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Current Fibroblasts News and Events

Current Fibroblasts News and Events, Fibroblasts News Articles.
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Blocking tumor signals can hinder cancer's spread
A University of Pennsylvania-led team used an inhibitor of an enzyme called p38α kinase to suppress the spread of melanoma to the lungs in a mouse model. (2020-05-28)
Rejuvenated fibroblasts can recover the ability to contract
A recent study from the Mechanobiology Institute at the National University of Singapore has shown that rejuvenated fibroblasts can recover their ability to self-contract. (2020-05-26)
Cell-culture based test systems for anticancer drug screening
As we know, a malignant tumor is a complex system of mutated cells which constantly interacts with and involves healthy cells in the body. (2020-05-21)
New rare disease with own facial features, cardiac defects and developmental delay
An international multicentre study describes a rare disease characterized by a series of recognizable facial features, cardiac defects and intellectual disability, which they propose to name as TRAF7 syndrome -according to the name of the gen that causes this pathology. (2020-05-19)
Why pancreatic ductal adenocarcinoma is so lethal
Pancreatic ductal carcinoma is a fast growing and invasive cancer, and now scientists understand the molecular dance that makes it so deadly. (2020-05-19)
A deeper connection to hyaline fibromatosis syndrome
EPFL scientists have uncovered the molecular biology behind Hyaline Fibromatosis Syndrome, a severe genetic disease. (2020-05-18)
Study reveals disparity between fibroblasts of different pancreatic diseases
Fibroblasts present in different pancreatic diseases are genetically distinct and their functions are 'programmed' by the unique environment of each disease, according to new research from the University of Liverpool (UK). (2020-05-18)
Can vaping scar your lungs? New insights and a possible remedy
Researchers report evidence that the compounds in e-cigarette liquid could potentially cause the body's tissue repair process to go haywire and lead to scarring inside the lungs. (2020-04-27)
Sanfilippo C syndrome: New brain cell models to evaluate therapies
The Sanfilippo syndrome type C is a severe neurodegenerative disease which appears during the first years of life and for which there is no treatment yet. (2020-04-24)
Interactions between cancer cells and fibroblasts promote metastasis
In order to colonize other organs and grow into metastases, tumor cells that detach from the parent tumor need to manipulate their new microenvironment and create a 'metastatic niche'. (2020-03-23)
Study finds molecule in lymphatic system implicated in autoimmune diseases
A study by investigators at Hospital for Special Surgery (HSS) has discovered a molecule in the lymphatic system that has the potential to play a role in autoimmune disease. (2020-03-20)
Possible treatment for breast cancer patients could roll out to clinical trial immediately
A worldwide collaborative study involving scientists at the University of Sussex has proposed a new treatment strategy for patients with a rare but aggressive subtype of cancer known as triple negative breast cancer. (2020-03-10)
'Primitive' stem cells shown to regenerate blood vessels in the eye
Johns Hopkins Medicine scientists say they have successfully turned back the biological hands of time, coaxing adult human cells in the laboratory to revert to a primitive state, and unlocking their potential to replace and repair damage to blood vessels in the retina caused by diabetes. (2020-03-09)
Scientists show drug may greatly improve cancer immunotherapy success
A study led by the University of Southampton, funded by Cancer Research UK, has shown a new drug -- originally developed to tackle the scarring of organ tissue -- could help to significantly improve the success rate of cancer immunotherapy treatment. (2020-03-02)
A molecular atlas of skin cells
Our skin protects us from physical injury, radiation and microbes, and at the same time produces hair and facilitates perspiration. (2020-02-27)
Structural framework for tumors also provides immune protection
Aggressive colorectal cancers set up an interactive network of checkpoints to keep the immune system at bay, scientists report. (2020-02-26)
New light shed on damaging impact of infrared and visible rays on skin
New research reveals for the first time that UV combined with visible and infrared light cause damage to the skin and we need to protect our skin against all three to prevent aging. (2020-01-23)
New radiotracer offers opportunities for earlier intervention after heart attack
A new radiotracer can effectively image fibroblast activation after a heart attack, identifying a window of time during which cardiac fibrosis can be prevented and the disease course altered. (2020-01-02)
Fibroblasts involved in healing spur tumor growth in cancer
The connective tissue cells known as fibroblasts are vitally important for our recovery from injury. (2019-12-19)
Study finds common cold virus can infect the placenta
For the first time, researchers have shown that a common cold virus can infect cells derived from human placentas, suggesting that it may be possible for the infection to pass from expectant mothers to their unborn children. (2019-12-02)
How do scars form? Fascia function as a repository of mobile scar tissue
In the riddle about the origin of scar tissue, researchers have reached an important next step. (2019-11-27)
Researchers identify a molecular mechanism involved in Huntington's disease
Researchers from the Institute of Neurosciences of the University of Barcelona (UBNeuro) and the August Pi i Sunyer Biomedical Research Institute (IDIBAPS) described a mechanism, the increase of proteinaceous synthesis, which takes part in the degeneration of the type of neurons that are affected in Huntington's disease, a genetic neurodegenerative disease. (2019-11-20)
New advances in the treatment of advanced lung cancer
The University of Barcelona (UB) and Hospital Clínic de Barcelona collaborate with Boehringer Ingelheim Inc. to improve the efficiency of nintedanib, an antiangiogenic and antifibrotic drug, for the treatment of lung cancer. (2019-11-19)
Master regulator in mitochondria is critical for muscle function and repair
New study identifies how loss of mitochondrial protein MICU1 disrupts calcium balance and causes muscle atrophy and weakness. (2019-11-14)
Mechanical signaling cascade central to fibrotic scar tissue development defined
In a new study published in Science Signaling, Cleveland Clinic researchers have identified a novel target for new therapies that may help to treat or prevent a host of fibrotic conditions, which contribute to nearly half of overall mortality in the United States. (2019-11-13)
Kidney cancer study uncovers new subtypes and clues to better diagnosis and treatment
In what is believed to be the most comprehensive molecular characterization to date of the most common -- and often treatment-resistant -- form of kidney cancer, researchers at Johns Hopkins' departments of pathology and oncology, Johns Hopkins Kimmel Cancer Center, and the Johns Hopkins University School of Medicine report evidence for at least three distinct subtypes of clear cell renal cell carcinoma (ccRCC), along with new revelations about the proteins that define them. (2019-10-31)
New insights could help block the path of cancer 'super-highways'
A key mechanism controlling tissue structure, which could help identify drugs that make it harder for cancer cells to spread, has been identified by researchers at the Francis Crick Institute. (2019-10-28)
Protective mediators can help heal injured tendon cells by attacking inflammation
Tendon tears, both to the rotator cuff and Achilles heel, are common injuries, especially in aged individuals. (2019-10-10)
Scientists have identified the presence of cancer-suppressing cells in pancreatic cancer
Researchers have identified cells containing a protein called Meflin that has a role in restraining the progression of pancreatic cancer. (2019-10-07)
Temple scientists ID new targets to treat fibrosis -- a feature of many chronic diseases
When it comes to repairing injured tissue, specialized cells in the body known as fibroblasts are called into action. (2019-10-04)
Stanford scientists find potential diagnostic tool, treatment for Parkinson's disease
Investigators at the Stanford University School of Medicine have pinpointed a molecular defect that seems almost universal among patients with Parkinson's disease and those at a high risk of acquiring it. (2019-09-26)
Smoothing wrinkles in mice -- without needles
In the quest for a more youthful appearance, many people slather ointments on their skin or undergo injections of dermal fillers. (2019-09-25)
A protein essential for chikungunya virus replication identified
Chikungunya is an infectious disease caused by a mosquito-borne virus transmitted to humans. (2019-09-25)
Promising steps towards a treatment for pulmonary fibrosis
Research published in the journal Science Translational Medicine on 25 September by members of the Cardiovascular Disease Mechanisms group at the MRC LMS in collaboration with Duke-NUS Medical School, National Heart Centre Singapore & National Heart and Lung Institute, Imperial College London, showed that blocking a protein called interleukin-11 (IL-11) using therapeutic antibodies can reverse the fibrosis in the lung. (2019-09-25)
New insights into the healing capacity of the heart
Researchers report that the Hippo pathway is important for maintaining adult murine cardiac fibroblasts in their resting state. (2019-09-25)
CU researchers identify potential target for cardiac fibrosis treatment
A research team led by scientists at the University of Colorado School of Medicine has identified a potential target for treating heart failure related to fibrosis. (2019-09-17)
New cardiac fibrosis study identifies key proteins that translate into heart disease
The formation of excess fibrous tissue in the heart, which underlies several heart diseases, could be prevented by inhibiting specific proteins that bind to RNA while its code is being translated. (2019-09-12)
CAR T-cell therapy may be harnessed to treat heart disease
CAR T-cell therapy, a rapidly emerging form of immunotherapy using patients' own cells to treat certain types of cancers, may be a viable treatment option for another life-threatening condition: heart disease. (2019-09-11)
Bioengineers explore cardiac tissue remodeling after aortic valve replacement procedures
Researchers have developed biomaterial-based 'mimics' of heart tissues to measure patients' responses to an aortic valve replacement procedure, offering new insight into the ways that cardiac tissue re-shapes itself post-surgery. (2019-09-11)
Key to targeting the spread of pancreatic cancer
Targeting the tissue around pancreatic cancer cells may be the key to stopping their spread and improving chemotherapy outcomes. (2019-08-12)
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