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Current Drug Development News and Events, Drug Development News Articles.
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Glazer receives grant to study light-activated cancer drugs
University of Kentucky assistant professor of chemistry Edith (2013-01-31)

Microdosing: Updating its role in developing new medicines
One of yesterday's most promising new tools for speeding the development of new medicines -- (2013-01-23)

Pandemic vaccination did not increase risk of fetal death
Pregnant women who were vaccinated against pandemic influenza were not at increased risk of experiencing fetal death. However, pregnant women who contracted influenza had an increased risk of fetal death. This was found in a register study of women who were pregnant during the influenza pandemic in 2009. (2013-01-16)

Researchers create flexible, nanoscale 'bed of nails' for possible drug delivery
Researchers at North Carolina State University have come up with a technique to embed needle-like carbon nanofibers in an elastic membrane, creating a flexible (2013-01-15)

Team finds gene that promotes drug resistance in cancer
Scientists from the UI and BYU have identified a gene that may be a target for overcoming drug resistance in cancer. The finding could improve prognostic and diagnostic tools for evaluating cancer and monitoring patient response to treatment. It also could lead to new therapies for eradicating drug-resistant cancer cells. (2013-01-14)

Medicinal toothbrush tree yields antibiotic to treat TB in new way
There are potentially new TB drugs in the pipeline from unusual sources. This compound is effective against resistant strains of TB. (2013-01-14)

Stem cell materials could boost research into key diseases
Stem cell manufacturing for drug screening and treatments for diseases such as Huntington's and Parkinson's could be boosted by a new method of generating stem cells, a study suggests. Scientists have developed a family of compounds that can support the growth of human embryonic stem cells on a large scale for use in drug testing or treatments. (2013-01-08)

Better approach to treating deadly melanoma identified by scientists
Scientists at the University of Manchester have identified a protein that appears to hold the key to creating more effective drug treatments for melanoma, one of the deadliest cancers. (2012-12-19)

Researchers find model system to study promising cancer drug
Researchers have found that the budding yeast is an acceptable model system to study KP1019, an anti-cancer drug that uses ruthenium, a rare metal, a new study found. (2012-12-18)

Regenstrief study finds that generic drugs often have incorrect safety labeling
A study by Regenstrief Institute researchers has found that more than two-thirds of generic drugs have safety-warning labels that differ from the equivalent brand-name drug. The majority of generics showed relatively small differences across their labels, but 9 percent showed differences of more than 10 side effects. Errors included out-of-date information, incomplete data and, in one case, information for the wrong drug altogether. (2012-12-13)

MicroRNA-218 targets medulloblastoma, most aggressive childhood brain cancer
A University of Colorado Cancer Center study published in the December issue of the Journal of Biological Chemistry shows that in medulloblastoma, a malignant brain tumor of children, microRNA-218 is especially low. The article also shows that adding microRNA-218 to neural stem cells engineered to develop medulloblastoma decreases the development of the cancer. (2012-12-12)

Pharmacy researcher finds most popular weight-loss drug strongly alters other drug therapies
A URI researcher has discovered that the weight-loss drug orlistat, known by the brand names Xenical and Alli, inhibits a key enzyme that may lead to (2012-12-10)

Research identifies a way to block memories associated with PTSD or drug addiction
New research from Western University could lead to better treatments for Post-Traumatic Stress Disorder (PTSD) and drug addiction by effectively blocking memories. The research by Nicole Lauzon and Steven Laviolette has identified a common mechanism in a region of the brain called the pre-limbic cortex, which can suppress the recall of memories linked to both aversive, traumatic experiences associated with PTSD and rewarding memories linked to drug addiction, without permanently altering memories. (2012-12-05)

University of Minnesota researchers find new target for Alzheimer's drug development
Researchers at the University of Minnesota's Center for Drug Design have developed a synthetic compound that, in a mouse model, successfully prevents the neurodegeneration associated with Alzheimer's disease. (2012-12-03)

Drug resistance biomarker could improve cancer treatment
Cancer therapies often have short-lived benefits due to the emergence of genetic mutations that cause drug resistance. A key gene that determines resistance to a range of cancer drugs has been reported in a study published by Cell Press November 21st in the journal Cell. The study reveals a biomarker that can predict responses to cancer drugs and offers a strategy to treat drug-resistant tumors based on their genetic signature. (2012-11-21)

Discovery offers new treatment for epilepsy
New drugs derived from components of a specific diet used by children with severe, drug-resistant epilepsy could offer a new treatment, according to research published today in the journal Neuropharmacology. (2012-11-20)

Toward competitive generic drug prices in Canada
The commitment of Canadian premiers to lower generic drug prices is a major change in how the country prices generic drugs, and government should learn from past attempts, states an article published in CMAJ (Canadian Medical Association Journal). (2012-11-19)

UBC professor wins Canada's top pharmaceutical research award
University of British Columbia microbiologist Robert E.W. Hancock has received the Prix Galien 2012 Research Award, widely considered the most prestigious honor in Canadian pharmaceutical research and innovation. Hancock is being recognized for pioneering work unraveling the complex interactions between antibiotics and bacteria. (2012-11-19)

Cutting-edge approaches to ensuring biologic drug quality focus of forum on bioassays
As a growing number of biologic drugs are treatments of choice for an expanding list of autoimmune disorders, inflammatory diseases, and certain cancers, bioassays play a critical role in establishing the functional integrity and potency of these products. Hosted by the United States Pharmacopeial Convention, the Fifth Bioassay Workshop will take place on Dec. 4-5, 2012, at USP's headquarters in Rockville, Md. The workshop will focus on the development, monitoring and validation/revalidation of bioassays. (2012-11-16)

Testing pain killers on humans could save money and speed the arrival of new drugs
Deliberately inflicting carefully controlled painful stimuli on human volunteers and seeing how well specific drugs reduce the feeling of pain can be an effective way of testing new drugs. So conclude two researchers who reviewed the available literature on these types of tests in a paper published in the British Journal of Pharmacology. (2012-11-08)

The role of stem cells in developing new drugs
DefiniGEN, a new spin-out company from the University of Cambridge, has been formed to supply hIPSC-derived cells to the drug discovery and regenerative medicine sectors. The company is based on the research of Dr. Ludovic Vallier, Dr. Tamir Rashid and Professor Roger Pedersen of the Anne McLaren Laboratory of Regenerative Medicine. (2012-10-31)

Attention, parents: UC research reveals a secret about your medicine cabinet
New research out of the University of Cincinnati suggests boys are more likely than girls to abuse over-the-counter drugs. (2012-10-29)

Experts call for increased neonatal inclusion in pediatric drug trials
Clinical drug trials are a vital part of pharmaceutical manufacturers gaining approval for use by the US Food and Drug Administration. A Commentary scheduled for publication in the Journal of Pediatrics assesses the issues surrounding the lack of clinical trials on medications used by children, most notably neonates, and how drug manufacturers and academic researchers could work together to create clinical trials that would benefit this underrepresented population. (2012-10-25)

Sam Houston state developing lab test for bath salts
Sam Houston State University received a federal grant from the National Institute of Justice to create a test for key components of bath salts in biological samples in crime labs. (2012-10-25)

Lauren Sciences LLC independently recognized as a Leading Drug Delivery Company, and its V-Smart Platform selected as a Significant Advance in BBB Technology, by Datamonitor Healthcare
Lauren Sciences LLC, a privately held biotechnology company furthering development of its new V-Smart nanovesicle platform technology, announced today that it has been independently recognized as a leading drug delivery company, and its V-Smart Platform selected as a significant advance in blood brain barrier technology, by Datamonitor Healthcare. (2012-10-22)

As MDR-TB continues to spread, efforts coordinating TB detection and treatment hold promise
A new partnership announced today will increase efforts to coordinate the development of complementary novel tools to fight TB, including drug-resistant TB, and identify emerging drug resistance trends around the globe. (2012-10-17)

Georgia State receives $3.9 million grant to Enhance Safety and Well-Being of Children of Drug Court Participants
Georgia State University has received a $3.9 million, five-year grant from the US Department of Health and Human Services for a project that will better the lives of children and families of substance-abusing individuals who receive treatment through the DeKalb County Drug Court. (2012-10-17)

Prospective Alzheimer's drug builds new brain cell connections
Washington State University researchers have developed a new drug candidate that dramatically improves the cognitive function of rats with Alzheimer's-like mental impairment. Their compound, which is intended to repair brain damage that has already occurred, is a significant departure from current Alzheimer's treatments, which either slow the process of cell death or inhibit cholinesterase, an enzyme believed to break down a key neurotransmitter involved in learning and memory development. (2012-10-11)

Synthetic liver enzyme could result in more effective drugs with fewer side effects
Medicines could be made to have fewer side effects and work in smaller doses with the help of a synthetic enzyme developed at Princeton University that makes drug molecules more resistant to breakdown by the human liver. (2012-10-09)

HIV drug shows efficacy in treating mouse models of HER2+ breast cancer
The HIV protease inhibitor, Nelfinavir, can be used to treat HER2-positive breast cancer in the same capacity and dosage regimen that it is used to treat HIV, according to a study published October 5 in the Journal of the National Cancer Institute. (2012-10-05)

Chloroquine makes comeback to combat malaria
Malaria-drug monitoring over the past 30 years has shown that malaria parasites develop resistance to medicine, and the first signs of resistance to the newest drugs have just been observed. At the same time, resistance monitoring at the University of Copenhagen shows that the previously efficacious drug chloroquine is once again beginning to work against malaria. In time that will ensure cheaper treatment for the world's poor. (2012-10-03)

Mayo Clinic physicians ID reasons for high cost of cancer drugs, prescribe solutions
A virtual monopoly held by some drug manufacturers in part because of the way treatment protocols work is among the reasons cancer drugs cost so much in the United States, according to a commentary by two Mayo Clinic physicians in the October issue of the journal Mayo Clinic Proceedings. Value-based pricing is one potential solution, they write. (2012-10-01)

UK-led project unravels the structures of membrane proteins
Potential new treatments for heart disease and infections by parasites or bacteria are now in the pipeline thanks to a €12m European project coordinated by the University of Leeds, UK. (2012-10-01)

Over 65s at increased risk of developing dementia with benzodiazepine
Patients over the age of 65 who begin taking benzodiazepine (a popular drug used to treat anxiety and insomnia) are at an approximately 50 percent increased risk of developing dementia within 15 years compared to never-users, a study published today on bmj.com suggests. (2012-09-27)

TB drug could reduce mortality for MDR-TB and XDR-TB cases
Results from an observational study evaluating a new anti-TB drug have found that the treatment can improve outcomes and reduce mortality among patients with both MDR-TB and XDR-TB. (2012-09-26)

Encyclopedia of Drug Metabolism and Interactions, 6-Volume Set
Wiley is pleased to announce publication of the state-of-the-art, 6-volume Encyclopedia of Drug Metabolism and Interactions. (2012-09-24)

Double assault on tough types of leukemias
Investigators have identified two promising therapies to treat patients with acute megakaryocytic leukemia, a rare form of leukemia where the number of cases is expected to increase with the aging population. One of the drugs, Alisertib, was potent against the proliferation of cancer cells and reversed the disease in mice. Clinical trials are slated for 2013. (2012-09-20)

Northeastern's Barnett Institute announces formation of leading analytics company, BioAnalytix, LLC
The Barnett Institute of Chemical and Biological Analysis, a part of Northeastern University's College of Science has partnered in the formation of BioAnalytix, LLC -- a company specializing in the application of advanced biologic drug characterization methods and technologies to enable better, faster and more effective drug development and commercialization. (2012-09-18)

Scientists use sound waves to levitate liquids, improve pharmaceuticals
Scientists at the US Department of Energy's Argonne National Laboratory have been using an (2012-09-13)

Most prescription drugs manufactured overseas -- are they safe?
Most pharmaceutical drugs in Canada are manufactured overseas in countries such as India, China and others, yet how can we be confident the drug supply is safe, writes a drug policy researcher in an opinion piece in CMAJ. (2012-09-10)

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