Current Gene Therapy News and Events

Current Gene Therapy News and Events, Gene Therapy News Articles.
Sort By: Most Relevant | Most Viewed
Page 1 of 25 | 1000 Results
Scientists develop new gene therapy for eye disease
Scientists from Trinity College Dublin have developed a new gene therapy approach that offers promise for one day treating an eye disease that leads to a progressive loss of vision and affects thousands of people across the globe. The study, which involved a collaboration with clinical teams in the Royal Victoria Eye and Ear Hospital and the Mater Hospital, also has implications for a much wider suite of neurological disorders associated with ageing. (2020-11-26)

Engineered "stealth bomber" virus could be new weapon against metastatic cancer
Researchers at Emory and Case Western Reserve have re-engineered an oncolytic adenovirus. The resulting virus is not easily caught by parts of the innate immune system, making systemic delivery possible without arousing a massive inflammatory reaction. (2020-11-25)

BICRA gene provides answers to patients, doctors and scientists
Researchers identified the BICRA gene as a new disease gene involved in a neurodevelopmental disorder and found evidence that BICRA functions in neural development in humans and flies. (2020-11-23)

New findings speed progress towards affordable gene therapy
In a promising advance for affordable, personalised medicine, researchers have used metal-organic frameworks to successfully deliver the genetic snipping tool CRISPR/Cas9 into human cancer cells. (2020-11-20)

A gene mutation that protects against disease
Called PCSK9Q152H, the mutation of the PCSK9 gene was initially thought to protect against cardiovascular diseases. Recent studies reveal that it may protect against other human illnesses, mainly liver diseases. It may allow the PCSK9Q152H mutant subjects to stay in good health and live longer. (2020-11-19)

In-stent thrombosis after antiplatelet therapy conversion while awaiting coronary bypass
In a new publication from Cardiovascular Innovations and Applications; DOI https://doi.org/10.15212/CVIA.2019.0589, Nathan Burke, Tawanna Charlton, Hussam Hawamdeh, and Ki Park from the University of Florida College of Medicine, Gainesville, Florida, USA consider a case study of in-stent thrombosis after antiplatelet therapy conversion while awaiting coronary bypass. (2020-11-19)

Non-hereditary mutation acts as natural gene therapy in patient with rare disease
Scientists at a research center supported by FAPESP identified a non-inherited mutation in blood cells from a patient with GATA2 deficiency that may have prevented bone marrow failure and other clinical manifestations. (2020-11-17)

NIH gene therapy startup to increase AAV gene therapy efficiency
Maximizing the efficiency of the adeno-associated virus (AAV) platform for gene therapy is the aim of a new pilot project of the National Institutes of Health (NIH). (2020-11-17)

Reversal of glial scar tissue back to neuronal tissue through neuroregenerative gene therapy
Brain or spinal cord injury often results in glial scar tissue that is correlated to neural functional loss. Glial scar is a well-known obstacle for neural regeneration. A research team led by Prof. Gong Chen at Jinan University, Guangzhou, published an article in the current issue of Frontiers in Cellular Neuroscience, demonstrating that glial scar tissue can be reversed back to neuronal tissue through NeuroD1-based neuroregenerative gene therapy. (2020-11-16)

First non-human primate study showing promise of gene therapy for stroke repair
Stroke is a leading cause of death and severe long-term disability with limited treatment available. A research team led by Prof. Gong Chen at Jinan University, Guangzhou, China recently reported the first non-human primate study demonstrating successful in vivo neural regeneration from brain internal glial cells for stroke repair. This work was published on Frontiers in Cell and Developmental Biology on November 5th, 2020. (2020-11-13)

Diet affects skin gene expression in both healthy and atopic dogs
Differences in skin gene expression were observed between healthy and atopic Staffordshire Bull Terriers as well as between dogs that ate either dry food or raw food. Raw food appeared to activate the skin's immune system as well as the expression of genes that increase antioxidant production or have anti-inflammatory effects. (2020-11-13)

Risk of AAV mobilization in gene therapy
New data highlight safety concerns for the replication of recombinant adeno-associated viral (rAAV) vectors commonly used in gene therapy. These findings, which emphasize the need for mobilization resistant AAV vectors (2020-11-13)

Born to be young?
The environment we experience in early-life is known to have major consequences on later-life health and lifespan. A new study led from the University of Turku in Finland using an avian model suggests that increased prenatal exposure to maternal thyroid hormones could have beneficial effects on the 'biological age' at birth. (2020-11-11)

How organ functions were shaped over the course of evolution
A large-scale study conducted by molecular biologists from Heidelberg University has yielded groundbreaking new insights into the evolution and regulation of gene expression in mammalian organs. The scientists investigated RNA synthesis and subsequent protein synthesis in the organs of humans and other representative mammals. They were able to demonstrate that the interplay of the two synthesis processes during evolution was crucial for shaping organ functions. (2020-11-11)

Penn researchers develop approach to prevent toxicity tied to neurological gene therapy
Penn Medicine researchers have developed a new targeted approach to prevent a toxicity seen in the sensory neurons of dorsal root ganglia after gene therapy to treat neurological disorders. It's an important hurdle to clear, as the field works toward more safe and effective gene therapies for patients with disorders like spinal muscular atrophy. (2020-11-11)

Researchers show safer, more targeted way to deliver CRISPR gene therapy
Biomedical researchers have come up with a novel way to use a beam of light to deliver CRISPR gene therapy molecules targeting illnesses. (2020-11-11)

Is proton therapy the silver bullet for children with brain cancer?
How safe is proton therapy for children with brain cancer compared to the conventional x-ray radiation delivered post-surgery? (2020-11-11)

3D printed stents that treat inflammation
POSTECH Professor Dong-Woo Cho's research team develops bioink-loaded esophageal stents for treating radiation esophagitis. (2020-11-10)

Induced liver regeneration enhances CRISPR/Cas9-mediated gene repair
Use of thyroid hormone to boost hepatocyte proliferation enhanced the efficiency of CRISPR/Cas9-mediated gene correction in the mouse liver. This dietary induction of hepatocyte regeneration may be a viable clinical strategy to enhance gene repair in the liver. (2020-11-10)

Technique to regenerate optic nerve offers hope for future glaucoma treatment
Scientists have used gene therapy to regenerate damaged nerve fibres in the eye, in a discovery that could aid the development of new treatments for glaucoma, one of the leading causes of blindness worldwide. (2020-11-05)

Antiangiogenic therapy can cause malignancy in kidney cancers
In some cases, this type of therapy increases the invasiveness and metastasis of kidney tumors. The study led by IDIBELL and the ICO identifies a biomarker that could predict the malignant response of patients to therapy. (2020-11-05)

The birth of a bacterial tRNA gene
The Microbial Evolutionary Dynamics Group at the Max Planck Institute for Evolutionary Biology in Plön has directly observed the birth of a tRNA gene, using experimental evolution of bacterial populations in the laboratory. (2020-11-03)

Expensive gene therapies raise challenges and opportunities: Expert panel report
Gene therapies are being approved for use in Canada, but could strain healthcare budgets and exacerbate existing treatment inequities across the country. However, there are opportunities to control spending, streamline approvals and support fair access through innovation, coordination and collaboration, according to a new expert panel report from the Council of Canadian Academies (CCA). (2020-11-03)

Brainstem neurons control both behaviour and misbehaviour
A recent study at the University of Helsinki reveals how gene control mechanisms define the identity of developing neurons in the brainstem. The researchers also showed that a failure in differentiation of the brainstem neurons leads to behavioural abnormalities, including hyperactivity and attention deficit. (2020-10-29)

Researchers find source of breast tumor heterogeneity and pathway that limits emergence
A team of researchers led by Dartmouth's and Dartmouth-Hitchcock's Norris Cotton Cancer Center has identified mammary basal cells as a contributing source to the development of heterogeneous tumor cell subpopulations and found that activation of the PKA signaling pathway can curtail their emergence, providing opportunities for new therapeutic approaches to breast cancer. (2020-10-28)

Yeast study yields insights into longstanding evolution debate
In a study published Oct. 27 in the journal Cell Reports, Yale scientists show how epigenetic mechanisms contribute in real time to the evolution of a gene network in yeast. Specifically, through multiple generations yeast cells were found to pass on changes in gene activity induced by researchers. (2020-10-27)

New approach to diagnosing genetic diseases using RNA sequencing increases yield
A new study from Baylor College of Medicine finds that starting genetic analysis with RNA sequencing can increase diagnostic yield and confidence in diagnosis. (2020-10-27)

Researchers uncover crucial gene for growth of Ewing sarcoma
Researchers have discovered a gene that is critical for the development of Ewing sarcoma, a rare type of developmental cancer that presents in bones and soft tissues. Exploring the pharmacological inhibition of RING1B as a clinical therapy to treat Ewing sarcoma could open the door for new treatments for the rare disease. (2020-10-23)

Acute kidney injury among African Americans with sickle cell trait and disease
New research examines the risk of acute kidney injury in people with sickle cell trait or disease, as well as the effect of acute kidney injury on kidney function decline in these individuals. Results from the study will be presented online during ASN Kidney Week 2020 Reimagined October 19-October 25. (2020-10-23)

ASTRO: Proton therapy for lung cancer may help reduce risk of heart diseases
Treating lung cancer patients with proton therapy may help reduce the risk of radiation-induced heart diseases. (2020-10-23)

Antiretroviral therapy can't completely stop accelerated cell aging seen in HIV
Untreated HIV infection is linked with epigenetic changes that suggest rapid aging. A new study by UCLA researchers shows that antiretroviral therapy given over two years was unable to completely restore age-appropriate epigenetic patterns, leaving patients more susceptible to aging-related illnesses. (2020-10-22)

Serum creatinine-to- cystatin C ratio predicts mortality
In patients initiating continuous renal replacement therapy for acute kidney injury, higher serum creatinine-to-cystatin C ratios were associated with lower mortality. (2020-10-21)

Scientists take major step toward Angelman Syndrome gene therapy
Babies born with a faulty maternal copy of the UBE3A gene will develop Angelman syndrome, a severe neurodevelopmental disorder with no cure and limited treatments. Now, for the first time, scientists at the UNC School of Medicine show that gene editing and gene therapy techniques can be used to restore UBE3A in human neuron cultures and treat deficits in an animal model of Angelman syndrome. (2020-10-21)

Scientists use gene therapy and a novel light-sensing protein to restore vision in mice
A newly developed light-sensing protein called the MCO1 opsin restores vision in blind mice when attached to retina bipolar cells using gene therapy. The National Eye Institute, part of the National Institutes of Health, provided a Small Business Innovation Research grant to Nanoscope, LLC for development of MCO1. The company is planning a U.S. clinical trial for later this year. (2020-10-21)

Rutgers finds new way to personalize treatments for prostate cancer
Rutgers researchers have discovered human gene markers that work together to cause metastatic prostate cancer - cancer that spreads beyond the prostate. (2020-10-19)

UCI-led study reveals restoration of retinal and visual function following gene therapy
A breakthrough study, led by researchers from the University of California, Irvine, results in the restoration of retinal and visual functions of mice models suffering from inherited retinal disease. (2020-10-19)

A new strategy for siRNA stabilization by an artificial cationic oligosaccharide
Instability of small interfering RNA (siRNA) is one of the obstacles in the development of siRNA-based drugs. Researchers at Tokyo Metropolitan Institute of Medical Science and Tokyo University of Science have developed a new strategy for improvement of siRNA stability by using an artificial cationic oligosaccharide combined with phosphorothioate linkages. (2020-10-16)

Monash discoveries suggest new breast cancer treatment
Findings by Monash Biomedicine Discovery Institute (BDI) researchers have pointed to a new combination of treatments that may help breast cancer patients with certain gene mutations. (2020-10-15)

Study identifies gene variants to help personalize treatment of eosinophilic esophagitis
A group of three gene variants, commonly inherited together, may provide clues to more successful treatment of pediatric eosinophilic esophagitis (EoE), a chronic inflammation of the food pipe often confused with gastroesophageal reflux disease (GERD). A new study, led by researchers from Nemours Children's Health System and published in Clinical Gastroenterology and Hepatology, identifies genetic variants that help predict which children with EoE may not respond to proton pump inhibitor (PPI) medication therapy as a long-term solution. (2020-10-15)

RNA editing of BFP using artificial APOBEC1 deaminase to restore the genetic
Various genetic diseases caused by point mutations have no established therapeutic approaches. Prof. Tsukahara and colleagues (Japan Advanced Institute of Science and Technology) are studying a therapeutic method using artificial RNA editing. (2020-10-14)

Page 1 of 25 | 1000 Results
   First   Previous   Next      Last   
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.