Current Dystonia News and Events

Current Dystonia News and Events, Dystonia News Articles.
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Clinic reduces GA1 brain injury risk by 83% with therapies developed over 30 years
A new study summarizes over 30 years of clinical experience in the treatment and management of glutaric acidemia type 1 (GA1), a rare and potentially devastating metabolic disorder caused by variants in the GCDH gene. The study followed the clinical course of 168 individuals with GA1 who were born between 1973 and 2019 and originated from 26 states and 6 countries. (2020-10-13)

Hospital improves on-time administration of medication to Parkinson patients
Amsterdam, NL, July 9, 2020 - Timely administration of anti-Parkinson drugs is a significant issue for hospitalized patients with Parkinson's disease (PD) with late or missed doses resulting in longer stays and worse outcomes. As part of a quality improvement project, a multidisciplinary team was able to change the culture at a US hospital by using a series of measures to ensure PD patients receive medications on time. Their findings are published in the Journal of Parkinson's Disease. (2020-07-09)

Researchers find brain cell that triggers tremor and how to control it
Researchers have improved our understanding of how tremor -- the most common movement disorder -- happens, opening the possibility of novel therapies for this condition. (2020-03-19)

An oral splint that can reduce Tourette syndrome tics
Osaka University researchers developed a new device that ameliorates the characteristic vocal and motor tics of Tourette syndrome. By biting down on the simple, removable oral splint, both adults and children with Tourette syndrome experienced a reduction in their tics. The action of biting down on the oral splint could serve as a sensory trick; sensory tricks are known to ameliorate motor symptoms in cervical dystonia. The device might be particularly effective in children. (2019-09-09)

Free thinking: researchers identify origins of free will in the brain
Neuroscientists led by Michael Fox, MD, PhD, of Beth Israel Deaconess Medical Center (BIDMC) used brain lesion network mapping -- a technique pioneered by Fox at BIDMC -- to find the anatomical origins of the perception of free will. Their findings were published today in the Proceedings of the National Academy of Sciences. (2018-10-02)

Mayo Clinic researchers uncover methods to quantify the yips and golfer's cramp
Almost every golfer knows the feeling. Minutes after a picture-perfect drive down the fairway, a cascade of inexplicable missed putts leads to a disappointing triple bogey. (2018-07-19)

Lightning carries potential danger to people with deep brain stimulators
Patients receiving deep brain stimulation are warned that their neurostimulators may dysfunction when confronted by electromagnetic fields generated by particular electrical devices found at work, home, and in the hospital. A new and potentially dangerous source of dysfunction has been identified: nearby lightening. (2018-05-01)

Mass. General-led team identifies genetic defect that may cause rare movement disorder
A Massachusetts General Hospital-led research team has found that a defect in transcription of the TAF1 gene may be the cause of X-linked dystonia parkinsonism (XDP), a rare and severe neurodegenerative disease. (2018-02-22)

New study explains how your brain helps you learn new skills
Researchers from the Gladstone Institutes uncovered how a special type of neuron improves the efficiency of procedural learning. They initially wanted to show how the specialized brain cells, called fast-spiking interneurons, cause movement disorders, such as Tourette's syndrome, dystonia, and dyskinesia. As it turns out, that isn't the case. But their work led them to an even greater discovery. (2018-02-08)

Deep brain stimulation: Improving outcomes in the treatment of movement disorders
For the first time, researchers from Charité have shown that, in patients with a type of movement disorder known as dystonia, a particular pattern of brain activity is linked to both the severity of symptoms and the clinical outcomes achieved through deep brain stimulation. Results from this study, which has been published in the journal Annals of Neurology*, may help to improve the way in which treatment is adapted to an individual patients needs. (2017-12-22)

New botulinum neurotoxin discovered -- potential to treat a number of medical conditions
The first new botulinum neurotoxin in almost half a century has been discovered by researchers at Stockholm University and Harvard Medical School. Botulinum toxins are widely used to treat a growing list of medical conditions. The article has been published in Nature Communications. (2017-08-03)

Review: Insomnia medication may wake up some patients from vegetative state
A systematic review of zolpidem for noninsomnia neurological disorders, including movement disorders and disorders of consciousness, finds reason for additional research. (2017-06-26)

Cause of an inherited neurological disorder discovered
Researchers at the University of Liverpool have identified the basis for how a single gene mutation can cause a rare neurological movement disorder known as dystonia. (2017-04-10)

Remarkable recovery in patients diagnosed with newly defined movement disorder
A team of researchers from UCL Great Ormond Street Institute of Child Health, University of Cambridge and the NIHR Rare Disease Bioresource have identified mutations in the KMT2B gene in 28 patients with dystonia. In most cases, the patients -- many of whom were young children who thought to have a diagnosis of cerebral palsy -- were unable to walk. Treatment with Deep Brain Stimulation restored or significantly improved independent walking and improved hand and arm movement. (2016-12-19)

Scientists develop new drug screening tool for dystonia
Duke University researchers have identified a common mechanism underlying separate forms of dystonia, a family of brain disorders that cause involuntary, debilitating and often painful movements, including twists and turns of different parts of the body. The research has led to the development of a new cell-based test that is being deployed on a large scale to identify new drug candidates to treat dystonia. (2016-12-08)

Salk scientists adapt computer program to gauge eye spasm severity
Program also could be used in research and diagnosis of facial tics in disorders like Tourette Syndrome, schizophrenia and Parkinson's disease (2016-10-24)

New breakthrough in understanding dystonia
Researchers at VIB-KU Leuven have managed to get a clearer view on the roots of dystonia, a neurological disorder that causes involuntary twisting movements. Led by Rose Goodchild and supported by the Foundation for Dystonia Research, the VIB scientists unraveled the mechanism by which DYT1 dystonia -- the disease's most common hereditary form -- causes cellular defects. The findings shed new light on this poorly understood condition -- and may, ultimately, lead to new medical approaches to overcome it. (2016-08-09)

Human brain recordings provide highly sought insights into cause of Parkinson's disease
Researchers at Yerkes National Primate Research Center, Emory University, are the first to systematically record neural activity in the human striatum, a deep brain structure that plays a major role in cognitive and motor function. These two functions are compromised in Parkinson's disease, which makes the neuron-firing abnormalities the study results revealed key to better understanding the pathophysiology of PD and, ultimately, developing better treatments and preventions. (2016-08-08)

Marijuana exposure in kids rose after recreational use legalized in Colorado
The legalization of recreational marijuana in Colorado was associated with both increased hospital visits and cases at a regional poison center because of unintentional exposure to the drug by children, suggesting effective preventive measures are needed as more states consider legalizing the drug, according to an article published online by JAMA Pediatrics. (2016-07-25)

Founder of movement disorders field to receive Parkinson's award
In honor of his immeasurable contributions to the study and treatment of movement disorders such as Parkinson's disease, Van Andel Research Institute (VARI) will present renowned neuroscientist and clinician Stanley Fahn, M.D., with the 2016 Jay Van Andel Award for Outstanding Parkinson's Disease Research. The award ceremony and Fahn's accompanying lecture will kick off VARI's annual Grand Challenges in Parkinson's Disease symposium, which will be held Sept. 26-27 at the Institute in Grand Rapids, Mich. (2016-04-27)

AAN updates guidelines: Botulinum toxin for spasticity, headache, other brain disorders
The American Academy of Neurology has updated its 2008 guidelines on the use of botulinum toxin for spasticity, cervical dystonia, blepharospasm and migraine headache, based on recent research. The guideline is published in the April 18, 2016, online issue of Neurology, the medical journal of the American Academy of Neurology, and will be presented at the 68th AAN Annual Meeting in Vancouver, Canada, April 15 to 21, 2016. (2016-04-18)

Intensive instrument playing can lead to movement disorders
In total, one in 6,600 persons will develop focal dystonia, whereas an estimated one in 100 musicians will succumb. This is the finding of an original article by Verena Eveline Rozanski and coauthors in the current issue of Deutsches √Ąrzteblatt International. (2016-01-22)

Redrawing the brain's motor map
Neuroscientists at Emory have refined a map showing which parts of the brain are activated during head rotation, resolving a decades-old puzzle. Their findings may help in the study of movement disorders affecting the head and neck. (2015-06-16)

Molecular imaging reveals marker of neurodegenerative disease
Brain researchers have been working for years on targeting a cellular process involved in neurodegeneration and cognitive dysfunction. A specialized molecular imaging agent does the job by binding to a transporter of the neurotransmitter acetylcholine, a major mediator of the central nervous system, say presenters at the 2015 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging. (2015-06-08)

Huntington's disease monkeys display progressive clinical changes and neurodegeneration
A preclinical, large animal model of Huntington's disease for assessing new therapeutics, which could ultimately provide better treatment options, possibly including altering the course of the disease. (2015-05-12)

Help for people with muscle cramps?
A new treatment may bring hope for people who suffer from muscle cramps or spasms from neuromuscular disorders, diseases such as multiple sclerosis or simply from nighttime leg cramps that keep people from sleeping, according to a study released today that will be presented at the American Academy of Neurology's 67th Annual Meeting in Washington, D.C., April 18-25, 2015. (2015-02-18)

Neurologists find movement tracking device helps assess severity of Parkinson's disease
A device that measures movement and balance can effectively help assess and track the progression of Parkinson's disease, even when medications are used to reduce Parkinson's symptoms (2015-02-03)

University of Minnesota-developed drug for rigid muscles moves ahead in clinical trials
A new formulation for a University of Minnesota-developed drug targeted at rare disorders is under development, with the potential to help a small number of Americans each year. The new formulation of the drug baclofen is designed to prevent serious complications that can occur when drug delivery is interrupted. (2014-09-24)

Deep brain stimulation improves non motor symptoms in Parkinson's disease
Deep brain stimulation (DBS) has become a well-recognized non-pharmacologic treatment that improves motor symptoms of patients with early and advanced Parkinson's disease. Evidence now indicates that DBS can decrease the number and severity of non motor symptoms of patients with Parkinson's disease as well, according to a review published in the Journal of Parkinson's Disease. (2014-06-25)

3-D computer model may help refine target for deep brain stimulation therapy for dystonia
Researchers led by investigators at Cedars-Sinai, using a complex set of data from records and imaging scans of patients who have undergone successful DBS implantation, have created 3-D, computerized models that map the brain region involved in dystonia. The models identify an anatomical target for further study and provide information for neurologists and neurosurgeons to consider when planning surgery and making device programming decisions. (2014-06-24)

A new twist on neuro disease: Discovery could aid people with dystonia, Parkinson's and more
New research in mice may finally open the door to solving long-standing mysteries about dystonia -- uncontrollable twisting and stiffening of neck and limb muscles -- and developing new options for patients who experience it alone or as a complication of conditions such as Parkinson's disease. (2014-06-17)

Scientists identify new protein in the neurological disorder dystonia
Researchers have discovered that the protein BiP plays a key role in a genetic mutation that is affiliated with early onset torsion dystonia. Their findings may lead to the first universal treatment for the neurological disorder, which affects nearly half a million Americans. (2014-05-06)

AAN issues findings on use of medical marijuana in treatment of certain brain diseases
A review by the American Academy of Neurology of available scientific research on the use of medical marijuana in brain diseases finds certain forms of medical marijuana can help treat some symptoms of multiple sclerosis, but do not appear to be helpful in treating drug-induced (levodopa) movements in Parkinson's disease. Not enough evidence was found to show if medical marijuana is helpful in treating motor problems in Huntington's disease, tics in Tourette syndrome, cervical dystonia and seizures in epilepsy. (2014-04-28)

Bachmann-Strauss Foundation awards $1.2 million to establish Centers of Excellence around US
The Bachmann-Strauss Dystonia and Parkinson Foundation has awarded $1.2 million in matching grants to establish Dystonia and Parkinson's Disease Centers of Excellence at three major US medical centers: The University of Alabama at Birmingham, the University of Florida and the University of California, San Francisco. The new centers will join the existing Center of Excellence at Beth Israel Medical Center in New York City. (2013-10-31)

Budnik gets EUREKA grant to study communication between nucleus and cytoplasm
University of Massachusetts Medical School Professor and Vice Chair of Neurobiology Vivian Budnik, Ph.D., has received a four-year, $1.3 million EUREKA (Exceptional Unconventional Research Enabling Knowledge Acceleration) grant from the National Institute of Neurological Disorders and Stroke to explore a novel mechanism of communication between the cytoplasm and the nucleus, called nuclear envelope budding, that may lead to new understandings for various tissue dystrophies and aging disorders. (2013-10-07)

Study finds factors that may cause fluctuations in deep brain stimulation levels over time
Deep brain stimulation therapy blocks or modulates electrical signals in the brain to improve symptoms in patients suffering from movement disorders such as Parkinson's disease, essential tremor and dystonia, but a new study suggests that several factors may cause electrical current to vary over time. (2013-07-10)

Long-term study reports deep brain stimulation effective for most common hereditary dystonia
In what is believed to be the largest follow-up record of patients with the most common form of hereditary dystonia -- a movement disorder that can cause crippling muscle contractions -- experts in deep brain stimulation report good success rates and lasting benefits. (2013-06-19)

Short-term benefits seen with repetitive transcranial magnetic stimulation for focal hand dystonia
Repetitive transcranial magnetic stimulation is being increasingly explored as a therapeutic tool for movement disorders associated with deficient inhibition throughout the central nervous system. This includes treatment of focal hand dystonia, characterized by involuntary movement of the fingers either curling into the palm or extending outward. (2013-04-09)

Mayo Clinic aids discovery of first dystonia gene found in African-Americans
A pair of studies tells the tale of how a neuroscientist at Mayo Clinic in Florida helped to discover the first African-American family to have inherited the rare movement disorder dystonia, which causes repetitive muscle contractions and twisting, resulting in abnormal posture. (2013-03-06)

Parkinson's disease brain rhythms detected
A team of scientists and clinicians at UC San Francisco has discovered how to detect abnormal brain rhythms associated with Parkinson's by implanting electrodes within the brains of people with the disease. (2013-03-04)

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