Current Genome Sequencing News and Events

Current Genome Sequencing News and Events, Genome Sequencing News Articles.
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Largest comprehensive Middle East GWAS reveals Arab genetic risk factors
A new study in Nature Communications confirms that the existing global dataset of human genomes, which overrepresent European populations, does not accurately reveal the genetic architecture of diseases affecting Arab populations in the Middle East. The Qatar Foundation-led study of genetic variants across more than 6,000 individuals in Qatar is largest of its kind and a foundation for implementing precision medicine in the Middle East. (2021-02-23)

Cre-controlled CRISPR: Conditional gene inactivation just got easier
The ability to turn a gene off only in a specific cell type is essential to modern life science. Thanks to the Cre-Controlled CRISPR it has just became simpler. The new method developed by researchers from the Center for Regenerative Therapies Dresden (CRTD) at TU Dresden with support from the DRESDEN-concept Genome Center (DCGC) offers a fast and easy approach for conditional gene inactivation. The findings were published in the journal ''Nature Communications.'' (2021-02-23)

Scientists identify potential contributor to hyper immune responses in patients with severe COVID-19
Researchers have pinpointed a helper T cell population in the lungs of patients with severe COVID-19 that may be central to the development of hyperinflammation, lung injury, and subsequent acute respiratory distress syndrome (ARDS) during disease (2021-02-23)

Tweaking corn kernels with CRISPR
Corn has a highly complex genome, making it a challenge to apply genome-editing techniques to it. CSHL Professor David Jackson and postdoctoral fellow Lei Liu used CRISPR to tinker with the corn genome promoter regions and modify stem cell growth. They figured out which sections influence kernel yield, and they hope to make targeted genome-editing in corn more precise and efficient. (2021-02-22)

'Jumping genes' repeatedly form new genes over evolution
A study, 'Recurrent Evolution of Vertebrate Transcription Factors by Transposase Capture,' published Feb. 19 in Science, investigates how genetic elements called transposons, or ''jumping genes,'' are added into the mix during evolution to assemble new genes through exon shuffling. (2021-02-22)

Don't focus on genetic diversity to save our species
Scientists at the University of Adelaide have challenged the common assumption that genetic diversity of a species is a key indicator of extinction risk. Published in the journal PNAS, the scientists demonstrate that there is no simple relationship between genetic diversity and species survival. But, Dr João Teixeira and Dr Christian Huber from the University of Adelaide's School of Biological Sciences conclude, the focus shouldn't be on genetic diversity anyway, it should be on habitat protection. (2021-02-22)

CovMT: Tracking virus mutations across the world
An interactive platform helps users visualize where SARS-CoV-2 mutations start, how wide they spread and how infectious they are. (2021-02-21)

Advancing understanding of hop genome to aid brewers, medical researchers
Oregon State University and U.S. Department of Agriculture researchers have significantly expanded the understanding of the hop genome, a development with important implications for the brewing industry and scientists who study the potential medical benefits of hops. (2021-02-21)

Sex that is not for reproduction
Conjugation (or mating) of ciliates is a unique phenomenon among living beings. They have sex not for reproduction or pleasure - they seek to increase genetic variation. Scientists from St Petersburg University, together with colleagues from Poland and France, have studied the mating process in five sibling species of the Paramecium aurelia complex. Their findings enabled them to describe genetic mechanisms behind this phenomenon. (2021-02-19)

First multi-whole-genome study of IBD in African Americans
In African Americans, the genetic risk landscape for inflammatory bowel disease (IBD) is very different from that of people with European ancestry, according to results of the first whole-genome study of IBD in African Americans. The authors say that future clinical research on IBD needs to take ancestry into account. (2021-02-19)

New revelations of tiger genomes
A new study reveals differences in the genomic history of tiger subspecies, pointing to the importance of understanding evolutionary history for future conservation (2021-02-18)

Scientists identify over 140,000 virus species in the human gut
Viruses are the most numerous biological entities on the planet. Now researchers at the Wellcome Sanger Institute and EMBL's European Bioinformatics Institute (EMBL-EBI) have identified over 140,000 viral species living in the human gut, more than half of which have never been seen before. (2021-02-18)

Electron cryo-microscopy sheds light on how bioenergy makers are made in our body
Scientists uncover how the body's energy makers are made. A new paper published in Science by Alexey Amunts' laboratory with an international team of researchers reports the molecular mechanism of membrane-tethered protein synthesis in mitochondria. (2021-02-18)

Genotoxic E. coli 'caught in the act'
Max Planck researchers and their collaborators reveal transformation of colon organoids in vitro. (2021-02-17)

Genetic study of Lewy body dementia supports ties to Alzheimer's and Parkinson's diseases
In a study led by National Institutes of Health (NIH) researchers, scientists found that five genes may play a critical role in determining whether a person will suffer from Lewy body dementia, a devastating disorder that riddles the brain with clumps of abnormal protein deposits called Lewy bodies. The results also supported the disorder's ties to Parkinson's and Alzheimer diseases. (2021-02-16)

Capuchin monkey genome reveals clues to its long life and large brain
An international team of scientists has sequenced the genome of a capuchin monkey for the first time, uncovering new genetic clues about the evolution of their long lifespan and large brains. Published in PNAS, the work was led by the University of Calgary in Canada and involved researchers at the University of Liverpool. (2021-02-15)

Large-scale study finds genetic testing technology falsely detects very rare variants
A technology that is widely used by commercial genetic testing companies is 'extremely unreliable' in detecting very rare variants, meaning results suggesting individuals carry rare disease-causing genetic variants are usually wrong, according to new research published in the BMJ. (2021-02-15)

Campylobacter strains exchange genes, can become more virulent and antibiotic resistant
Campylobacter bacteria persist throughout poultry production, and two of the most common strains are exchanging genetic material, which could result in more antibiotic-resistant and infectious Campylobacter strains. (2021-02-15)

Study reveals mutations that drive therapy-related myeloid neoplasms in children
Research from scientists at St. Jude Children's Research Hospital found mutations up to two years before cancer developed, showing an opportunity for early interventions. (2021-02-12)

Scientists identify how harmless gut bacteria "turn bad"
An international team of scientists has determined how harmless E. coli gut bacteria in chickens can easily pick up the genes required to evolve to cause a life-threatening infection. Their study, published in Nature Communications, warns that such infections not only affect the poultry industry but could also potentially cross over to infect humans. (2021-02-12)

Liquid biopsy for colorectal cancer could guide therapy for tumors
A new study from Washington University School of Medicine in St. Louis demonstrates that a liquid biopsy examining blood or urine can help gauge the effectiveness of therapy for colorectal cancer that has just begun to spread beyond the original tumor. Such a biopsy can detect lingering disease and could serve as a guide for deciding whether a patient should undergo further treatments due to some tumor cells evading an initial attempt to eradicate the cancer. (2021-02-12)

New research identifies biological causes of muscle weakness in later life
A new largescale genetic analysis has found biological mechanisms that contribute to making people more susceptible to muscle weakness in later life, finding that diseases such as osteoarthritis and diabetes may play a large role in susceptibility. (2021-02-11)

Affordable CRISPR app reveals unintended mutations at site of CRISPR gene repair
Scientists have developed an affordable, downloadable app that scans for potential unintended mistakes when CRISPR is used to repair mutations that cause disease. The app reveals potentially risky DNA alterations that could impede efforts to safely use CRISPR to correct mutations in conditions like sickle cell disease and cystic fibrosis. The development of the new tool, called DECODR (which stands for Deconvolution of Complex DNA Repair), was reported today in The CRISPR Journal by researchers from ChristianaCare's Gene Editing Institute. (2021-02-11)

New improved dog reference genome will aid a new generation of investigation
Researchers at Uppsala University and the Swedish University of Agricultural Sciences have used new methods for DNA sequencing and annotation to build a new, and more complete, dog reference genome. This tool will serve as the foundation for a new era of research, helping scientists to better understand the link between DNA and disease, in dogs and in their human friends. The research is presented in the journal Communications Biology. (2021-02-10)

Researchers release analysis of largest, most diverse genetic data set
Researchers at the University of Maryland School of Medicine (UMSOM) and their colleagues published a new analysis today in the journal Nature from genetic sequencing data of more than 53,000 individuals, primarily from minority populations. (2021-02-10)

Unusual DNA folding increases the rates of mutations
DNA sequences that can fold into shapes other than the classic double helix tend to have higher mutation rates than other regions in the human genome. New research shows that the elevated mutation rate in these sequences plays a major role in determining regional variation in mutation rates across the genome. (2021-02-09)

Not a living fossil: How the Coelacanth recently evolved dozens of new genes
The research shows the dramatic effect traveling DNA can have on the creation of genes and provide a glimpse into some of the forces that shaped the genome of one of the most ancient and mysterious organisms. (2021-02-09)

An end to invasive biopsies?
Hebrew Unievrsity researchers have found a less invasive and more accurate options for diagnoses using a simple blood test that detects DNA fragments. (2021-02-08)

Researchers develop platform to identify cancer mutations that may be responsive to drug therapies
A Cleveland Clinic-led team of researchers has developed a personalized genomic medicine platform that will help advance accelerate genomic medicine research and genome-informed drug discovery, according to new study results published recently in Genome Biology. (2021-02-08)

Distinctness of mental disorders traced to differences in gene readouts
A new study suggests that differences in the expression of gene transcripts - readouts copied from DNA that help maintain and build our cells - may hold the key to understanding how mental disorders with shared genetic risk factors result in different patterns of onset, symptoms, course of illness, and treatment responses. Findings from the study, conducted by researchers at the National Institute of Mental Health, part of NIH, appear in the journal Neuropsychopharmacology. (2021-02-08)

In-depth analysis identifies causes and mitigation efforts in COVID-19 cluster
As part of the response to the cluster, Brigham researchers also conducted a case-control study and whole-genome sequencing to identify factors that may have been involved in the virus's spread as well as the most likely chain of transmission. The lessons gleaned from their data have helped inform infection control efforts. (2021-02-08)

SSRgenotyper: A new tool to digitally genotype simple sequence repeats
Simple sequence repeats (SSRs) are common components of genomic DNA that are widely used in genetic studies at the level of populations and individuals. However, the process of genotyping SSRs -- determining which individuals have which alleles -- still relies on time-consuming and potentially hazardous lab-based methods. SSRgenotyper is a new software tool that automates the process of genotyping entirely from sequenced reads and generates multiple file types for further downstream analysis. (2021-02-05)

Non-teleost ray-finned fishes exhibit mosaic genomic features of lobe- and ray-finned fishes
A research team led by Prof. HE Shunping from the Institute of Hydrobiology of the Chinese Academy of Sciences has discovered through genome sequencing that the non-teleost ray-finned fishes--bichir, paddlefish, bowfin and alligator gar--exhibit mosaic genomic features of lobe- and ray-finned fishes. (2021-02-05)

NUI Galway demonstrate the promise of precision genomics in cancer treatment
Researchers at NUI Galway have identified genomic signatures in women developing the most common type of breast cancer that can be associated with long-term survival. The NUI Galway team analysed the genomes of breast cancer patients to look for associations with survival rates using advanced statistical techniques. (2021-02-04)

Surprising new research: We're more like primitive fishes than once believed
People traditionally think that lungs and limbs are key innovations that came with the vertebrate transition from water to land. But in fact, the genetic basis of air-breathing and limb movement was already established in our fish ancestor 50 million years earlier. This, according to a recent genome mapping of primitive fish conducted by the University of Copenhagen, among others. The new study changes our understanding of a key milestone in our own evolutionary history. (2021-02-04)

New combination therapy offers chance of healing hepatitis B
Around 260 million people, more than three percent of the global population, are chronically infected with the hepatitis B virus (HBV); in the long term, this often leads to complications such as liver cirrhosis and liver cancer. A cure is not yet possible with the available medication. Scientists at the German Center for Infection Research (DZIF) and the University Hospital Eppendorf (UKE) have now investigated a new combination therapy that has proven highly effective in their infection model. (2021-02-04)

Special Issue: Human genome at 20
In February 2001, the first drafts of the human genome were published. (2021-02-04)

Thoughts on plant genomes
The growing world population and the challenges posed by climate change make the control of these natural resources one of the most crucial issues for all humanity in the future. In this regard, genome sequence information is of fundamental importance for understanding natural diversity and evolution of living organisms as well as for the design of breeding strategies aimed to produce new varieties with suitable traits. (2021-02-03)

Genetics study finds ancestral background can affect Alzheimer's disease risk
Genetics contributes to the risk of developing Alzheimer's disease, and the APOE gene is the strongest genetic risk factor, specifically the APOE4 allele. However, it has been known for a while that the risk due to the APOE4 allele differs considerably across populations, with Europeans having a greater risk from the APOE4 allele than Africans and African Americans. (2021-02-03)

Geisinger-GeneDx research identifies frequent genetic causes of cerebral palsy
Researchers have discovered a strong link between genetic changes known to cause neurodevelopmental disabilities and cerebral palsy, further debunking birth asphyxia as its major cause. (2021-02-02)

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