Current Folate News and Events

Current Folate News and Events, Folate News Articles.
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Technion researchers discover new pathway for attacking cancer cells
The folate cycle is a process essential to DNA and RNA production. As a result, it is highly important to both cancer cells and healthy cells. Because DNA production is a critical stage in cell division, and thus in tumor growth, the folate cycle is a common target for chemotherapy. However, for the very same reason, there are significant side effects to attacking it. (2021-02-05)

Vegan diet significantly remodels metabolism in young children
University of Helsinki researchers report a comprehensive pilot study on the metabolic effects of full vegan diet on young children. The study found vegan children to have remarkably altered metabolism and lower vitamin A and D status compared to children with no special diet. (2021-01-21)

Mothers of children with Autism found to have significantly different metabolite levels
Blood sample analysis showed that, two to five years after they gave birth, mothers of children with autism spectrum disorder (ASD) had several significantly different metabolite levels compared to mothers of typically developing children. That's according to new research recently published in BMC Pediatrics by a multidisciplinary team from Rensselaer Polytechnic Institute, Arizona State University, and the Mayo Clinic. (2021-01-13)

Excess folic acid during pregnancy harms brain development of mice
A study of pregnant mice found high levels of folic acid were associated with significant changes in brain development of offspring. (2020-10-05)

Research finds people who eat pasta have better overall quality diets than those who don't
Good news for pasta eaters! New research published in Frontiers in Nutrition this month, analyzing the diets of adults and children who eat pasta, has revealed good news about one of America's favorite foods. The research found that pasta consumption in both children and adults is associated with a better diet quality and better nutrient intakes than that of those adults and children who do not eat pasta. Furthermore, In adult women, pasta-eaters showed a beneficial weight-related outcome. (2020-08-26)

Multivitamin, mineral supplement linked to less-severe, shorter-lasting illness symptoms
Older adults who took a daily multivitamin and mineral supplement with zinc and high amounts of vitamin C in a 12-week study experienced sickness for shorter periods and with less severe symptoms than counterparts in a control group receiving a placebo. (2020-08-18)

Keeping pinto beans away from the dark side
New slow-darkening pinto bean varieties show benefits for farmers and consumers (2020-07-22)

Summer favorite bitter gourd genome shows unusual domestication, insight into evolution
The genomic architecture of the Long-read bitter gourd (Momordica charantia) has been elucidated to show nonclassic domestication. This study provides valuable insight into evolution under human influence. (2020-06-16)

Addressing the safety of high folate levels in the older population and implications for fortification in Ireland
A new study from The Irish Longitudinal Study on Ageing (TILDA) at Trinity College challenges claims from some international scientific circles, that having high blood levels of folate (folic acid) increases the risk of poor cognition in older adults, especially in those with low levels of vitamin B12. On the contrary the study found that having higher folate seemed to be associated with better cognitive function in these older adults. (2020-06-15)

Cellular stress causes cancer cell chemoresistance
Resistance of cancer cells against therapeutic agents is a major cause of treatment failure, especially in recurrent diseases. An international team around the biochemists Robert Ahrends from the University of Vienna and Jan Medenbach from the University of Regensburg identified a novel mechanism of chemoresistance which has now been published in ''Nature Communications''. (2020-06-10)

Princeton team develops 'poisoned arrow' to defeat antibiotic-resistant bacteria
Poison is lethal all on its own -- as are arrows -- and together, they can take down the strongest opponents. A team of Princeton researchers have found an antibiotic that simultaneously punctures bacterial walls and destroys folate within their cells -- killing like a poisoned arrow -- while proving immune to antibiotic resistance. (2020-06-03)

UMN trial shows hydroxychloroquine has no benefit over placebo in preventing COVID-19
Today, University of Minnesota Medical School researchers published the results from the first randomized clinical trial testing hydroxychloroquine for the post-exposure prevention of COVID-19. (2020-06-03)

Adequate folate levels linked to lower cardiovascular mortality risk in RA patients
Decreased folate levels in the bloodstream have been associated with an increased risk of cardiovascular mortality in patients with rheumatoid arthritis, shedding light on why those patients are more susceptible to heart and vascular disease, according to research published today in JAMA Network Open by experts at The University of Texas Health Science Center at Houston (UTHealth). (2020-02-26)

Low folate levels can indicate malnutrition in hospital patients
About 10% of patients who come to complex care hospitals may have low levels of folate and other indicators of malnutrition, investigators say. (2020-02-18)

Study investigates rates of adverse events for common rheumatoid arthritis drug
Investigators have been able to far more accurately determine rates of adverse events for people taking methotrexate, finding small-to-moderate elevations in risks for skin cancer, gastrointestinal, infectious, lung, and blood adverse events. (2020-02-17)

New study highlights importance of grain foods in infant diets
Undertaken to inform the development of the first-ever Dietary Guidelines (2020-2025) to include specific recommendations for infants and toddlers, this study analyzed infant data from the 2001-2016 National Health and Nutrition Examination Survey (NHANES). It found grain consumption by infants aged 6-23 months was generally associated with significantly higher nutrient intakes, better diet quality scores, and broader food group intake relative to non-consumers. (2020-01-21)

Are women getting adequate nutrition during preconception and pregnancy?
In a Maternal & Child Nutrition analysis of published studies on the dietary habits of women who were trying to conceive or were pregnant, most studies indicated that women do not meet nutritional recommendations for vegetable, cereal grain, or folate intake. (2019-12-04)

Weight-loss surgery cuts risk of birth defects
Children born to women who underwent gastric bypass surgery before becoming pregnant had a lower risk of major birth defects than children born to women who had severe obesity at the start of their pregnancy. That's according to a matched cohort study by researchers at Karolinska Institutet and Örebro University published in the scientific journal JAMA. The findings indicate that weight-loss and improved blood sugar control could reduce the risk of major birth defects. (2019-10-15)

High lead levels during pregnancy linked to child obesity, NIH-funded study suggests
Children born to women who have high blood levels of lead are more likely be overweight or obese, compared to those whose mothers have low levels of lead in their blood, according to a study funded by the National Institutes of Health and Health Resources and Services Administration. (2019-10-03)

Maternal lead exposure, intergenerational risk of childhood overweight/obesity and folate
An observational study of 1,442 mother-child pairs examined associations between lead blood levels in mothers and intergenerational risk of their children being overweight or obese and whether adequate folate levels in mothers mitigated that risk. (2019-10-02)

Tortillas tell the story of folate deficiency in Mexico: study
A new study hat accounts for folic acid fortification in staple foods made from wheat and corn, such as bakery bread and tortillas, found that large proportion of women of childbearing age have FA intake below levels recommended by the World Health Organization, potentially raising the risk for neural tube defects in their offspring. The study is one of a few to investigate FA intake after fortification, and the first such report for Mexico. (2019-09-17)

Skin cancer risk in athletes: The dangers of ultraviolet radiation
The dangers of ultraviolet radiation exposure, which most often comes from the sun, are well-known. Speaking at The Physiological Society's Extreme Environmental Physiology conference next week, W. Larry Kenney, Penn State University, will discuss how broad its effects can be, from premature aging to cancer, and how this can be influenced by different skin tones and the use of sunscreen. (2019-08-30)

Lower levels of dietary vitamins and antioxidants are linked to frailty in older adults
Researchers from The Irish Longitudinal Study on Ageing (TILDA) at Trinity College Dublin have shown in the largest study to-date that lower levels of specific dietary vitamins and antioxidants are associated with frailty. The study examined the association of vitamin B12, folate, vitamin D, lutein and zeaxanthin levels with frailty. (2019-08-22)

New BioIVT research examines potential link between HIV integrase inhibitor drugs and neural tube defects during pregnancy
BioIVT announced that researchers in its Transporter Sciences Group have co-authored a peer-reviewed paper, which investigates the inhibitory effects of a class of HIV drugs known as integrase inhibitors on folate transporter pathways. Previously published studies had appeared to show a correlation between exposure to dolutegravir, and other HIV integrase inhibitor drugs, at conception and an increased risk of neural-tube defects, which can cause conditions such as spina bifida in infants. (2019-08-15)

Folic acid reduces risk of neural tube defects linked to HIV drug dolutegravir
HIV drug doluteglavir interferes with the binding of folate to its receptor, thus promoting neural tube defects. Folic acid supplementation can mitigate the risk of the medication in an animal model. (2019-07-23)

Study finds micronutrient deficiencies common at time of celiac disease diagnosis
Micronutrient deficiencies, including vitamins B12 and D, as well as folate, iron, zinc and copper, are common in adults at the time of diagnosis with celiac disease. These deficiencies should be addressed at that time, according to a study by Mayo Clinic researchers. (2019-06-24)

Epigenetic study provides new approaches to combination therapies for aggressive cancers
A recent study by CeMM reveals how the interaction of the epigenetic protein BRD4 with the metabolic enzyme MTHFD1 controls gene expression and cell proliferation. The results of the study have now been published in the renowned journal Nature Genetics. They suggest novel approaches for the development of combination therapies for aggressive cancers. (2019-05-27)

Promising new drugs for old pathogen Mtb
UConn researchers are targeting a metabolic pathway, the dihydrofolate reductase pathway, crucial for amino acid synthesis to treat TB infections. (2019-03-28)

Researchers determine seasonal risk threshold for patients with folate deficiency
The possible association between sun exposure and folate levels in human blood has been a major topic of discussion among experts all around the world. However, no one has demonstrated it until now. (2019-02-01)

Folate deficiency creates hitherto unknown problems in connection with cell division
Folate deficiency creates more problems in connection with DNA replication than researchers had hitherto assumed, researchers from the University of Copenhagen show in a new study. Once a person lacks folate, the damage caused by this cannot be reversed. The researchers therefore encourage people to be more aware of the level of folate in the blood. (2018-12-14)

Preparation, characterization of major degradation products of Pralatrexate injection
The major degradation products of pralatrexate drug product formed under hydrolytic and light stress conditions were identified, synthesized and characterized using advanced spectroscopic techniques such as NMR, HR-MS and IR. (2018-12-12)

Link between neonatal vitamin D deficiency and schizophrenia confirmed
Newborns with vitamin D deficiency have an increased risk of schizophrenia later in life, a team of Australian and Danish researchers has reported. The discovery could help prevent some cases of the disease by treating vitamin D deficiency during the earliest stages of life. The study found newborns with vitamin D deficiency had a 44 percent increased risk of being diagnosed with schizophrenia as adults compared to those with normal vitamin D levels. (2018-12-06)

We have more than enough calories, but what about other nutrients?
A new study is the first to quantitatively map the flow of energy, protein, fat, essential amino acids and micronutrients from 'field-to-fork' at a global level and identify hotspots where nutrients are lost. The study shows that while we produce far more nutrients than is required for the global population, inefficiencies in the supply chain leave many people nutrient deficient. (2018-09-14)

Study finds significant proportion of older adults are deficient in vitamin B12 and folate
The study suggests that voluntary food fortification is ineffective in preventing deficiency or low status of these vitamins among older people. The results are of relevance not just for Ireland but for all countries that do not have mandatory fortification. (2018-06-26)

Vast majority of poor, urban women don't use prenatal vitamins before pregnancy, study shows
A study of more than 7,000 low-income, urban mothers enrolled in the Boston Birth Cohort found that fewer than 5 percent of them started folic acid supplementation and used it almost daily before pregnancy, a widely recommended public health measure designed to prevent potentially crippling birth defects. (2018-05-24)

Hypertensive patients may benefit from folic acid supplements
Hypertensive adults with low platelet count who took a combined daily pill of both enalapril and folic acid saw a 73 percent reduction in their risk of first stroke compared to patients who took only enalapril daily, according to a study published in the Journal of the American College of Cardiology. (2018-05-07)

UMN Medical School study uncovers new findings on antimicrobial drug synergy
New data from a study led by researchers from the University of Minnesota Medical School could change how future antimicrobial drug combinations are discovered and developed. (2018-03-27)

Upper limit for intake of folate is invalid -- government urged to fortify flour with folic acid
There is no need for an upper limit of folate intake, according to a study by Queen Mary University of London and the School of Advanced Study, University of London. (2018-01-30)

Study links low carbohydrate intake to increased risk of birth defects
Women who are pregnant or planning to become pregnant may want to avoid diets that reduce or eliminate carbohydrates, as they could increase the risk of having babies with neural tube birth defects, according to a new study from the University of North Carolina at Chapel Hill. (2018-01-25)

Molecular imaging technique identifies lung nodules for resection in osteosarcoma patient
Utility of near-infrared molecular imaging in a patient undergoing pulmonary metastasectomy for osteosarcoma has been reported by researchers from Perelman School of Medicine at the University of Pennsylvania and Purdue University. The work is reported in an article in the Journal of Biomedical Optics published this week by SPIE, the international society for optics and photonics. (2018-01-05)

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