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Scientists are developing a way to counter ulcerative colitis
Ulcerative colitis (UC) is a long-term condition that results in inflammation and ulcers of the colon and rectum. (2019-10-28)
Repurposing heart drugs to target cancer cells
This study has highlighted a novel senolytic drug - drug that eliminates senescent cells -- that are currently being used to treat heart conditions that could be repurposed to target cancer cells, and a range of other conditions. (2019-10-21)
Taking RTKI drugs during radiotherapy may not aid survival, worsens side effects
Taking certain cancer-fighting drugs while undergoing radiation therapy may not increase survival for patients, but may, instead, increase side effects, according to a team of researchers. (2019-10-10)
Computer kidney sheds light on proper hydration
A new computer kidney developed at the University of Waterloo could tell researchers more about the impacts of medicines taken by people who don't drink enough water. (2019-10-07)
Just add water: U-M chemists suggest a fix for insoluble drugs
Stable metal organic frameworks are prized for their ability to capture carbon dioxide or harvest atmospheric water, but U-M researchers have developed a use for unstable metal organic frameworks: as a system for drug delivery. (2019-10-03)
Off-label medication orders on the rise for children, Rutgers study finds
US physicians are increasingly ordering medications for children for conditions that are not approved by the Food and Drug Administration, according to a Rutgers study. (2019-09-16)
Some cancer drugs in clinical trials don't work by hitting their targets
Multiple cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interacting with their intended molecular targets, according to a new study. (2019-09-11)
Scientists find psychiatric drugs affect gut contents
Scientists have found that antidepressants and other psychiatric drugs can change the quantity and composition of gut bacteria in rats. (2019-09-08)
Should patients continue blood thinners after experiencing gastrointestinal bleeding?
Anticoagulants and antiplatelet drugs, which are blood thinners such as warfarin and aspirin, are commonly taken to reduce the risk of potentially fatal blood clots, but they carry an increased risk of gastrointestinal bleeding. (2019-09-05)
Electronic dance music party-goers at increased risk for drug-related emergencies
People who frequent electronic dance music (EDM) parties often use multiple drugs simultaneously and experience adverse effects with some ending up in the emergency department, say researchers at New York University School of Medicine and Rutgers University. (2019-08-21)
Novel combination of drugs may overcome drug-resistant cancer cells
A new study led by investigators from Brigham and Women's Hospital suggests that a combination of three drugs, including a new class of glucose-6-phosphate dehydrogenase inhibitors, could overcome cross-therapy resistance. (2019-08-20)
Nearly 1 in 2 swingers uses recreational drugs to intensify sex, survey suggests
Nearly one in two swingers uses recreational drugs to intensify the experience, with women more likely to do so than either straight or bisexual men, suggest the results of a Dutch survey, published online in the journal Sexually Transmitted Infections. (2019-08-12)
Medication in the environment affects feeding behavior of fish
Scientists are increasingly warning that prescription drugs can affect wildlife and ecosystems when they find their way into the environment. (2019-08-07)
Most independent charity drug assistance programs exclude the uninsured
A new study by researchers at the Johns Hopkins Bloomberg School of Public Health examined independent charity prescription drug assistance programs in the U.S. and found that nearly all--97 percent--did not provide coverage for uninsured patients. (2019-08-06)
Brand-brand competition is unlikely to reduce list prices of medicines
Greater brand-brand competition alone will likely not lower list prices of brand-name drugs in the US, according to a study published July 30 in the open-access journal PLOS Medicine by Ameet Sarpatwari of Brigham and Women's Hospital and Harvard Medical School, and colleagues. (2019-07-30)
New gene found for a deadly childhood cancer offers possibility of targeted drug therapy
Neuroblastoma accounts for 15% of total childhood cancer deaths and survival rates of high-risk neuroblastoma patients is 50%. (2019-07-26)
People are more likely to try drugs for the first time during the summer
American teenagers and adults are more likely to try illegal or recreational drugs for the first time in the summer, a new study shows. (2019-07-23)
'Trojan horse' anticancer drug disguises itself as fat
A stealthy new drug-delivery system disguises chemotherapeutics as fat in order to outsmart, penetrate and destroy tumors. (2019-07-18)
Early benefit assessment reveals weaknesses in the development of new drugs
In the British Medical Journal, IQWiG researchers analyse the first 216 AMNOG assessments of new drugs and derive proposals for more targeted drug development. (2019-07-11)
Novel computer model supports cancer therapy
Researchers from the Life Sciences Research Unit (LSRU) of the University of Luxembourg have developed a computer model that simulates the metabolism of cancer cells. (2019-07-02)
PBS restrictions result in outdated and unsafe care
Prescribing restrictions for anti-epileptic drugs expose flaws in the review process of the Pharmaceutical Benefits Scheme (PBS), a University of Queensland researcher proposes. (2019-07-01)
Study shows some generics can cost medicare recipients more than brand-name drugs
Medicare Part D enrollees may pay more out of pocket for high-priced specialty generic drugs than their brand-name counterparts, according to new research by health policy experts at Vanderbilt University Medical Center and the University of North Carolina at Chapel Hill. (2019-07-01)
Long delays prescribing new antibiotics hinder market for needed drugs
US hospitals wait over a year on average to begin prescribing newly developed antibiotics, a delay that might threaten the supply or discourage future development of needed drugs, according to a University of Wisconsin-Madison study. (2019-06-26)
Commonly prescribed drugs could increase the risk of dementia, says a new study
New research suggests that regular use of certain types of commonly prescribed drugs used to treat bladder conditions, Parkinson's disease and depression, could significantly increase the risk of dementia in later life. (2019-06-24)
Explorers and soldiers don't worry -- anesthesia works in Antarctica!
New research presented at this year's Euroanaesthesia congress (the annual meeting of the European Society of Anaesthesiology) in Vienna, Austria (June 1-3) shows that commonly used anesthetic drugs still work, even after exposure to the extreme environmental conditions of the Antarctic. (2019-05-31)
The FASEB Journal: Alternative molecular mechanisms observed in cancer cells
Current anti-cancer drugs can be quite effective but too often, tumors are not fought off completely and end up returning. (2019-05-30)
Using fruit flies to identify new treatment for a colorectal cancer patient
Erdem Bangi and colleagues demonstrate a new approach to developing personalized therapy for a patient with treatment-resistant colorectal cancer: using a fruit fly genetically modified with a patient's own cancer mutations to test candidate treatments. (2019-05-22)
Five rules to tackle antibiotic resistance
Current efforts to tackle antibiotic resistance are 'not nearly radical enough,' a leading scientist says. (2019-05-14)
Index that tracks impact of pharmaceuticals worldwide to relaunch, focus on more diseases
The Global Health Impact Index, developed by faculty at Binghamton University, State University of New York to rank pharmaceutical companies based on their drugs' impact on global health, is launching a new, more-robust model that addresses even more diseases worldwide. (2019-05-06)
External reference drug pricing could save Medicare tens of billions
A new study by researchers at the Johns Hopkins Bloomberg School of Public Health found that prices for brand-name prescription drugs averaged 3.2 to 4.1 times higher in the US when compared with prices in the United Kingdom, Japan and the Canadian province of Ontario. (2019-05-06)
New study finds river wildlife contain cocaine, pharmaceuticals and pesticides
For the first time, researchers at King's College London, in collaboration with the University of Suffolk, have found a diverse array of chemicals, including illicit drugs and pesticides in UK river wildlife. (2019-04-30)
Drugs to prevent stroke and dementia show promise in early trial
Treatments that prevent recurrence of types of stroke and dementia caused by damage to small blood vessels in the brain have moved a step closer, following a small study. (2019-04-25)
Study identifies gender differences in reported adverse drug reactions
In a British Journal of Clinical Pharmacology study, investigators uncovered numerous gender differences in reports of adverse drug reactions sent to the National Pharmacovigilance Centre in the Netherlands. (2019-04-03)
Drugs used to enhance sexual experiences, especially in UK
Combining drugs with sex is common regardless of gender or sexual orientation, reveals new research by UCL and the Global Drug Survey into global trends of substance-linked sex. (2019-04-01)
New mathematical model could be key to designing effective therapies for brain disorders
A collaboration between researchers from the UAB Institute of Neurosciences (INc) and the pharmaceutical company GlaxoSmithKline, published in March in Trends in Pharmacological Sciences, describes a mathematical model to quantify the activity of biased G-protein-coupled receptors. (2019-03-28)
New 'pulsing' ultrasound technique improves drug delivery to brains of mice
Using rapid short-pulse sequences of ultrasound helps drugs reach the brains of mice, according to new research. (2019-03-26)
Antiepileptics increase the risk of pneumonia among persons with Alzheimer's disease
People with Alzheimer's disease using antiepileptic drugs have twice the risk of pneumonia compared to non-users, a new study from the University of Eastern Finland shows. (2019-03-21)
Smarter drug release thanks to control over encapsulation
Researchers at Eindhoven University of Technology and Utrecht University have discovered the parameters that govern the encapsulation of drugs. (2019-03-19)
Two for the price of one: Mechanistic insights lead to drug repositioning
A University of Tsukuba-led team confirmed that the binding of the cancer-promoting protein stratifin to phosphorylated SKP1 prevents the formation of a ubiquitinating enzyme complex. (2019-03-07)
Possible pathway to new therapy for Alzheimer's disease
Researchers have uncovered an enzyme and a biochemical pathway they believe may lead to the identification of drugs that could inhibit the production of beta-amyloid protein, the toxic initiator of Alzheimer's disease (AD). (2019-02-19)
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