Current Gastroenterology News and Events | Page 25

Current Gastroenterology News and Events, Gastroenterology News Articles.
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Economy could reduce colorectal cancer screening rate
Even in the best economic environment, only half of the people who need colorectal cancer screening receive the life-saving test. Those without health insurance or with limited coverage that does not include colorectal cancer screenings are even less likely to be screened. During March, Colorectal Cancer Awareness Month, the AGA is working to raise awareness of how the economy could negatively impact cancer screening. A bill in Congress could help bridge the gap. (2009-02-25)

Do imaging findings imply malignant potential at multi-detector row computed tomography?
Solid pseudopapillary tumors of the pancreas are rare and predominantly occur in young women. The histopathology could not be predictive of aggressive behaviors of this tumor; however, a research group in China found that imaging features of SPT on multi-detector row computed tomography were well correlated with the aggressive behaviors. (2009-02-21)

What is potentially pathogenic role of anti-tTG IgA in the development of celiac disease?
Anti-tissue transglutaminase IgA is currently used to screen patients for celiac disease; however, its origins and role in celiac disease have not been well characterized. Currently there are two models for the origin of anti-tTG IgA, the hapten-carrier model and the molecular mimicry model (which are not necessarily exclusive). The observation that celiac patients produce antibodies against deamidated gliadin peptides warrants a correlation analysis of the antibodies. (2009-02-21)

Is it effective of low-dose furazolidone-based quadruple regimens for H pylori infection?
The prevalence of Helicobacter pylori resistant to antibiotics was increased. Furazolidone has been used for the eradication of H pylori for many years. A study from China used low dose furazolidon as a component of quadruple rescue therapy. It suggests that the eradication rates were good taking account of the fact that all patients had failed to respond to at least once previous treatment, and the side effects were relatively minor. (2009-02-21)

Non-invasive diagnostic tools for assessment of function and structure of the stomach mucosa
Risks for gastric cancer or peptic ulcer diseases are low in subjects with healthy stomach mucosa but are remarkably high in those with (2009-02-21)

A safe, well-tolerated, and effective treatment for metastatic esophageal cancer
Patients with metastatic esophageal squamous cell cancer face a dismal prognosis, as no effective standard chemotherapy exists. A research group in China investigated the efficacy, toxic reaction and survival period of Oxaliplatin combined with capecitabine in treatment of patients with in patients with metastatic esophageal squamous cell cancer, and assessed the efficacy, toxicity and survival of the combination therapy. (2009-02-21)

A potential molecular target for biotherapy esophageal squamous cell carcinomas
A research group from China examined the expressions of N-cadherin and E-cadherin in specimens of 62 normal esophageal epithela, 31 adjacent atypical hyperplastic epithelia and 62 esophageal squamous cell carcinomas (ESCCs). They found that E-cadherin and N-cadherin expression is correlated with the invasion and aggravation of ESCC. The down-regulation of N-cadherin lowers the invasiveness of EC9706 cell line. (2009-02-19)

Proteasome inhibition affects epigenetic mechanisms
A research group from United States examined the effects of ethanol-induced proteasome inhibition, and the effects of proteasome inhibition in the regulation of epigenetic mechanisms. Proteasome inhibition plays a critical role in regulating the gene expression of key enzymes in the remethylation pathway, such as betainehomocysteine methyltransferase, and links to liver injury in alcoholic liver disease. (2009-02-19)

New therapy with stem cells to treat Crohn's disease
Hospital Clinic de Barcelona is leading the world in the application of an innovative cellular therapy that uses stem cells to treat Crohn's disease, a chronic genetic disease that affects one percent of the population in Spain and which has considerable impact on the quality of life of the patients. (2009-02-19)

Should intra-abdominal pressure measurement be a routine for all pancreatitis patients?
A research group from Lithuania assessed the value of widely used clinical scores in the early identification of acute pancreatitis (AP) patients who are likely to suffer from intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS). They found that IAH and ACS are rare in patients with mild AP, and recommend measuring the (intra-abdominal pressure) IAP in cases when patients present with SAP. (2009-02-19)

A useful method to diagnose chest pain with foregut symptoms
A research group from China evaluated the diagnosis of chest pain with foregut symptoms in Chinese patients. They concluded that esophageal manometric studies, 24-hour intra-esophageal pH monitoring and Holter electrocardiography are significant for the differential diagnosis of chest pain, particularly in patients with foregut symptoms. (2009-02-19)

What is the most effective therapy for low-dose aspirin induced peptic ulcer?
A research group from Japan investigated the usefulness of anti-ulcer drugs for the prevention and treatment of low-dose aspirin induced peptic ulcer. They found that H2 receptor antagonist therapy was effective for both the prevention and treatment of low-dose aspirin induced peptic ulcer, similar to the effects of (proton pump inhibitors) PPIs, while cytoprotective anti-ulcer drugs were ineffective in preventing ulceration. (2009-02-19)

Supplement of probiotics provides a new therapy for ulcerative colitis
Ulcerative colitis (UC) is a non-specific chronic inflammation of intestinal tract and the primary therapies are limited by the side-effects, poor compliance of patient and the high rates of relapse. The supplements of probiotics provide a new therapy for UC. A research group in China compared the effects of four strains of probiotics (E.feacalis, L.acidophilus, C.butyricum and B.adolescentis) in order to find one or two obvious effective strains. (2009-02-17)

Biochemical markers for non-invasive assessment of primary biliary cirrhosis
Needle liver biopsy has been used as the (2009-02-17)

What are the histologic features of intrahepatic neonatal cholestasis?
A research group from Brazil compare the histologic features of the liver in intrahepatic neonatal cholestasis (IHNC) with infectious, genetic-endocrine-metabolic, and idiopathic etiologies. A significant difference was observed in IHNC of infectious etiology, which presented with more severe erythropoiesis than genetic-endocrine-metabolic and idiopathic etiologies and should prompt an investigation for infection. (2009-02-14)

What are the mechanisms of PPAR-gamma-inhibiting pancreatic carcinoma growth?
A research group in China investigated the PPAR-gamma activation on the growth of pancreatic carcinoma, especially its regulation on the tumor angiogenesis. Their results show that Activation of PPAR-gamma inhibits the growth of pancreatic carcinoma both in vitro and in vivo. Suppression of tumor angiogenesis by down-regulating the expression of VEGF may be one of the mechanisms by which PPAR-gamma activation inhibits the growth of pancreatic carcinoma. (2009-02-14)

Are capecitabine and irinotecan bevacizumab effective for colorectal cancer patients?
A research group from Germany investigate the efficacy and safety of capecitabine plus irinotecan +/- bevacizumab in advanced or metastatic colorectal cancer patients. They found that both regimens were well tolerated and offered effective tumor growth control in this outpatient setting. Severe gastrointestinal toxicities and thromboembolic events were rare and if observed were never fatal. (2009-02-14)

NIH report finds costs of digestive diseases has grown to more than $141 billion a year
Digestive, liver and pancreatic diseases result in more than 100 million outpatient visits and 13 million hospitalizations annually at a cost of $141.8 billion. A new report commissioned by the National Institutes of Health finds that costs, doctor visits, prescription costs and hospitalizations related to digestive diseases have risen significantly in recent years. The Burden of Digestive Diseases in the United States report is summarized in Gastroenterology, the official journal of the American Gastroenterological Association Institute. (2009-02-10)

Infliximab may help prevent post-operative Crohn's disease recurrence
The administration of infliximab after intestinal resective surgery was found to be effective at preventing endoscopic and histological recurrence of Crohn's disease. To date, there have been no randomized controlled trials evaluating infliximab for postoperative Crohn's disease prevention. (2009-02-01)

Clinical Gastroenterology and Hepatology most influential journal in field of clinical medicine
The American Gastroenterological Association Institute journal, Clinical Gastroenterology and Hepatology, is the medical journal with the most impact on the field of clinical medicine, according to a recent analysis of Essential Science Indicators data by Thompson Reuters. This impact was measured by the greatest percentage increase in citations for any clinical medical journal. (2009-01-21)

A further study of Helicobacter pylori reducing gastric blood flow
A research group from Sweden investigated the mechanisms underlying the reduction in gastric blood flow induced by a luminal water extract of Helicobacter pylori (H. pylori). They found that the H. pylori water extract reduces gastric mucosal blood flow acutely through iNOS- and nerve-mediated pathways. (2009-01-18)

What is the risk factor for gastric cancer in a Costa Rican?
A research group from Costa Rican evaluated risk factors for gastric cancer in Costa Rican regions with contrasting gastric cancer incidence rates (GCIR). They found that although a pro-inflammatory cytokine genetic profile showed an increased risk for developing gastric cancer (GC), the characteristics of Helicobacter pylori (H. pylori) infection, in particular the status of cagA and vacA genotype distribution seemed to play a major role in GCIR variability in Costa Rica. (2009-01-18)

Clinical features of hepatocellular carcinoma associated with autoimmune liver disease
A research group from Japan characterized the clinical features of hepatocellular carcinoma (HCC) associated with autoimmune liver disease. They evaluated the literature on HCC associated with autoimmune hepatitis and primary biliary cirrhosis. (2009-01-18)

ASGE recognizes 56 endoscopy units for quality and safety through Endoscopy Unit Recognition Program
The American Society for Gastrointestinal Endoscopy has recognized 56 endoscopy units as part of its new program specifically dedicated to promoting quality in endoscopy, in all settings where it is practiced in the United States. The ASGE Endoscopy Unit Recognition Program honors endoscopy units that follow the ASGE guidelines on privileging, quality assurance, endoscopy reprocessing and CDC infection control guidelines. (2009-01-15)

Converting adult somatic cells to pluripotent stem cells using a single virus
A Boston University Medical School research team has found a more efficient way to create induced pluripotent stem cells using a single virus vector instead of multiple viruses in the reprogramming process. The ability to combine four vectors into single (2009-01-07)

Antioxidants offer pain relief in patients with chronic pancreatitis
Antioxidant supplementation was found to be effective in relieving pain and reducing levels of oxidative stress in patients with chronic pancreatitis. (2009-01-01)

A new light on the anti-tumor mechanisms of Scutellaria barbata
A research group in China investigated the growth inhibitory and apoptotic effects of Scutellaria barbata D.Don (S. barbata) and determined the underlying mechanism of its anti-tumor activity in mouse liver cancer cell line H22. They found that extracts from S. barbata can effectively inhibit the proliferation and induce apoptosis of H22 cells involving loss of mitochondrial transmembrane potential, release of cytochrome C, and activation of caspase-3. (2008-12-31)

What is the pathogenesis of C. jejuni-related disease?
A research group from United Kingdom investigated the mechanisms by which Campylobacter jejuni (C. jejuni ) causes inflammation and diarrhea. They found that C. jejuni causes two distinct patterns of disease comprising watery diarrhea (especially in children) and a condition that is normally self limiting but mimics ulcerative colitis. (2008-12-31)

A rigorous method for liver biopsy
A research group from Italy describes a rigorous method based on the fundamentals of measurement theory, which metrically defines the changes of magnitude of liver tissue prime basic structural elements occurring during the course of B and C chronic hepatitis. The method can be considered the first step toward quantification and automation of other liver tissue structures metrical description. (2008-12-31)

Is bismuth a safe medicine for the treatment peptic ulcer disease?
Researchers in Canada and Germany performed a systematic review and meta-analysis examining adverse events arising from the use of bismuth compounds in Helicobacter pylori (H. pylori) eradication therapy. They concluded that Bismuth is a safe and well-tolerated to treat of H. pylori. The only adverse event occurring more commonly was dark stools. (2008-12-31)

The prevalence of gluten-sensitive enteropathy in iron-deficient anemia patients
A research group from Iran investigated the prevalence of gluten-sensitive enteropathy (GSE) in a large group of patients with iron deficiency anemia (IDA) of obscure origin. They found that there is a high prevalence of GSE in patients with IDA of obscure origin. Gluten-free diet can improve anemia in GSE patients who have mild duodenal lesions without villous atrophy. (2008-12-31)

What are protective effects of anti-ricin A-chain aptamer?
A group from New York University School of Medicine investigated the therapeutic potential of an RNA ligand (aptamer) specific for the catalytic ricin A-chain (RTA), the protective effects of a 31-nucleotide RNA aptamer, which formed a high affinity complex with RTA, against ricin-induced toxicity in cell-based luciferase translation and cell cytotoxicity assays were evaluated. (2008-12-29)

Arterial infusion using gabexate mesilate: Is it effective therapy for severe acute pancreatitis?
Continuous regional arterial infusion (CRAI) of protease inhibitors and antibiotics has been applied to treat severe acute pancreatitis (SAP), but the evidence of its value is still scarce. A prospective study was conducted to confirm the efficacy of CRAI using gabexate mesilate for SAP. The abdominal pain, SIRS, and the average length of hospitalization decreased significantly with CRAI compared to non-CRAI. This study suggests that CRAI using gabexate mesilate was effective against SAP. (2008-12-29)

How to enhance nonthermal effects of ultrasound
High-intensity focused ultrasound is a rapidly developing noninvasive technology for tumor treatment. A research group in China investigated the pathological characteristics of nonthermal damage induced by pulsed high intensity focused ultrasound (PHIFU) combined with ultrasound contrast agent (UCA) in rabbit liver VX2 tumor. The results showed that non-thermal effects of PHIFU combined with UCA could be used to treat tumor. And this would provide a new method of therapy for tumor. (2008-12-29)

Chronic gastrointestinal symptoms in Korean population
A research group in Korea surveyed chronic gastrointestinal symptoms and health-related quality of life in the Korean general population. Dyspepsia was found to be the most common chronic gastrointestinal symptom, and the prevalence of GERD as well as IBS was lower than that in Western countries. The presence of chronic gastrointestinal symptoms was found to have a negative impact on the HRQOL. (2008-12-29)

Acute gastric injury due to high-dose analgesics?
A new study has documented the gastrointestinal complications of high dose acetaminophen, a commonly used drug. The study investigated the acute high dose ingestion of analgesics, nonsteroidal anti-inflammatory drugs and acetaminophen, with suicidal intent. The study results surprisingly indicated that acetaminophen induces gastric lesions. (2008-12-29)

May hepatic granulomas be part of the histological spectrum of chronic hepatitis C?
Granulomas are sometimes found in the livers of patients with abnormal liver tests, and this can trigger an exhaustive search for the cause. A group from the University of Texas Medical branch in Galveston evaluated over 4,000 liver biopsies from their institution in the last decade to find the most common associations. Chronic hepatitis C was the most common association. (2008-12-29)

A new screening test for chronic abdominal pain
Fifty patients with undiagnosed chronic abdominal pain of bowel origin underwent barium meal follow through (BMFT), BMFT with pneumocolon (BMFTP). Adding pneumocolon to BMFT not only helped in detecting ileo-cecal abnormalities better but also revealed other colonic abnormalities simultaneously obviating the need of colonoscopy and barium enema in a large subset of patients thereby lowering cost of screening these subjects which is quite important for developing poor nations where health budgets are quite low. (2008-12-29)

What is the clinical character of Fitz-Hugh-Curtis syndrome?
A research group from South Korea analyzed the clinical characteristics of patients diagnosed with Fitz-Hugh-Curtis syndrome. They concluded that in cases suspected to be Fitz-Hugh-Curtis syndrome, abdominal CT, rather than abdominal sonography, assists in the diagnosis. For women of childbearing age with acute pain in the upper right abdomen alone or together with pain in the lower abdomen, Fitz-Hugh-Curtis syndrome should be considered during differential diagnosis. (2008-12-23)

What is the mechanism of the chronic radiation enteritis?
Radiotherapy in pelvic or abdominal area is a critical dose-limiting organ for intestine. A research group in France has shown that each colorectal irradiation dose fraction during the radiotherapy protocol influenced colonic inflammatory responses, modified the immune balance and led to long-term persistence of the adaptive immune imbalance. (2008-12-23)

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