Current Drug Discovery News and Events

Current Drug Discovery News and Events, Drug Discovery News Articles.
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New Tel Aviv University study reveals 'Achilles' heel' of cancer cells
A new study from Tel Aviv University (TAU) shows, for the first time, how an abnormal number of chromosomes (aneuploidy) -- a unique characteristic of cancer cells that researchers have known about for decades -- could become a weak point for these cells. The study could lead to the development of future drugs that will use this vulnerability to eliminate the cancer cells. (2021-01-27)

Gut microbiota reveals whether drug therapies work in inflammatory bowel diseases
A study recently completed at the University of Helsinki indicates that the gut microbiota of patients suffering from inflammatory gastrointestinal disorders can be used to predict whether they will benefit from expensive therapies. The study also confirms the key role of therapies that have a beneficial effect on the gut microbiota in inflammatory bowel diseases. (2021-01-26)

University of Cincinnati research unveils possible new combo therapy for head and neck cancer
Researchers at the University of Cincinnati have tested a new combination therapy in animal models to see if they could find a way to make an already effective treatment even better. Since they're using a Food and Drug Administration-approved drug to do it, this could help people sooner than later. (2021-01-22)

Unlocking 'the shape of water' in mechanisms of antibiotic resistance
Researchers captured and comparted hi-res images of ribosome structures from sensitive and resistant bacteria and report that a water molecule needed for antibiotic binding was not present in the ribosomes from the drug-resistant bugs. (2021-01-19)

Study suggests compound protects myelin, nerve fibers
A compound developed at Oregon Health & Science University appears to protect nerve fibers and the fatty sheath, called myelin, that covers nerve cells in the brain and spinal cord. The new research in a mouse model advances earlier work to develop the compound - known as sobetirome - that has already showed promise in stimulating the repair of myelin. (2021-01-13)

Endocrine Society recommends government negotiation and other policies to lower out-of-pocket costs
The Endocrine Society is calling on policymakers to include government negotiation as part of an overall strategy to reduce insulin prices in its updated position statement published today in The Journal of Clinical Endocrinology & Metabolism. (2021-01-12)

New drug form may help treat osteoporosis, calcium-related disorders
Purdue University innovators developed a stabilized form of human calcitonin, which is a peptide drug already used for people with osteoporosis. Researchers at Purdue created a prodrug form of the peptide hormone to increase its effectiveness as an osteoporosis treatment. (2021-01-06)

ADDF presents vision of a consortium to accelerate research into speech and language biomarkers for Alzheimer's disease
In a commentary in Exploration in Medicine, Alzheimer's experts lay out a vision for a worldwide research consortium that can give clinicians -- and patients -- the answers to which speech and language changes may signal Alzheimer's in the form of digital biomarkers. (2021-01-05)

UC researcher urges caution using remdesivir to treat COVID-19
Research at the University of Cincinnati, however, contends that this antiviral drug is being used too indiscriminately when treating patients hospitalized with the virus. The study is published in the journal Fundamental & Clinical Pharmacology. (2020-12-29)

HKU chemists develop a new drug discovery strategy for "undruggable" drug targets
A research team led by Dr Xiaoyu LI from the Research Division for Chemistry, Faculty of Science, in collaboration with Professor Yizhou LI from School of Pharmaceutical Sciences, Chongqing University and Professor Yan CAO from School of Pharmacy, Second Military Medical University in Shanghai has developed a new drug discovery method targeting membrane proteins on live cells. (2020-12-28)

New drug inhibits the growth of cancer cells
Blocking gene expression in mitochondria in mice stops cancer cells from growing (2020-12-22)

Sex-specific Alzheimer's treatment could benefit males over females
A University of Ottawa study found a specific Alzheimer's treatment is effective in male and not female mice, providing a window into the biology of the disease and the effectiveness of targeted treatments. (2020-12-21)

January issue of SLAS Discovery "Cryo-EM: The Resolution Revolution and Drug Discovery"
The January edition of SLAS Discovery features the cover article, ''Cryo-EM: The Resolution Revolution and Drug Discovery'' by Taiana Maia de Oliveira, Ph.D., Lotte van Beek, Ph.D., Fiona Shilliday, Ph.D., Judit E. Debreczeni, Ph.D., and Chris Phillips, Ph.D., from AstraZeneca. (2020-12-21)

Scientists discover a new type of brain cell that could help detect distance
A new kind of brain cell has been discovered which will help to understand how we remember where we left objects, such as car keys and mobile phones. (2020-12-21)

Three-dimensionally reconstituted organoids that are just like human organs
POSTECH-Seoul National University Hospital research team publishes the new concept of assembloids in Nature. (2020-12-18)

New recipe for antibiotic could prevent deafness
Stanford Medicine scientists have discovered a simple method of reformulating gentamicin, a commonly used and highly effective antibiotic, that could prevent its toxic side effect of hearing loss. (2020-12-16)

Undruggable diseases gain a new RNA drug-discovery tool
A new RNA-targeting tool enables scientists to tackle difficult molecular recognition problems to aid drug discovery for incurable diseases. (2020-12-15)

Genes could be key to new COVID-19 treatments, study finds
Potential treatments for Covid-19 have been identified after the discovery of five genes associated with the most severe form of the disease. (2020-12-11)

NUS researchers finds best combination of available therapies against COVID-19
Researchers from the National University of Singapore have utilised a ground-breaking AI platform to find an optimal combination of available therapies against COVID-19. The research team identified the drug combination from over 530,000 possibilities within two weeks, cutting down the number of tests typically needed by hundreds of thousands. (2020-12-10)

Using targeted microbubbles to administer toxic cancer drugs
New research has shown how microbubbles carrying powerful cancer drugs can be guided to the site of a tumour using antibodies. Microbubbles are small manufactured spheres half the size of a red blood cell - and scientists believe they can be used to transport drugs to highly specific locations within the body. (2020-12-08)

Potential cancer therapy may boost immune response
A new approach to cancer therapy shows potential to transform the commonly used chemotherapy drug gemcitabine into a drug that kills cancer cells in a specialized way, activating immune cells to fight the cancer, according to a study led by Cedars-Sinai Cancer investigators. (2020-12-07)

Drug for rare disorder shows promise for treating herpes viruses
New research shows that the antiviral activity of the drug -- called phenylbutyrate, or PBA -- was even better when used along with acyclovir, a common HSV-1 treatment. When used in combination, less acyclovir is needed to effectively suppress the virus compared to acyclovir alone -- this is important because acyclovir is also known to have toxic side effects in the kidneys. (2020-12-07)

Protein molecules in cells function as miniature antennas
Researchers led by Josef Lazar from IOCB Prague have demonstrated that molecules of fluorescent proteins act as antennas with optical properties (i.e. the ability to absorb and emit light) dependent on their spatial orientation. First discovered in jellyfish, fluorescent proteins are nowadays widely used in studies of molecular processes in living cells and organisms. The newly described properties of these molecules will find applications in basic biological research as well as in novel drug discovery. (2020-12-02)

Imagining perfect molecules using AI - a benchmarking system for generative chemistry
Insilico Medicine together with collaborators announces the publication of Molecular Sets (MOSES), a benchmarking system for generative chemistry models. (2020-11-30)

World's first: Drug guides stem cells to desired location, improving their ability to heal
Scientists at Sanford Burnham Prebys Medical Discovery Institute have created a drug that can lure stem cells to damaged tissue and improve treatment efficacy--a scientific first and major advance for the field of regenerative medicine. (2020-11-24)

New plant-based gel to fast-track 'mini-organs' growth, improve cancer treatment
Monash University researchers have created the world's first bioactive plant-based nanocellulose hydrogel to support organoid growth for biomedical applications. This includes cancer development and treatment. (2020-11-24)

Understanding ion channel inhibition to open doors in drug discovery
Scientists have discovered how drug-like small molecules can regulate the activity of therapeutically relevant ion channels - and their findings could transform ongoing drug development efforts. The study reveals how a drug-like small molecule, called Pico145, binds to the TRPC5 channel, thereby preventing the channel from opening.  (2020-11-23)

Mother's touch lingers in her child's genes
Mothers leave their mark on their children in many ways - and Melbourne researchers have discovered a protein called SMCHD1 is involved in this 'imprinting' process. SMCHD1 switches certain genes off, altering how a cell behaves. The new research has revealed that when an egg cell (or oocyte) is fertilised by a sperm, the egg cell's SMCHD1 lingers within the developing embryo, switching off at least 10 different genes and impacting the embryo's development - which could potentially have a lifelong impact on the offspring. (2020-11-23)

Potential new target to combat inflammatory diseases
An international team of researchers have uncovered a drug-like compound that blocks a crucial inflammatory pathway, potentially paving the way for a new treatment for a host of diseases - including COVID-19. WEHI's Associate Professor Seth Masters and his research team discovered the compound could prevent up-regulation of CD14, a key inflammatory protein. The discovery was recently published in EBioMedicine. (2020-11-19)

Insights in the search for new antibiotics
A collaborative research team from the University of Oklahoma, the Memorial Sloan Kettering Cancer Center and Merck & Co. published an opinion article in the journal, Nature Chemical Biology, that addresses the gap in the discovery of new antibiotics. (2020-11-19)

New effective and safe antifungal isolated from sea squirt microbiome
By combing the ocean for antimicrobials, scientists at the University of Wisconsin-Madison have discovered a new antifungal compound that efficiently targets multi-drug-resistant strains of deadly fungi without toxic side effects in mice. (2020-11-19)

Gold nanoparticles turn the spotlight on drug candidates in cells
A team including researchers from Osaka University has developed a surface-enhanced Raman scattering (SERS) microscopy technique for tracking small molecules in live cells. The technique uses gold nanoparticles to boost the signal from alkyne group tags attached to the molecules. The alkyne group has a minimal effect on the drug molecule behavior and provides a signal that can be easily distinguished from the cell background. Their technique is expected to be useful in drug discovery. (2020-11-18)

UTSA researcher examines drug overdose mortality in the Hispanic community
UTSA researcher Manuel Cano, assistant professor in the Department of Social Work at UTSA is shedding light to understand the topic of drug overdose deaths in the Hispanic community. In the article ''Drug Overdose Deaths Among US Hispanics: Trends (2000-2017) and Recent Patterns'' published in ''Substance Use & Misuse'' Cano used national death certificate data (data recording all deaths of U.S. residents) to examine drug overdose mortality in different Hispanic subgroups, based on heritage, place of birth and gender. (2020-11-18)

Solving a mystery: How the TB bacterium develops rapid resistance to antibiotics
These slow growing bacteria have long puzzled TB researchers with their fairly rapid resistance to antibiotics. Researchers may have been barking up the wrong tree in exploring genetics, because the answer seems to lie in the epigenetic domain. (2020-11-18)

December special issue of SLAS Discovery features 'drug discovery targeting COVID-19'
The December edition of SLAS Discovery, ''Drug Discovery Targeting COVID-19'' is a special collection assembled by Associate Editor Timothy Spicer (Scripps, FL, USA), focusing on drug discovery efforts toward the current global pandemic of COVID-19caused by the novel coronavirus, SARS-CoV-2. (2020-11-17)

December issue SLAS Technology features 'advances in technology to address COVID-19'
The December issue of SLAS Technology is a special collection featuring the cover article, ''Advances in Technology to Address COVID-19'' by editors Edward Kai-Hua Chow, Ph.D., (National University of Singapore), Pak Kin Wong, Ph.D., (The Pennsylvania State University, PA, USA) and Xianting Ding, Ph.D., (Shanghai Jiao Tong University, Shanghai, China). (2020-11-17)

Singapore scientists identify potential new biomarker to better personalize cancer therapy
Testing for mutations in RNF43, a protein that affects key cancer cell-growth pathway Wnt, gives clinicians actionable insights to tailor treatments better. (2020-11-13)

Approved JAK inhibitor baricitinib shows promise against cytokine storm in COVID-19 clinical study
A clinical study involving 601 patients in Italy and Spain suggests that the JAK inhibitor drug baricitinib may enhance survival rates of patients (2020-11-13)

Interactive virtual reality emerges as a new tool for drug design against COVID-19
Bristol scientists have demonstrated a new virtual reality [VR] technique which should help in developing drugs against the SARS-CoV-2 virus - and enable researchers to share models and collaborate in new ways. The innovative tool, created by University of Bristol researchers, and published in the Journal of Chemical Information and Modeling, will help scientists around the world identify anti-viral drug leads more rapidly. (2020-11-12)

Large-scale cancer proteomics study profiles protein changes in response to drug treatments
Through large-scale profiling of protein changes in response to drug treatments in cancer cell lines, researchers at The University of Texas MD Anderson Cancer Center have generated a valuable resource to aid in predicting drug sensitivity, to understand therapeutic resistance mechanisms and to identify optimal combination treatment strategies. (2020-11-05)

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