Current Drug Delivery News and Events

Current Drug Delivery News and Events, Drug Delivery News Articles.
Sort By: Most Relevant | Most Viewed
Page 1 of 25 | 1000 Results
Targeted delivery of highly toxic anti-cancer drug to brain tumors
University of Houston biomedical researcher Sheeren Majd is reporting the development and testing of a new nano-carrier as a potential treatment to deliver highly toxic medicine to glioblastomas, the most common and aggressive form of primary brain tumors. (2021-02-23)

Dynamics of nanoparticles using a new isolated lymphatic vessel lumen perfusion system
Nanoparticles introduced into the body enter the lymphatic vessels. A research group led by Shinshu University Graduate School of Medicine has developed a new isolated lymphatic vessel lumen perfusion system that can move carbon nanotubes and other nanoparticles into surgically removed lymphatic vessels. The group succeeded in developing a novel experimental system to evaluate how nanoparticles move in lymphatic vessels and how they affect the physiological movement of lymphatic vessels. (2021-02-19)

Get a load of ZIF! Better delivery of cancer immunotherapy
An antibody loaded onto a porous metal organic framework is released by the acidic environment that surrounds tumors, avoiding the adverse effects of administering the antibody alone. (2021-02-11)

Ionic liquid uniformly delivers chemotherapy to tumors while destroying cancerous tissue
A Mayo Clinic team, led by Rahmi Oklu, M.D., Ph.D., a vascular and interventional radiologist at Mayo Clinic, in collaboration with Samir Mitragotri, Ph.D., of Harvard University, report the development of a new ionic liquid formulation that killed cancer cells and allowed uniform distribution of a chemotherapy drug into liver tumors and other solid tumors in the lab. This discovery could solve a problem that has long plagued drug delivery to tumors. (2021-02-11)

Scientists suggested using non-symmetrical magnets for target drug delivery
A team of scientists from Immanuel Kant Baltic Federal University and the University of Genoa suggested combining permanent magnets of different shapes to target magnetic particles with drugs at the organs of lab mice. Such a combination secured a magnetic driving force that was ten times stronger compared to regular cylindrical magnets. (2021-02-09)

Nanocarriers in the enhancement of therapeutic efficacy of natural drugs
https://doi.org/10.15212/bioi-2020-0040 Announcing a new article publication for BIO Integration journal. In this review article the authors Xiuling Li, Shunung Liang, Chee Hwee Tan, Shuwen Cao, Xiaoding Xu, Phei Er Saw and Wei Tao from Sun Yat-sen University, Guangzhou, China, Guangzhou University of Chinese Medicine, Guangzhou, China and Center for Harvard Medical School, Boston, MA, USA discuss the potential benefits of four plants endogenous to China and the enhancement of their therapeutic efficacy by nanotechnology intervention. (2021-02-09)

3D-printed bioresorbable airway stent
An ETH Zurich research team is using 3D printing to produce a new type of bioresorbable airway stent. This could greatly simplify the future treatment of upper airway obstruction. (2021-02-03)

Bottoms are up at the HIV Research for Prevention Virtual Conference
Researchers seeking to develop on-demand and behaviorally congruent HIV prevention options for anal sex are reporting the results of three early phase clinical trials of rectal microbicides at the HIV Research for Prevention Virtual Conference. The Phase I studies, led by the National Institutes of Health-funded Microbicide Trials Network, found both of two gel-based products well-tolerated, with higher doses of the active drugs likely required to provide protection from HIV and other sexually transmitted infections. (2021-02-02)

"Genetic SD-card": Scientists obtained new methods to improve the genome editing system
Researchers take a step in the development of genome editing technology. Currently it is possible to deliver genetic material of different sizes and structures to organs and tissues. This is the key to eliminating DNA defects and treating more patients. (2021-02-02)

Novel 3D printed stents deliver breakthrough treatment for oesophageal cancer
World-first 3D printed oesophageal stents developed by the University of South Australia could revolutionise the delivery of chemotherapy drugs to provide more accurate, effective and personalised treatment for patients with oesophageal cancer. (2021-02-02)

BU researchers identify promising therapeutic agent against melanoma
There have been great advances in treating melanoma over the past five years, however, even with these treatments many patients quickly develop drug resistance and die from their disease. A new study from Boston University School of Medicine (BUSM) has discovered that a drug (YK-4-279) that was previously created to target one specific type of protein has much broader use against a family of proteins that act to promote melanoma. (2021-02-01)

Accurate drug dosages with proton traps
Researchers at Linköping University, Sweden, have developed a proton trap that makes organic electronic ion pumps more precise when delivering drugs. The new technique may reduce drug side effects, and in the long term, ion pumps may help patients with symptoms of neurological diseases for which effective treatments are not available. The results have been published in Science Advances. (2021-01-29)

Medicaid expansion in New York has improved maternal health, study finds
A new Columbia University study has found that Medicaid expansion in 2014 in New York State was associated with a statistically significant reduction in severe maternal morbidity in low-income women during delivery hospitalizations compared with high-income women. The decrease was even more pronounced in racial and ethnic minority women than in White women. Until now there was little research on the link between ACA Medicaid expansion and maternal health outcomes. (2021-01-29)

How a cancer drug carrier's structure can help selectively target cancer cells
Porphyrins are interesting drug delivery vehicles that can specifically accumulate in cancer cells. However, how the structure of the drug-conjugated porphyrin affects its ability to penetrate and accumulate within cancer cells is not well understood. Researchers from Tokyo University of Science now investigate the correlation between the structure and tumor accumulation of porphyrin derivatives. Their findings can help to optimize drug delivery, possibly advancing cancer treatment. (2021-01-28)

Nanoparticle drug delivery technique shows promise for treating pancreatic cancer
Veterans Affairs researchers have designed a new way to deliver pancreatic cancer drugs that could make fighting the disease much easier. (2021-01-28)

'Smart' cartilage cells programmed to release drugs when stressed
Researchers at Washington University School of Medicine in St. Louis have engineered cartilage cells to release an anti-inflammatory drug in response to stresses such cells undergo when they are compressed during weight bearing and movement. (2021-01-27)

Gut microbiota reveals whether drug therapies work in inflammatory bowel diseases
A study recently completed at the University of Helsinki indicates that the gut microbiota of patients suffering from inflammatory gastrointestinal disorders can be used to predict whether they will benefit from expensive therapies. The study also confirms the key role of therapies that have a beneficial effect on the gut microbiota in inflammatory bowel diseases. (2021-01-26)

Targeted health messaging needed in era of vaping, researchers say
Health authorities should develop targeted health messages for vaping product and e-liquid packaging to encourage smokers to switch from cigarettes to e-cigarettes and to prevent non-smokers from taking up vaping, a researcher at the University of Otago, Wellington, New Zealand, says. (2021-01-26)

Titanium oxide nanotubes facilitate low-cost laser-assisted photoporation
Toyohashi University of Technology developed a nanosecond pulse laser-assisted photoporation method using titanium-oxide nanotubes (TNTs) for highly efficient and low-cost intracellular delivery. HeLa - human cervical cancer cells were cultured in the nanotubes and submerged in a solution of biomolecules. After cells were exposed to nanosecond pulse laser, we successfully delivered propidium iodide (PI) and fluorescent dextran into cells with high efficiency and cell viability. (2021-01-25)

3-D printed Biomesh minimizes hernia repair complications
A newly-designed 3D-printed Biomesh effectively minimized postsurgical complications of hernia repair in an animal model. (2021-01-25)

University of Cincinnati research unveils possible new combo therapy for head and neck cancer
Researchers at the University of Cincinnati have tested a new combination therapy in animal models to see if they could find a way to make an already effective treatment even better. Since they're using a Food and Drug Administration-approved drug to do it, this could help people sooner than later. (2021-01-22)

UTMB team proves potential for reducing pre-term birth by treating fetus as patient
The results of a study by researchers at the University of Texas Medical Branch may pave the way for a new medicine delivery system that could reduce the incidence of pre-term labor and premature birth by allowing physicians to treat the 'fetus as the patient'. The study has been published in Science Advances. (2021-01-22)

Drug-delivery microcapsules tagged with zirconium-89 can be tracked by PET imaging
Polymer and radionuclide chemists report major advance in microcapsule drug delivery systems. Their microcapsules -- labeled with radioactive zirconium-89 -- are the first example of hollow polymer capsules capable of long-term, multiday positron emission tomography imaging in vivo. In previous work, the researchers showed that the hollow capsules could be filled with a potent dose of the cancer drug doxorubicin, which could then be released by therapeutic ultrasound that ruptures the microcapsules. (2021-01-20)

New delivery method promises relief from antipsychotic medication's adverse side effects
A team of neuroscientists and engineers at McMaster University has created a nasal spray to deliver antipsychotic medication directly to the brain instead of having it pass through the body. (2021-01-15)

Researchers identify nanoparticles that could deliver therapeutic mRNA before birth
Researchers at Children's Hospital of Philadelphia and the School of Engineering and Applied Science at the University of Pennsylvania have identified ionizable lipid nanoparticles that could be used to deliver mRNA as part of fetal therapy. The proof-of-concept study, published today in Science Advances, engineered and screened a number of lipid nanoparticle formulations for targeting mouse fetal organs and has laid the groundwork for testing potential therapies to treat genetic diseases before birth. (2021-01-13)

Nanotechnology prevents premature birth in mouse studies
In a study in mice and human cells, Johns Hopkins Medicine researchers say that they have developed a tiny, yet effective method for preventing premature birth. (2021-01-13)

Acta Pharmaceutica Sinica B volume 10, issue 11 publishes
Acta Pharmaceutica Sinica B Volume 10, Issue 11 Publishes Special Issue: Tumor Microenvironment and Drug Delivery Guest Editors: Huile Gao, West China School of Pharmacy, Sichuan University, Chengdu, China; Zhiqing Pang, Fudan University, Shanghai, China and Wei He, China Pharmaceutical University, Nanjing, China (2021-01-11)

Confined growth of ZIF-8 in organosilica nanoparticles to regulate mRNA translation
mRNA based technology is a hot topic particularly in light of the recent clinical trials of mRNA vaccines against COVID-19 pandemic. However, the hard-to-transfect nature in antigen presenting cells (APCs) has been a long-standing challenge for mRNA expression to proteins. Scientists in Australia developed dendritic mesoporous organosilica nanoparticles (DMONs) with ZIF-8 grown partially inside the mesopores. The resultant DMONs-ZIF-8 showed enhanced mRNA delivery efficiency and safety profile than commercial products and DMONs modified with a toxic polymer. (2021-01-09)

Botulism breakthrough? Taming botulinum toxin to deliver therapeutics
Currently there's no treatment for botulism once the toxin gets into neurons. This novel treatment neutralized the toxin with a second, modified botulinum toxin that delivered a mini antibody into the cells - reversing paralysis in mice. (2021-01-08)

Skin-to skin contact with fathers may help newborns after caesarean delivery
Separating infants and their mothers after a Caesarean section delivery is common. A new study published in Acta Paediatrica has found that providing skin-to-skin contact with the father may provide benefits to a newborn. (2021-01-06)

CytoDel announces successful intra-neuronal antibody delivery without a viral vector
Preclinical data published in Science Translational Medicine showed that post-symptomatic administration of Cyto-111 produced antidotal rescue in three animal species following a lethal botulism challenge. Study authors concluded, '' atoxic BoNT derivatives can be harnessed to deliver therapeutic protein moieties to the neuronal cytoplasm where they bind and neutralize intracellular targets in experimental models. The generalizability of this platform might enable delivery of antibodies and other protein-based therapeutics to previously inaccessible intraneuronal targets.'' (2021-01-06)

Toxin chimeras slip therapeutics into neurons to treat botulism in animals
Taking advantage of the chemical properties of botulism toxins, two teams of researchers have fashioned non-toxic versions of these compounds that can deliver therapeutic antibodies to treat botulism, a potentially fatal disease with few approved treatments. (2021-01-06)

New strategy to fight botulinum toxin - expert available
Published research shows a new ''Trojan horse'' approach that produces strong antidotal efficacy in treating lethal botulism. (2021-01-06)

Heat treatment may make chemotherapy more effective
The study, published in the Journal of Materials Chemistry B, found that ''loading'' a chemotherapy drug on to tiny magnetic particles that can heat up the cancer cells at the same time as delivering the drug to them was up to 34% more effective at destroying the cancer cells than the chemotherapy drug without added heat. (2021-01-05)

Nanoparticle drug-delivery system developed to treat brain disorders
To facilitate successful delivery of therapeutic agents to the brain, a team of bioengineers, physicians, and collaborators at Brigham and Women's Hospital and Boston Children's Hospital created a nanoparticle platform, which can facilitate therapeutically effective delivery of encapsulated agents in mice with a physically breached or intact BBB. In a mouse model of traumatic brain injury (TBI), they observed that the delivery system showed three times more accumulation in brain than conventional methods of delivery. (2021-01-01)

UC researcher urges caution using remdesivir to treat COVID-19
Research at the University of Cincinnati, however, contends that this antiviral drug is being used too indiscriminately when treating patients hospitalized with the virus. The study is published in the journal Fundamental & Clinical Pharmacology. (2020-12-29)

Cannabis use blunts stress reactivity in female rats
Female rats that inhaled vaporized cannabis daily for a month developed a blunted physiological response to stress, according to a new study by Washington State University researchers. In contrast, male rats that were provided access to the same potency of cannabis over the same 30-day window did not experience any physiological changes in how they responded to a stressful situation. (2020-12-22)

Review on functional hydrogel coatings
Hydrogel-coated substrates combine the merits of both the substrates and hydrogels, enabling new functions and applications. Typical applications of hydrogel coatings can be found in both medical and non-medical areas, such as soft devices and robotics, invasive medical devices and implants. The emerging topic of functional hydrogel coatings are reviewed from three aspects: functions and applications of hydrogel coatings, methods of preparing hydrogel coatings with strong adhesion, and tests to evaluate the adhesion. (2020-12-22)

Filled buprenorphine prescriptions for opioid use disorder during COVID-19 pandemic
The COVID-19 pandemic has disrupted health care delivery in the United State, and researchers in this study examined changes in total US retail pharmacy sales and sales of buprenorphine products with a US Food and Drug Administration-approved indication for treatment of opioid use disorder. (2020-12-21)

Research brief: Researchers discover new way to deliver DNA-based therapies for diseases
University of Minnesota Twin Cities researchers in the Department of Chemistry have created a new polymer to deliver DNA and RNA-based therapies for diseases. For the first time in the industry, the researchers were able to see exactly how polymers interact with human cells when delivering medicines into the body. This discovery opens the door for more widespread use of polymers in applications like gene therapy and vaccine development. (2020-12-18)

Page 1 of 25 | 1000 Results
   First   Previous   Next      Last   
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.