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Current Drug Development News and Events, Drug Development News Articles.
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'One size fits all' medication approach doesn't work in pregnancy
New research led by the University of South Australia shows that a blanket approach to prescribing medication during pregnancy may put low birth weight babies at risk for the rest of their lives. (2020-09-08)

Temporal-spatial order property of hollow multishelled structures enables sequential drug release
A recent research led by Prof. WANG Dan and Prof. ZHANG Suojiang from the Institute of Process Engineering (IPE) of the Chinese Academy of Sciences studied the diffusion and transport mechanism of antimicrobial molecules through HoMSs, and discovered that the unique temporal-spatial order property of HoMSs can realize the sequential drug release for the first time. (2020-09-08)

Genetic study of proteins is a breakthrough in drug development for complex diseases
An innovative genetic study of blood protein levels, led by researchers in the MRC Integrative Epidemiology Unit (MRC-IEU) at the University of Bristol, has demonstrated how genetic data can be used to support drug target prioritisation by identifying the causal effects of proteins on diseases. (2020-09-07)

Finding cortisone alternatives with fewer side effects
Many people use cortisone of a regular basis. It is used for treating rheumatism, asthma, multiple sclerosis, or even COVID-19. Steroidal medication such as cortisone is highly effective but also possesses severe side effects. Henriette Uhlenhaut, professor at Technical University of Munich (TUM), and her team are examining the beneficial effects of cortisone in order to lay the groundwork for the development of similar drugs with fewer side effects. (2020-09-02)

Antiretroviral therapy fails to treat one-third of HIV patients in Malawi hospital
Antiretroviral therapy (ART) failure and drug resistance are extremely common in patients living with HIV who are admitted to hospital in Malawi, according to new research published in Lancet HIV. (2020-09-02)

One quarter of prescription drugs in Canada may be in short supply
Research from the Centre for Health Evaluation and Outcome Sciences (CH√ČOS) sheds new light on the factors behind drug shortages in Canada, a common problem across the country. (2020-09-01)

There's a shortage of info on drugs for children in Canada
The research team manually reviewed monographs of all new drugs approved by Health Canada between 2007 and 2016. During this time, Health Canada approved 281 drugs, 270 of which had clear benefit for children. However, only 75 (28 per cent) of the drug monographs were approved for children and there were only 10 (4 per cent) drugs approved for use in newborns. (2020-09-01)

Narcolepsy drug did not increase risk of fetal malformation
Modafinil is used to treat conditions such as narcolepsy. Reports have associated the drug with an increased risk of malformation in babies born to mothers who had taken it while pregnant. Now, a large registry study involving over two million pregnant women in Sweden and Norway shows that there is no such association. The study, which is published in JAMA, was conducted by researchers at Sweden's Karolinska Institutet and the Norwegian Institute of Public Health. (2020-09-01)

How antibiotics interact
Understanding bottleneck effects in the translation of bacterial proteins can lead to a more effective combination of antibiotics / study in 'Nature Communications' (2020-08-31)

Scientists develop first drug-like compounds to inhibit elusive cancer-linked enzymes
Structural biology techniques helped researchers target the nuclear receptor-binding SET domain family for the first time; its malfunction is associated with several types of cancer. (2020-08-31)

Search for COVID-19 drugs boosted by SARS discovery
An extensive search and testing of current drugs and drug-like compounds has revealed compounds previously developed to fight SARS might also work against COVID-19. Using the National Drug Discovery Centre, researchers from the Walter and Eliza Hall Institute identified drug-like compounds that could block a key coronavirus protein called PLpro. Initially developed as potential treatments for SARS, the compounds prevented the growth of the SARS-CoV-2 virus (which causes COVID-19) in the laboratory. (2020-08-27)

Antiviral used to treat cat coronavirus also works against SARS-CoV-2
Researchers at the University of Alberta are preparing to launch clinical trials of a drug used to cure a deadly disease caused by a coronavirus in cats that they expect will also be effective as a treatment for humans against COVID-19. (2020-08-27)

Molecule secreted by cancer-associated fibroblasts promotes anticancer drug resistance
Joint research at Kumamoto University in Japan discovered a new mechanism for anticancer drug resistance in gastric cancer. Experiments clarified that the Annexin A6 molecule contained in extracellular vesicles (EVs) is secreted by cancer-associated fibroblasts (CAFs) and taken up by gastric cancer cells, resulting in resistance to anticancer drug treatment. New drug development that targets Annexin A6 and cancer-associated fibroblasts (CAFs) may be possible. (2020-08-21)

Synthetic drug ebselen could be repurposed to treat SARS-CoV-2 by targeting main protease at distant
The synthetic drug ebselen can bind to both the catalytic region and a previously unknown distant site on the SARS-CoV-2 virus' main protease, according to a molecular simulation analysis of the drug's interactions with this enzyme. (2020-08-14)

Heavy class A drug use linked to heightened risk of sight loss in US military
Heavy use of class A drugs, such as heroin, methamphetamine, or cocaine is linked to a heightened risk of partial or total blindness among US military personnel, finds research published online in the journal BMJ Military Health. (2020-08-13)

Lack of females in drug dose trials leads to overmedicated women
Women are more likely than men to suffer adverse side effects of medications because drug dosages have historically been based on clinical trials conducted on men, suggests new research from the University of California, Berkeley, and the University of Chicago. (2020-08-12)

Malaria discovery could expedite antiviral treatment for COVID-19
New research into malaria suggests targeting enzymes from the human host, rather than from the pathogen itself, could offer effective treatment for a range of infectious diseases, including COVID-19. (2020-08-11)

SFU chemist's new process fast-tracks drug treatments for viral infections and cancer
Discovering antiviral and anticancer drugs will soon be faster and cheaper thanks to new research from Simon Fraser University chemist Robert Britton and his international team. (2020-08-07)

Cannabinoids may affect activity of other pharmaceuticals
Cannabinoid-containing products may alter the effects of some prescription drugs, according to Penn State College of Medicine researchers. They published information that could help medical professionals make safe prescribing choices for their patients who use prescription, over-the-counter or illicit cannabinoid products. (2020-08-03)

A simple screening process may enhance monoclonal antibody-based drug development
By screening potential monoclonal antibody (mAb)-based drugs solely based on a measure of their colloidal stability, scientists may be able to weed out mAbs that do not respond efficiently in solution early in the (2020-07-31)

Yale to lead trial of potential COVID-19 treatment
Yale School of Medicine and the biopharmaceutical firm AI Therapeutics have launched a multi-institutional clinical trial of a drug for treating COVID-19. Known as LAM-002A (apilimod), the drug has a proven safety record. Preliminary research has shown it can block cellular entry and trafficking of the SARS-CoV-2 virus, the cause of COVID-19. (2020-07-27)

Antiviral method against herpes paves the way for combatting incurable viral infections
Researchers at Lund University in Sweden have discovered a new method to treat human herpes viruses. The new broad-spectrum method targets physical properties in the genome of the virus rather than viral proteins, which have previously been targeted. The treatment consists of new molecules that penetrate the protein shell of the virus and prevent genes from leaving the virus to infect the cell. It does not lead to resistance and acts independently of mutations in the genome of the virus. (2020-07-24)

Some "inactive" drug ingredients may not be inert
The inactive ingredients that make up a major component of drug formulations may not be as inactive as previously thought, researchers report. (2020-07-23)

New drug targets clots: A potential treatment for heart attack and stroke prevention
Monash researchers have developed a drug that can be potentially given as a preventative against heart attack. The drug -- which has been studied in human cells and animal models -- literally blocks the minute changes in blood flow that preempts a heart attack and acts on the platelets preventing the platelet-triggered clot before it can kill or cause damage. (2020-07-22)

New french prescribing rules result in decreased prescribing of certain sleep drugs
In France, the implementation of new prescribing rules for the sedative-hypnotic drug zolpidem led to an important and immediate decrease in use. This decline was partially compensated for by a rise in the use of a nonbenzodiazepine drug called zopiclone. (2020-07-14)

Biomedical Sciences researchers discover first-in-class broad-inhibitor of paramyxovirus polymerases
A new antiviral drug that is effective against a broad range of human pathogens in the paramyxovirus family, such as the human parainfluenzaviruses and measles virus, has been discovered by researchers in the Institute for Biomedical Sciences at Georgia State University. (2020-07-13)

Differential scanning calorimetry to quantify protein-ligand binding
A team of researchers from Kazan Federal University, Russia, led by Dr. Igor Sedov, reported an application of capillary differential scanning calorimetry technique for the study of the binding of albumin, a plasma transport protein, with different drug ligands. (2020-07-11)

Discovery of a novel drug candidate to develop effective treatments for brain disorders
Researchers at IIT-Istituto Italiano di Tecnologia discovered a novel chemical compound, which has the potential to became a new drug for the treatment of core symptoms of brain disorders like Down syndrome and autism. Results are obtained in preclinical models where the new compound ameliorated difficulties in cognitive tasks, social interactions and repetitive behaviors. Researchers aim to create a start-up company in order to further develop this compound and make it a treatment for patients (2020-07-10)

TARA biosystems demonstrates in vitro cardiac biology model mimics human drug response
TARA Biosystems today reported study results demonstrating the ability of TARA's in vitro human cardiac models to reproduce drug responses similar to those observed in humans. (2020-07-07)

Cancer cells make blood vessels drug resistant during chemotherapy
Scientists have identified how inflammatory changes in tumors caused by chemotherapy trigger blood vessel anomalies and thus drug-resistance. Through mice experiment, the team also found that the combined usage of an inhibitor and anticancer drug makes chemotherapy more effective. (2020-07-01)

New pharmaceuticals: public research combines efficiency with contained costs
Is the basic research that goes into the development of new drugs more efficiently conducted by public-sector scientists, pharmaceutical firms, or independent private laboratories? What role do each of these groups play in determining prices of innovative pharmaceuticals, which have risen steeply over the last years? To answer these questions, economists Francesca Barigozzi, of the University of Bologna, and Izabela Jelovac, of the CNRS, designed and studied a model inspired by game theory. (2020-06-29)

Molecular simulations show how drugs block key receptors
Many pharmaceuticals work by targeting what are known as ''G-protein-coupled receptors''. In a new study, scientists from Uppsala University describe how they have been able to predict how special molecules that can be used in new immunotherapy against cancer bind to these receptors. The researchers' calculation methods, presented in the journal Angewandte Chemie are a vital contribution to future structure-based drug design. (2020-06-24)

Entry point for curbing the evolution of antibiotic resistance discovered
Medications work better when bacteria have a genetic defect / publication in 'Nature Communications'. (2020-06-24)

Product recommendation systems can help with search of antiviral drugs
Scientists from Skoltech and the Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of RAS checked the ability of artificial intelligence that suggest products to buy, recommend new antiviral compounds. The researchers found that advanced algorithms can effectively suggest both music, movies to buy, and compounds with antiviral activity. (2020-06-22)

Breakthrough discovery to transform prostate cancer treatment
A novel formulation of the prostate cancer drug abiraterone acetate - currently marketed as Zytiga - will dramatically improve the quality of life for people suffering from prostate cancer, as pre-clinical trials by the University of South Australia show the new formulation improves the drug's effectiveness by 40 per cent. (2020-06-20)

Addressing the drug problem in health and social care will produce better outcomes
Researchers at the Finnish Institute for Health and Welfare (THL) have evaluated the impact of decriminalization policy in different settings. The new study reviews reports, peer-review articles, and critical response papers on the topic. (2020-06-12)

A compound unlike any other
A compound discovered in the gills of wood-eating clams could be the solution to a group of parasites responsible for some of the world's most common infections. (2020-06-11)

Yale researchers find potential treatment for Rett Syndrome
An experimental cancer drug can extend the life of mice with Rett Syndrome, a devastating genetic disorder that afflicts about one of every 10,000 to 15,000 girls within 6 to 18 months after birth, Yale researchers report June 10 in the journal Molecular Cell. (2020-06-10)

Scientists use machine learning to predict major clinical forms of drug cardiotoxicity
Scientists use machine learning to predict major clinical forms of drug cardiotoxicity. (2020-06-09)

BU researcher: Screening for drug use can be reasonable, but not evidence-based
In the June 9 issue of JAMA, the US Preventive Services Task Force (USPSTF) recommends that clinicians screen for unhealthy drug use (that is, any use of drugs that are illegal or medications not used for medical purposes) for all adult patients, but admits that there is still little evidence weighing the benefits and risks of this practice. (2020-06-09)

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