Current Enzyme News and Events

Current Enzyme News and Events, Enzyme News Articles.
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UIC researchers invent new gene-editing tool
Researchers have discovered a new gene-editing technique that allows for the programming of sequential cuts -- or edits -- over time. (2021-02-23)

Silencing the alarm
Like a scene from a horror movie, tomato fruitworm caterpillars silence their food plants' cries for help as they devour their leaves. That is the finding of a multidisciplinary team of researchers, who said the results may yield insights into the abilities of crop plants -- such as tomato and soybean -- to withstand additional stressors, like climate change. (2021-02-17)

Neandertal gene variants both increase and decrease the risk for severe COVID-19
Last year, researchers at Karolinska Institutet in Sweden and the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany showed that a major genetic risk factor for severe COVID-19 is inherited from Neandertals. Now the same researchers show, in a study published in PNAS, that Neandertals also contributed a protective variant. Half of all people outside Africa carry a Neandertal gene variant that reduces the risk of needing intensive care for COVID-19 by 20 percent. (2021-02-16)

Study identifies never-before-seen dual function in enzyme critical for cancer growth
In developing therapies for hard-to-treat breast and ovarian cancers in patients with BRCA gene mutations, scientists aim to identify ways to keep cancer cells from using DNA break repair pathways. New findings demonstrate a previously-unknown capability for polymerase theta (pol theta) - a key enzyme in this repair function - that shows promise as a new avenue for treatment development. (2021-02-11)

The chemistry lab inside cells
Osaka University scientists describe a novel protein that spurs the post-translational modifications of the amino acid tryptophan to create an enzyme cofactor. This work may lead to the creation of new biological catalysts. (2021-02-10)

Metabolism: Researchers first to shed light on structure of huge enzyme complex
A new method has enabled the natural structure of particularly large and complex enzymes to be revealed. Scientists at Martin Luther University Halle-Wittenberg (MLU) and TU Berlin have published their findings in the journal Cell Reports. They investigated a multi-enzyme complex that plays an essential role in metabolism and have discovered that it functions differently than previously thought. This will help scientists better understand certain diseases. (2021-02-10)

Study identifies 'Achilles heel' of bacteria linked to Crohn's disease
The discovery of an ''Achilles heel'' in a type of gut bacteria that causes intestinal inflammation in patients with Crohn's disease may lead to more targeted therapies for the difficult to treat disease, according to Weill Cornell Medicine and NewYork-Presbyterian investigators. (2021-02-05)

Garlic and selenium increase stress resistance in carps, says a RUDN University biologist
A biologist from RUDN University confirmed that selenium nanoparticles and garlic extract can effectively reduce the negative impact of stress on the health of grass carp in the breeding industry. (2021-02-04)

Hydrogen-producing enzyme protects itself against oxygen
Hydrogen-producing enzymes are beacons of hope in biohydrogen research. However, they are so vulnerable to oxygen in the air that it has not been possible to exploit their potential on a larger scale. The recently discovered [FeFe]-hydrogenase CbA5H from the bacterium Clostridium beijerinckii resists the oxygen attack. (2021-02-02)

Remdesivir disrupts COVID-19 virus better than other similar drugs
New PME research shows how the COVID-19 drug remdesivir works at the molecular level, which could help scientists determine how best to use it to treat the disease. (2021-01-29)

Sloan Kettering Institute scientists solve a 100-year-old mystery about cancer
A long-standing mystery is why fast-growing cells, like cancer cells and immune cells, rely on a seemingly inefficient form of metabolizing glucose to power their activities. In a new study, scientists at the Sloan Kettering Institute offer a compelling solution. (2021-01-21)

Breakthrough in understanding 'tummy bug' bacteria
Scientists have discovered how bacteria commonly responsible for seafood-related stomach upsets can go dormant and then ''wake up''. (2021-01-20)

Target of new cancer treatment valid for breast as well as blood cancers: study
Newly published research shows that a new anti-cancer drug developed at the University of Alberta, set to begin human trials this year, may work against breast cancer as well as blood cancer. (2021-01-20)

Researchers discover mechanism behind most severe cases of a common blood disorder
G6PD deficiency affects about 400M people worldwide and can pose serious health risks. Now, researchers think they've found the cause of the most severe cases, which could finally lead to treatments. (2021-01-19)

Expanding the boundaries of CO2 fixation
Design and realization of synthetic enzymes open up an alternative to natural photorespiration (2021-01-09)

UC researcher urges caution using remdesivir to treat COVID-19
Research at the University of Cincinnati, however, contends that this antiviral drug is being used too indiscriminately when treating patients hospitalized with the virus. The study is published in the journal Fundamental & Clinical Pharmacology. (2020-12-29)

Scientists pinpoint molecular cause for severe disorder in children
A team of scientists from the University of Ottawa have opened a window into the cause of a rare genetic disorder that causes mortality in young children. (2020-12-22)

Enzyme discovery can help rein in blood vessels that fuel cancer
Most living things need oxygen to grow and thrive. Even cancerous tumors. That's why tumors will readily sprout new blood vessels if their oxygen is starved, creating new lifelines for survival. A study published today from Scripps Research pinpoints the precise molecular machinery that makes this happen, providing scientific insights that can potentially be translated into medicines that help kill tumors and stop cancer from spreading in the body. (2020-12-22)

New energy conversion layer for biosolar cells
A research team from the Ruhr-Universit├Ąt Bochum, together with colleagues from Lisbon, has produced a semi-artificial electrode that could convert light energy into other forms of energy in biosolar cells. The technique is based on the photosynthesis protein Photosystem I from cyanobacteria. The group showed that they could couple their system with an enzyme that used the converted light energy to produce hydrogen. (2020-12-21)

New discovery opens novel pathway for high-titer production of drop-in biofuels
Using an unusual, light-dependent enzyme and a newly discovered enzymatic mechanism, researchers from Aarhus University and Massachusetts Institute of Technology have enabled the biological synthesis of high-yield industry relevant production of climate neutral drop-in fuels from biowaste. The study along with the new discovery has been published in Nature Communications. (2020-12-17)

ACE2 protein protects against severe COVID-19: Study
Female COVID-19 patients face less severe disease complications and a lower risk of dying than male patients thanks to hormones and chromosomes that contribute to a stronger immune response, according to new research from a University of Alberta-led team. (2020-12-17)

Blocking DNA repair enzyme could help treat certain cancers
Researchers at the Francis Crick Institute have found a new way to prevent some tumours from repairing their own DNA, a function that is essential for cancer cell survival. This discovery could lead to much needed new treatments for certain types of the disease. (2020-12-16)

RNA basic building block produced biocatalytically for the first time
Researchers from TU Graz and acib succeed in the first enzyme-driven biocatalytic synthesis of nucleic acid building blocks. This facilitates the development of antiviral agents and RNA-based therapeutics. (2020-12-15)

Carrots are healthy, but active enzyme unlocks full benefits
Carrots are a good source of beta-carotene, which is a precursor of vitamin A. But to get the full health benefits of this superfood, you need an active enzyme to produce this vitamin. (2020-12-11)

A gene from ancient bacteria helps ticks spread Lyme disease
One reason ticks spread Lyme disease so well goes back to a unique evolutionary event. Researchers reporting in the journal Cell on December 10, 2020 discovered that an antibacterial enzyme in ticks, Dae2, protects them from bacteria found on human skin, while still allowing them to harbor Borrelia burgdorferi, the bacterium that causes Lyme disease. Ticks acquired the gene for this enzyme 40 million years ago from an unknown species of ancient bacteria. (2020-12-10)

Understanding bacteria's metabolism could improve biofuel production
A new study reveals how bacteria control the chemicals produced from consuming 'food.' The insight could lead to organisms that are more efficient at converting plants into biofuels. (2020-12-03)

Potential means of improving learning and memory in people with mental illnesses
More than a dozen drugs are known to treat symptoms such as hallucinations, erratic behaviors, disordered thinking and emotional extremes associated with schizophrenia, bipolar disorder and other severe mental illnesses. But, drug treatments specifically able to target the learning, memory and concentration problems that may accompany such disorders remain elusive. (2020-12-03)

Breaking the rules of chemistry unlocks new reaction
Scientists have broken the rules of enzyme engineering to unlock a new method for creating chemical reactions that could unlock a wide range of new applications -- from creating new drugs to food production. (2020-12-01)

Penn researchers unlock the door to tumor microenvironment for CAR T cells
Combining chimeric antigen receptor (CAR) T cell therapy with a PAK4 inhibitor drug allowed the engineered cells to punch their way through and attack solid tumors, leading to significantly enhanced survival in mice. (2020-11-30)

Defined blockade
The addition and removal of methyl groups on DNA plays an important role in gene regulation. In order to study these mechanisms more precisely, a German team has developed a new method by which specific methylation sites can be blocked and then unblocked at a precise time through irradiation with light (photocaging). As reported in the journal Angewandte Chemie, the required regent is produced enzymatically, in situ. (2020-11-24)

Breakthrough in studying the enzyme that ultimately produces fish odour syndrome
Fish odour syndrome (trimethylaminuria) is a debilitating disease, in which the liver cannot break down the smelly chemical trimethylamine which is produced by enzymes from bacteria residing in the gut leaving people with a fish like odour. Researchers from the University of Warwick are paving the way to prevent the syndrome after a breakthrough in studying the enzyme in the gut which produces trimethylamine. (2020-11-23)

Unlocking cheaper chemicals
A new technique to make cheaper more efficient biological enzyme hybrids could have valuable applications in future water recycling, targeted drug manufacturing and other industries, Flinders University green chemistry researchers say in a new publication. The model enzyme system, which immobilises a catalyst enzyme hybrid for continuous flow use in the high-speed vortex fluidic device, showed a 16-fold increase in its efficiency, the researchers say in American Chemical Society journal, ASC Applied Materials & Interfaces. (2020-11-22)

Glyphosate may affect human gut microbiota
More than half of bacterial species in the core of the human gut microbiome are potentially sensitive to glyphosate, shows new research. Researchers from the University of Turku Finland, introduced the first bioinformatics resource to determine and test the potential sensitivity of organisms to glyphosate. (2020-11-20)

Biofriendly protocells pump up blood vessels
In a new study published today in Nature Chemistry, Professor Stephen Mann and Dr Mei Li from Bristol's School of Chemistry, together with Associate Professor Jianbo Liu and colleagues at Hunan University and Central South University in China, prepared synthetic protocells coated in red blood cell fragments for use as nitric oxide generating bio-bots within blood vessels. (2020-11-20)

Discovery illuminates how cell growth pathway responds to signals
A basic science discovery by researchers at the Johns Hopkins Bloomberg School of Public Health reveals a fundamental way cells interpret signals from their environment and may eventually pave the way for potential new therapies. (2020-11-20)

Ribosome assembly - The final trimming step
Ribosomes synthesize all the proteins in cells. Studies mainly done on yeast have revealed much about how ribosomes are put together, but an Ludwig-Maximilians-Universitaet (LMU) in Munich team now reports that ribosome assembly in human cells requires factors that have no counterparts in simpler model organisms. (2020-11-20)

Gut microbiome manipulation could result from virus discovery
Scientists have discovered how a common virus in the human gut infects and takes over bacterial cells - a finding that could be used to control the composition of the gut microbiome, which is important for human health. The Rutgers co-authored research, which could aid efforts to engineer beneficial bacteria that produce medicines and fuels and clean up pollutants, is published in the journal Nature. (2020-11-18)

Promising results from in vitro combination therapy against COVID-19
Researchers at Karolinska Institutet in Sweden report promising results from an in vitro combination therapy against COVID-19. In a study published in EMBO Molecular Medicine, the researchers show that a combination of remdesivir, an approved drug against COVID-19, and hrsACE2, a medicine currently in phase II trials for COVID-19 treatment, reduced the viral load of SARS-CoV-2 and inhibited viral replication in cell cultures and organoids. (2020-11-17)

Newly discovered enzyme helps make valuable bioactive saponins
A team led by researchers from Osaka University discovered a new enzyme, closely related to the CSyGT family of enzymes involved in producing cellulose in plant cell walls. Unexpectedly, they found the new enzyme is responsible for a key step in the biosynthesis of saponins, bioactive products with high-value applications in medicine and the food industry. The new enzyme opens up novel routes for commercial production of these valuable compounds in microbial cells. (2020-11-16)

Cellular powerplant recycles waste gases
Carbon monoxide is a very poisonous gas. Humans die within minutes when they inhale it. However, some microorganisms tolerate carbon monoxide. Knowledge about how these bacteria survive opens a window into the primeval times of the earth and the origin of life. At the same time, they might be useful for the future as they can be used to clean waste gases and produce biofuels. Scientists from the Max Planck Institute for Marine Microbiology in Bremen have now made a surprising discovery. (2020-11-16)

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