Current Genome News and Events

Current Genome News and Events, Genome News Articles.
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Meta-Apo supports cheaper, quicker microbiome functional assessment
A new algorithm called Meta-Apo, developed by researchers led by JING Gongchao of the Qingdao Institute of BioEnergy and Bioprocess Technology (QIBEBT) of the Chinese Academy of Sciences (CAS) may reduce the need for expensive, time-consuming whole-genome sequencing computations to understand how a microbiome functions. (2021-01-22)

UMD researcher expands plant genome editing with newly engineered variant of CRISPR-Cas9
Recently named a Web of Science 2020 Highly Cited Researcher, Yiping Qi of the University of Maryland already has a new high-profile publication in 2021 introducing SpRY, a newly engineered variant of the famed gene editing tool CRISPR-Cas9. SpRY removes the barriers of what can and can't be targeted for gene editing, making it possible for the first time to target nearly any genomic sequence in plants for potential mutation. (2021-01-22)

Why remdesivir does not fully stop the coronavirus
Their results explain why the drug has a rather weak effect (2021-01-18)

What the lungfishes' genome teaches us about the vertebrates' conquest of land
The genome of the Australian lungfish is the largest sequenced animal genome and helps us to better understand the conquest of land by vertebrates - study led by evolutionary biologists from the University of Konstanz (2021-01-18)

CCNY's David Lohman finds Asian butterfly mimics different species as defense mechanism
Many animal and insect species use Batesian mimicry - mimicking a poisonous species - as a defense against predators. The common palmfly, Elymnias hypermnestra (a species of satyrine butterfly), which is found throughout wide areas of tropical and subtropical Asia, adds a twist to this evolutionary strategy: the females evolved two distinct forms, either orange or dark brown, imitating two separate poisonous model species, Danaus or Euploea. (2021-01-14)

New molecular structures associated with ALS
Researchers from the University of Seville and the University of Pavia have identified a link between Amyotrophic Lateral Sclerosis (ALS) and the accumulation of DNA-RNA hybrids in the genome. The accumulation of these hybrids causes increased genomic damage and boosts genetic instability. This finding will make it possible to better understand the molecular basis of the disease, as well as to propose new solutions to curb it. (2021-01-13)

Inferring human genomes at a fraction of the cost promises to boost biomedical research
A new method, developed by Olivier Delaneau's group at the SIB Swiss Institute of Bioinformatics and the University of Lausanne, offers game-changing possibilities for genetic association studies and biomedical research. For less than $1 in computational cost, GLIMPSE is able to statistically infer a complete human genome from a very small amount of data. It offers a first realistic alternative to current approaches, and so allows a wider inclusion of underrepresented populations. (2021-01-13)

Chloroplasts on the move
How different plants can share their genetic material with each other (2021-01-11)

Breakthrough on diarrhea virus opens up for new vaccines
Researchers at UmeƄ University in Sweden have for the first time at the atomic level succeeded in mapping what a virus looks like that causes diarrhea and annually kills about 50,000 children in the world. The discovery may in the long run provide the opportunity for completely new types of treatments for other viral diseases such as COVID-19. (2021-01-11)

Genomes reveal insights into much-loved Aussie animals
Researchers have brought together expertise in bioinformatics, cytogenetics, developmental and molecular biology to produce and analyse the first ever echidna genome and a greatly improved, high quality platypus genome sequence. (2021-01-07)

Unusual sex chromosomes of platypus, emu and duck
Three studies uncovered the unusual sex chromosomes of platypus, emu and Peking duck. Platypus have five pairs of sex chromosomes forming an unusual chain shape, while the sex chromosomes of emu and duck are not as different between sexes as those of human. The studies were led or co-led by Qi Zhou's group at the University of Vienna and Zhejiang University of China and are published as research papers in the journals Nature, Genome Research and GigaScience. (2021-01-07)

Integrator: A guardian of the human transcriptome
In a joint collaboration, Danish and German researchers have characterized a cellular activity that protects our cells from potentially toxic by-products of gene expression. This activity is central for the ability of multicellular organisms to uphold a robust evolutionary 'reservoir' of gene products. (2021-01-05)

New mammal reference genome helps ID genetic variants for human health
A new reference genome assembly identified more than 85 million genetic variants in the rhesus macaque, the largest database of genetic variation for any one nonhuman primate species to date. (2020-12-23)

Fungal RNA viruses: Unexpected complexity affecting more than your breakfast omelet
Traditional approaches for studying fungal RNA viruses have relied upon sequence similarity, resulting in an underestimation of RNA viral genome diversity. Researchers from the University of Tsukuba used an advanced technological approach called Fragmented and Primer Ligated Double Stranded RNA sequencing, or FLDS, to identify viral sequences that were previously overlooked. They identified novel viruses and viral genome structures and show that FLDS is a powerful tool for understanding RNA viral genome diversity. (2020-12-21)

HSE researchers use neural networks to study DNA
HSE scientists have proposed a way to improve the accuracy of finding Z-DNA, or DNA regions that are twisted to the left instead of to the right. To do this, they used neural networks and a dataset of more than 30,000 experiments conducted by different laboratories around the world. Details of the study are published in Scientific Reports. (2020-12-17)

Improved macaque genome enhances biomedical utility
Using advanced sequencing technology, researchers present a new, improved and far more complete reference genome for the rhesus macaque - one of the most important animal models in biomedical research. (2020-12-17)

Scientists found out genes involved in a compound in lichens with antiviral activity
Lichens are of great importance both ecologically and as a biological model. These organisms produce a wide range of secondary metabolites, including usnic acid, a compound with unknown biological function but which in-vitro studies have found to present antiviral, neuroprotective and anti-cancer activity. An international research team led by the Complutense University of Madrid has identified the cluster of biosynthetic genes involved in the production of this compound. (2020-12-11)

Deadly, emergent cancer becoming endemic in Tasmanian devils, reducing extinction threat
An emergent transmissible cancer that once threatened Tasmanian devils with extinction appears to be transitioning to a state of endemism, researchers report. (2020-12-10)

'Off switch' during error-prone cell cycle phase may fix CRISPR's unwanted changes problem
Turning off gene-editing until it reaches cell cycle phases where more accurate repairs are likely to happen offers a promising fix to CRISPR-Cas9's problem with unwanted genetic changes. (2020-12-04)

Researchers developed a sequence analysis pipeline for virus discovery
A novel bioinformatics pipeline identifies both previously known and novel viruses. (2020-12-03)

Advancing gene editing with new CRISPR/Cas9 variant
Researchers report the ability to improve safety and efficacy using a CRISPR-Cas9 variant known as miCas9. (2020-12-03)

Study highlights strategies for boosting accuracy of personal genetic risk scores
As the consumer genetics industry rapidly expands, more and more people are turning to DNA-based services to learn their risk of developing a wide range of diseases. However, the risk scores from these genetic tests are not always as precise as they could be, according to a new study from Scripps Research. The scientists examine many approaches to calculating the scores and recommend that personal genomics organizations adopt standards that will raise the bar for accuracy. (2020-12-03)

New DNA scanning method could lead to quicker diagnosis of cancer and rare disease
Scientists at the University of Nottingham have made a major breakthrough in genome sequencing, which will enable them to search for the underlying causes of diseases in human DNA quicker than ever before. (2020-11-30)

Researchers have discovered new links between miscarriage and maternal genes
Researchers at the Estonian Genome Center at the University of Tartu described hitherto undiscovered associations between miscarriage and maternal genes, reveals a recent article published in the Nature Communication. (2020-11-25)

New wheat and barley genomes will help feed the world
An international research collaboration, including scientists from the University of Adelaide's Waite Research Institute, has unlocked new genetic variation in wheat and barley - a major boost for the global effort in breeding higher-yielding wheat and barley varieties. (2020-11-25)

Wheat diversity due to cross-hybridization with wild grasses
Bread wheat can grow in highly diverse regional environments. An important reason for its great genetic variety is the cross-hybridization with many chromosome fragments from wild grasses. This is shown by the genome sequences of 10 wheat varieties from four continents, which an international consortium including researchers from the University of Zurich has now decoded. (2020-11-25)

Barley pan-genome: IPK scientists reach milestone on the way to 'transparent' barley
An international research team led by the Leibniz Institute of Plant Genetics and Crop Plant Research (IPK) has reached a milestone on the way to the 'transparent' barley plant. With the complete sequencing of 20 different genotypes, the scientists completed the first step in decoding the genetic information of the entire species 'barley' -- the barley pan-genome. Breeders will greatly benefit from these new findings, which have today been published in the renowned magazine Nature. (2020-11-25)

Global collaboration is unlocking wheat's genetic potential
In a paper published Wednesday, Nov. 25, 2020, in Nature, Kansas State University researchers, in collaboration with the international 10+ Genome Project led by the University of Saskatchewan, have announced the complete genome sequencing of 15 wheat varieties representing breeding programs around the world -- an invaluable resource to improve global wheat production. (2020-11-25)

Decoding gigantic insect genome could help tackle devastating locust crises
A 'game changing' study deciphering the genetic material of the desert locust by researchers at the University of Leicester, could help combat the crop-ravaging behaviour of the notorious insect pest which currently exacerbates a hunger crisis across many developing countries. (2020-11-24)

Single-cell technique could provide 'egg health' indicators
Using the power of single-cell analysis, researchers at the Babraham Institute have assessed the effects of age on egg cells (oocytes) in mice, particularly looking to identify genomic and epigenetic factors that relate to reduced developmental competence. The knowledge uncovered by this research provides new insights into the mechanisms underlying egg quality and is relevant to the development of techniques to assess the quality of human egg cells, an area of growing importance as the use of fertility treatments increases. (2020-11-18)

Genetic code evolution and Darwin's evolution theory should consider DNA an 'energy code'
Darwin's theory of evolution should be expanded to include consideration of a DNA stability ''energy code'' - so-called ''molecular Darwinism'' - to further account for the long-term survival of species' characteristics on Earth, according to Rutgers scientists. (2020-11-16)

Shining a light on the role of the genome's 'dark matter' in cancer development
Innovative research by scientists at Duke-NUS Medical School has shed light on the mysterious role of long non-coding RNAs in the development of pancreatic cancer and suggests potential new targets for precision cancer therapies. (2020-11-13)

New genome alignment tool empowers large-scale studies of vertebrate evolution
Three papers published November 11 in Nature present major advances in understanding the evolution of birds and mammals, made possible by new methods for comparing the genomes of hundreds of species. Researchers at the UC Santa Cruz Genomics Institute developed a powerful new genome alignment method that has made the new studies possible, including the largest genome alignment ever achieved of more than 600 vertebrate genomes. (2020-11-11)

240 mammals help us understand the human genome
A large international consortium led by scientists at Uppsala University and the Broad Institute of MIT and Harvard has sequenced the genome of 130 mammals and analysed the data together with 110 existing genomes to allow scientist to identify which are the important positions in the DNA. This new information can help both research on disease mutations in humans and how best to preserve endangered species. The study is published in Nature. (2020-11-11)

In the Netherlands, two-way transmission of SARS-CoV-2 transmission on mink farms
In the Netherlands, whole genome sequencing of SARS-CoV-2 outbreaks on 16 mink farms has revealed virus transmission between human to mink, as well as from mink to human. (2020-11-10)

RNA structures of coronavirus reveal potential drug targets
The SARS-CoV-2 coronavirus RNA genome structure was studied in detail by researchers from the University of Groningen, the International Institute of Molecular and Cell Biology in Warsaw, and Leiden University. The RNA structures are potential targets for the development of drugs against the virus. The results were published on 10 November as 'Breakthrough paper' in the journal Nucleic Acid Research. (2020-11-10)

Parents, MDs agree: genome sequencing as first-tier diagnostic benefits infants in ICU
A vast majority of doctors and parents of babies in intensive care, with diseases of unknown origin, believe genomic sequencing is beneficial in managing care, according to two new papers published by Rady Children's Institute for Genomic Medicine. (2020-11-05)

SARS-CoV-2 uses 'genome origami' to infect and replicate inside host cells
Scientists at the University of Cambridge, in collaboration with Justus-Liebig University, Germany, have uncovered how the genome of SARS-CoV-2 - the coronavirus that causes COVID-19 - uses genome origami to infect and replicate successfully inside host cells. (2020-11-05)

Plant viruses hijack the defence system of plants, but there might be a way to strike back
Recently discovered interactions between plant and viral proteins open up new avenues for making plants resistant to viruses, thus safeguarding crop yields in changing climate conditions. (2020-11-03)

UConn researcher identifies genetic elements involved in heart development
Justin Cotney, assistant professor of genetics and genome sciences in the UConn School of Medicine, has identified a suite of genes and regulatory elements critical to normal heart development. (2020-11-03)

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