Current Drug Development News and Events | Page 24

Current Drug Development News and Events, Drug Development News Articles.
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Preventing eggs' death from chemotherapy
Young women who have cancer treatment often lose their fertility because chemotherapy and radiation can damage or kill their immature ovarian eggs, called oocytes. Now, Northwestern Medicine® scientists have found the molecular pathway that can prevent the death of immature ovarian eggs due to chemotherapy, potentially preserving fertility and endocrine function. Scientists achieved this in mice by adding a currently approved chemotherapy drug, imatinib mesylate, to another chemotherapy drug cisplatin. (2013-06-17)

A new target for cancer drug development
Harvard Stem Cell Institute researchers have identified in the most aggressive forms of cancer a gene known to regulate embryonic stem cell self-renewal, beginning a creative search for a drug that can block its activity. (2013-06-17)

Doubling of deaths among sick mums-to-be amid poor evidence on drug safety in pregnancy
The lack of hard data on the safety and effectiveness of a wide range of drugs in pregnancy has hindered the treatment of pregnant women, contributing to a doubling of deaths amongst mums-to-be with an underlying health problem over the past 20 years, argues an editorial in the Drug and Therapeutics Bulletin. (2013-06-12)

Nanotechnology helps track and improve drug action in pancreatic cancer
Scientists from Sydney's Garvan Institute of Medical Research, in collaboration with colleagues from the Beatson Institute for Cancer Research in Glasgow UK, have been able to show ways in which we can markedly improve drug targeting of solid tumors, using tiny 'biosensors' along with new advanced imaging techniques. In real time and in three dimensions, these technologies can show us how cancers spread and how active cancer cells respond to a particular drug. (2013-06-12)

Commonly-prescribed drugs may influence the onset and progression of Alzheimer's disease
Multiple drug classes commonly prescribed for common medical conditions are capable of influencing the onset and progression of Alzheimer's disease. (2013-06-12)

Drug development venture links translational research, business to launch new therapeutics
An innovative new public-private drug development enterprise Emory University aims to transition scientific discoveries more rapidly and efficiently from university laboratories into the marketplace. The new venture is expected to provide global solutions to address worldwide drug development and commercialization needs. (2013-06-12)

Stem cells reach standard for use in drug development
Drug development for a range of conditions could be improved with stem cell technology that helps doctors predict the safety and the effectiveness of potential treatments. Medical Research Council scientists at the University of Edinburgh have been able to generate cells in the laboratory that reach the gold standard required by the pharmaceutical industry to test drug safety. (2013-06-11)

Drug prevents post-traumatic stress-like symptoms in mice
When injected into mice immediately following a traumatic event, a new drug prevents the animals from developing memory problems and increased anxiety that are indicative of post-traumatic stress disorder (PTSD). Howard Hughes Medical Institute scientists utilized mouse studies to suggest that a receptor called Oprl1 is altered in mice with PTSD-like symptoms. (2013-06-05)

NJIT researcher shows data mining EMRs can detect bad drug reactions
NJIT assistant professor Mei Liu, Ph.D., a computer scientist, has recently shown in a new study that electronic medical records can validate previously reported adverse drug reactions and report new ones. (2013-06-05)

Science academies issue 'G-Science' statements to call world leaders' attention to global challenges
Science academies from around the globe issued joint statements today to call world leaders' attention to the role science, technology, and innovation can play in the pursuit of sustainable development, and to raise their awareness of the emerging threat of drug resistance in infectious agents including tuberculosis. (2013-05-29)

The German National Academy of Sciences Leopoldina makes recommendations for the G8 summit
In partnership with 13 other national science academies the Leopoldina has elaborated two statements which will be handed to the governments participating in the upcoming G8 summit in Lough Erne. The academies are calling the heads of state and government of the eight leading industrialized nations to focus their attention on two topics in the immediate future: drug-resistant infectious agents and sustainable development. (2013-05-29)

New chemical approach to treat Alzheimer's
Scientists at the University of Liverpool and Callaghan Innovation in New Zealand have developed a new chemical approach to help harness the natural ability of complex sugars to treat Alzheimer's disease. (2013-05-29)

OHSU scientists advance understanding of brain receptor; may help fight neurological disorders
Researchers at Oregon Health & Science University have discovered important new properties in a common brain receptor that has been implicated in a wide range of neurological disorders. The discovery may help in the development of drugs to combat the disorders. (2013-05-28)

Evaluating a new way to open clogged arteries
A new study from MIT analyzes the potential usefulness of a new treatment that combines the benefits of angioplasty balloons and drug-releasing stents, but may pose fewer risks. (2013-05-21)

Innovative screening method uses RNA interference technology to identify 'lethal' and 'rescuer' genes
Lethal and rescuer genes are defined as genes that when inactivated result in cell death or enhanced cell growth, respectively. The ability to identify these genes in large-scale automated screening campaigns could lead to the discovery of valuable new drug targets. A genome-wide lethality screen that relies on RNA interference technology and led to the validation of 239 gene candidates essential for cell survival is described in ASSAY and Drug Development Technologies. (2013-05-16)

Popular diabetes drug does not improve survival rates after cancer: Study
Despite previous scientific studies that suggest diabetes drug metformin has anti-cancer properties, a new, first-of-its-kind study from Women's College Hospital has found the drug may not actually improve survival rates after breast cancer in certain patients. (2013-05-09)

Time to tumor growth helps predict survival benefit of Bevacizumab for patients with metastatic colorectal cancer
Certara™, a leading provider of software and scientific consulting services to improve productivity and decision-making from drug discovery through drug development, announced that its Pharsight Consulting Services has developed a mathematical model of tumor growth inhibition, which when combined with baseline prognostic factors, predicts treatment effect with bevacizumab for patients with metastatic colorectal cancer. These results are published online in the Journal of Clinical Oncology, together with an editorial by Michael Maitland, MD, Ph.D., from the University of Chicago. (2013-05-08)

IDIBELL license to Minoryx a patent of a product to treat a rare neurodegenerative disease
IDIBELL has signed a licensing agreement with the Spanish biotechnology company Minoryx of a patent for the treatment of X-linked adrenoleukodystrophy, a rare serious neurodegenerative disease, which has no effective treatment. (2013-05-07)

New class of drug targets skin cancer
A new class of drug targeting skin cancer's genetic material has been successfully tested in humans for the first time, opening the way to new treatments for a range of conditions from skin cancers to eye diseases. (2013-05-06)

Identifying inhibitors of human proteins that promote tumor formation
Tumor repressor genes, which inhibit tumor formation, can be (2013-05-03)

Research suggests new approach for spinal muscular atrophy
Spinal muscular atrophy is a debilitating neuromuscular disease that in its most severe form is the leading genetic cause of infant death. By experimenting with an ALS drug in two very different animal models, researchers at Brown University and Boston Children's Hospital have identified a new potential mechanism for developing an SMA treatment. (2013-04-09)

Arrhythmia drug may increase cancer risk
One of the most widely used medications to treat arrhythmias may increase the risk of developing cancer, especially in men and people exposed to high amounts of the drug. That is the conclusion of a new retrospective study published early online in CANCER, a peer-reviewed journal of the American Cancer Society. The study's results indicate that a potential link between amiodarone and cancer warrants further investigation. (2013-04-08)

Study reveals how diabetes drug delays ageing in worms
A widely prescribed type 2 diabetes drug slows down the ageing process by mimicking the effects of dieting, according to a study from Wellcome Trust researchers using worms to investigate how the drug works. (2013-03-28)

Scientists awarded special collaborative grant to develop anti-addiction medication
As part of an unprecedented national effort to develop new drugs to treat neurological disorders, scientists from the Florida campus of the Scripps Research Institute have been awarded an innovative grant from the National Institute of Neurological Disorders and Stroke to help people break their addiction to nicotine. (2013-03-27)

Researchers developing antiviral drug to combat contagious norovirus
A Kansas State University-led team is researching ways to stop the spread of norovirus, a contagious stomach illness that infects one in 15 Americans each year. (2013-03-25)

New chemo drug gentler on fertility, tougher on cancer
A new gentler chemotherapy drug in the form of nanoparticles has been designed by scientists to be less toxic to a young woman's fertility but extra tough on cancer. This is the first cancer drug tested while in development for its effect on fertility using a novel, quick in vitro test designed by the scientists. (2013-03-22)

Government decision to promote abstinence for drug users 'is about saving money not science'
The UK government's decision to promote abstinence for drug users (2013-03-21)

Scripps Research and Takeda Pharmaceuticals announce expanded research collaboration
The Scripps Research Institute and the Takeda Pharmaceutical Company have announced plans to expand their recent research collaboration to search for new drug targets for a variety of diseases. (2013-03-13)

Sanford-Burnham Medical Research Institute and Mayo Clinic extend collaborative agreement
Sanford-Burnham Medical Research Institute and Mayo Clinic signed a new collaborative agreement to build a therapeutic drug pipeline aimed at a variety of diseases with unmet medical needs. Under this agreement, Mayo Clinic scientists will work with researchers in Sanford-Burnham's Conrad Prebys Center for Chemical Genomics to conduct early-stage drug discovery, including assay development, high-throughput screening, and lead identification. (2013-03-11)

Mayo Clinic and Sanford-Burnham extend research agreement
To expand and speed the development of new drugs for its patients, Mayo Clinic has entered a formal collaboration with Sanford-Burnham Medical Research Institute. (2013-03-11)

A nanogel-based treatment for lupus
In this issue of the Journal of Clinical Investigation, Tarek Fahmy and colleagues at Yale University report the development of a nanogel-based delivery system that targets an immunosuppressive drug (mycophenolic acid) directly to tissues associated with immune cells. (2013-03-01)

11th International Congress on Targeted Anticancer Therapies
A range of new and promising targeted drugs currently under development for improved cancer therapy will be presented during the 11th International Congress on Targeted Anticancer Therapies, Paris, March 4-6 2013. Over 500 oncologists and scientists from all over the world will review and discuss cancer therapies of the future. (2013-02-28)

Flu breakthrough: New drug developed to combat flu pandemic
CSIRO scientists have helped to design a new drug to safeguard against epidemic and pandemic flu strains -- as published in Science today. (2013-02-21)

New flu drug stops virus in its tracks
A new class of influenza drug has been shown effective against drug-resistant strains of the flu virus, according to a study led by University of British Columbia researchers. (2013-02-21)

Myth that UK supply of innovative new pharma drugs is drying up
The widely held belief that the UK supply of innovative new medicines has conspicuously dwindled in recent decades, is not borne out by the evidence, reveals research published in the online journal BMJ Open. (2013-02-20)

Young malaria parasites refuse to take their medicine, may explain emerging drug resistance
New research has revealed that immature malaria parasites are more resistant to treatment with key antimalarial drugs than older parasites, a finding that could lead to more effective treatments for a disease that kills one person every minute and is developing resistance to drugs at an alarming rate. (2013-02-18)

A new way of looking at drug discovery
Garret FitzGerald from Penn, has long said the current drug-development system in the United States is in need of change, (2013-02-17)

Tuberculosis and neglected diseases targeted by new center
A major new center to boost the development of drugs to tackle the foremost diseases of the developing world is to be created at the University of Dundee. The Centre is being established with joint funding from the Wellcome Trust and the Bill & Melinda Gates Foundation. (2013-02-13)

UT Arlington engineer wins NSF award to support microfluidic analyses of tissue, cell samples
A UT Arlington mechanical engineer has been honored by the National Science Foundation with a $400,000 Early Career Development grant to support her work with microfluidic devices, which promise to improve 3D tissue and cell sample analyses. (2013-02-07)

For drug makers, new 3-D control opens wealth of options
A team of scientists anchored at Yale University has demonstrated a new, highly versatile approach for quickly assembling drug-like compounds, establishing a broad new route to drug discovery and medical treatment. They report their results in the journal Science on Feb. 8. (2013-02-07)

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