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High-fructose diet during and after pregnancy can cause a fatty liver in offspring
A diet high in fructose-containing sugars eaten during pregnancy or while breastfeeding can cause offspring to have a fatty liver, increasing their chances of developing obesity or type 2 diabetes. This is according to a new rat study published in The Journal of Physiology. (2017-04-26)

Obesity amplifies genetic risk of nonalcoholic fatty liver disease
An international study based at UT Southwestern Medical Center revealed a striking genetic-environmental interaction: Obesity significantly amplifies the effects of three gene variants that increase risk of nonalcoholic fatty liver disease (NAFLD) by different metabolic pathways. (2017-04-25)

Risk of obesity influenced by changes in our genes
A child's risk of obesity as they grow up can be influenced by modifications to their DNA prior to birth, a new University of Southampton study has shown. (2017-04-25)

Popular belief that saturated fats clog up arteries 'plain wrong' say experts
The widely held belief among doctors and the public that saturated fats clog up the arteries, and so cause coronary heart disease, is just 'plain wrong,' contend experts in an editorial published online in the British Journal of Sports Medicine. (2017-04-25)

Vitamin A + high-fat diet = increased risk for obesity, diabetes
Vitamin A is an essential nutrient that the human body needs to function properly. But new research presented today at the American Physiological Society (APS) annual meeting at Experimental Biology 2017 in Chicago suggests that normal levels of vitamin A within a high-fat diet can negatively affect expression of liver genes associated with glucose and fat metabolism. (2017-04-25)

'Diet' products can make you fat, study shows
High-fat foods are often the primary target when fighting obesity, but sugar-laden 'diet' foods could be contributing to unwanted weight gain as well. (2017-04-25)

Maternal high-fat diet may increase offspring risk for liver disease
A new mouse study suggests that exposure to a high-fat diet in the womb and immediately after birth promotes more rapid progression of nonalcoholic fatty liver disease later in life. Nonalcoholic fatty liver disease is the most common chronic liver disease diagnosed in adults and children. (2017-04-24)

Four exciting diabetes and obesity research discoveries
With more than one-third of adults in the US considered obese, researchers are searching for new ways to treat obesity and associated health problems such as type 2 diabetes. The Experimental Biology 2017 meeting (EB 2017) will showcase new insights into the causes of obesity and research that could inform new strategies for losing weight. (2017-04-22)

When liver immune cells turn bad
A high-fat diet and obesity turn 'hero' virus-fighting liver immune cells 'rogue,' leading to insulin resistance, a condition that often results in type 2 diabetes, according to research published today in Science Immunology. (2017-04-21)

In roundworms, fats tip the scales of fertility
Two University of Colorado Boulder scientists have discovered how fat levels in a tiny soil-dwelling roundworm (C. elegans) can tip the balance between whether the worm makes eggs or sperm. Although the researchers discovered this phenomenon in worms, the research could have implications for future studies into human fertility and reproductive development. (2017-04-20)

Nutrient offers hope to stop deadly march toward cirrhosis, liver cancer
A new study suggests that one type of omega 3 fatty acid offers people who are obese or have a poor diet a chance to avoid serious liver damage. (2017-04-19)

High-fat, high-carb diet a cause of osteoarthritis
Saturated fat is a prime suspect in the onset of osteoarthritis after QUT scientists found it changed the composition of cartilage, particularly in the weight-bearing joints of the hip and knee. (2017-04-18)

Do BAT receptors hold the key to treating obesity and diabetes?
According to research published online in The FASEB Journal, scientists have discovered a way to increase the amount of metabolism-boosting brown adipose tissue (BAT) ('good' fat) by employing two receptors on BAT cells as potential therapeutic targets. (2017-04-17)

Sympathetic nervous system is critical in regulating energy expenditure and thermogenesis
New study suggests that your brain, not your white blood cells, keeps you warm. (2017-04-17)

Research suggests bans on trans fats linked to healthier communities
People living in areas that restrict trans fats in foods had fewer hospitalizations for heart attack and stroke compared to residents in areas without restrictions, according to a new study conducted by researchers at the University of Chicago Medicine and Yale School of Medicine. (2017-04-14)

Ban on trans fats in diet may reduce heart attacks and stroke
People living in areas that restrict trans fats in foods had fewer hospitalizations for heart attack and stroke compared to residents in areas without restrictions, according to a study led by a Yale researcher. This finding suggests the benefit of limiting trans fats could have widespread impact as trans fat restrictions are set to expand nationwide. (2017-04-12)

Mouse experiment sheds light on the dietary benefits of extra virgin olive oil
Experiments carried out in mice have revealed that a compound commonly found in extra virgin olive oil can reverse some of the negative effects of a high-fat diet. This compound, called hydroxytyrosol, was able to reverse markers of insulin resistance and non-alcoholic fatty liver disease in mice fed on a high-fat diet. The results are published this week in the open-access journal Lipids in Health and Disease. (2017-04-10)

Protein hampers the positive power of brown and beige fat
Too much of a protein already associated with prostate cancer appears to also diminish the energy burning power of brown fat, scientists report. (2017-04-10)

What obese fruit flies may tell us about the evolution of cold tolerance
Researchers have hypothesized that migrations into higher, colder latitudes may lead to evolution of fast-burning metabolisms that keep cells warm in chilly conditions. In Developmental Cell, researchers show that a gene that has previously been identified as one of the key genes in humans that differs in people from arctic latitudes and people from tropical latitudes, helps flies burn energy from fat. When the gene is knocked out, flies become obese and burn less energy. (2017-04-10)

Attitudes vary across groups regarding meal choice in restaurants
Differences in opinions between parents and children and executives of restaurant chains represent a challenge in terms of promoting healthy eating habits. In order to better understand those opinions, researchers surveyed parents and children dining at participating restaurants, as well as executives of restaurant chains, to obtain more information on healthy children's meals. (2017-04-06)

Fatty liver diagnosis improved with magnetic resonance
Taking tissue samples from the liver to diagnose fatty liver can be replaced in most cases by a painless magnetic resonance investigation. This is the conclusion of a new study from Linköping University in Sweden, published in the scientific journal Gastroenterology. The authors propose that the current value considered to be a normal amount of fat in the liver should be lowered. (2017-04-06)

High fat, high sugar diet during pregnancy 'programs' for health complications
Eating a high-fat, high-sugar diet when pregnant 'programs' both mother and child for potential health complications later in life by disrupting metabolic processes within the mother's body, researchers have found. The study is the first to reveal the mechanisms which cause the link between eating an obesity-promoting diet during pregnancy and an increased risk of problems such as type 2 diabetes, obesity and hypertension in both parent and child. (2017-04-05)

Regular exercise, not BMI, before stroke may predict disability later
A new study suggests it's the amount of regular exercise people get, not the amount of body fat they have, that may predict just how well they recover from a stroke. The study is published in the April 5, 2017, online issue of Neurology®, the medical journal of the American Academy of Neurology. (2017-04-05)

Monounsaturated fats help roundworms live longer, Stanford researchers say
Pudgy roundworms storing a particular type of fat live longer than their more svelte counterparts, according to a study by researchers at the Stanford University School of Medicine. (2017-04-05)

Study: Liver responds positively to leptin treatment in patients with lipodystrophy
Researchers at Michigan Medicine have found the livers of patients with a rare disease that affects metabolism have responded positively to leptin therapy. (2017-04-04)

Treating polycystic ovary syndrome early may help prevent later drop in fertility
In adolescent girls with polycystic ovary syndrome (PCOS), bringing the amount of abdominal visceral fat and liver fat down to normal restores ovulation, normalizes the symptoms of androgen excess, and may help prevent future subfertility, new research from Spain suggests. The results of the study will be presented Tuesday, April 4, at ENDO 2017, the annual meeting of the Endocrine Society, in Orlando. (2017-04-04)

Disrupted stress hormone signals in bone cells protect from diet-induced obesity
A high-calorie diet, even without a high amount of fat, causes bone loss, and both high-calorie and high-fat diets induce excessive fat gain and insulin resistance, a new study conducted in mice finds. Study results, to be presented Tuesday at ENDO 2017, the Endocrine Society's 99th annual meeting in Orlando, Fla., found that some of these negative effects happened because of an increase in the actions of glucocorticoids, or stress hormones, in the skeleton. (2017-04-04)

Low-calorie sweeteners promote fat accumulation in human fat
Low-calorie, artificial sweeteners appear to play havoc with the body's metabolism, and large consumption of these sugar substitutes could promote fat accumulation, especially in people who are already obese, preliminary research suggests. The study results will be presented Monday at ENDO 2017, the Endocrine Society's 99th annual meeting in Orlando, Fla. (2017-04-03)

Elimination of specific neurons outside the brain triggers obesity
A research team from Instituto Gulbenkian de Ciencia (Portugal) developed a new genetic technique that allows the elimination of specific neurons of the peripheral nervous system without affecting the brain. Using this novel technique in mice, the researchers were able to study the function of the neurons that innervate the adipose tissue, and saw that their elimination results in mice pounding up very quickly. This study was published on April 3rd in Nature Communications. (2017-04-03)

Early-life BPA exposure reprograms gene expression linked to fatty liver disease
Exposure during infancy to the common plasticizer bisphenol A (BPA) (2017-04-01)

Giving brown fat a green light
Since the discovery in 2009 that brown fat can be active in adult humans, researchers around the world have worked to unveil ways to switch on this fat. Scientists at Joslin Diabetes Center now have identified a new route to throw the switch. (2017-03-29)

Stop eating! You are full
A novel role as appetite suppressant for BH4, a well-known enzyme cofactor. (2017-03-28)

Survivors of childhood brain tumors have increased body fat
These findings suggest that one of the most important risk factors for heart disease and type 2 diabetes, which is excess total and central fat in the body, is present relatively early in survivors of childhood brain tumors. This may program their future risk of these diseases and impact their outcomes. (2017-03-24)

Does boosting 'good' cholesterol really improve your health?
A new review addresses the mysteries behind 'good' HDL cholesterol and why boosting its levels does not necessarily provide protection from cardiovascular risk for patients. It appears that augmenting the function of HDL cholesterol, rather than its concentration, is key. (2017-03-22)

New role for immune cells in preventing diabetes and hypertension
Immune cells which are reduced in number by obesity could be a new target to treat diseases such as type 2 diabetes and hypertension that affect overweight people, according to a collaborative study between the University of Manchester, Lund University and the University of Salford. (2017-03-17)

Fat cells step in to help liver during fasting
How do mammals keep two biologically crucial metabolites in balance during times when they are feeding, sleeping, and fasting? The answer may require rewriting some textbooks. (2017-03-16)

'Low-content' nutritional claims on packaged goods misleading for consumers
Today, supermarket shelves are filled with products that make a variety of claims related to their perceived health benefits. Because there is no uniformity to what these statements mean, consumers are often left confused and ill informed. A new study found that simply making a low-content claim on the label was not a reliable indicator of a product's actual nutritional quality and that these claims may give consumers a false sense of confidence about the healthfulness of their food. (2017-03-15)

'No fat' or 'no sugar' label equals no guarantee of nutritional quality
Terms such as no-fat or no-sugar, low-fat or reduced-salt on food packaging may give consumers a sense of confidence before they purchase, but these claims rarely reflect the actual nutritional quality of the food, according to a new study led by researchers at the University of North Carolina at Chapel Hill. (2017-03-15)

Probiotics may not always be a silver bullet for better health
UNSW Sydney researchers have investigated the impact of probiotics on gut health and cognitive function. In rats fed on 'junk' diets, the probiotic medicine was able to significantly impact microbial composition in the gut and prevent memory loss. But for rats on a healthy diet, the probiotic did little to influence microbial composition and actually impaired memory function. (2017-03-14)

Supplemental fat not necessary when canola meal is fed to weanling pigs
New research from the University of Illinois shows that adding supplemental dietary fat is not necessary to avoid reduced growth performance when replacing soybean meal with canola meal in diets fed to weanling pigs. (2017-03-13)

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