Current Drug News and Events

Current Drug News and Events, Drug News Articles.
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BU researchers identify promising therapeutic agent against melanoma
There have been great advances in treating melanoma over the past five years, however, even with these treatments many patients quickly develop drug resistance and die from their disease. A new study from Boston University School of Medicine (BUSM) has discovered that a drug (YK-4-279) that was previously created to target one specific type of protein has much broader use against a family of proteins that act to promote melanoma. (2021-02-01)

Gut microbiota reveals whether drug therapies work in inflammatory bowel diseases
A study recently completed at the University of Helsinki indicates that the gut microbiota of patients suffering from inflammatory gastrointestinal disorders can be used to predict whether they will benefit from expensive therapies. The study also confirms the key role of therapies that have a beneficial effect on the gut microbiota in inflammatory bowel diseases. (2021-01-26)

University of Cincinnati research unveils possible new combo therapy for head and neck cancer
Researchers at the University of Cincinnati have tested a new combination therapy in animal models to see if they could find a way to make an already effective treatment even better. Since they're using a Food and Drug Administration-approved drug to do it, this could help people sooner than later. (2021-01-22)

UC researcher urges caution using remdesivir to treat COVID-19
Research at the University of Cincinnati, however, contends that this antiviral drug is being used too indiscriminately when treating patients hospitalized with the virus. The study is published in the journal Fundamental & Clinical Pharmacology. (2020-12-29)

UTSA researcher examines drug overdose mortality in the Hispanic community
UTSA researcher Manuel Cano, assistant professor in the Department of Social Work at UTSA is shedding light to understand the topic of drug overdose deaths in the Hispanic community. In the article ''Drug Overdose Deaths Among US Hispanics: Trends (2000-2017) and Recent Patterns'' published in ''Substance Use & Misuse'' Cano used national death certificate data (data recording all deaths of U.S. residents) to examine drug overdose mortality in different Hispanic subgroups, based on heritage, place of birth and gender. (2020-11-18)

Approved JAK inhibitor baricitinib shows promise against cytokine storm in COVID-19 clinical study
A clinical study involving 601 patients in Italy and Spain suggests that the JAK inhibitor drug baricitinib may enhance survival rates of patients (2020-11-13)

Computer vision helps find binding sites in drug targets
Scientists from the iMolecule group at Skoltech developed BiteNet, a machine learning (ML) algorithm that helps find drug binding sites, i.e. potential drug targets, in proteins. BiteNet can analyze 1,000 protein structures in 1.5 minutes and find optimal spots for drug molecules to attach. (2020-10-27)

New blood cancer treatment works by selectively interfering with cancer cell signalling
University of Alberta scientists have identified the mechanism of action behind a new type of precision cancer drug for blood cancers that is set for human trials, according to research published in Nature Communications. (2020-10-22)

New drug that can prevent the drug resistance and adverse effects
A research team in Korea is garnering attention for having developed an anticancer drug that could potentially prevent drug resistance. The Korea Institute of Science and Technology (KIST) announced that a team of researchers led by Dr. Kwang-meyung Kim at the Theragnosis research center successfully developed a cancer-specific anticancer drug precursor that can prevent the drug resistance. (2020-10-21)

Promising treatment for aggressive childhood cancer
A drug has shown great promise in the treatment of neuroblastoma, an aggressive form of childhood cancer. The study was led by researchers at Lund University in Sweden, and is published in the journal Science Translational Medicine. (2020-10-06)

Sex-specific adverse drug effects identified by Columbia University algorithm
Columbia University researchers developed an algorithm that uses real-world data to identify sex-specific adverse drug effects, the fourth-leading cause of death in the U.S. (2020-10-02)

Drugs bill warning over US/UK trade deal
The NHS would spend billions of pounds more on drugs if it had to pay US prices following a US/UK trade deal. According to a new study by researchers at Brigham and Women's Hospital in Boston, Harvard Medical School, and the University of Oxford, NHS England would have spent over £5 billion more on 50 brand-name prescription drugs widely used in primary care if it had paid US prices in 2018. (2020-09-10)

Temporal-spatial order property of hollow multishelled structures enables sequential drug release
A recent research led by Prof. WANG Dan and Prof. ZHANG Suojiang from the Institute of Process Engineering (IPE) of the Chinese Academy of Sciences studied the diffusion and transport mechanism of antimicrobial molecules through HoMSs, and discovered that the unique temporal-spatial order property of HoMSs can realize the sequential drug release for the first time. (2020-09-08)

Genetic study of proteins is a breakthrough in drug development for complex diseases
An innovative genetic study of blood protein levels, led by researchers in the MRC Integrative Epidemiology Unit (MRC-IEU) at the University of Bristol, has demonstrated how genetic data can be used to support drug target prioritisation by identifying the causal effects of proteins on diseases. (2020-09-07)

Antiretroviral therapy fails to treat one-third of HIV patients in Malawi hospital
Antiretroviral therapy (ART) failure and drug resistance are extremely common in patients living with HIV who are admitted to hospital in Malawi, according to new research published in Lancet HIV. (2020-09-02)

One quarter of prescription drugs in Canada may be in short supply
Research from the Centre for Health Evaluation and Outcome Sciences (CHÉOS) sheds new light on the factors behind drug shortages in Canada, a common problem across the country. (2020-09-01)

How antibiotics interact
Understanding bottleneck effects in the translation of bacterial proteins can lead to a more effective combination of antibiotics / study in 'Nature Communications' (2020-08-31)

Antiviral used to treat cat coronavirus also works against SARS-CoV-2
Researchers at the University of Alberta are preparing to launch clinical trials of a drug used to cure a deadly disease caused by a coronavirus in cats that they expect will also be effective as a treatment for humans against COVID-19. (2020-08-27)

Molecule secreted by cancer-associated fibroblasts promotes anticancer drug resistance
Joint research at Kumamoto University in Japan discovered a new mechanism for anticancer drug resistance in gastric cancer. Experiments clarified that the Annexin A6 molecule contained in extracellular vesicles (EVs) is secreted by cancer-associated fibroblasts (CAFs) and taken up by gastric cancer cells, resulting in resistance to anticancer drug treatment. New drug development that targets Annexin A6 and cancer-associated fibroblasts (CAFs) may be possible. (2020-08-21)

Synthetic drug ebselen could be repurposed to treat SARS-CoV-2 by targeting main protease at distant
The synthetic drug ebselen can bind to both the catalytic region and a previously unknown distant site on the SARS-CoV-2 virus' main protease, according to a molecular simulation analysis of the drug's interactions with this enzyme. (2020-08-14)

Heavy class A drug use linked to heightened risk of sight loss in US military
Heavy use of class A drugs, such as heroin, methamphetamine, or cocaine is linked to a heightened risk of partial or total blindness among US military personnel, finds research published online in the journal BMJ Military Health. (2020-08-13)

Lack of females in drug dose trials leads to overmedicated women
Women are more likely than men to suffer adverse side effects of medications because drug dosages have historically been based on clinical trials conducted on men, suggests new research from the University of California, Berkeley, and the University of Chicago. (2020-08-12)

SFU chemist's new process fast-tracks drug treatments for viral infections and cancer
Discovering antiviral and anticancer drugs will soon be faster and cheaper thanks to new research from Simon Fraser University chemist Robert Britton and his international team. (2020-08-07)

Cannabinoids may affect activity of other pharmaceuticals
Cannabinoid-containing products may alter the effects of some prescription drugs, according to Penn State College of Medicine researchers. They published information that could help medical professionals make safe prescribing choices for their patients who use prescription, over-the-counter or illicit cannabinoid products. (2020-08-03)

Some "inactive" drug ingredients may not be inert
The inactive ingredients that make up a major component of drug formulations may not be as inactive as previously thought, researchers report. (2020-07-23)

New drug targets clots: A potential treatment for heart attack and stroke prevention
Monash researchers have developed a drug that can be potentially given as a preventative against heart attack. The drug -- which has been studied in human cells and animal models -- literally blocks the minute changes in blood flow that preempts a heart attack and acts on the platelets preventing the platelet-triggered clot before it can kill or cause damage. (2020-07-22)

New french prescribing rules result in decreased prescribing of certain sleep drugs
In France, the implementation of new prescribing rules for the sedative-hypnotic drug zolpidem led to an important and immediate decrease in use. This decline was partially compensated for by a rise in the use of a nonbenzodiazepine drug called zopiclone. (2020-07-14)

Cancer cells make blood vessels drug resistant during chemotherapy
Scientists have identified how inflammatory changes in tumors caused by chemotherapy trigger blood vessel anomalies and thus drug-resistance. Through mice experiment, the team also found that the combined usage of an inhibitor and anticancer drug makes chemotherapy more effective. (2020-07-01)

Addressing the drug problem in health and social care will produce better outcomes
Researchers at the Finnish Institute for Health and Welfare (THL) have evaluated the impact of decriminalization policy in different settings. The new study reviews reports, peer-review articles, and critical response papers on the topic. (2020-06-12)

A compound unlike any other
A compound discovered in the gills of wood-eating clams could be the solution to a group of parasites responsible for some of the world's most common infections. (2020-06-11)

Yale researchers find potential treatment for Rett Syndrome
An experimental cancer drug can extend the life of mice with Rett Syndrome, a devastating genetic disorder that afflicts about one of every 10,000 to 15,000 girls within 6 to 18 months after birth, Yale researchers report June 10 in the journal Molecular Cell. (2020-06-10)

BU researcher: Screening for drug use can be reasonable, but not evidence-based
In the June 9 issue of JAMA, the US Preventive Services Task Force (USPSTF) recommends that clinicians screen for unhealthy drug use (that is, any use of drugs that are illegal or medications not used for medical purposes) for all adult patients, but admits that there is still little evidence weighing the benefits and risks of this practice. (2020-06-09)

How magnetic fields and 3D printers will create the pills of tomorrow
Doctors could soon be administering an entire course of treatment for life-threatening conditions with a 3D printed capsule controlled by magnetic fields thanks to advances made by University of Sussex researchers. (2020-06-09)

Advances in nanoparticles as anticancer drug delivery vector: Need of this century
This review article provides a summary of current advances in the use of nanoparticles (NPs) as anticancer drug-delivery vectors. (2020-06-04)

Nordic countries struggle with a severe drug overdose problem
Despite the fact that the Nordic countries are often seen as ideal in practically every global ranking of quality of life and social equality, the number of drug-related deaths in these countries are among the highest in Europe. (2020-05-27)

Target trials support drug safety in pregnant patients
Out of concern for fetal safety, pregnant people have typically been excluded from drug trials. And when human health is on the line, drug studies assessing fetal safety in animal models may be viewed as far from definitive. (2020-05-27)

Brief intervention could keep lower-risk drug use from becoming riskier: BU study
A new pilot randomized trial by researchers from the Boston University School of Public Health (BUSPH) and School of Medicine (BUSM) and Boston Medical Center (BMC) finds that a brief intervention for people with lower-risk drug use may help prevent increased and riskier use, as well as other health issues. (2020-05-11)

A drug proves effective in the treatment of intestinal ischemia-reperfusion in animals
The medicine, tested on rabbits, reduces complications from the treatment for the disease, a common veterinarian emergency among dogs and horses that stops blood circulation in the intestine. (2020-05-05)

New understanding of asthma medicines could improve future treatment
New research has revealed new insights into common asthma aerosol treatments to aid the drug's future improvements which could benefit hundreds of millions of global sufferers. (2020-04-27)

Experimental drug offers hope for preventing cancer relapse
A drug that is well-tolerated in patients and prevents cancer coming back in mice has been identified by researchers at the Francis Crick Institute. (2020-04-14)

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