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Current Embryonic Stem Cells News and Events, Embryonic Stem Cells News Articles.
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"Genetic SD-card": Scientists obtained new methods to improve the genome editing system
Researchers take a step in the development of genome editing technology. Currently it is possible to deliver genetic material of different sizes and structures to organs and tissues. This is the key to eliminating DNA defects and treating more patients. (2021-02-02)

Generation of conjunctivae in a dish
Researchers from Osaka University generated functional conjunctival tissue in a dish. By identifying the protein epidermal growth factor and keratinocyte growth factor for the development and maturation of conjunctival cells, respectively, they showed functional, mucin-producing conjunctival tissues can be formed from human induced pluripotent stem cells. This study could help with identifying novel drugs for dry eye syndrome and could further open new avenues for regenerative therapies. (2021-02-02)

Stem cell study illuminates the cause of a devastating inherited heart disorder
Penn Medicine scientists have uncovered the molecular causes of a congenital form of dilated cardiomyopathy (DCM)-- one of multiple congenital disorders caused by inherited mutations in a gene called LMNA. The scientists used stem cell techniques to grow human heart muscle cells containing DCM-causing mutations in LMNA. They found that these mutations severely disrupt the structural organization of DNA in the nucleus of heart muscle cells. (2021-02-01)

Synthetic biology reinvents development
The research team have used synthetic biology to develop a new type of genetic design that can reproduce some of the key processes that enable creating structures in natural systems, from termite nests to the development of embryos. (2021-02-01)

New protein neutralizes COVID in tiny human kidney
Northwestern Medicine scientists have developed a new protein that acts as a trickster to neutralize the COVID-19 infection in a human kidney organoid, a miniature organ made from stem cells in the lab. (2021-02-01)

Blood discoveries advance efforts to grow organs, battle cancer
Researchers have developed a simple and efficient way to generate ''hemogenic endothelial cells,'' the first stop in the production line of blood cells. (2021-01-28)

NUS scientists discover a new pathway essential for blood formation
Scientists from the National University of Singapore have discovered how a protein called Tip60 plays a vital role in the renewal of blood cells in the body. Without it, the stem cells that make new blood suffer catastrophic damage. This discovery could lead to better treatments for life-threatening blood-related diseases like leukemia. (2021-01-28)

Researchers use patients' cells to test gene therapy for rare eye disease
Scientists at the National Eye Institute (NEI) have developed a promising gene therapy strategy for a rare disease that causes severe vision loss in childhood. A form of Leber congenital amaurosis, the disease is caused by autosomal-dominant mutations in the CRX gene, which are challenging to treat with gene therapy. (2021-01-28)

How blood stem cells maintain their lifelong potential for self-renewal
A characteristic feature of all stem cells is their ability to self-renew. But how is this potential maintained throughout life? Scientists at the German Cancer Research Center (DKFZ) and the Heidelberg Institute for Stem Cell Technology and Experimental Medicine* (HI-STEM) have now discovered in mice that cells in the so-called ''stem cell niche'' are responsible for this, (2021-01-27)

Two anti-viral enzymes transform pre-leukemia stem cells into leukemia
Viral infections and space travel similarly trigger inflammation and the enzymes APOBEC3C and ADAR1; UC San Diego researchers are developing ways to inhibit them as a means to potentially lower cancer risk for both astronauts and people on Earth. (2021-01-26)

Metoclopramide inhibits proliferation of leukemia stem cells
A research team at Inselspital, Bern University Hospital and the University of Bern has identified and tested the use of an agent that can effectively inhibit the proliferation of leukemia stem cells. Metoclopramide (MPR), used as an anti-emetic medication, interrupts the unique CD93 signaling pathway that only leukemia stem cells use to proliferate. This opens up a therapeutic approach using MPR to selectively eliminate leukemia stem cells. (2021-01-26)

Oncotarget: Drug-resistant cells grow exponentially in metastatic prostate cancer
The Oncotarget authors show that the drug-resistant, metastasis-causing cells are capable of producing drug-resistant, exponentially growing tumors, responsible for tumor growth as a patient receives different treatments (2021-01-25)

Aging-US: Growth factor beta type 1 and hypoxia-inducible factor 1 transcription complex
''The Aging-US authors report for the first time that in human breast cancer, AML and embryonic cells, HIF-1 and AP-1 upregulate the expression of TGF-β'' (2021-01-25)

Identification of Oligo-DNA that promotes skeletal muscle differentiation
Skeletal muscle is the largest tissue in the human body and is responsible not only for locomotion but for energy metabolism and heat production. Myoblasts play an important role in maintaining muscle homeostasis, but it has been reported that the differentiation ability of myoblasts decreases with age and disease and this will be one of the causes of muscle atrophy. To prevent muscle atrophy, researchers of Shinshu University studied molecules that promote myoblast differentiation. (2021-01-25)

A stem cell based cell culture model for nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) is a widespread condition in the Western World. In order to improve our understanding of the basic mechanisms underlying the etiology of NAFLD, Dr. Nina Graffmann, Prof. James Adjaye and the team of the Institute for Stem Cell research and Regenerative Medicine, University Hospital Duesseldorf, differentiated induced pluripotent stem cells (iPSCs) derived from healthy donors and NAFLD patients into hepatocyte-like cells (HLCs). (2021-01-25)

University of Cincinnati student uses zebrafish to study spinal deformities
Oriana Zinani, a doctoral student in molecular developmental biology at the University of Cincinnati, is part of a team of researchers using zebrafish embryos to study a gene mutation that causes scoliosis, a sideways curvature of the spine that typically occurs in humans just before puberty. (2021-01-22)

Proteins unspool DNA so cells can take on unique properties
New research reveals how proteins, called 'pioneer transcription factors,' help turn on key genes that give cell types their unique properties and functions. (2021-01-22)

Exercising muscle combats chronic inflammation on its own
Biomedical engineers at Duke University have demonstrated that human muscle has an innate ability to ward off damaging effects of chronic inflammation when exercised. The discovery was made possible through the use of lab-grown, engineered human muscle, demonstrating the potential power of the first-of-its-kind platform in such research endeavors. (2021-01-22)

Rethink immigration policy for STEM doctorates
A streamlined process for awarding green cards to international STEM doctoral students graduating from U.S. universities could benefit American innovation and competitiveness, including leveling the field for startups eager to attract such highly skilled workers, according to a new study by researchers from Cornell University and the University of California, San Diego. (2021-01-21)

Designer DNA therapeutic wipes out cancer stem cells, treats multiple myeloma in mice
UC San Diego study supports launch of Phase I clinical trial to test a designer DNA agent -- an antisense oligonucleotide that targets a gene called IRF4 -- in patients with multiple myeloma. (2021-01-20)

NIH researchers identify new genetic disorder that affects brain, craniofacial skeleton
Researchers at the National Institutes of Health (NIH) have discovered a new genetic disorder characterized by developmental delays and malformations of the brain, heart, and facial features. (2021-01-20)

Hematopoietic stem cell transplants may provide long-term benefit for people with MS
A new study shows that intense immunosuppression followed by a hematopoietic stem cell transplant may prevent disability associated with multiple sclerosis (MS) from getting worse in 71% of people with relapsing-remitting MS for up to 10 years after the treatment. The research is published in the January 20, 2021, online issue of Neurology®, the medical journal of the American Academy of Neurology. The study also found that in some people their disability improved over 10 years after treatment. (2021-01-20)

Cartilage matrix as natural biomaterial for cartilage regeneration
A working group at MedUni Vienna develops strategies for regeneration of articular cartilage and has found that natural cartilage matrix is suitable as a biomaterial for improved cartilage regeneration. (2021-01-20)

OHIO researchers ID potential target for anti-viral drugs to battle COVID
This is a non-coding section of the RNA, which means that it is not translated into a protein, but it is likely key to the virus's replication. (2021-01-20)

CRISPR technology to cure sickle cell disease at UIC
The first cases treated with gene-editing technology were recently published in an article co-authored by Dr. Damiano Rondelli, the Michael Reese Professor of Hematology at the UIC College of Medicine. The article reports two patients have been cured of beta thalassemia and sickle cell disease after their own genes were edited with CRISPR-Cas9 technology. The two researchers who invented this technology received the Nobel Prize in Chemistry in 2020. (2021-01-20)

Getting under your skin: Molecular research builds new understanding of skin regeneration
New research from Northwestern University has found new evidence deep within the skin about the mechanisms controlling skin repair and renewal. (2021-01-19)

Lasers & molecular tethers create perfectly patterned platforms for tissue engineering
Researchers at the University of Washington have developed a technique to modify naturally occurring biological polymers with protein-based biochemical messages that affect cell behavior. Their approach, published the week of Jan. 18, 2021 in the Proceedings of the National Academy of Sciences, uses a near-infrared laser to trigger chemical adhesion of protein messages to a scaffold made from biological polymers such as collagen, a connective tissue found throughout our bodies. (2021-01-18)

FGF23 hormone from red blood cell precursors promotes hematopoietic stem cell mobilization
A Kobe University research group have discovered that fibroblast growth factor-23 (FGF23) produced by erythroblasts (cells that are the precursors of red blood cells) promotes the movement of hematopoietic stem cells into the peripheral blood. It is hoped that this discovery will enable new strategies to be developed for harvesting hematopoietic stem cells from bone marrow transplant donors. (2021-01-18)

A mathematical study describes how metastasis starts
A scientific study carried out by the Universidad Carlos III de Madrid (UC3M) and the Universidad Complutense de Madrid (UCM) has produced a mathematical description of the way in which a tumor invades the epithelial cells and automatically quantifies the progression of the tumor and the remaining cell islands after its progression. The model developed by these researchers could be used to better understand the biophysical characteristics of the cells involved when developing new treatments for wound healing, organ regeneration, or cancer progression. (2021-01-18)

Novel organoid models: Illuminating path to cervical cancers
How do tumors develop in the cervix? Many new details are now known about this question. This is also thanks to Dr. Cindrilla Chumduri from the Biocentre at the University of Würzburg. (2021-01-18)

A rift in the retina may help repair the optic nerve
In experiments in mouse tissues and human cells, Johns Hopkins Medicine researchers say they have found that removing a membrane that lines the back of the eye may improve the success rate for regrowing nerve cells damaged by blinding diseases. (2021-01-14)

Retinal cell transplant clears experimental hurdle toward treating blindness
Retinal cells derived from adult human eye stem cells survived when transplanted into the eyes of monkeys, an important early step in the validation of this approach for treating blindness, according to a study by Liu, et al recently published in Stem Cell Reports. The retinal pigment epithelium (RPE), a layer of pigmented cells in the retina, is essential for sustaining normal vision. Blindness due to RPE dysfunction, such as macular degeneration, affects about 200 million people worldwide. (2021-01-14)

Scientists take important step toward using retinal cell transplants to treat blindness
Latest discovery is promising step in use of cell therapy to treat retinal diseases (2021-01-14)

Reverse engineering 3D chromosome models for individual cells
A new computational technique that uses heat map data to reverse engineer highly detailed models of chromosomes and researchers have uncovered new information about the close spatial relationships that chromatin folding creates between genes. (2021-01-14)

Discovery of 'adolescent' skeletal stem cells might someday help prevent osteoporosis
A new study reported in STEM CELLS reveals a unique population of skeletal stem cells (SSCs) that function during the transitional period between rapid bone growth and bone maintenance. (2021-01-13)

A niche for the eye
What if the degenerative eye conditions that lead to glaucoma, corneal dystrophy, and cataracts could be detected and treated before vision is impaired? Recent findings from the lab of Investigator Ting Xie, PhD, at the Stowers Institute for Medical Research point to the ciliary body as a key to unlocking this possibility. (2021-01-13)

Scientists are a step closer to developing 'smart' stem cells - made from human fat
These new, adaptive stem cells can lie dormant until needed, a new animal study using human cells shows. (2021-01-13)

MicroLED neural probe for neuroscience
Associate Professor Hiroto Sekiguchi and Ph.D. candidate Hiroki Yasunaga at Toyohashi University of Technology have developed a MicroLED neural probe for neuroscience. This MicroLED tool can optogenetically control and observe neural activity in the brain. Neural activity was successfully recorded using the neural probe, and sufficient light output was obtained from the MicroLED to activate neural activity. The developed MicroLED tool will contribute to the development of neuroscience research-purposed optogenetic technology. (2021-01-12)

Hope for children with rare heart condition: novel stem cell therapy to save the day
In a new study, scientists at Okayama University isolated cardiac stem cells and assessed their potential use as regenerative therapy in young patients with cardiac defects. They confirmed the safety and effectiveness of their proposed treatment in early-phase trials and even identified the mechanism through which the stem cells improved cardiac function. Based on these preliminary findings, they hope to proceed to larger clinical trials and move towards pharmaceutical approval in the future. (2021-01-12)

SARS-CoV-2 can infect neurons and damage brain tissue, study indicates
Using both mouse and human brain tissue, researchers at Yale School of Medicine have discovered that SARS-CoV-2 can directly infect the central nervous system and have begun to unravel some of the virus's effects on brain cells. The study, published today in the Journal of Experimental Medicine (JEM), may help researchers develop treatments for the various neurological symptoms associated with COVID-19. (2021-01-12)

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