Current Gene Regulation News and Events | Page 24

Current Gene Regulation News and Events, Gene Regulation News Articles.
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Loss of a gene long ago puts marine mammals at risk today, as environments change
Ancient loss of gene function across ancestral marine mammal lineages may now be putting modern marine mammals at risk, leaving them defenseless against toxic organophosphates. (2018-08-09)

Environmental regulations drove steep declines in US factory pollution
A new study by UC Berkeley economists shows that between 1990 and 2008, air pollution levels plummeted. The evidence shows that environmental regulation and the associated cleanup of production processes played important roles in those steep declines. Manufacturers are producing the same types of goods, but they've taken significant steps to clean up their production processes, the authors say. (2018-08-08)

Epigenetic markers of ovarian cancer
Insilico Medicine and its collaborators from Johns Hopkins and Insilico Medicine, used an integrated approach by coupling identification of genome-wide expression patterns in multiple cohorts of primary ovarian cancer samples and normal ovarian surface epithelium with innovative computational analysis of gene expression data, leading to the discovery of novel cancer-specific epigenetically silenced genes. The study reveals 43 genes abnormally methylated in ovarian cancer and identifies methylation of an engulfment gene, GULP1, as a potential biomarker of ovarian cancer. (2018-08-06)

Twin study highlights importance of both genetics and environment on gene activity
A study in PLOS Genetics used a unique cohort of over 700 pairs of twins to identify the factors influencing chemical modifications to DNA across the genome. The study compared found that epigenetic marks are more similar between identical twins -- highlighting the role of DNA sequence variation in regulating gene activity. Sites at which epigenetic variation is strongly linked to environmental exposures -- such as smoking and obesity - are also partly under genetic control. (2018-08-03)

Medical researchers from MSU suggested a new approach of targeted cancer therapy
A team from the Faculty of Medicine, MSU has analysed a link between the p53 protein, tumor dissemination and 'cell suicide' and discussed possible approaches to predict metastases development and their treatment. They also discussed new chemical compounds that might influence the process of metastasis. The study was supported by a grant from Russian Science Foundation (RSF). The results were published in the Cancers journal. (2018-08-01)

Scientists identify new mechanisms underlying pediatric kidney cancer
Connecting two previously unrelated insights about the formation of pediatric kidney cancer, researchers at UT Southwestern Medical Center have uncovered the means by which the cancer continues to grow, providing potential targets for more effective treatments in the future. (2018-08-01)

How do young people feel about guns, gun regulation in US?
National polls track adult opinions about guns and gun regulation but how do young feel about that? A new research letter describes youth opinions on guns and gun regulation that were drawn from themes in text message survey responses. The majority of the 772 survey respondents were white females with an average age of 18. Most survey respondents reported the belief that gun control laws could help reduce mass shootings. (2018-07-30)

Public views of gene editing for babies depend on how it would be used
A new Pew Research Center survey finds a majority of Americans support the idea of using gene editing with the goal of delivering direct health benefits for babies. Yet, a majority also considers the use of gene editing to boost a baby's intelligence as something that takes technology 'too far.' (2018-07-26)

Researchers discover system that could reduce neurodegeneration in Huntington's disease
The neuroscientist Dr David Vilchez and his team at CECAD, the University of Cologne's Cluster of Excellence for Aging Research, have made an important step towards understanding the mechanisms that cause the neurodegenerative disorder Huntington's disease. Particularly, they identified a system blocking the accumulation of toxin protein aggregates, which are responsible for neurodegeneration. The results have now been published in the journal 'Nature Communications'. (2018-07-26)

Naturalistic driving study investigates self-regulation behavior in early Alzheimer's disease
Driving is a complex task that involves perceptual, motor and cognitive abilities. These abilities may be affected in early Alzheimer Disease (AD) patients. Nevertheless, they continue to drive for more years than people with other dementia syndromes perhaps because of a deficit in self-awareness that prevents them from perceiving their driving difficulties and adapting accordingly. (2018-07-26)

One gene to rule them all: Regulating eusociality in ants
A single gene associated with insulin signaling likely drove the evolutionary rise of an ant queen's reproductive royalty, researchers suggest. (2018-07-26)

Genetic variation may increase risk of liver damage in patients with chronic hepatitis B
A new study has shown that genetic variation may increase the risk of severe liver damage in Caucasians with chronic hepatitis B infection. (2018-07-26)

Combined approach offers hope to lung cancer patients who become resistant to drugs
Three drugs together block growth from without and within. (2018-07-25)

Switching sides: The betrayal of an anti-cancer gene
Reeducating cells in the tumor microenvironment reverses some of the malignancy. (2018-07-25)

Ebola virus gene stolen and preserved by myotis bats, study finds
A gene from the deadly Ebola virus that allows the virus to escape from the human immune system has been identified in the genome of a group of bats that is found worldwide, including North America. The gene appears to have been stolen from the virus by the bats and adapted to regulate their own immune response, according to a recent study led by Georgia State University. (2018-07-24)

Blindness gene discovered
Researchers from UNIGE have investigated a recessive genetic disorder that destroys the eyes from developing and results in childhood blindness. After analysing the genomes of each member of a consanguineous family with affected children, the geneticists pinpointed pathogenic mutations in a new gene, MARK3, as being the cause. They subsequently confirmed their findings by modifying the homologous gene in drosophila flies, which resulted in abnormal eye development and blindness. (2018-07-23)

Imaging in living cells reveals how 'junk DNA' switches on a gene
Researchers have captured video showing how pieces of DNA once thought to be useless can act as on-off switches for genes. A team led by researchers at Princeton University has captured how this 'junk DNA' finds and activates a target gene in living cells. The video allows researchers to see the enhancers as they find and connect to a gene to kick-start its activity. (2018-07-23)

A peek into the interplay between sleep and wakefulness
The ventrolateral preoptic nucleus (VLPO) in the brain plays a critical role in the initiation and maintenance of sleep, while the lateral posterior part of the hypothalamus contains neuronal populations implicated in maintenance of arousal. Now, a University of Tsukuba-centered study reveals that these arousal-related neurons are heavily innervated by GABAergic neurons in the preoptic area including the VLPO. The work provides important information to understand the mechanisms that control animals' sleep/wakefulness states. (2018-07-20)

Analytical tool predicts genes that can cause disease by producing altered proteins
A new computational tool predicts genes that can cause disease due to the production of truncated or altered proteins that take on a new or different function, rather than those that lose their function. (2018-07-19)

The tale of mRNA mixed tail
IBS biologists have identified how mixed tails -- made of different nucleotides -- protect mRNA from degradation for longer. This study could bring new insights to our understanding of gene regulation in healthy and diseased states. (2018-07-19)

Identified RNA molecules that regulate action of male hormone in prostate cancer
A study detected in tumoral tissue hundreds of RNAs that do not encode proteins but appear to regulate effects of androgens and androgen receptors on gene expression in tumors. By investigating the connection between the presençe of these molecules and tumor aggressiveness, the research paves the way for new scientific approaches focusing on the transcription process of noncoding RNA. (2018-07-18)

Self-control and obesity: Gender matters in children
A toddler's self-regulation -- the ability to change behavior in different social situations -- may predict whether he or she will be obese come kindergarten, but the connection appears to be much different for girls than for boys. (2018-07-16)

Pattern of association between toddler self-regulation, kindergarten obesity risk
Obesity is among the long-term adult health consequences associated with poor self-regulation during childhood. This study of a nationally representative group of U.S. children suggests the pattern of an association between levels of toddler self-regulation and risk for obesity at kindergarten age differs between boys and girls. (2018-07-16)

A gene required for addictive behavior
Cocaine can have a devastating effect on people. It directly stimulates the brain's reward center, and, more importantly, induces long-term changes to the reward circuitry that are responsible for addictive behaviors. Alban de Kerchove d'Exaerde from the Université Libre de Bruxelles, Belgium, and his colleagues have now uncovered that a gene called Maged1 plays a crucial role in controlling these pathological changes. This finding was published today in EMBO Reports. (2018-07-12)

Rice plants evolve to adapt to flooding
Although water is essential for plant growth, excessive amounts can waterlog and kill a plant. In South and Southeast Asia, where periodic flooding occurs during the rainy season, the water depth can reach several meters for many months. (2018-07-12)

Dodder genome sequencing sheds light on evolution of plant parasitism
To gain insight into the evolution of dodders, and provide important resources for studying the physiology and ecology of parasitic plants, the laboratory of Dr. WU Jianqiang from the Kunming Institute of Botany, Chinese Academy of Sciences, combined PacBio sequencing and Illumina transcriptome sequencing technology to obtain a high-quality genome of the dodder Cuscuta australis. (2018-07-11)

Researchers clarify role of mutations in glioblastoma
Researchers from the UNC Lineberger Comprehensive Cancer Center investigated whether the location of the mutation within the sequence of the PIK3CA gene affected the mutation's ability to help drive growth of glioblastoma tumors. They also evaluated whether the location of the mutation would affect the cancer's response to certain treatments. (2018-07-11)

Regulation reality gap for small businesses bodes ill for Brexit
Small business owners lack understanding of critical regulations and compound the problem with over-confidence, shows research from the University of Bath which suggests small businesses will struggle to comply with the raft of regulatory changes post Brexit. (2018-07-10)

Mapping the genetic controllers in heart disease
Researchers have developed a 3D map of the gene interactions that play a key role in cardiovascular disease, a study in eLife reports. (2018-07-10)

Researchers develop a new method for turning skin cells into pluripotent stem cells
Researchers at the University of Helsinki, Finland, and Karolinska Institutet, Sweden, have for the first time succeeded in converting human skin cells into pluripotent stem cells by activating the cell's own genes. (2018-07-06)

A gene linked to job-related exhaustion in shift workers increases the risk of Alzheimer's
A new study shows that a variation in the melatonin receptor 1A gene is linked to the risk of Alzheimer's disease in the elderly. The same research team has previously demonstrated that the same genetic variation reduces tolerance to shift work among the working age population. (2018-07-06)

Hungry? A newly discovered neural circuit may be the cause
A particular subset of neurons located in an enigmatic region of the hypothalamus plays a central role in regulating feeding and body weight in mice, a new study reveals. (2018-07-05)

Summer fun: How plants beat the heat
Researchers at the RIKEN Center for Sustainable Resource Science in Japan have discovered a gene in plants that helps protect them from excessive heat. Published in the scientific journal Plant Cell, the study shows that the newly found gene prevents the destabilization of chloroplast membranes that occurs at very high temperatures. (2018-07-04)

Loss of cilia leads to melanoma
Most cells in the human body have a cilium, a slender cell protuberance that picks up signals from the cell's external environment. Researchers at the University of Zurich have now shown that these fine sensory antennae play a key role in the formation of melanoma. When cilia are prevented from developing in benign pigment cells, the cells degenerate and develop an aggressive form of melanoma. (2018-07-02)

Gene discovery unlocks mysteries to our immunity
Australia's national science agency CSIRO has identified a new gene that plays a critical role in regulating the body's immune response to infection and disease. (2018-07-01)

The novel function of self-renewal factor of spermatogonial stem cells is identified
A research team found a novel function of FGF2 in mammalian testis. Although it has demonstrated that both GDNF and FGF2 are the self-renewal factor for spermatogonial stem cells (SSCs) in vitro, present study revealed that FGF2 acts to facilitate the differentiation of SSCs in vivo. The understanding of molecular mechanism regulating SSCs has potential for future applications for male infertility treatment. (2018-06-29)

Novel drug therapy partially restores hearing in mice
A small-molecule drug is the first to preserve hearing in a mouse model of an inherited form of progressive human deafness, report investigators at the University of Iowa, Iowa City, and the National Institutes of Health's National Institute on Deafness and Other Communication Disorders (NIDCD). The study, which appears online in Cell, sheds light on the molecular mechanism that underlies a form of deafness (DFNA27), and suggests a new treatment strategy. (2018-06-28)

New insights into the epigenetic control of hematopoiesis
Wistar scientists have characterized a novel function for the INTS13 protein that is part of a large protein complex regulating gene transcription, called Integrator. According to study results, INTS13 is required for monocytic maturation, promoting expression of lineage-specific genes. (2018-06-28)

Cancer-causing virus HTLV-1 changes DNA loops to 'affect tens of thousands of genes'
A human virus that causes a rare form of leukaemia increases the risk of disease by changing the way DNA loops inside our cells. (2018-06-27)

New regulatory axis revealed for the cancer relevant matrix metalloprotease MMP14
Membrane-associated metalloprotease, MMP14, plays a significant role in different cancer tissues -- for instance in breast cancer and melanoma patients high MMP14 levels increase the risk to develop metastasis. The study, conducted at the University of Helsinki, revealed that Prox1 negatively regulates MMP14 protein levels by suppressing transcription of the MMP14 gene. (2018-06-26)

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