Current Fluoroquinolones News and Events

Current Fluoroquinolones News and Events, Fluoroquinolones News Articles.
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Research suggests greater access to specific HIV and tuberculosis medications is needed
A specific combination of HIV and TB treatments, difficult to obtain in certain parts of the world, decreased mortality risk for patients with HIV and multidrug-resistant TB. (2020-08-07)

Many antibiotic substitutions for self-reported penicillin allergies likely unnecessary
Diagnostic testings or evaluations show that the vast majority of patient-reported allergies to penicillin could be disproven. (2020-06-30)

Wildlife in Catalonia carry bacteria resistant to antimicrobials used in human health
A study performed in Catalonia by IRTA-CReSA, UAB and Torreferrussa Wildlife Center demonstrates that the enteric bacteria of wildlife origin in Catalonia exhibits a high prevalence and diversity of antibiotic resistance genes. The study, published in the PLoS ONE journal, emphasizes that these antibiotics are classified by the World Health Organization as critically important for human health. (2019-11-12)

Antibiotics with novel mechanism of action discovered
Many life-threatening bacteria are becoming increasingly resistant to existing antibiotics. Swiss researchers co-headed by the University of Zurich have now discovered a new class of antibiotics with a unique spectrum of activity and mechanism of action - a major step in the fight against antimicrobial resistance. By disrupting outer membrane synthesis, the antibiotics effectively kill Gram-negative bacteria. (2019-10-23)

Commonly used antibiotics may lead to heart problems
Scientists have shown for the first time a link between two types of heart problems and one of the most commonly prescribed classes of antibiotics. (2019-09-10)

80% cut in antibiotics entering Thames is needed to avoid surge in superbugs
The amount of antibiotics entering the River Thames would need to be cut by as much as 80 per cent to avoid the development and spread of antibiotic-resistant 'superbugs', a new study has shown. It found that across three-quarters of the Thames catchment, the antibiotics present, due to effluent discharge, were likely to be at levels high enough for antibiotic-resistant bacteria to develop. (2019-09-04)

E. coli superbug strains can persist in healthy women's guts
A study of over 1,000 healthy women with no urinary tract infection symptoms showed nearly 9% carried multi-drug resistant Escherichia coli strains in their guts. Additional findings highlight likely reasons behind the pandemic of resistant E. coli strains. They show the value of checking a patients' carrier-status to predict resistant infections, and the need to re-think the clinical significance of bacteria in the urine without symptoms, because pandemic strains can be highly pathogenic to the urinary system and treatment resistant. (2019-07-23)

Researchers identify faster, more effective drug combinations to treat tuberculosis
Study describes a way to reduce the duration of tuberculosis treatment by using an approach called 'artificial intelligence-parabolic response surface' that allows researchers to quickly identify three or four drug combinations among billions of possible combinations to treat TB up to five times faster than current therapies. (2019-05-14)

Drug interactions in ER's common but preventable, Rutgers study finds
In a recent Rutgers study, 38 percent of patients discharged from the emergency department had at least one drug interaction resulting from a newly prescribed medicine. The study, which was published in the American Journal of Emergency Medicine, identified the most common prescription drug combinations that may result in a negative interaction. (2019-02-26)

Zoonoses: Antimicrobial resistance shows no signs of slowing down
Data released today by the European Centre for Disease Prevention and Control (ECDC) and European Food Safety Authority (EFSA) reveal that antimicrobials used to treat diseases that can be transmitted between animals and humans, such as campylobacteriosis and salmonellosis, are becoming less effective. (2019-02-26)

Even as hospitals cut risky antibiotic use in-house, patients often go home with them
Even as hospitals try to cut back on prescribing powerful but risky antibiotics called fluoroquinolones, a new study shows that many patients still head home with prescriptions for the drugs -- increasing their risk of everything from 'superbug' infections to torn tendons. In fact, the hospitals that are actively trying to reduce inpatient fluoroquinolone use were twice as likely to discharge patients with a new prescription for one of them. (2019-02-13)

Caution, tasteless! Viruses and antimicrobially resistant bacteria in foods
Salmonella in eggs, noroviruses in frozen berries, hepatitis E viruses in domestic pigs and wild boar and resistant bacteria in meat: pathogenic microorganisms are one of the most common causes of foodborne illnesses. Every year, they cause more than 100,000 cases of disease in Germany -- some of them fatal. (2018-11-08)

How drug resistant TB evolved and spread globally
The most common form of Mycobacterium tuberculosis (TB) originated in Europe and spread to Asia, Africa and the Americas with European explorers and colonialists, reveals a new study led by UCL and the Norwegian Institute of Public Health. (2018-10-17)

Ciprofloxacin has dramatic effects on the mitochondrial genome
A study carried out at the University of Eastern Finland and published in Nucleic Acids Research investigated the effect of ciprofloxacin on mitochondria, the important cell organelles in our body that produce the energy for cellular function. Ciprofloxacin stopped normal maintenance and transcription of mitochondrial DNA by changing mtDNA topology, causing impaired mitochondrial energy production and blocking cellular growth and differentiation. (2018-10-01)

Complete makeover in fight of multidrug-resistant tuberculosis
Several new medicines have been found to be more effective than traditional ones used to treat multidrug-resistant tuberculosis (MDR-TB), according to a new international collaborative study led by the Research Institute of the McGill University Health Centre (RI-MUHC) in Montreal, with these findings precipitating a complete overhaul of worldwide TB treatment guidelines. The study, led by Dr. Dick Menzies, is published in the British medical journal The Lancet today. (2018-09-06)

The dark side of antibiotic ciprofloxacin
Researchers have found that ciprofloxacin, a widely prescribed antibiotic, increases the risk of tears and rupture on the main artery of the body, the aorta, in a mouse model of human aortic aneurysms and dissections, a disease that carries high risk of death from aortic rupture. (2018-07-25)

Oral antibiotics linked to increased kidney stone risk
The potential to promote antibiotic resistance in bacteria isn't the only reason to avoid using antibiotics when possible. A new study reveals that antibiotics are also linked with an increased risk of developing kidney stones, with the greatest risk among children. The findings appear in an upcoming issue of the Journal of the American Society of Nephrology. (2018-05-10)

Oral antibiotics may raise risk of kidney stones
Pediatric researchers have found that children and adults treated with some oral antibiotics have a significantly higher risk of developing kidney stones. This is the first time that these medicines have been linked to this condition. The strongest risks appeared at younger ages and among patients most recently exposed to antibiotics. (2018-05-10)

Are antibiotic courses prescribed for sinus infection too long?
Most antibiotic courses to treat an acute sinus infection in adults were 10 days or longer, even though the Infectious Diseases Society of America recommends five to seven days for uncomplicated cases. (2018-03-26)

Combined resistance to multiple antibiotics: A growing problem in the EU
On the occasion of the 10th European Antibiotic Awareness Day, the European Centre for Disease Prevention and Control (ECDC) is releasing its latest EU-wide data on antibiotic resistance, as well as its guidance on prevention and control of carbapenem-resistant Enterobacteriaceae (CRE). In 2016, combined resistance to several antibiotic groups continued to increase for Escherichia coli and Acinetobacter species. This situation is of great concern as patients infected with these multidrug-resistant bacteria have very limited treatment options. (2017-11-15)

Antimicrobial use in Danish animals continues downward trend
The total antimicrobial consumption in Danish animals has continued to decrease for the third consecutive year. This is one of the findings of the annual DANMAP report for 2016 from Statens Serum Institut as well as the National Veterinary Institute and the National Food Institute, which are both departments under the Technical University of Denmark. (2017-10-05)

Tuberculosis drug may work better than others in its class
Treatment of tuberculosis involves a combination of several drugs, sometimes including drugs from a class known as fluoroquinolones. Using computer simulations, scientists have shown that the fluoroquinolone known as moxifloxacin may be superior to two other commonly used fluoroquinolones, according to a new paper in PLOS Computational Biology. (2017-08-17)

Prediciting TB's behavior
Research led by scientists at Harvard Medical School reveals that when it comes to predicting response to treatment and risk of dying, molecular tests that detect resistance to a class of TB drugs known as fluoroquinolones may be as good and even superior to traditional drug-sensitivity tests conducted in lab cultures. (2017-08-03)

Increasing susceptibility of Staphylococcus aureus in the United States
Findings from a study that looked at susceptibility trends of Staphylococcus aureus in US hospital patients showed that key antibiotics used to treat the bacteria became more active over the course of the study, a rare occurrence. (2017-06-04)

Antibiotic therapy for nearly 1 in 4 adults with pneumonia does not work
Approximately one in four (22.1 percent) adults prescribed an antibiotic in an outpatient setting (such as a doctor's office) for community-acquired pneumonia does not respond to treatment, according to a new study presented at the 2017 American Thoracic Society International Conference. (2017-05-21)

Antibiotic use for travelers' diarrhea favors particularly resistant super bacteria
Every year, millions of travelers visit countries with poor hygiene, and approximately one third of them return home carrying antibiotic-resistant ESBL intestinal bacteria. A traveler who resorts to using antibiotics will pick up the most resistant strains of common 'super bacteria,' proves a recent Finnish study. (2017-02-09)

Antibiotics, not dirty hospitals, the main cause of C. difficile epidemic
Restricting the use of a common antibiotic was more important than a high profile 'deep clean' of hospitals in massively reducing UK antibiotic resistant Clostridium difficile (C. diff) cases, a major new study has found. (2017-01-24)

Decrease in the use of broad-spectrum antibiotics in Austrian dairy cows is necessary
A study on the use of antibiotics on Austrian dairy farms by the Institute of Veterinary Public Health at Vetmeduni Vienna showed that dairy cattle are less frequently treated with antibiotics than pigs and poultry. The use of broad-spectrum antibiotics such as cephalosporins should nevertheless be reduced to avoid resistance to these important human antibiotics. The study was published in the Berliner and Münchner Tierärztlichen Wochenschrift. (2016-11-18)

Multidrug-resistant bacteria from chickens pose risk to human health
Isolates of a common poultry pathogen collected from animals in Indian bird markets were mostly resistant to multiple classes of antibiotics. The study provides the first data on prevalence and isolation of Helicobacter pullorum in India. The research is published Nov. 4 in Applied and Environmental Microbiology, a journal of the American Society for Microbiology. (2016-11-04)

Common antibiotics may be linked to temporary mental confusion
Antibiotics may be linked to a serious disruption in brain function, called delirium, and other brain problems, more than previously thought, according to a 'Views and Reviews' article published in the Feb. 17, 2016, online issue of Neurology®, a medical journal of the American Academy of Neurology. (2016-02-17)

Slight change to antibacterial drug may improve TB treatments
Researchers with Vanderbilt University have discovered that one small chemical change to an existing antibacterial drug results in a compound that is more effective against its target enzyme in tuberculosis. (2016-02-15)

C. diff study provides insight into antibiotic resistance and risks for infection
Exposure to specific antibiotics is linked to the development of certain strains of antibiotic-resistant C. difficile, one of the fastest growing bacteria superbugs, according to a new study published by Stuart Johnson, M.D., of Loyola University Health System, Loyola University Chicago Stritch School of Medicine and the Hines VA Medical Hospital. (2016-02-04)

Scientists take steps to make weak TB drugs strong again
Biophysicists have discovered why the bacteria that cause tuberculosis (TB) are naturally somewhat resistant to antibiotics known as fluoroquinolones. Their findings, based on mapping the detailed three-dimensional structure of the drugs interacting with an essential enzyme in the TB germ, also reveal why some TB drugs are more potent than others and suggest how drug developers can make fluoroquinolones more efficacious against mutations that make the lung disease drug resistant. (2016-01-18)

Finafloxacin for the treatment of urinary tract infections
Results from a double-blind phase 2 clinical study show that finafloxacin was a more effective and safe option than ciprofloxacin for the treatment of complicated urinary tract infections and acute pyelonephritis. This research is being presented at ASM's 55th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC/ICC). (2015-09-20)

New increase in antimicrobial use in animals in Denmark
Antimicrobial usage in animals in Denmark continued to increase in 2013 -- mainly due to an increased use in pigs. However, antimicrobial use in pigs is still 12 percent lower than in 2009. In general, livestock received very little of the critically important antimicrobials, which are used to treat humans. These findings appear in the annual DANMAP report from Statens Serum Institut and the National Food Institute, Technical University of Denmark. (2014-10-09)

A way to end recurrent urinary tract infections? Study with mice gives hope
Mouse study finds that FDA-approved compound helps rid bladder of 'reservoir populations' of bacteria that cause recurrent UTIs. (2014-03-25)

Antibiotic-resistant typhoid likely to spread despite drug control program
Restricting the use of antibiotics is unlikely to stop the spread of drug resistance in typhoid fever, according to a study funded by the Wellcome Trust and published in the journal eLife. (2013-12-10)

Study finds no increased risk of retinal detachment with use of certain antibiotics
In contrast to findings of a recent study, researchers in Denmark did not find an association between use of a class of antibiotics known as fluoroquinolones (such as ciprofloxacin) and an increased risk of retinal detachment, according to a study appearing in the Nov. 27 issue of JAMA. (2013-11-26)

Study examines risk of severe blood sugar swings among diabetics taking fluoroquinolones
Diabetic patients taking oral fluoroquinolones, a frequently prescribed class of antibiotics, were found to have a higher risk of severe blood sugar-related problems than diabetic patients taking other kinds of antibiotics, according to a recent study from Taiwan published in Clinical Infectious Diseases. The increased risk was low, but clinicians should consider the higher risk when treating diabetic patients with fluoroquinolones, especially moxifloxacin, and prescribe them cautiously, the study's authors concluded. (2013-08-15)

Risk of kidney disease doubled with use of fluoroquinolone antibiotics
The risk of acute kidney disease is doubled for people taking oral fluoroquinolone antibiotics, according to a study of published in CMAJ. (2013-06-03)

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