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Current Estrogen News and Events, Estrogen News Articles.
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Different hormone therapies affect brain function differently
Sex hormones influence the structure and function of the brain, but little is known about the effect of hormone therapies (HT) on changes in the brain during menopause. A new study shows smaller increases in structural brain changes related to aging were associated with hormone-level changes from transdermal estradiol or oral conjugated equine estrogen. Study results are published online in Menopause, the journal of The North American Menopause Society (NAMS). (2020-06-10)

Physical activity in all of its forms may help maintain muscle mass in midlife
Loss of estrogen has an effect on muscles and leads to a decline in muscle mass. Physical activity in all of its forms may help maintain muscle mass in midlife. (2020-06-08)

'Terminator' protein halts cancer-causing cellular processes
New research from the lab of Hening Lin, professor of chemistry and chemical biology in the College of Arts and Sciences, finds that a protein called TiPARP acts as a terminator for several cancer-causing transcription factors, including HIF-1, which is implicated in many cancers, including breast cancer. The research demonstrates that TiPARP, therefore, is a tumor suppressor. (2020-06-03)

Estrogen's role in the sex differences of alcohol abuse
Fluctuating estrogen levels may make alcohol more rewarding to female mice, according to new research in JNeurosci. Untangling the involved signaling pathways could unveil sex-based treatments for alcohol use disorders. (2020-06-01)

Does estrogen influence alcohol use disorder?
A new study from researchers at the University of Illinois at Chicago shows that high estrogen levels may make alcohol more rewarding to female mice. (2020-06-01)

African-American and white women share genes that increase breast cancer risk
The same genes that greatly increase the risk of breast cancer in US white women, including women of Ashkenazi Jewish descent, also greatly increase breast cancer risk among African-American women. (2020-05-19)

Identification of a determining factor in luminal cancer cells
Researchers at IRB Barcelona discover a new mechanism in estrogen receptor-positive breast cancer cells. The inhibition of CPEB2, a key factor in the estrogen signalling pathway, causes cancer cells to proliferate less and protects mice against luminal breast cancer. (2020-05-18)

Genome study links DNA changes to the risks of specific breast cancer subtypes
An analysis of genetic studies covering 266,000 women has revealed 32 new sites on the human genome where variations in DNA appear to alter the risks of getting breast cancer. (2020-05-18)

Genes may play a role in weight gain from birth control
A woman's genetic make-up may cause her to gain weight when using a popular form of birth control, according to a study from researchers at the University of Colorado Anschutz Medical Campus. (2020-05-12)

Killing 'sleeper cells' may enhance breast cancer therapy
The anti-cancer medicine venetoclax could improve the current therapy for estrogen receptor-positive (ER+) breast cancer - the most common form of breast cancer in Australia - according to preclinical studies led by Walter and Eliza Hall Institute researchers. The promising preclinical results for this 'triple therapy' have underpinned a phase 1 clinical trial in Melbourne, Australia, that is combining venetoclax with hormone therapy and CDK4/6 inhibitors in patients with ER+ breast cancer. (2020-05-06)

Researchers identify unique glucose-sensing neurons that regulate blood sugar
At Baylor College of Medicine and other institutions, researchers have identified a group of unique glucose-sensing neurons in the brain and how they work together to prevent severe hypoglycemia in mice. (2020-05-01)

Study shows immunotherapy prior to surgery may help destroy high-risk breast cancer
A new study led by Yale Cancer Center (YCC) researchers shows women with high-risk HER2-negative breast cancer treated before surgery with immunotherapy, plus a PARP inhibitor with chemotherapy, have a higher rate of complete eradication of cancer from the breast and lymph nodes compared to chemotherapy alone. (2020-04-28)

Researchers discover a key to the survival of dormant breast cancer cells
Trying to understand why dormant breast cancer cells survive despite being starved of estrogen to prevent growth, researchers from Dartmouth's and Dartmouth-Hitchcock's Norris Cotton Cancer Center found that breakdown of fat to produce energy supports cancer cell survival. This type of fat metabolism is activated by metformin, an anti-diabetes drug being tested in clinical trials as an anti-cancer agent. Their findings suggest that metformin actually has context-dependent effects on cancer cells. (2020-04-22)

Research provides new insights into menopause and weight gain
Can women in menopause get the benefits of hormone replacement therapy without the health risks? A new UCLA study conducted with mice points in that direction, but additional research is necessary. UCLA biologists report April 13 that a gene called reprimo, which is expressed by certain neurons in the brain, may play a role in menopause-related weight gain, a phenomenon not linked to increased eating. (2020-04-13)

Androgen receptor stops tumor growth in the most common form of breast cancer
Researchers say they have found a viable new therapeutic strategy for estrogen receptor-positive (ER+) breast cancer, even cancers that are resistant to current standard of care treatments. They will present the results of their new preclinical study accepted for presentation at ENDO 2020, the Endocrine Society's annual meeting, and publication in a special supplemental section of the Journal of the Endocrine Society. (2020-03-31)

New drug combination restores beta cell function in animal model
In a new study in mice, Helmholtz Zentrum München in collaboration with Novo Nordisk, demonstrated for the first time that a targeted combinatorial drug treatment is able to restore beta cell function, achieve beta cell redifferentiation and therefore potentially open new ways for diabetes remission. (2020-02-20)

Postmenopause vitamin D deficiency associated with disc degeneration and lower back pain
Lumbar disc degeneration and resulting lower back pain become greater concerns with age and disproportionately affect women more than men, likely as a result of decreasing estrogen levels during menopause. A new study demonstrates that vitamin D deficiency, smoking, high body mass index (BMI), and osteoporosis are risk factors for greater back pain. Study results are published online today in Menopause, the journal of The North American Menopause Society (NAMS). (2020-02-12)

Sex hormone-related protein levels may impact stroke risk in women
Women with lower blood levels of a protein that binds to and transports sex hormones like estradiol and testosterone may have a higher risk of ischemic stroke. Hormonal biomarkers may someday improve the ability to predict ischemic stroke risk in women. (2020-02-12)

Prolonged use of hormone therapy may minimize muscle loss associated with aging
Skeletal muscle mass and strength are critical in helping prevent falls, fractures, and disability. Yet, they continue to decline during the menopause transition. A new study showed that the prolonged use (defined as ≥13 mo) of hormone therapy (HT) was associated with higher muscle mass and less chance of sarcopenia. Study results are published online today in Menopause, the journal of The North American Menopause Society (NAMS). (2020-02-12)

Utah researchers discover key protein in endometrial cancer growth
New research, published today in the journal Cancer Research, outlines findings scientists hope will advance our understanding of endometrial cancer and lead to more effective treatments. (2020-02-11)

Fat-fighting drug discovery
Cancer-fighting compound fights obesity and diabetes. (2020-02-06)

Not all hormone therapy protects equally against heart disease in postmenopausal women
Hormone therapy has proven to slow down heart fat deposition and the progression of atherosclerosis, depending on the type of hormone therapy and route of administration. A new study compared the effects of conjugated equine estrogens (CEE) and 17β-estradiol and contrasted oral and transdermal delivery to determine their effectiveness in preventing heart disease. Study results are published online today in Menopause, the journal of The North American Menopause Society (NAMS). (2020-02-05)

Gene variants provide insight into brain, body incongruence in transgender
Some of the first biological evidence of the incongruence transgender individuals experience, because their brain indicates they are one sex and their body another, may have been found in estrogen receptor pathways in the brain of 30 transgender individuals. (2020-02-05)

New therapy option identified for early-stage breast cancer
Radionuclide therapy has been successful in delaying the growth of disseminated tumor cells in early-stage breast cancer. Radium-233 dichloride not only impacts cells directly hit by radiation but also has significant effects on cells outside of the radiation field, according to research published in The Journal of Nuclear Medicine. (2020-02-05)

Unanticipated response to estrogen at the single cell level
A team led by researchers at Baylor College of Medicine found that not only do individual mammalian cells in a population fail to respond synchronously to estrogen stimulation, neither do individual gene copies, known as alleles. (2020-01-27)

Oral hormone-blocking drug may help with heavy menstrual bleeding
In women with uterine fibroids, the drug elagolix suppresses ovarian hormone production and prevents heavy menstrual bleeding. (2020-01-23)

Hormone resistance in breast cancer linked to DNA 'rewiring'
Garvan researchers have revealed changes to the 3D arrangement of DNA linked to treatment resistance in ER+ breast cancer. (2020-01-16)

Estrogen may facilitate the growth of liver metastases in non-sex-specific cancers
A study led by Dr. Pnina Brodt shows that the liver immune microenvironment reacts to metastatic cells differently in male and that in female mice and estrogen can indirectly contribute to the growth of metastases. These findings provide a rationale for further exploration of the role of sex hormones in female cancer patients and the potential benefits of anti-estrogen drugs such as tamoxifen in the treatment of hormone-independent cancers that metastasize to the liver. (2020-01-16)

UMass Amherst researchers identify new mechanism involved in promoting breast cancer
A new approach to studying the effects of two common chemicals used in cosmetics and sunscreens found they can cause DNA damage in breast cells at surprisingly low concentrations, while the same dose did not harm cells without estrogen receptors. (2020-01-15)

BPA activates immune response in mice that passes down through generations
Some plastic food and beverage containers still contain bisphenol A (BPA), which can mimic the hormone estrogen. Although experts say that small amounts of BPA detected in foods are unlikely to cause problems, some people worry that constant low-level exposures could have health effects, especially for developing fetuses, infants and children. Now, researchers report in ACS' Journal of Proteome Research that in mice, BPA activates an immune response that persists for at least three generations. (2020-01-15)

Investigational drugs block bone loss in mice receiving chemotherapy
Studying mice, researchers from Washington University School of Medicine in St. Louis have found a driver of bone loss related to cancer treatment. Radiation and chemotherapy can halt cell division in bone, which results in a stress response called senescence. This process is independent of hormones that affect bone health, such as estrogen. Such bone loss can be stopped by treating the mice with either of two investigational drugs already being evaluated in clinical trials, according to the researchers. (2020-01-13)

Are some antidepressants less risky for pregnant women?
About one in ten women in Québec will suffer from depression during pregnancy. Without treatment, the illness carries risks for both mother and child. Yet antidepressants are not without consequences for fetal development. The team of professor Cathy Vaillancourt at the Institut National de la Recherche Scientifique (INRS) is studying the effects of these drugs in order to identify the least harmful ones. (2020-01-08)

Study of veterans details genetic basis for anxiety, links anxiety and depression
A massive genomewide analysis of approximately 200,000 military veterans has identified six genetic variants linked to anxiety, researchers from Yale and colleagues at other institutions report Jan. 7, 2019 in the American Journal of Psychiatry. (2020-01-07)

Genetic study provides most comprehensive map of risk to date of breast cancer risk
A major international study of the genetics of breast cancer has identified more than 350 DNA 'errors' that increase an individual's risk of developing the disease. The scientists involved say these errors may influence as many as 190 genes. (2020-01-07)

Hyperactive FOXA1 reprograms endocrine-resistant breast cancer to become metastatic
A team led by researchers at Baylor College of Medicine and Harvard Medical School has unveiled a novel mechanism that helps explain how endocrine-resistant breast cancer acquires metastatic behavior, opening the possibility of new therapeutic strategies. (2019-12-11)

Therapeutic inhibition of Mcl-1 blocks cell survival in estrogen receptor-positive breast cancers
While estrogen receptor - + breast cancers express high levels of three anti-apoptotic Bcl-2 family members, pharmacological inhibition of Bcl-2 and/or Bcl-xL fails to induce cell death in ER + breast cancer cell lines, due to rapid and robust Mcl-1 upregulation. Cells treated with a pharmacological inhibitor of cap-dependent translation, or with the mTORC1 inhibitor RAD001/everolimus, displayed reduced protein levels of Mcl-1 under basal conditions, and failed to upregulate Mcl-1 protein expression following treatment with ABT-263... (2019-11-26)

Perimenopause often signals beginning of sexual dysfunction
For some women, sex becomes less satisfying with age, with a pronounced decline during perimenopause. A new study indicates that sexual dysfunction increases by nearly 30% during perimenopause, and vaginal dryness most often has the greatest effect on desire, arousal, lubrication, and overall satisfaction. Study results were published this week in Menopause, the journal of The North American Menopause Society (NAMS). (2019-11-15)

New insights into cause and treatments for aggressive form of breast cancer
Potential environmental risk factors and new targets for treating an aggressive form of breast cancer have been identified, according to new data presented at the Society for Endocrinology annual conference in Brighton. The study suggests that exposure to common chemicals in our everyday environment may increase the risk of developing a difficult to treat type of breast cancer and highlights strategies for new treatment using combination therapy. (2019-11-11)

Estrogen's opposing effects on mammary tumors in dogs
Estrogen's role in canine mammary cancer is more complex than previously understood, according to new research led by the University of Pennsylvania School of Veterinary Medicine. The nuanced findings may help explain why dogs spayed at a young age are more likely to develop more aggressive cancers, the team says. (2019-11-01)

Polymerized estrogen shown to protect nervous system cells
In research published today in Nature Communications, an interdisciplinary team from Rensselaer Polytechnic Institute demonstrated how estrogen -- a natural hormone produced in the body -- can be polymerized into a slow-releasing biomaterial and applied to nervous system cells to protect those cells and even promote regeneration. (2019-10-23)

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