments for the disease. (2020-06-23)

UTEP researchers uncover brain mechanisms in fruit flies that may impact future learning
A research team from The University of Texas at El Paso has made strides in understanding how memories are formed through the brain mechanisms of fruit flies. Their findings could enhance our understanding of brain disorders such as post-traumatic stress disorder and substance addiction. (2020-06-23)

Stanford researchers develop artificial synapse that works with living cells
Researchers have created a device that can integrate and interact with neuron-like cells. This could be an early step toward an artificial synapse for use in brain-computer interfaces. (2020-06-15)

Viewing dopamine receptors in their native habitat
A new study led by UT Southwestern researchers reveals the structure of the active form of one type of dopamine receptor, known as D2, embedded in a phospholipid membrane. (2020-06-11)

Solving a Parkinson's disease puzzle through protein design
EPFL researchers, in collaboration with UTSW and UCSD scientists, have developed a computational protein design approach, and used it to obtain the first ever high-resolution structure of an activated dopamine receptor in its natural cell membrane environment. The breakthrough will open up a new dimension in drug discovery for Parkinson's disease and perhaps other disorders. (2020-06-11)

Dopamine signaling allows neural circuits to generate coordinated behaviors
As part of the study, the MIT research team invented a new open-source microscopy platform complete with a parts list and online instructions for other labs to build their own. (2020-06-11)

Antihistamines and similar drugs could slow down Huntington's disease
Scientists have described a potential new therapeutic strategy for slowing down early-stage Huntington's disease in a new study published today in eLife. (2020-06-09)

New discovery may lead to effective and natural treatment for Parkinson's disease
McLean Hospital researchers have identified two molecules naturally produced by the body that stimulate the production of dopamine, the molecule that is in short supply in the brains of patients with Parkinson's disease. (2020-06-04)

Some people are easily addicted to drugs, but others do not
Research team led by Prof. Joung-Hun Kim and Dr. Joo Han Lee of POSTECH and Dr. Ja Wook Koo of KBRI publishes new findings in Biological Psychiatry (2020-06-02)

Estrogen's role in the sex differences of alcohol abuse
Fluctuating estrogen levels may make alcohol more rewarding to female mice, according to new research in JNeurosci. Untangling the involved signaling pathways could unveil sex-based treatments for alcohol use disorders. (2020-06-01)

Does estrogen influence alcohol use disorder?
A new study from researchers at the University of Illinois at Chicago shows that high estrogen levels may make alcohol more rewarding to female mice. (2020-06-01)

New study shows how ketamine combats depression
The anaesthetic drug ketamine has been shown, in low doses, to have a rapid effect on difficult-to-treat depression. Researchers at Karolinska Institutet now report that they have identified a key target for the drug: specific serotonin receptors in the brain. Their findings, which are published in Translational Psychiatry, give hope of new, effective antidepressants. (2020-05-31)

Researchers examine data to identify optimal vasopressor treatment for rare type of stroke
Results of an Electronic Health Record (EHR) study assessing the most commonly used medications for raising blood pressure in patients with nontraumatic subarachnoid hemorrhage (SAH), a rare type of stroke, have been published in Neurosurgical Focus by scientists at The University of Texas Health Science Center at Houston (UTHealth). (2020-05-29)

Molecular pair offers potential for Parkinson's treatment, finds NTU Singapore-Harvard study
A promising molecular pair has offered hope that could lead to the development of a new treatment to slow down Parkinson's disease, a study by Nanyang Technological University, Singapore (NTU Singapore) and Harvard University has found. (2020-05-27)

Significant differences exist among neurons expressing dopamine receptors
An international collaboration, which included the involvement of the research team from the Institut de Neurociències of the UAB (INC-UAB), has shown that neurons expressing dopamine D2 receptors have different molecular features and functions, depending on their anatomical localization within the striatum. This research, conducted with mouse models and published in Nature Communications, opens the door to develop better treatments for diseases in which dopamine is altered, such as schizophrenia, addictions and Parkinson's disease. (2020-05-13)

Parkinson's dyskinesia mechanism explained
The mechanism underlying Parkinson's dyskinesia has been unknown, until now. An international collaboration led by Scripps Research, Florida has found a key cause, and with it, potentially, a new route to providing relief. (2020-05-01)

Schizophrenia drug combined with radiation shows promise in treating deadly brain tumors
UCLA researchers found adding a drug once commonly used to treat schizophrenia to traditional radiation therapy helped improve overall survival in mice with glioblastoma. (2020-05-01)

New study could lead to therapeutic interventions to treat cocaine addiction
A new study explains how cocaine modifies functions in the brain revealing a potential target for therapies aimed at treating cocaine addiction. The study was published this week in Cell Reports. (2020-04-22)

Development of attachable sticker-type rechargeable batteries
Dr. Yoon Hana at Korea Institute of Energy Research(KIER), Professor Kim Young-Jin at Korea Advanced Institute of Science and Technology(KAIST) and Professor Kim Seungchul at Pusan National University(PNU) jointly developed 're-attachable micro-supercapacitors(MSCs) using highly swollen laser-induced-graphene electrodes' and their research findings were listed in Chemical Engineering Journal, one of the world-renowned in the field. (2020-04-14)

Sweet as: The science of how diet can change the way sugar tastes
Researchers at the University of Sydney have discovered the basic science of how sweet taste perception is fine-tuned in response to different diets. While it has long been known that food can taste different based on previous experience, until now we didn't know the molecular pathways that controlled this effect. (2020-04-09)

Mount Sinai researchers discover a novel role for dopamine that impacts gene expression related to cocaine abuse
Scientists at the Icahn School of Medicine at Mount Sinai have discovered a new role for the brain chemical dopamine that is independent of classic neurotransmission. The new role appears to be critical to changes in gene expression related to chronic exposure to, or abuse of, cocaine, according to a study published Friday, April 10, 2020 in the journal Science. (2020-04-09)

Follow your gut
We may try to consciously make good food choices, but our bodies have their own way of weighing in. A new study reveals a learning mechanism orchestrated by the digestive and nervous systems that leads animals to actively seek out certain foods. These results are a step towards understanding how eating-related disorders, such as obesity, occur. (2020-04-06)

How dopamine drives brain activity
Using a specialized magnetic resonance imaging (MRI) sensor that can track dopamine levels, MIT neuroscientists have discovered how dopamine released deep within the brain influences distant brain regions. (2020-04-01)

Jumping genes help make neurons in a dish
The conversion of skin cells into brain cells relies on proper insertion of L1 elements. (2020-03-26)

Lactation changes how mom's neurons communicate -- but it's reversible
Lactation temporarily changes how a mother's neurons behave, according to new research in mice published in JNeurosci. (2020-03-23)

Ritalin and similar medications cause brain to focus on benefits of work, not costs
New research from cognitive neuroscientists at Brown and Radboud universities has pinpointed how stimulants such as Ritalin and Adderall can change people's motivation to complete difficult tasks. (2020-03-19)

A new window into psychosis
A recent study in mice led a team of researchers in Japan to believe that psychosis may be caused by problems with specialized nerve cells deep within the brain, as well as a certain kind of learning behavior. The researchers hope this could provide insight into the emergence of delusions in patients with psychosis or schizophrenia with the aim of finding ways to help them. (2020-03-18)

The need for speed
Scientists at the National Centre for Biological Sciences (NCBS), Bangalore show that parallel neural pathways that bypass the brain's tight frequency control enable animals to move faster. In their study, the scientists chose to study speed regulation in larval zebrafish during a reflex behaviour called the optomotor response. (2020-03-12)

Neuroscientists discover new structure of important protein in the brain
A novel structure of a so-called 'neurotransmitter: sodium symporter' has been mapped at the University of Copenhagen. The discovery adds to the researchers' knowledge of neurotransmitters in the brain and may lead to better drugs for, for example, ADHD, depression and epilepsy. (2020-03-06)

Researchers discover a previously unappreciated neurotransmitter system in the brain
Within this system, the transmission of signals between neurons in the brain occurs via the trace amine-associated receptor 5 (TAAR5). The results of the study will allow the development of new types of drugs for depression, schizophrenia and anxiety disorders. (2020-03-05)

Triglycerides control neurons in the reward circuit
Energy-dense food, obesity and compulsive food intake bordering addiction: the scientific literature has been pointing to connections between these for years. Scientists at the CNRS and Université de Paris have just shown for the first time how fatty nutrients act on the brain in the reward circuit. Published in Cell Metabolism on 5 March 2020, these results shed new light on the connection between food and eating disorders. (2020-03-05)

High sugar diet may impair metabolic health & maternal care after pregnancy
Rats on a high sugar diet during pregnancy have altered levels of sex steroid hormones and dopamine in their brains, which may lead to behavioural changes that can affect care of offspring and motivation, as well as increasing the risk of diabetes and liver disease, according to a study published in the Journal of Endocrinology. (2020-02-28)

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