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A novel pathway for prevention of heart attack and stroke
A recent Finnish study could pave the way for preventing brain and cardiac ischemia induced by atherosclerosis. (2014-08-21)

Gene therapy protects mice from lethal heart condition, MU researchers find
A new gene therapy developed by researchers at the University of Missouri School of Medicine has been shown to protect mice from a life-threatening heart condition caused by muscular dystrophy. (2014-08-19)

BGRF announces OncoFinder algorithm for reducing errors in transcriptome analysis
The BGRF proposes a new concept for signalome-wide analysis of changes in intracellular pathways, called OncoFinder, which allows for accurate and robust cross-platform analysis of gene expression data. This new technique will allow scientists to derive useful information from and compare the hundreds of thousands of data sets obtained using legacy equipment as well as data sets obtained from biological samples preserved in paraffin blocks and partially-degraded samples. (2014-08-17)

Researchers identify a mechanism that stops progression of abnormal cells into cancer
Researchers from Boston University School of Medicine report that a tumor suppressor pathway, called the Hippo pathway, is responsible for sensing abnormal chromosome numbers in cells and triggering cell cycle arrest, thus preventing progression into cancer. (2014-08-14)

Discovery of new form of dystrophin protein could lead to therapy for some DMD patients
Scientists have discovered a new form of dystrophin, a protein critical to normal muscle function, and identified the genetic mechanism responsible for its production. Studies of the new protein isoform, published online Aug. 10 in Nature Medicine and led by a team in The Research Institute at Nationwide Children's Hospital, suggest it may offer a novel therapeutic approach for some patients with Duchenne muscular dystrophy, a debilitating neuromuscular condition that usually leaves patients unable to walk on their own by age 12. (2014-08-10)

University of Minnesota research finds key piece to cancer cell survival puzzle
An international team led by Eric A. Hendrickson of the University of Minnesota and Duncan Baird of Cardiff University has solved a key mystery in cancer research: What allows some malignant cells to circumvent the normal process of cell death that occurs when chromosomes get too old to maintain themselves properly? (2014-08-07)

Scientists uncover key piece to cancer cell survival puzzle
A chance meeting between two leading UK and US scientists could have finally helped solve a key mystery in cancer research. Professor Duncan Baird and his team from Cardiff University, working in collaboration with Eric A. Hendrickson from the University of Minnesota, have identified a specific gene that human cells require in order to survive chromosomal defects. (2014-08-07)

Differential gene expression in proximal and distal nerve segments after sciatic nerve injury
A study, reported in the Neural Regeneration Research, identifies differential gene expression in the proximal and distal segments of a nerve during Wallerian degeneration, analyzes dynamic biological changes of these genes, and provides a useful platform for the detailed study of nerve injury and repair during Wallerian degeneration. (2014-07-29)

Researchers identify potential biomarker for AD
Researchers from Boston University School of Medicine report variants in a new gene, PLXNA4, which may increase the risk of developing Alzheimer's disease. The discovery of this novel genetic association may lead to new drug treatment options that target PLXNA4 specifically. These findings appear in the Annals of Neurology. (2014-07-28)

Malcolm K. Brenner receives Pioneer Award for advances in gene-modified T cells targeting cancer
Malcolm K. Brenner, M.D., Ph.D., Baylor College of Medicine has devoted his career in basic and clinical research toward understanding how tumors are able to escape detection by the body's immune defense system, and developing genetically modified T cells that can effectively target tumors. (2014-07-24)

Mutated gene linked to both autism and intellectual disability
Autism spectrum disorder and intellectual disability often occur together and may even share similar genetic causes. Researchers reporting in the Cell Press journal Cell Reports have now linked mutations in a particular gene to the two disorders in humans. By revealing these genetic changes and their potential impact on common brain processes, researchers may uncover treatment approaches that could benefit a variety of patients. (2014-07-24)

New regions of genetic material are involved in the development of colon cancer
Most research on human cancer genes have been focused on regions of the coding genome, but just before each gene, there is a regulatory region which controls the expression and activity of the adjacent gene. Until now, very little was known of the role exerted such DNA fragment in tumor development. An article published today in Nature in collaboration with the group of Manel Esteller shows that these regions are also altered in cancer. (2014-07-23)

Splice-switching oligonucleotide therapeutics is new method for editing gene transcript
In splice-switching, an innovative therapeutic approach, targeted oligonucleotide drugs alter the editing of a gene transcript to produce the desired form of a protein. (2014-07-17)

The human δ2 glutamate receptor gene is not mutated in spinocerebellar ataxia patients
Recent studies have demonstrated that glutamate receptor δ2 gene (GRID2) is closely related to cerebellar functions in mice. This gene is predominantly located in postsynaptic dendrites of parallel fiber-Purkinje cell synapses in the cerebellum and contains potential fragile sites within large introns. These fragile sites easily develop spontaneous mutation, which leads to Purkinje cell death, contributing to the manifestation of spinocerebellar ataxia in mice. (2014-07-17)

A new genome editing method brings the possibility of gene therapies closer to reality
This study published online in Cell Stell Cell provides an important theoretical foundation for stem cell-based gene therapy. (2014-07-11)

BMSCs with Nogo-66 receptor gene silencing for repair of spinal cord injury
After central nervous system injury, the increase in Nogo protein is mediated by Nogo-66 receptor gene, leading to the collapse of growth cones and inhibiting the extension of neuronal neurites. (2014-07-09)

Researchers find genetic link to autism known as CHD8 mutation
In a collaboration involving 13 institutions around the world, researchers have broken new ground in understanding what causes autism. The results are being published in Cell magazine July 3, 2014: 'Disruptive CHD8 Mutations Define a Subtype of Autism in Early Development.' 'We finally got a clear cut case of an autism specific gene,' said Raphael Bernier, the lead author, and UW associate professor in the Department of Psychiatry and Behavioral Sciences and the clinical director of the Autism Center at Seattle Children's. (2014-07-03)

Surprisingly stable long-distance relationships
Contrary to what was thought, sequences of DNA called enhancers find their targets long before they are activated during embryonic development, scientists EMBL Heidelberg have found. Their study, published in Nature, also reveals that, surprisingly, the degree of complexity of enhancers' interactions in the fruit fly is comparable to what is seen in vertebrates. (2014-07-03)

Christof von Kalle, M.D., Ph.D. receives Pioneer Award
In recognition of his leadership and accomplishments, Dr. von Kalle has received a Pioneer Award from Human Gene Therapy, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. (2014-07-01)

Fruit flies help scientists uncover genes responsible for human communication
Toddlers acquire communication skills by babbling until what they utter is rewarded; however, the genes involved in learning language skills are far from completely understood. Now, using a gene identified in fruit flies by a University of Missouri researcher, scientists involved in a global consortium have discovered a crucial component of the origin of language in humans. (2014-06-25)

Frederic Bushman, Ph.D. receives Pioneer Award for advancing therapeutic gene delivery methods
Frederic D. Bushman, Ph.D.'s early pioneering work in understanding how HIV reproduces by inserting its genetic material into the DNA of a host cell led to key advances in the ability to move pieces of DNA and whole genes between cells. (2014-06-24)

Scientists break the genetic code for diabetes in Greenland
New Danish genetics research explains the high incidence of type 2 diabetes in the Greenlandic population. The ground-breaking findings have just been published in the prestigious scientific journal Nature. (2014-06-18)

Overweight + gene mutation = elevated liver values in children
A study carried out at the Institute of Biomedicine of the University of Eastern Finland shows that a common mutation in the PNPLA3 gene combined with overweight results in elevated ALAT values in children. The ALAT value is an indicator of liver metabolism. (2014-06-17)

New book from CSHLPress covers all aspects of MYC biology
Written and edited by experts in the field, 'MYC and the Pathway to Cancer' from Cold Spring Harbor Perspectives in Medicine covers all aspects of MYC biology. The contributors discuss its normal functions in the control of cell growth, cell competition, pluripotency, and development, as well as the molecular basis for the effects of the MYC protein on transcription. In addition, they examine how MYC interacts with other proteins, induces apoptosis, and impacts metabolism, genomic stability, and microRNA expression. (2014-06-13)

Obesity gene linked to hormonal changes that favor energy surplus
A new study from Uppsala University demonstrates that elderly humans carrying a common variant of the fat mass and obesity gene FTO also have a shifted endocrine balance. Low blood concentrations of the satiety hormone leptin and high blood concentrations of the hunger promoting hormone ghrelin makes carriers of the FTO gene put on weight. The findings are published in the journal Diabetes. (2014-06-11)

Scientists unravel the genetic secrets of nature's master of mimicry
Scientists investigating how one of the greatest shape shifters in the natural world is able to trick predators to avoid being eaten have identified the gene behind the fascinating feat. (2014-06-11)

City of Hope links specific gene to adult growth of brain cells, learning and memory
Learning and memory are regulated by a region of the brain known as the hippocampus. New research from City of Hope has found that stimulating a specific gene could prompt growth -- in adults -- of new neurons in this critical region, leading to faster learning and better memories. (2014-06-09)

Doing more means changing less when it comes to gene response, new study shows
An international team led by scientists at the University of Turku in Finland studied thermally-adapted fish populations to discover that the more biological functions a gene has, the less it responds to environmental change. (2014-06-05)

Unexpected diversity of egg yolk proteins play a key role in ant sociality and castes
In the advanced online edition of Molecular Biology and Evolution, Claire Morandin et al. performed molecular evolutionary analyses on the egg yolk forming protein, Vitellogenin, and its many forms, amongst seven Formica ant species. (2014-06-03)

Study shows tale of 2 prognoses in pediatric brain tumor, pilocytic astrocytoma
Research presented at the American Society for Clinical Oncology Annual Meeting 2014 used a newly designed test for K:B fusion to show that point mutations lead to a more dangerous form of the disease than does K:B fusion. (2014-06-02)

How breast cancer 'expresses itself'
Two Tel Aviv University researchers have found that 'gene regulation,' the process that shuts off certain parts of a cell's DNA code or blueprint in healthy breast tissue cells, may also play a critical role in the development of breast cancer. Their research proves a significant link between breast-specific genes and the pathology of cancer. (2014-05-29)

Powerful tool combs family genomes to find shared variations causing disease
Scientists at the University of Utah, the University of Texas MD Anderson Cancer Center in Houston and colleagues have developed a powerful tool called pVAAST that combines linkage analysis with case control association to help researchers and clinicians identify disease-causing mutations in families faster and more precisely than ever before. (2014-05-29)

Gene therapy extends survival in an animal model of spinal muscular atrophy
To make up for insufficient amounts of SMN protein, the cause of the inherited neuromuscular disease spinal muscular atrophy (SMA), researchers have successfully delivered a replacement SMN1 gene directly to the spinal cords of animal models of SMA. A new study demonstrating that enough copies of the SMN1 gene can be delivered to the spinal cord motor neurons to extend the survival of the treated animals is published in Human Gene Therapy. (2014-05-22)

Novel RNAi therapy silences mutated Huntington's disease gene and reduces symptoms
A targeted gene silencing strategy blocks production of the dysfunctional huntingtin (Htt) protein, the cause of Huntington's disease, a fatal, inherited neurodegenerative disorder. The effectiveness of this RNA interference approach in reducing levels of mutant Htt protein and disease symptoms in a mouse model of the disease is described in Human Gene Therapy. (2014-05-21)

Unlocking the potential of bacterial gene clusters to discover new antibiotics
A method for activating biosynthetic silent gene clusters could aid in the discovery of new antibiotics. (2014-05-20)

Molecular regulation of hypoxic-ischemic brain damage
Dr. Lijun Yang and co-workers from Beijing Friendship Hospital, Capital Medical University in China prepared whole brain slices from a rat model of oxygen-glucose deprivation and explored dynamic expression pattern of Olig1 during hypoxic-ischemic brain damage and after miRNA-9 transfection. (2014-05-12)

Scientists decode epigenetic mechanisms distinguishing stem cell function and blood cancer
Researchers at Dartmouth's Norris Cotton Cancer Center have published results from a study in Cell Reports that discovers a new mechanism that distinguishes normal blood stem cells from blood cancers. (2014-05-09)

The Pael-R gene does not mediate the changes in rotenone-induced PD model cells
Currently, the pathogenesis of Parkinson's disease is not entirely clear, but it has been generally considered to be the result of interactions among various genetic and environmental factors. (2014-05-06)

Genetic diagnosis can rule out a suspected Huntington's chorea patient
Huntington's disease is an autosomal-dominant inherited neurodegenerative disease with a distinct phenotype, but the pathogenesis is unclear. (2014-05-05)

Novel analyses improve identification of cancer-associated genes from microarray data
Researchers a the Dartmouth Institute for Quantitative Biomedical Sciences developed a new gene expression analysis approach for identifying cancer genes. The paper entitled, 'How to get the most from microarray data: advice from reverse genomics,' was published online March 21, 2014, in BMC Genomics. The study results challenge the current paradigm of microarray data analysis and suggest that the new method may improve identification of cancer-associated genes. (2014-05-02)

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