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Current Drug Delivery News and Events, Drug Delivery News Articles.
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Lithuanian researchers propose combination of methods to improve anticancer drug delivery
Application of low-intensity pulsed ultrasound in combination with microbubbles might enhance the delivery of chemotherapy medication used for treating cancers. In their study, a team of Lithuanian researchers from three universities - KTU, LSMU and VMU - claim that the rate of microbubble survival time is the best indicator for determining the efficiency of sonoporation, i.e. ultrasound-induced laceration of the cancer cell membrane. (2020-12-17)

The bull's eye: New modified stem cells can deliver drugs specifically to tumor cells
Targeting drugs to cancer tissues is a major challenge in cancer treatment. Mesenchymal stem cells (MSCs) are known for their ability to find and target tumor cells in the body, but using MSCs for drug delivery has been tricky, because upon loading with drugs, MSCs lose their viability and migratory ability. Now, researchers from Tokyo University of Science have successfully modified MSCs to deliver large quantities of anti-cancer drugs in a targeted manner to developing cancer cells. (2020-12-16)

New screening platform leads to discovery of next-generation prodrugs for type 1 diabetes
Researchers at Brigham and Women's Hospital and the Broad Institute teamed up to design next-generation β-cell-targeting proliferators: zinc-binding prodrugs (ZnPD). To achieve this, the researchers engineered a new screening platform, the Disque Platform, to better represent β-cells in the lab. Utilizing the Disque Platform, researchers identified a ZnPD drug which exhibited a 2.4-fold increase in β-cell numbers in culture, out-performing its native drug, harmine, and avoiding off-target effects. (2020-12-16)

Dartmouth-led research featured in national journal focused on health system performance
New findings published by Dartmouth researchers and featured in a special issue of Health Services Research, are helping to generate new insights and knowledge about the prevalence, roles, and impact of integrated health systems. (2020-12-15)

Majority of pregnant women who tested positive for COVID-19 were asymptomatic, study finds
Illustrates how pandemic disproportionally impacted vulnerable populations and underserved communities (2020-12-11)

Inhaled vaccine induces fast, strong immune response in mice and non-human primates
Researchers demonstrate in a study publishing December 10 in the journal Med that a phage-based inhalation delivery system for vaccines generates potent antibody responses in mice and non-human primates, without causing lung damage. The findings suggest that a safe and effective lung delivery system could one day be used for vaccines and therapeutics against respiratory diseases. (2020-12-10)

Using targeted microbubbles to administer toxic cancer drugs
New research has shown how microbubbles carrying powerful cancer drugs can be guided to the site of a tumour using antibodies. Microbubbles are small manufactured spheres half the size of a red blood cell - and scientists believe they can be used to transport drugs to highly specific locations within the body. (2020-12-08)

New treatment in development for irritable bowel syndrome with constipation
Researchers devised a plan to treat IBS with constipation by delivering chenodeoxycholic acid in a bilayered capsule, finding that this mode of delivery could decrease colon cramping and thus produce a better patient experience. (2020-12-08)

Medicine-carriers made from human cells can cure lung infections
Scientists used human white blood cell membranes to carry two drugs, an antibiotic and an anti-inflammatory, directly to infected lungs in mice. The nano-sized drug delivery method successfully treated both the bacterial growth and inflammation in the mice's lungs. The study shows a potential new strategy for treating infectious diseases, including COVID-19. (2020-12-03)

COVID-19: Fall in cancer drug treatment rose quickly following 'rapid' NHS guidance
The number of patients starting anticancer therapies dropped by more than 30 per cent in April, the month following the UK's first COVID-19 lockdown, but went above pre-pandemic levels within three months, finds a new study of NHS England data co-led by UCL researchers. (2020-11-27)

New research shows Vype ePen 3 highly preferred by vapers
New research published today shows that Vype ePen 3, BAT's flagship vapour product, can provide smokers with similar levels of nicotine as standard cigarettes and, with exclusive use, could be used to avoid many of the risks associated with smoking. (2020-11-24)

Sound waves power new advances in drug delivery and smart materials
Sound waves have been part of science and medicine for decades, but the technologies have always relied on low frequencies. Now researchers have revealed how high frequency sound waves could revolutionise the field of ultrasound-driven chemistry. (2020-11-24)

Minimizing the impact of restaurant shutdowns, restrictions in china amid COVID-19 crisis
A new study led by the UH Conrad N. Hilton College of Hotel and Restaurant Management identifies aspects of restaurant operations in China that benefitted the bottom line despite the turmoil caused by the COVID-19 pandemic. (2020-11-23)

Adverse childhood experiences and at-risk drinking, cannabis, and illicit drug use
New research from the Prevention Research Center of the Pacific Institute for Research and Evaluation suggests that adverse childhood experiences, often referred to as child maltreatment, are associated with increased odds of substance use among women urban Emergency Department patients. (2020-11-22)

UIC researchers describe fundamental processes behind movement of magnetic particles
Researchers from the University of Illinois Chicago describe several fundamental processes associated with the motion of magnetic particles through fluids as they are pulled by a magnetic field. (2020-11-18)

UTSA researcher examines drug overdose mortality in the Hispanic community
UTSA researcher Manuel Cano, assistant professor in the Department of Social Work at UTSA is shedding light to understand the topic of drug overdose deaths in the Hispanic community. In the article ''Drug Overdose Deaths Among US Hispanics: Trends (2000-2017) and Recent Patterns'' published in ''Substance Use & Misuse'' Cano used national death certificate data (data recording all deaths of U.S. residents) to examine drug overdose mortality in different Hispanic subgroups, based on heritage, place of birth and gender. (2020-11-18)

'Alarming' COVID-19 study shows 80% of respondents report significant symptoms of depression
A new national survey, looking at how the COVID-19 pandemic has impacted young US adults' loneliness, reveals ''significant depressive symptoms'' in 80% of participants. (2020-11-16)

Approved JAK inhibitor baricitinib shows promise against cytokine storm in COVID-19 clinical study
A clinical study involving 601 patients in Italy and Spain suggests that the JAK inhibitor drug baricitinib may enhance survival rates of patients (2020-11-13)

Risk of childhood asthma by caesarean section is mediated through the early gut microbiome
New study highlights long-term perturbations of the early gut microbiome as a possible mechanism for the observed association between caesarean section and increased risk of developing asthma. (2020-11-12)

Modelling microswimmers for drug delivery
An international group of theoretical physicists led by Abdallah Daddi-Moussa-Ider from Düsseldorf, Germany, has modelled the motion of microscopic, motile bodies - either powered micro-machines or living cells - in viscous liquid drops, using the Navier-Stokes equations. This work, which has applications in materials science and medicine, is now published in EPJ E. (2020-11-11)

Researchers show safer, more targeted way to deliver CRISPR gene therapy
Biomedical researchers have come up with a novel way to use a beam of light to deliver CRISPR gene therapy molecules targeting illnesses. (2020-11-11)

Precision chemo-immunotherapy for pancreatic cancer?
Pancreatic cancer is highly lethal: according to the National Cancer Institute, only about 10 percent of patients remain alive five years after diagnosis. Now, a preclinical study from the lab of Marsha Moses, PhD at Boston Children's Hospital, reports marked and lasting tumor regression in a mouse model, using a highly selective, potent, engineered antibody-drug combination. (2020-11-05)

Do cesarean delivery's effects on birth hormones impact a newborn's neurodevelopment?
Cesarean section delivery and vaginal delivery lead to different hormonal exposures that may affect a newborn's development, according to an article published in the Journal of Neuroendocrinology. (2020-11-04)

Intensive lab experiences and online learning during the COVID-19 pandemic
For students studying ecology and evolution, it's important to experience the processes and concepts they are learning about nature in nature. As a result of the COVID-19 pandemic, however, field-based courses rapidly transitioned to online only delivery. An article published in Ecology and Evolution discusses the potential advantages of pairing an intensive lab experience with an otherwise online delivery. (2020-11-04)

Lighting the way to selective membrane imaging
A team of scientists at Kanazawa University have shown how water-soluble tetraphenylethene molecules can become fluorescent when aggregating at a biomembrane-mimetic liquid-liquid interface. This work may lead to new optical molecular probes and smart vesicles for delivering pharmaceuticals directly to cells. (2020-11-04)

Hormone differences
During birth, hormones in the body surge in both mother and baby, sent along by the nervous system. These stress hormones are there to spur delivery and to help a baby adapt to living outside the womb. A new study finds how one is born can have an effect on the amount of stress hormones released at the time of delivery. For example, vaginal delivery had the highest presence of birth signaling hormones. (2020-11-04)

COVID-19 control measures shorten hospital stays for moms, babies
A new study from Cedars-Sinai shows new infection prevention practices implemented during the coronavirus pandemic have resulted in significantly shorter hospital stays for mothers and their babies, with no changes in the rates of cesarean deliveries, complications or poor outcomes. (2020-11-02)

Models for potential precursors of cells endure simulated early-Earth conditions
Membraneless compartments--models for a potential step in the early evolution of cells--have been shown to persist or form, disappear, and reform in predictable ways through multiple cycles of dehydration and rehydration. (2020-10-28)

Computer vision helps find binding sites in drug targets
Scientists from the iMolecule group at Skoltech developed BiteNet, a machine learning (ML) algorithm that helps find drug binding sites, i.e. potential drug targets, in proteins. BiteNet can analyze 1,000 protein structures in 1.5 minutes and find optimal spots for drug molecules to attach. (2020-10-27)

Study shows how tiny compartments could have preceded cells
Researchers used Argonne's Advanced Photon Source to study membraneless compartments as they underwent wet-dry cycles, shedding light on prebiotic Earth. (2020-10-27)

A heart-breast cancer-on-a-chip monitoring system
Dual-organ system enables the measurement of cardiac toxicity arising from breast cancer chemotherapy. A collaborative team, which includes a group from the Terasaki Institute for Biomedical Innovation, has developed an organs-on-a-chip system that more widely examines the responses of breast cancer and heart tissues to therapeutic breast cancer drugs. (2020-10-26)

New blood cancer treatment works by selectively interfering with cancer cell signalling
University of Alberta scientists have identified the mechanism of action behind a new type of precision cancer drug for blood cancers that is set for human trials, according to research published in Nature Communications. (2020-10-22)

New drug that can prevent the drug resistance and adverse effects
A research team in Korea is garnering attention for having developed an anticancer drug that could potentially prevent drug resistance. The Korea Institute of Science and Technology (KIST) announced that a team of researchers led by Dr. Kwang-meyung Kim at the Theragnosis research center successfully developed a cancer-specific anticancer drug precursor that can prevent the drug resistance. (2020-10-21)

Boron nitride nanofilms for protection from bacterial and fungal infections
NUST MISIS material scientists have presented antibacterial nano-coatings based on boron nitride, which are highly effective against microbial pathogens (up to 99.99%). They can become a safe alternative to the usual antibiotics in implantology since they do not have typical negative side effects. The results of the work are published in the international scientific journal ACS Applied Materials & Interfaces. (2020-10-20)

Anti-inflammatory therapy shows promise in slowing progression of multiple sclerosis
Intranasal administration of an anti-inflammatory drug helped reduce disease progression in a preclinical model of multiple sclerosis, according to recent research out of the University of Alberta. (2020-10-20)

NUS study reveals severe air pollution drives food delivery consumption and plastic waste
When the air outside is bad, office workers are more likely to order food delivery than go out for lunch, which in turn increases plastic waste from food packaging, according to a study by researchers from the National University of Singapore. (2020-10-19)

All-terrain microrobot flips through a live colon
A rectangular robot as tiny as a few human hairs can travel throughout a colon by doing back flips, Purdue University engineers have demonstrated in live animal models. (2020-10-15)

Layer of strength, layer of functionality for biomedical fibers
Wound dressing, tissue scaffolding, controlled and sustained drug delivery, and cardiac patching are all biomedical processes requiring a material that combines strength with functionality. Core-sheath polymer fibers, fibers comprised of a strong core surrounded by a biologically applicable sheath layer, are an affordable way to meet these requirements. In the journal Applied Physics Reviews, researchers discuss methods of producing core-sheath polymer fibers and their promising applications. (2020-10-13)

More than 40% of women suffer from constipation during pregnancy and right after childbirth
Women are 2-3 times more likely to suffer from constipation during pregnancy and right after childbirth than at any other time in their life, a new study from the University of Eastern Finland shows. (2020-10-09)

New drug carrier systems
A UD research team has devised tiny cargo-carrying systems many times smaller than a human hair, made from molecules called peptides that help provide structure for cells and tissues. The team has reported advances in the nanoparticle design that allow them to control the shape of the nanoparticles to allow them to better bind to tissue in the body and stay in a particular location. (2020-10-08)

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