Current Frailty News and Events

Current Frailty News and Events, Frailty News Articles.
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See how they run: 'Exercise protein' doubles running capacity, restores function and extends healthy lifespans in older mice
A new study shows that humans express a powerful hormone during exercise and that treating mice with the hormone improves physical performance, capacity and fitness. Researchers say the findings present new possibilities for addressing age-related physical decline. (2021-01-20)

NAD+ can restore age-related muscle deterioration
Scientists at EPFL have discovered that Alzheimer's-like protein aggregates underly the muscle deterioration seen in aging. But the aggregates can be reversed by boosting the levels of nicotinamide adenine dinucleotide (NAD+), which turns on the defense systems of mitochondria in cells and restores muscle function. (2021-01-19)

Physical frailty syndrome: a cacophony of multisystem dysfunction
Aging experts synthesize converging evidence that the aging-related pathophysiology underpinning the clinical presentation of phenotypic frailty is a state of lower functioning due to severe dysregulation of the complex dynamics in our bodies that maintains health and resilience. When severity passes a threshold, the clinical syndrome and its phenotype are diagnosable. This paper summarizes evidence meeting criteria for physical frailty as a product of complex system dysregulation distinct from the cumulative-deficit-based frailty index of multimorbiditys. (2021-01-14)

Nurse involvement promotes discussion of advanced care planning during office visits
Most doctors would agree that advanced care planning (ACP) for patients, especially older adults, is important in providing the best and most appropriate health care over the course of a patient's life. (2021-01-11)

Initial severity of COVID-19 not associated with later respiratory complications
A new study published online in the Annals of the American Thoracic Society examines the recovery of lung function and overall wellness in individuals who had varying degrees of COVID-19 severity. Little is known about lung health following infection with SARS-CoV-2, the virus that causes COVID-19, and whether later respiratory problems, fatigue and ill health are associated with the disease's initial severity. (2021-01-08)

Frailty is a factor in higher mortality for women awaiting liver transplants
Women awaiting liver transplants in the United States are known to be about one-third more likely than men to become too ill to undergo surgery or die before receiving a liver. Now a study headed by UC San Francisco and Columbia University highlights the role that frailty plays in this gender gap. (2020-12-30)

GSA publishes three new research articles on COVID-19 and aging
The Gerontological Society of America's highly cited, peer-reviewed journals are continuing to publish scientific articles on COVID-19. The following were published between November 16 and December 2, 2020; all are free to access. (2020-12-14)

Many older adults hospitalized with the flu face persistent functional decline
In a study of older adults admitted to the hospital with influenza and other acute respiratory illnesses during the 2011-2012 flu season, functional decline was common--and for some, this decline was persistent and catastrophic. The findings are published in the Journal of the American Geriatrics Society. (2020-12-09)

Healthy muscles are a carrot on a string for healthy lungs
Scientists show effectiveness of carrot-based Japanese herbal medicine called ''Ninjin'yoeito'' in improving muscle atrophy in the hind legs of mice exposed to cigarette smoke through an increased expression of PGC-1α, positioning the medicine as a potential treatment for sarcopenia frailty-related complications with chronic obstructive pulmonary disease (COPD). Their findings were published online in the international scientific journal ''International Journal of Chronic Obstructive Pulmonary Disease'' on November 27, 2020. (2020-12-02)

New studies find financially exploited seniors show brain differences and are more frail
Two recent studies led by USC provide new insight into factors that put older adults at risk for financial exploitation. One study found that those who report being financially exploited show differences in the activity of brain regions tied to decision-making and social judgments compared to those without a history of financial exploitation. The other showed that financially exploited seniors are frailer physically -- with particular deficits in vision and hearing -- compared to their peers. (2020-11-18)

COVID-19 patients with spinal fractures are twice as likely to die
Patients with COVID-19 and vertebral fractures are twice as likely to die from the disease, according to a study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism. (2020-10-21)

Improved mobility in frail and elderly adults linked to common gene variant
Variations in a gene that regulates dopamine levels in the brain may influence the mobility of elderly and frail adults, according to research published today. The finding adds to a growing body of evidence hinting that lower dopamine levels could contribute to the slower, often disabling walking patterns seen in some elderly populations. (2020-10-12)

Delirium a key sign of COVID-19 in frail, older people
A new analysis of data from researchers at King's College London using information from the COVID Symptom Study app and patients admitted to St Thomas' Hospital in London, has shown that delirium - a state of acute confusion associated with a higher risk of serious illness and death - is a key symptom of COVID-19 in frail, older people. (2020-09-30)

How vitamin C could help over 50s retain muscle mass
New research shows that vitamin C could help over 50s retain muscle mass in later life. The new study shows that older people who eat plenty of vitamin C - commonly found in citrus fruits, berries and vegetables - have the best skeletal muscle mass. This is important because people tend to lose skeletal muscle mass as they get older - leading to sarcopenia (a condition characterised by loss of skeletal muscle mass and function), frailty and reduced quality of life. (2020-08-26)

Cancer and its treatment may accelerate the aging process in young patients
A new study examines the effects of cancer and its treatment on the aging process. Investigators found that expression of a gene associated with aging is higher in young patients with cancer after treatment with chemotherapy and in young cancer survivors who are frail. The findings are published early online in CANCER, a peer-reviewed journal of the American Cancer Society (ACS). (2020-08-24)

High blood pressure and salt, anti-aging factor Klotho key
The mechanism behind salt-intake and hypertension has been elucidated for the first time, through vascular non-canonical Wnt5a/RhoA under Klotho deficiency. (2020-08-19)

Childhood maltreatment linked to higher risk of multiple health conditions in later life
People who suffer one or more forms of maltreatment in childhood have a higher chance of multimorbidity in later life. (2020-08-19)

Risk of sepsis greatest for patients with frailty, older age or urinary tract infections
Patients with frailty, older age and urinary tract infections (UTIs) are at greatest risk of developing sepsis following infection consultations in primary care, research has found. (2020-07-24)

Difference between cystatin C- and creatinine-based eGFRs contains clinical information
It is common to see clinic patients whose eGFR by creatinine and cystatin are different by >15 mL/min. Potok et al surmised that these differences, usually overlooked in favor of a combined eGFR, carry important information. The authors examined the intra-individual difference in eGFR by cystatin vs. creatinine (eGFRDiff) and found that eGFRDiff may hold prognostic information as a negative eGFRDiff at any level of kidney function was associated with higher risk of frailty, CVD, and death. (2020-07-16)

Don't Let social isolation keep you from being active
Researchers from the University of Sao Paulo in Brazil recently reported on the dangers of physical inactivity for older adults during the COVID-19 pandemic. Their paper was published in the Journal of the American Geriatrics Society. (2020-07-15)

Study highlights multiple health risks among a people living longer with HIV
A suite of articles in The Journal of Infectious Diseases contains the first swath of important data from the world's largest study of cardiovascular disease (CVD) prevention in people with HIV. (2020-07-10)

Regular physical activity can maintain or improve frailty
Frailty is the medical term for becoming weaker or experiencing lower levels of activity or energy. Becoming frail as we age increases our risk for poor health, falls, disability, and other serious concerns. In this study, researchers examined the benefits of assistance that helps older adults follow their prescribed medications and prevent falls, frailty, and loneliness. (2020-06-11)

Age affects decisions related to breast cancer surgery
A new BJS (British Journal of Surgery) study indicates that breast cancer surgery is safe for patients who are older than 70 years of age, but age can influence the decision to undergo surgery. (2020-06-03)

Dementia gene raises risk of severe COVID-19
Having a faulty gene linked to dementia doubles the risk of developing severe COVID-19, according to a large-scale study. (2020-05-26)

SCAI releases official position statement on optimal percutaneous interventional therapy for complex coronary artery disease
The Society for Cardiovascular Angiography and Interventions (SCAI) has published a position statement addressing optimal percutaneous coronary intervention (PCI) treatment of patients with complex coronary artery disease (CAD). (2020-05-14)

UBC professor encourages seniors to pick up weights to combat frailty
Physical exercise may not be top of mind for older adults during the COVID-19 outbreak. But according to one UBC Okanagan researcher, strength training can be an effective way to stay healthy while at home. A recent study from UBCO professor Jenn Jakobi shows that strength training with free-weights that progresses in intensity is effective in combating declining health often observed with adult aging. (2020-05-04)

Elderly patients with pneumonia twice as likely to die as those with broken hips, yet underestimate the danger of pneumonia
Elderly patients who are hospitalised with pneumonia are twice as likely to die as those hospitalised with hip fractures -- yet many elderly people fail to accurately assess their risk of pneumonia, concludes research due to be presented at the European Congress of Clinical Microbiology and Infectious Diseases (ECCMID). (2020-04-17)

'Frailty' from age 40 -- what to look out for
With all eyes on avoiding major illness this year, health researchers are urging people as young as 40 to build physical and mental health to reduce or even avoid 'frailty' and higher mortality risk. A new study published online in BMC Geriatrics found 'pre-frailty occurs in 45% of people aged 40-49 - which is about the same percentage of people aged 70-75. (2020-04-15)

Leaving its mark: How frailty impacts the blood
Fifteen blood metabolites are key for diagnosing the age-related disorder, frailty, new study finds. (2020-04-06)

Adding a measure of patient frailty to Medicare payment model could lead to fairer reimbursement for clinicians
Researchers identified a way to measure frailty using patients' medical claims that more accurately predicts costs-of-care, especially for clinicians with disproportionate shares of frail patients. Adding this measure to Medicare's value-based payment models could lead to fairer reimbursement for clinicians who care for patients with greater needs. Findings from a retrospective cohort study are published in Annals of Internal Medicine. (2020-04-06)

Gut enzyme IAP found to prevent aging and frailty in animal models
Studying mice and fruitflies, researchers found that the enzyme intestinal alkaline phosphotase helped prevent intestinal permeability and gut-derived systemic inflammation, resulting in less frailty and extended life span. (2020-03-26)

Frailty may be highly predictive of complications, death in patients with mitral valve disease
Frailty measurements have become increasingly important in assessing surgical risk in patients with mitral valve disease, and research published online today in The Annals of Thoracic Surgery shows that frailty plays a significant role in outcomes following mitral valve procedures. (2020-03-19)

Tool for identifying frail patients to reduce surgical risk works in health system setting
UPMC research shows that the Risk Analysis Index, which takes 30 seconds to complete, can be implemented at scale for health systems to identify frail patients and reduce surgical risk. (2020-03-02)

Elder-friendly care after emergency surgery greatly improves outcomes for older patients
Tailoring care for older patients who have had emergency surgery can reduce complications and deaths, decrease the length of hospital stays and cut down on the need for alternate care at discharge, according to a new study led a University of Alberta researcher. (2020-02-18)

Mediterranean diet promotes gut bacteria linked to 'healthy ageing' in older people
Eating a Mediterranean diet for a year boosts the types of gut bacteria linked to 'healthy' ageing, while reducing those associated with harmful inflammation in older people, indicates a five-country study, published online in the journal Gut. (2020-02-17)

New measure of biological age can predict health risks
People age in different ways. Biological age is a metric that scientists use to predict health risks, the relevance of which can be enhanced by combining different markers. Particularly important markers are frailty and the epigenetic clock, write researchers from Karolinska Institutet in a study published in eLife. (2020-02-11)

Frailty can affect how well older adults fare following emergency surgery
A new study in the Journal of the American Geriatrics Society sought to gain more information about how frailty affects older adults in the months after surgery. The research team wanted to test their theory that these people would have a higher risk for death a year after surgery, have higher rates of being sent to long-term care facilities rather than to their homes, and have poorer health one year after surgery. (2020-02-11)

Inequitable medicare reimbursements threaten care of most vulnerable
Hospitals, doctors and Medicare Advantage insurance plans that care for some of the most vulnerable patients are not reimbursed fairly by Medicare, according to recent findings in JAMA. (2020-02-07)

Lower levels of lymphocyte blood cells may indicate increased risk of death
Lower levels of lymphocyte blood cells -- a condition called lymphopenia -- could be an early warning for future illness, as low counts were associated with a 60% increase in death from any cause, found a Danish study in CMAJ (Canadian Medical Association Journal). (2020-01-13)

New frailty index may help determine adverse outcomes in older patients after hospital discharge
A new frailty index shows promise in determining how acute illness affects functional ability in older patients admitted to hospital, according to a new study in CMAJ (Canadian Medical Association Journal) co-led by researchers from Dalhousie University, Canada, and University College London (UCL), United Kingdom. (2020-01-06)

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