Current Drug Dependence News and Events

Current Drug Dependence News and Events, Drug Dependence News Articles.
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Gut microbiota reveals whether drug therapies work in inflammatory bowel diseases
A study recently completed at the University of Helsinki indicates that the gut microbiota of patients suffering from inflammatory gastrointestinal disorders can be used to predict whether they will benefit from expensive therapies. The study also confirms the key role of therapies that have a beneficial effect on the gut microbiota in inflammatory bowel diseases. (2021-01-26)

White turns into (extreme-)ultraviolet
Researchers from the Max Born Institute for Nonlinear Optics and Short Pulse Spectroscopy (MBI) have developed a new method to modify the spectral width of extreme-ultraviolet (XUV) light. By employing a novel phase-matching scheme in four-wave mixing, they could compress the spectral width of the initial broadband light by more than hundred times. The detailed experimental and theoretical results have been published in Nature Photonics. (2021-01-25)

University of Cincinnati research unveils possible new combo therapy for head and neck cancer
Researchers at the University of Cincinnati have tested a new combination therapy in animal models to see if they could find a way to make an already effective treatment even better. Since they're using a Food and Drug Administration-approved drug to do it, this could help people sooner than later. (2021-01-22)

Marijuana use typically drops at the beginning of the year, then climbs in summer and fall
Marijuana use increases throughout the calendar year, with use up 13 percent on average at the end of each year compared to the beginning. (2021-01-11)

UC researcher urges caution using remdesivir to treat COVID-19
Research at the University of Cincinnati, however, contends that this antiviral drug is being used too indiscriminately when treating patients hospitalized with the virus. The study is published in the journal Fundamental & Clinical Pharmacology. (2020-12-29)

Cannabis could reduce fentanyl use, reduce overdose risk: Study
New research suggests that cannabis use by people in care for opioid addiction might improve their treatment outcomes and reduce their risk of being exposed to fentanyl in the contaminated unregulated drug supply. (2020-12-18)

Machine learning boosts the search for 'superhard' materials
Superhard materials are in high demand in industry, from energy production to aerospace, but finding suitable new materials has largely been a matter of trial and error based on classical materials such as diamonds. Now researchers have reported a machine learning model that can accurately predict the hardness of new materials, allowing scientists to more readily find compounds suitable for use in a variety of applications. (2020-12-17)

Researchers find conformational disorder tuning charge carrier mobility in 2D perovskites
Researchers from the University of Science and Technology of China synthesized a series of 2D organic-inorganic hybrid perovskites films with large organic spacer cations, and found that mobility and broadband emission showed strong dependence on the molecular conformational order of organic cations. (2020-11-23)

UTSA researcher examines drug overdose mortality in the Hispanic community
UTSA researcher Manuel Cano, assistant professor in the Department of Social Work at UTSA is shedding light to understand the topic of drug overdose deaths in the Hispanic community. In the article ''Drug Overdose Deaths Among US Hispanics: Trends (2000-2017) and Recent Patterns'' published in ''Substance Use & Misuse'' Cano used national death certificate data (data recording all deaths of U.S. residents) to examine drug overdose mortality in different Hispanic subgroups, based on heritage, place of birth and gender. (2020-11-18)

Chronic alcohol use reshapes the brain's immune landscape, driving anxiety and addiction
Deep within the brain, a small almond-shaped region called the amygdala plays a vital role in how we exhibit emotion, behavior and motivation; it's also strongly implicated in alcohol abuse. Now, for the first time, a Scripps Research team has identified important changes to anti-inflammatory mechanisms and cellular activity in the amygdala that drive alcohol addiction. (2020-11-16)

Approved JAK inhibitor baricitinib shows promise against cytokine storm in COVID-19 clinical study
A clinical study involving 601 patients in Italy and Spain suggests that the JAK inhibitor drug baricitinib may enhance survival rates of patients (2020-11-13)

Computer vision helps find binding sites in drug targets
Scientists from the iMolecule group at Skoltech developed BiteNet, a machine learning (ML) algorithm that helps find drug binding sites, i.e. potential drug targets, in proteins. BiteNet can analyze 1,000 protein structures in 1.5 minutes and find optimal spots for drug molecules to attach. (2020-10-27)

New blood cancer treatment works by selectively interfering with cancer cell signalling
University of Alberta scientists have identified the mechanism of action behind a new type of precision cancer drug for blood cancers that is set for human trials, according to research published in Nature Communications. (2020-10-22)

New drug that can prevent the drug resistance and adverse effects
A research team in Korea is garnering attention for having developed an anticancer drug that could potentially prevent drug resistance. The Korea Institute of Science and Technology (KIST) announced that a team of researchers led by Dr. Kwang-meyung Kim at the Theragnosis research center successfully developed a cancer-specific anticancer drug precursor that can prevent the drug resistance. (2020-10-21)

Study finds lowering nicotine decreases addictiveness of smoking in vulnerable populations
A study in JAMA Network Open provides evidence that, even in smokers from vulnerable populations, reducing nicotine content to low levels decreases addictiveness - a timely finding as the Food and Drug Administration considers a policy to lower nicotine content in all cigarettes sold in the U.S. (2020-10-20)

Promising treatment for aggressive childhood cancer
A drug has shown great promise in the treatment of neuroblastoma, an aggressive form of childhood cancer. The study was led by researchers at Lund University in Sweden, and is published in the journal Science Translational Medicine. (2020-10-06)

Sex-specific adverse drug effects identified by Columbia University algorithm
Columbia University researchers developed an algorithm that uses real-world data to identify sex-specific adverse drug effects, the fourth-leading cause of death in the U.S. (2020-10-02)

College students with disabilities at greater risk for substance abuse
College students with physical and cognitive disabilities use illicit drugs more, and have a higher prevalence of drug use disorder, than their non-disabled peers, according to a Rutgers study. (2020-09-21)

'Best' hospitals should be required to deliver tobacco treatment
A UCLA-led report published today in the Journal of the American Medical Association Internal Medicine exposes what the authors call a weakness in the high-profile 'Best Hospitals Honor Roll' published annually by US News and World Report. (2020-09-21)

Who stole the light?
Free electron X-ray lasers deliver intense ultrashort pulses of x-rays, which can be used to image nanometer-scale objects in a single shot. When the x-ray wavelength is tuned to an electronic resonance, magnetization patterns can be made visible. When using increasingly intense pulses, however, the magnetization image fades away. The mechanism responsible for this loss in resonant magnetic scattering intensity has now been clarified. (2020-09-18)

Drugs bill warning over US/UK trade deal
The NHS would spend billions of pounds more on drugs if it had to pay US prices following a US/UK trade deal. According to a new study by researchers at Brigham and Women's Hospital in Boston, Harvard Medical School, and the University of Oxford, NHS England would have spent over £5 billion more on 50 brand-name prescription drugs widely used in primary care if it had paid US prices in 2018. (2020-09-10)

Rutgers-led national survey uncovers doctors' misconceptions about nicotine risks
Most doctors misperceive the risks of nicotine, the addictive chemical in tobacco products, according to a Rutgers-led national survey. (2020-09-09)

Temporal-spatial order property of hollow multishelled structures enables sequential drug release
A recent research led by Prof. WANG Dan and Prof. ZHANG Suojiang from the Institute of Process Engineering (IPE) of the Chinese Academy of Sciences studied the diffusion and transport mechanism of antimicrobial molecules through HoMSs, and discovered that the unique temporal-spatial order property of HoMSs can realize the sequential drug release for the first time. (2020-09-08)

Genetic study of proteins is a breakthrough in drug development for complex diseases
An innovative genetic study of blood protein levels, led by researchers in the MRC Integrative Epidemiology Unit (MRC-IEU) at the University of Bristol, has demonstrated how genetic data can be used to support drug target prioritisation by identifying the causal effects of proteins on diseases. (2020-09-07)

Antiretroviral therapy fails to treat one-third of HIV patients in Malawi hospital
Antiretroviral therapy (ART) failure and drug resistance are extremely common in patients living with HIV who are admitted to hospital in Malawi, according to new research published in Lancet HIV. (2020-09-02)

One quarter of prescription drugs in Canada may be in short supply
Research from the Centre for Health Evaluation and Outcome Sciences (CHÉOS) sheds new light on the factors behind drug shortages in Canada, a common problem across the country. (2020-09-01)

Nanomaterials based strategies for treatment of hypoxic tumor
Hypoxic tumor microenvironment restricts efficiency of tumor therapies and leads to serious results of tumor recurrence and high mortality. Different strategies to treat hypoxic tumors based on nanomaterials have been utilized to eliminate the side effects of hypoxia on tumor therapies. The strategies could be summarized into two classes, i) elevating oxygen level in tumor by nanomaterials and ii) diminishing oxygen dependence of nanomaterials for hypoxic tumor therapy. (2020-08-31)

How antibiotics interact
Understanding bottleneck effects in the translation of bacterial proteins can lead to a more effective combination of antibiotics / study in 'Nature Communications' (2020-08-31)

Antiviral used to treat cat coronavirus also works against SARS-CoV-2
Researchers at the University of Alberta are preparing to launch clinical trials of a drug used to cure a deadly disease caused by a coronavirus in cats that they expect will also be effective as a treatment for humans against COVID-19. (2020-08-27)

Researchers develop a yeast-based platform to boost production of rare natural molecules
Researchers at Concordia University in Montreal and in Berkeley, California outline a method to synthesize complex bioactive molecules much more quickly and efficiently. Using cutting-edge synthetic biology approaches, They were able to produce a large amount of benzylisoquinoline alkaloid (BIA) to synthesize an array of natural and new-to-nature chemical structures in a yeast-based platform. This can provide a blueprint for the large-scale production of thousands of products, including the opioid analgesics morphine and codeine. (2020-08-27)

A toxic trio of parental problems strongly linked to childhood sexual abuse
A new study has found that adults who had parents who struggled with substance dependence, intimate partner violence and mental illness are more than 10 times more likely to have been victims of childhood sexual abuse than those whose parents did not have these problems, once age and race are taken into account. (2020-08-25)

Opioid prescription rates for knee surgery vary, but higher strength dosage common
Examining insurance data, Penn researchers found 36% of patients received an opioid prescription that was stronger than the CDC-recommended dose. (2020-08-25)

Molecule secreted by cancer-associated fibroblasts promotes anticancer drug resistance
Joint research at Kumamoto University in Japan discovered a new mechanism for anticancer drug resistance in gastric cancer. Experiments clarified that the Annexin A6 molecule contained in extracellular vesicles (EVs) is secreted by cancer-associated fibroblasts (CAFs) and taken up by gastric cancer cells, resulting in resistance to anticancer drug treatment. New drug development that targets Annexin A6 and cancer-associated fibroblasts (CAFs) may be possible. (2020-08-21)

A new iron based superelastic alloy capable of withstanding extreme temperatures
Researchers from Tohoku University's Graduate School of Engineering have discovered a novel iron-based superelastic alloy (SEA) capable of withstanding extreme temperatures--both high and low. (2020-08-20)

These drugs carry risks and may not help, but many dementia patients get them anyway
Nearly three-quarters of older adults with dementia have filled prescriptions for medicines that act on their brain and nervous system, but aren't designed for dementia, a new study shows. That's despite the special risks that such drugs carry for older adults -- and the lack of evidence that they actually ease the dementia-related behavior problems that often prompt a doctor's prescription in patients with Alzheimer's disease and related disorders. (2020-08-18)

NIH study suggests opioid use linked to pregnancy loss, lower chance of conception
Opioid use among women trying to conceive may be associated with a lower chance of pregnancy, suggests a National Institutes of Health study. Moreover, opioid use in early pregnancy may be associated with a greater chance of pregnancy loss. (2020-08-18)

Chatbots delivering psychotherapy help decrease opioid use after surgery
A study showed that patients receiving messages from a chatbot used a third fewer opioids after fracture surgery, and their overall pain level fell, too. (2020-08-17)

Synthetic drug ebselen could be repurposed to treat SARS-CoV-2 by targeting main protease at distant
The synthetic drug ebselen can bind to both the catalytic region and a previously unknown distant site on the SARS-CoV-2 virus' main protease, according to a molecular simulation analysis of the drug's interactions with this enzyme. (2020-08-14)

Heavy class A drug use linked to heightened risk of sight loss in US military
Heavy use of class A drugs, such as heroin, methamphetamine, or cocaine is linked to a heightened risk of partial or total blindness among US military personnel, finds research published online in the journal BMJ Military Health. (2020-08-13)

Lack of females in drug dose trials leads to overmedicated women
Women are more likely than men to suffer adverse side effects of medications because drug dosages have historically been based on clinical trials conducted on men, suggests new research from the University of California, Berkeley, and the University of Chicago. (2020-08-12)

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