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Current Fibroblasts News and Events, Fibroblasts News Articles.
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Engineered blood vessels may be an option in cardiac bypass
The first-ever human use of completely biologically engineered blood vessels grown from a person's own cells could be an option for people who have vessels too damaged for heart bypass, researchers reported at the American Heart Association's Scientific Sessions 2005. (2005-11-15)
Researchers identify gene's role in suppressing longevity
HHMI researchers have determined that a gene present in mouse cells limits the number of times that a cell can divide. (2005-07-19)
Genetic on-off switches pinpointed in human genome
In another step to decipher information in the human genome, scientists have discovered the location and sequence of over 10,000 DNA regions that function as genetic on-off switches, or (2005-06-29)
MIT tissue engineers implant viable, vascularized 3D muscles
MIT researchers have used a novel cocktail of cells to coax muscle tissue to develop its own vascular network, a process called pre-vascularization. (2005-06-20)
Muscle-derived stem cell culture doesn't need to be pure for incontinence treatment
A pure culture of muscle-derived stem cells (MDC) may not be needed to cure stress urinary incontinence, according to a University of Pittsburgh study. (2005-05-23)
Compound inhibits one critical pathway in breast cancer growth
A compound that suppresses the growth of cancer cells and is relatively non-toxic to normal cells may one day be useful for treating several types of cancer, researchers report in this week's Proceedings of the National Academy of Sciences. Laboratory experiments in human breast cancer cells suggest that the compound inhibits the constant activation of a protein called Stat3 that is found in several different types of cancer. (2005-03-07)
Red wine lovers, take heart: More evidence points to the drink's cardiac heath benefits
New research on rat heart cells suggests that a well-known antioxidant found in red wine, called resveratrol, may benefit heart tissue by limiting the effects of a condition called cardiac fibrosis. (2004-12-07)
Cigarette smoke a culprit in poor healing and increased scarring
Cigarette smoke, whether first- or second-hand, complicates the careful cellular choreography of wound healing, according to a paper by University of California, Riverside researchers that was included in the 2004 Press Book of the 44th Annual Meeting of the American Society For Cell Biology (ASCB). (2004-12-06)
Pain reliever may help treat life-threatening childhood disease
A drug withdrawn from pharmacy shelves over 20 years ago may point the way to a new treatment for spinal muscular atrophy, or SMA, a muscle-wasting and often life-threatening childhood disease. (2004-11-29)
Peripheral timekeeping: Mammalian cells outside the brain have their own circadian clocks
Researchers have discovered that individual fibroblast cells contain independent, self-sustaining circadian (ca. (2004-11-23)
Gene linked to enlargement of the factory where proteins are processed
Part of a cellular mechanism that regulates the folding of new proteins into their proper shapes also includes a genetic response that enlarges the factory where both protein folding and packaging of proteins occurs. (2004-11-01)
Normal cells in tumors may aid cancer growth
Normal cells that live among the cancer cells in a tumor may not be the innocent bystanders they are usually assumed to be. (2004-10-15)
Anticancer drug zebularine specifically targets tumor cells
A novel anticancer drug that inhibits a process known as DNA methylation is preferentially taken up by tumor cells as compared to normal cells, according to a group of researchers led by scientists from the Keck School of Medicine of the University of Southern California. (2004-08-23)
UCLA study discovers adult stem cells migrate to lung and contribute to pulmonary fibrosis
UCLA researchers for the first time identified and then stopped a type of adult stem cell from migrating to the lung and contributing to pulmonary fibrosis in an animal model. (2004-08-02)
Medical implants work better when you rough them up, study finds
Medical implants - from catheters that deliver long-term life support to joint replacements - may work better when their surfaces are on the rough side, new research suggests. (2004-06-14)
Researchers identify two potential protein targets for new drug therapies for pancreatic cancer
Researchers at Fox Chase Cancer Center in Philadelphia have identified two proteins in pancreatic cancer that may be potential targets for new, more specific drug therapies against this deadly disease. (2004-06-05)
UCR study says second-hand smoke affects healing
Researchers at the University of California, Riverside have found that breathing (2004-04-06)
Why passive smoking hinders healing
Being exposed to high levels of 'second-hand' smoke can reduce the speed at which wounds heal, leading to a lack of healing or greater levels of scarring. (2004-04-04)
Research points in new direction for cancer clues
A new report from a team of Vanderbilt-Ingram Cancer Center scientists demonstrates that tumors can develop from completely normal epithelial cells solely because of changes in signals from nearby supporting cells. (2004-02-10)
Bone marrow-derived stem cells active in pulmonary fibrosis
Adult stem cells have long been thought to be restricted in their potential to differentiate and regenerate tissues in which they reside. (2004-01-15)
Predicting progression of common cancers
New results based on a genomics approach reveal similarities between the molecular programs in normal wound healing and tumor progression and metastasis and suggest that a wound-like phenotype is a general risk factor for metastasis and aggressive behavior in many of the most common cancers. (2004-01-13)
Bone marrow stem cells build new circulation to lungs
A bone marrow stem cell transplant restored circulation to injured blood vessels in animals with pulmonary hypertension, according to a study presented today at the American Heart Association's Scientific Sessions 2003. (2003-11-10)
Study offers genetic clues to causes of mysterious skin disease
People suffering from scleroderma, a debilitating, sometimes-fatal skin disease, may one day benefit from a study that gives doctors their first look at the genes behind the poorly understood disease. (2003-09-29)
Fibroblasts hold clues to fat, scars and inflammation
Scientists used to think that fibroblasts - the cells that form basic tissue structures - were little more than scaffolding on which more important cells would climb. (2003-09-25)
Heart may heal with help from oxygen-sensitive genes, new study suggests
Researchers have uncovered a mechanism that the heart may use to repair tissue damaged during a heart attack. (2003-09-15)
Fears of second-hand smoke confirmed
New study confirms the fears of many in a work and social environment that exposure to second-hand smoke can lead to a deadly and debilitating disease. (2003-07-29)
New study demonstrates bone protein can reverse kidney failure
A new study led by investigators at Beth Israel Deaconess Medical Center (BIDMC) has shown that a protein used to heal fractured bones is effective in repairing and reversing chronic renal disease, a leading cause of morbidity and mortality throughout the U.S. (2003-06-26)
In vitro study suggests acrylamide causes DNA damage
Acrylamide, a possible human carcinogen that has been found in a variety of fried and starch-based foods, appears to exert its mutagenicity (the capacity to induce mutations) by forming DNA adducts and introducing genetic mutations, according to a study in the June 18 issue of the Journal of the National Cancer Institute. DNA adducts can interfere with the DNA replication process and lead to mutations and, in theory, to tumor formation. (2003-06-17)
New material improves treatment of urinary incontinence
At least 40 percent of postmenopausal women suffer from stress urinary incontinence, according to researchers who are developing a new material that could eventually offer better treatment for the condition. (2003-05-20)
Cell density determines extent of damage caused by cigarette smoke exposure
New findings may offer roadmap to predicting how the body will respond to a deadly habit - collagen plays key role. (2003-02-12)
Cellular pathway includes a 'clock' that steers gene activity
Researchers have discovered a biochemical (2002-11-07)
Chemical switch determines if healthy cells are killed by chemotherapy
Investigators at Washington University School of Medicine in St. Louis have discovered a mechanism that helps explain why healthy cells are not killed by DNA-damaging cancer chemotherapy drugs. (2002-10-03)
Scientists discover protein identifies damage to DNA
Scientists at the University of North Carolina at Chapel Hill have identified a protein that becomes part of the critical process by which the genetic information called DNA repairs itself following damage by sunlight, pollution or other trauma. (2002-05-13)
Astrocytes play starring role in neural stem cell development
HHMI researchers have discovered that astrocytes -- brain cells once thought to be little more than a component of the supportive scaffold for neurons -- actually trigger the maturation and proliferation of adult neural stem cells. (2002-05-03)
Findings link disease specific anitbodies to activation of T cells for the first time
Harbor-UCLA Research & Education Institute (REI) announced new findings indicating that antibodies specific to Graves' disease bind to cell surface receptors distinct from thyroid-stimulating hormone (TSH) receptors. (2002-01-24)
UC Riverside scientists discover wound-healing substance
New research with chickens at the University of California, Riverside has identified a protein pivotal in healing the animals' injuries. (2002-01-23)
Researchers study muscle cell damage that occurs when astronauts return from space
Astronauts returning from a bout of weightlessness experience painful tearing of muscle cells when they set foot on earth. (2001-04-17)
UCSF-led study points to pivotal, early event in cancer development
Researchers led by UCSF scientists report that they may have identified a pivotal event in the development of breast cancer, with an unexpected revelation regarding the behavior of mammary epithelial cells. (2001-01-30)
Syndecan-4 regulates wound repair in vivo
Cell surface heparan sulfate proteoglycans (HSPG) can be divided generally into two gene families: syndecans and glypicans. (2001-01-09)
Jefferson scientists show inhibiting specific enzyme may lead to therapy for scleroderma
Jefferson Medical College researchers report that blocking the action of a specific enzyme may someday prove to be an effective treatment for scleroderma, a potentially life- threatening disease that results in the overproduction of collagen and which can affect the skin, joints and multiple internal organs. (2000-10-25)
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