Current Fatty Liver Disease News and Events

Current Fatty Liver Disease News and Events, Fatty Liver Disease News Articles.
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Give the heart a ketone? It may be beneficial
There is growing evidence that ketone bodies may be beneficial to heart disease patients regardless of the method of delivery used to increase ketone delivery to the heart. A Journal of the American College of Cardiology review paper examines emerging evidence regarding ketone bodies' effects on the heart and the potential for ketone therapy as a cardiovascular intervention in heart disease patients. (2021-02-23)

High fructose diets could cause immune system damage
People who consume a diet high in fructose could risk damaging their immune systems. (2021-02-22)

Cancer control: Non-DNA changes induce metabolism variations in hepatocellular carcinomas
Mechanisms underlying metabolic variations in hepatocellular carcinoma (HCC), a fast growing and invasive cancer, remain unclear. Now, researchers from Fudan University, China identified signatures of ''m6A,'' the most abundant ''post-transcriptional RNA modification,'' that segregate HCC into sub-types with distinct metabolic characteristics. They have also developed a novel m6A score that can quantify such modifications and aid risk assessment, prediction of prognosis, and response to treatment in patients with HCC. (2021-02-22)

Store fat or burn it? Targeting a single protein flips the switch
As obesity becomes a growing issue worldwide - nearly tripling over the last-half century - scientists are trying to gain a better understanding of the condition at the molecular level. Now, new research led by UC San Francisco scientists suggests that a single protein could play an outsize role in weight gain. (2021-02-18)

Lab-grown 'mini-bile ducts' used to repair human livers in regenerative medicine first
Scientists at the University of Cambridge have used a technique to grow bile duct organoids - often referred to as 'mini-organs' - in the lab and shown that these can be used to repair damaged human livers. This is the first time that the technique has been used on human organs. (2021-02-18)

Organoids grown from bile duct cells repair human livers; may aid liver transplant processes
Organoids grown from bile duct epithelial cells can be used to repair damaged bile ducts in transplanted human livers, researchers report. (2021-02-18)

Fatty tissue accumulated in the neck linked to heart problems, study finds
Researchers from the University of Granada warn that an accumulation of fatty tissue in the neck (both the double chin and the deeper deposits, located between muscles and around the cervical vertebrae) is a predictor of central and overall adiposity, cardiometabolic risk, and a pro-inflammatory profile in sedentary young adults (2021-02-17)

FSU College of Medicine researcher develops new possibilities to prevent sudden cardiac death
Stephen Chelko, an assistant professor of biomedical sciences at the Florida State University College of Medicine, has developed a better understanding of the pathological characteristics behind arrhythmogenic cardiomyopathy, as well as promising avenues for prevention. (2021-02-17)

Skies of blue: Recycling carbon emissions to useful chemicals and reducing global warming
Researchers optimize a novel process for the efficient conversion of carbon emissions into useful chemicals like acetate using microbes (2021-02-17)

Understanding cellular clock synchronization
In humans, the disruption of circadian clocks is the cause of many metabolic diseases. Thanks to an observation tool based on bioluminescence, a research (UNIGE) were able to demonstrate that cells that compose a particular organ can be in-phase, even in the absence of the central brain clock. Indeed, the scientists managed to restore circadian function in the liver in completely arrhythmic mice, demonstrating that neurons are not unique in their ability to coordinate. (2021-02-17)

Cytoglobin: key player in preventing liver disease
Researchers have discovered that the use of Cytoglobin (CYGB) as an intravenous drug could delay liver fibrosis progression in mice. CYGB, discovered in 2001 by Professor Norifumi Kawada, is present in hepatic stellate cells, the cells that produce fibrotic molecules such as collagens when the liver has acute or chronic inflammation induced by different etiologies. The enhancement of CYGB on these cells or the injection of recombinant CYGB has the effect of suppressing liver damage and cirrhosis. (2021-02-16)

Researchers identify muscle factor that controls fat metabolism
In a recent study, published in The Journal of Clinical Investigation, University Hospitals (UH) Cleveland Medical Center and Case Western Reserve University School of Medicine researchers have found that skeletal muscle significantly affects how the body stores and metabolizes fat. (2021-02-15)

Going the distance--insights into how cancer cells spread
In a study published in Nature Communications, cancer researchers at Kanazawa University identify mechanisms by which malignant tumor cells extend their toxicity to distinct cell types and in turn help them spread. (2021-02-12)

Ionic liquid uniformly delivers chemotherapy to tumors while destroying cancerous tissue
A Mayo Clinic team, led by Rahmi Oklu, M.D., Ph.D., a vascular and interventional radiologist at Mayo Clinic, in collaboration with Samir Mitragotri, Ph.D., of Harvard University, report the development of a new ionic liquid formulation that killed cancer cells and allowed uniform distribution of a chemotherapy drug into liver tumors and other solid tumors in the lab. This discovery could solve a problem that has long plagued drug delivery to tumors. (2021-02-11)

Routine blood tests could be key to stopping the silent killer of liver disease
New research has shown that results of blood tests routinely performed by GPs everywhere contain a hidden fingerprint that can identify people silently developing potentially fatal liver cirrhosis. The researchers have developed an algorithm to detect this fingerprint that could be freely installed on any clinical computer, making this a low-cost way for GPs to carry out large scale screening using patient data they already hold. (2021-02-11)

Lipid epoxides target pain, inflammatory pathways in neurons
When modified using a process known as epoxidation, two naturally occurring lipids are converted into potent agents that target multiple cannabinoid receptors in neurons, interrupting pathways that promote pain and inflammation, researchers report. These modified compounds, called epo-NA5HT and epo-NADA, have much more powerful effects than the molecules from which they are derived, which also regulate pain and inflammation. (2021-02-10)

Lipid composition of microalgae of the Kaliningrad Region was determined
Scientists from the Immanuel Kant Baltic Federal University and Kemerovo State University determined the qualitative and quantitative composition of fatty acids that the lipids of microalgae comprise. The results are expected to benefit medical science, cosmetology, energy production and the production of feed additives and functional food. (2021-02-09)

Type 2 diabetes: drugs initially increase glucose production
Although SGLT-2 inhibitors are central to the treatment of diabetes, their exact mode of action was hitherto unknown. A study shows that there is a direct correlation between the elimination of glucose via the kidneys and new glucose production in the liver. (2021-02-08)

Beyond secretion of insulin,the novel function of β cell in regulating glucose homeostasis
In a new study published in Journal of Extracellular Vesicles, Chen-Yu Zhang's group and Antonio Vidal-Puig's group at University of Cambridge report that pancreatic β cells secrete miR-29 family members (miR-29a, miR-29b and miR-29c) in response to high levels of free fatty acids (FFAs). These β cell-derived miR-29s are delivered to the liver, promoting insulin resistance and enhancing hepatic glucose output. (2021-02-07)

Drug 'breakthrough' gives longest-ever survival in nonresectable liver cancer patients
New follow-up data from a landmark study of liver cancer patients treated with a combination of an immunotherapy drug (atezolizumab) and a monoclonal antibody (bevacizumab) has shown the longest-ever survival time in a frontline phase 3 trial of systemic therapy in advanced hepatocellular carcinoma (HCC), demonstrating a 'major breakthrough' in the field. (2021-02-05)

Peginterferon-lambda shows strong antiviral action to accelerate clearance of COVID-19
A clinical study led by Dr. Jordan Feld, a liver specialist at Toronto Centre for Liver Disease, University Health Network (UHN), showed an experimental antiviral drug can significantly speed up recovery for COVID-19 outpatients - patients who do not need to be hospitalized. This could become an important intervention to treat infected patients and help curb community spread, while COVID-19 vaccines are rolled out this year. (2021-02-05)

Cancer leading cause of death among people with diabetes
Cancer is the leading cause of death among people with diabetes in England. (2021-02-04)

New combination therapy offers chance of healing hepatitis B
Around 260 million people, more than three percent of the global population, are chronically infected with the hepatitis B virus (HBV); in the long term, this often leads to complications such as liver cirrhosis and liver cancer. A cure is not yet possible with the available medication. Scientists at the German Center for Infection Research (DZIF) and the University Hospital Eppendorf (UKE) have now investigated a new combination therapy that has proven highly effective in their infection model. (2021-02-04)

Synthesized very-long-chain polyunsaturated fatty acids improved retinal function in mice
A University of Utah ophthalmologist is investigating how lipids known as VLC-PUFAs could be used to prevent eye disease thanks to a new way to synthesize them for research. (2021-02-04)

Two studies shed light on how, where body can add new fat cells
DALLAS - Feb. 3, 2021 - Gaining more fat cells is probably not what most people want, although that might be exactly what they need to fight off diabetes and other diseases. How and where the body can add fat cells has remained a mystery - but two new studies from UT Southwestern provide answers on the way this process works. (2021-02-03)

Scientists discover plants' roadblock to specialty oil production
Attempts to put genes for making specialty fatty acids into crops have led to plants that make less oil. Now scientists have identified the mechanism behind the oil-production slowdown. The work paves the way for making at least one industrially important specialty fatty acid in plants--and may work for many others. (2021-02-03)

Engineering immunity
University of New Mexico researchers study the use of virus-like particles to create a stable and effective malaria vaccine. (2021-02-03)

Liver cancer 'signature' in gut holds clues to cancer risk
People with non-alcohol-related liver cancer have a unique gut microbiome profile which could help predict disease risk, a new UNSW Sydney study has found. (2021-02-03)

Combining PD-1inhibitor with VEGF inhibitor in chemotherapy of cholangiocarcinoma patient
Cholangiocarcinoma is the second most frequent liver cancer. Many patients miss the opportunity of having a surgery performed on them and its control has always been considered difficult. Here, doctors from The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China, present a case of stage 4 cholangiocarcinoma. (2021-02-02)

International research network identifies triggers for severe course of liver cirrhosis
Acute-on-chronic liver failure (ACLF) is a common cause of death in patients with cirrhosis. In ACLF the progressive loss of function of the scarred liver can no longer be compensated (acute decompensation). As a result, other organs such as the kidney or brain fail. The triggers for acute decompensation of liver cirrhosis and an ACLF are most frequently bacterial infections, liver inflammation caused by alcohol, or a combination of both factors. (2021-02-02)

Halved risk for severe retinal disease in extremely premature infants
Risk for a severe form of retinopathy of prematurity, which can cause blindness in extremely premature babies, was halved when the newborns were given a new supplement combining various fatty acids. This was shown in a Swedish study led from the University of Gothenburg. (2021-02-01)

How vitamins, steroids and potential antivirals might affect SARS-CoV-2
Evidence is emerging that vitamin D -- and possibly vitamins K and A -- might help combat COVID-19. A new study from the University of Bristol published in the journal of the German Chemical Society Angewandte Chemie has shown how they - and other antiviral drugs -- might work. The research indicates that these dietary supplements and compounds could bind to the viral spike protein and so might reduce SARS-CoV-2 infectivity. (2021-01-29)

Our gut-brain connection
MIT researchers developed an 'organs-on-a-chip' system that replicates interactions between the brain, liver, and colon. They modeled the influence microbes living in the gut have on both healthy brain tissue and tissue samples derived from patients with Parkinson's disease. (2021-01-29)

Study introduces mRNA-LNP as a safe therapeutic intervention for liver regeneration
When severely or chronically injured, the liver loses its ability to regenerate. A new study led by researchers at the Center for Regenerative Medicine at Boston University School of Medicine (BUSM) and Boston Medical Center (BMC) now describes a safe new potential therapeutic tool for the recovery of liver function in chronic and acute liver diseases. (2021-01-27)

Consuming omega-3 fatty acids could prevent asthma
New research suggests that a higher dietary intake of long chain omega-3 fatty acids in childhood may reduce the risk of developing subsequent asthma, but only in children carrying a common gene variant. The study, led by Queen Mary University of London, is in collaboration with the University of Bristol and University of Southampton, UK, and Karolinska Institutet, Sweden. (2021-01-27)

Research shows people with high omega-3 index less likely to die from COVID-19
Researchers with the Fatty Acid Research Institute (FARI) and collaborators at Cedars-Sinai Medical Center in Los Angeles and in Orange County, CA, have published the first direct evidence that higher omega-3 blood levels may reduce risk for death from COVID-19 infection. The report was published in the journal Prostaglandins, Leukotrienes and Essential Fatty Acids on January 20, 2021. (2021-01-26)

A stem cell based cell culture model for nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) is a widespread condition in the Western World. In order to improve our understanding of the basic mechanisms underlying the etiology of NAFLD, Dr. Nina Graffmann, Prof. James Adjaye and the team of the Institute for Stem Cell research and Regenerative Medicine, University Hospital Duesseldorf, differentiated induced pluripotent stem cells (iPSCs) derived from healthy donors and NAFLD patients into hepatocyte-like cells (HLCs). (2021-01-25)

The liver processes coconut oil differently than rapeseed oil
Coconut oil has increasingly found its way into German kitchens in recent years, although its alleged health benefits are controversial. Scientists at the University of Bonn have now been able to show how it is metabolized in the liver. Their findings could also have implications for the treatment of certain diarrheal diseases. The results are published in the journal Molecular Metabolism. (2021-01-25)

Anti-freeze for cell membranes
Mosses and flowering plants took different genetic routes to evolve a similar defense mechanism. (2021-01-25)

ACSL1 as a main catalyst of CoA conjugation of propionic acid-class NSAIDs in liver
Researchers from Kanazawa University have found that propionic acid-class nonsteroidal anti-inflammatory drugs (NSAIDs), including ibuprofen, form ''conjugates'' with coenzyme A (CoA) by one of the acyl-CoA synthetases, ACSL1, in liver. These conjugates have the covalent binding ability to cellular proteins that may lead to liver injury, a rare severe side effect of NSAID treatment. This knowledge could help pharmaceutical companies to generate pain control options with fewer risks of severe side effects. (2021-01-22)

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