Current Ghrelin News and Events

Current Ghrelin News and Events, Ghrelin News Articles.
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Gut hormone blocks brain cell formation and is linked to Parkinson's dementia
A gut hormone, ghrelin, is a key regulator of new nerve cells in the adult brain, a Swansea-led research team has discovered. It could help pave the way for new drugs to treat dementia in patients with Parkinson's Disease. (2020-10-21)

USC study underscores the gut-brain connection, shows hunger hormone impacts memory
Rats that lacked the hormone ghrelin tended to eat more frequently and gained more weight. They also showed signs that they could not remember when they had last eaten. (2020-10-12)

Ghrelin may be an effective treatment for age-related muscle loss
The hormone, ghrelin, may help protect the elderly population from muscle loss, according to a study being presented at e-ECE 2020. The study found that administering a particular form of ghrelin to older mice helped to restore muscle mass and strength. As muscle-related diseases are a serious health concern in the elderly population, these findings suggest a potential new treatment strategy for muscle loss to enable the aging population to remain fit and healthy. (2020-09-08)

Elevated "hunger" hormone leaves trauma-exposed teens at higher risk for PTSD
Research suggests that acyl-ghrelin is an especially predictive biomarker of PTSD. (2020-08-20)

A deep look into the gut's hormones
Researchers from the Hubrecht Institute and Utrecht University generated an in-depth description of the human hormone-producing cells of the gut. These cells are difficult to study, as they are very rare and unique to different species of animals. The researchers developed tools to study human hormone-producing cells in mini-guts grown in the lab, called organoids. Their findings offer potential new avenues for the treatment of diseases such as type 2 diabetes and obesity. (2020-05-13)

Mindfulness helps obese children lose weight
Mindfulness-based therapy may help reduce stress, appetite and body weight in children with obesity and anxiety, according to a study published in Endocrine Connections. They reported that obese children on a calorie-restricted diet alongside mindfulness therapy lose more weight and are less stressed and hungry, than children on a calorie-restricted diet alone. (2020-02-07)

Limiting mealtimes may increase your motivation for exercise
Limiting access to food in mice increases levels of the hormone, ghrelin, which may also increase motivation to exercise, according to a study published in the Journal of Endocrinology. The study suggests that a surge in levels of appetite-promoting hormone, ghrelin, after a period of fasting prompted mice to initiate voluntary exercise. (2019-10-18)

Scientists link 'hunger hormone' to memory in Alzheimer's study
Scientists at The University of Texas at Dallas have found evidence suggesting that resistance to the 'hunger hormone' ghrelin in the brain is linked to the cognitive impairments and memory loss associated with Alzheimer's disease (AD). The findings, based on observations of postmortem brain-tissue samples from Alzheimer's patients and on experiments with a mouse model of AD, also suggest a possible treatment strategy for the incurable neurodegenerative disorder. (2019-09-03)

Perception of lower socioeconomic standing stimulates appetite
Recent research suggests that the psychological consequences of being in a disadvantaged position in society may stimulate appetite and increase eating regardless of one's ability to access healthier foods. (2019-07-09)

'Hunger hormone' enhances memory
A team of neuroscience researchers at the University of Southern California have identified a surprising new role for the 'hunger hormone' ghrelin. Ghrelin has previously been recognized for its unique role in sending hunger signals from the gut to the brain, but, as presented this week at the annual meeting of the Society for the Study of Ingestive Behavior, these new findings suggest that it may also be important for memory control. (2019-07-09)

Unpacking the links: Chronic stress, fertility and the 'hunger hormone'
A new study suggests high levels of the hormone ghrelin, which stimulates appetite and is also released during stress, could be harmful to some aspects of reproductive function. (2019-05-10)

Evening exercise will not ruin sleep and might even reduce appetite
With growing time demands, many middle-aged adults are finding time to engage in exercise increasingly difficult. For many, even the thought of fitting exercise in after a busy day at work can be as tiring as it is unappetizing. The standing belief that high-intensity exercise should be avoided in the early evening due to its effect on sleep only serves to act as another barrier to exercise at this time. (2019-02-20)

Gut hormone increases response to food
The holiday season is a hard one for anyone watching their weight. The sights and smells of food are hard to resist. One factor in this hunger response is a hormone found in the stomach that makes us more vulnerable to tasty food smells, encouraging overeating and obesity. (2018-12-12)

Debate: Is the gut or the brain more important in regulating appetite and metabolism?
Whether gut or brain hormones are more important for the regulation of appetite and metabolism is not clearly defined. Imbalances in the control of appetite and metabolism can lead to obesity and diabetes, which have a negative impact on people's health and healthcare costs. In a live debate to be held at the Society for Endocrinology annual conference in Glasgow, leading experts will debate this issue in a session entitled, 'This house believes that the gut is the conductor of the endocrine orchestra.' (2018-11-18)

Low carb diets can help maintain weight loss by increasing number of calories burned
A low carbohydrate diet could help people maintain their weight loss by increasing the number of calories burned, finds a large US feeding trial published by The BMJ today. (2018-11-14)

Weight loss success linked with active self-control regions of the brain
New research suggests that higher-level brain functions have a major role in losing weight. In a study among 24 participants at a weight-loss clinic, those who achieved greatest success in terms of weight loss demonstrated more activity in the brain regions of the lateral prefrontal cortex associated with self-control. The results of the study were published in Cell Metabolism on Oct. 18. (2018-10-18)

Brain changes responsible for the appetite effects of cannabis identified in animal studies
New research on how cannabis use alters eating behavior could lead to treatments for appetite loss in chronic illness, according to experts at Washington State University. Using a new procedure to dose lab rats with cannabis vapor, the researchers found how the drug triggers hunger hormones. They also identified specific brain regions that shift to 'hungry' mode while under the influence, according to a report they shared this week at the Society for the Study of Ingestive Behavior. (2018-07-17)

Researchers find that hunger hormones offer promising avenue for addiction treatment
Hormones that signal the body's state of hunger and fullness could be the key to new treatments for drug and alcohol addiction. That is the consensus of an expert panel convened this week at the annual meeting of the Society for the Study Ingestive Behavior, the leading international research conference on food and fluid intake. Gut hormones have received considerable attention from scientists seeking to understand overeating and obesity, which led the panelists to discover that those hormones are also involved in addiction. (2018-07-17)

Hungry? A newly discovered neural circuit may be the cause
A particular subset of neurons located in an enigmatic region of the hypothalamus plays a central role in regulating feeding and body weight in mice, a new study reveals. (2018-07-05)

URI drug study produces 'promising therapy' for alcohol abuse
A University of Rhode Island College of Pharmacy professor is working to change that, and a new clinical trial is right around the corner. Fatemeh Akhlaghi, the Ernest Mario Distinguished Chair in Pharmaceutics, is part of a team working to develop a novel medication to treat alcohol use disorder, the term scientists and health practitioners use. (2018-06-28)

Neurons derived from super-obese people respond differently to appetite hormones
US scientists have successfully generated hypothalamic-like neurons from human induced pluripotent stem cells (hiPSCs) taken from the blood and skin cells of super-obese individuals and people with a normal body weight. The researchers found that the brain cells derived from the super obese were more likely to dysregulate hormones related to feeding behavior and hunger, as well as obesity-related genes and metabolic pathways. The work appears April 19 in the journal Cell Stem Cell. (2018-04-19)

Why you feel hungrier after you lose weight
Blame it on hormones: one hunger hormone continues to be elevated after you lose weight, making you feel hungry even though your new, slanker body has had enough to eat. (2018-02-08)

Evening hours may pose higher risk for overeating, especially when under stress, study finds
Experiments with a small group of overweight men and women have added to evidence that 'hunger hormone' levels rise and 'satiety (or fullness) hormone' levels decrease in the evening. The findings also suggest that stress may increase hunger hormone levels more in the evening, and the impact of hormones on appetite may be greater for people prone to binge eating. (2018-01-16)

Biochemists link synthetic compound to hunger-hormone production
New research conducted at Syracuse University suggests that a man-made cousin of a small molecule found in olive oil can disrupt the hunger-signaling pathway. (2017-07-27)

A flip switch for binge-eating?
Researchers have identified a subgroup of neurons in the mouse brain that, upon activation, immediately prompt binge-like eating. (2017-05-25)

Research elucidates hormone ghrelin's role in blood glucose regulation
UT Southwestern research investigating the blood glucose-regulatory actions of the hormone ghrelin may have implications for development of new treatments for diabetes. (2017-05-09)

New appetite control mechanism found in brain
A newly discovered molecule increases appetite during fasting -- and decreases it during gorging. The neuron-exciting protein, named NPGL -- apparently aims to maintain body mass at a constant, come feast or famine. An evolutionary masterstroke, but not great news for those looking to trim down -- or beef up for the summer. (2017-04-28)

The search for obesity drugs targets hunger's complex chemistry
Discoveries of hormones related to weight and appetite in the '90s helped spur a search for obesity treatments targeting those hormones -- with disappointing results. Now scientists are taking a new tack that could finally yield promising treatments, according to a story in Chemical & Engineering News (C&EN) that was produced in collaboration with the American Chemical Society's open-access journal ACS Central Science. C&EN is the weekly newsmagazine of ACS. (2017-03-29)

Departure of migratory birds from stopover sites is hormone-controlled
It had been unclear which physiological signals triggered the birdsdecision to continue their flight. A team led by researchers from Vetmeduni Vienna now identified, for the first time, the hormone ghrelin as a signal for the birds brains. Ghrelin, an appetite-regulating hormone in humans, was measured at high levels in satiated garden warblers. Birds injected with additional ghrelin exhibited decreased appetite and increased migratory restlessness. The results were published in PNAS. (2017-02-07)

Sleep deprivation may cause people to eat more calories
Sleep deprivation may result in people consuming more calories during the following day, according to a systematic review and meta-analysis led by researchers at King's College London. The meta analysis combined the results of many previous small intervention studies to produce a more robust answer and found that sleep-deprived people consumed an average of 385 kcal per day extra, which is equivalent to the calories of about four and a half slices of bread. (2016-11-02)

Small study shows the effects of smoking on reducing calorie intake
A study presented Sept. 5, 2016, at this year's European Respiratory Society International Congress shows that smoking reduces calorie intake, possibly modulated by its effect on levels of the hormone ghrelin (also known as the hunger hormone). The study was conducted by Dr. Konstantina Zachari and colleagues, Harokopio University Athens, Greece, in collaboration with Athens Medical School Greece. (2016-09-04)

Blocking release of the hormone ghrelin may mediate low blood sugar effect
Researchers at UT Southwestern Medical Center have identified a previously unknown role of a cellular signaling molecule involved in release of the 'hunger hormone' ghrelin, a finding that could have implications for optimal treatment of children taking beta blockers. (2016-08-22)

AgriLife researcher takes close look at 'inflamm-aging'
In research recently published in the premier science journal Aging, Dr. Yuxiang Sun and colleagues investigated the role of the ghrelin receptor, growth hormone secretagogue receptor, or GHSR, in age associated adipose tissue inflammation and insulin resistance in mice. (2016-08-22)

Greater production of 'feeling full' hormone could be responsible for weight loss
A study that might hold the key to why octogenarians are prone to losing weight has been conducted by Plymouth University academic, Professor Mary Hickson. (2016-08-05)

Soy-based protein boosts hunger hormone and stimulates appetite
Researchers have discovered a protein that stimulates secretion of ghrelin, an appetite-stimulating hormone produced in the stomach. When fed to mice, the protein, called soy-ghretropin, increased blood levels of ghrelin and boosted their appetite. (2016-07-19)

'Hunger' neurons in the brain are regulated by protein activated during fasting
Neurons in the brain that control hunger are regulated by AMPK, a protein activated during fasting, report researchers from Tufts University School of Medicine. The study sheds light on the biological mechanisms that regulate feeding behavior, and serves as a potential model for the broad study of synapse formation. (2016-07-06)

New insights uncovered into Prader-Willi syndrome
A study published in the journal Human Molecular Genetics by researchers at Children's Hospital Los Angeles provides novel insights into the brain mechanisms underlying the insatiable hunger and subsequent obesity in patients with Prader-Willi syndrome. (2016-06-14)

Study reveals how altered gut microbes cause obesity
Obesity is linked to changes in our gut microbes -- the trillions of tiny organisms that inhabit our intestines. But the mechanism has not been clear. In a new study published in Nature, a Yale-led team of researchers has identified how an altered gut microbiota causes obesity. (2016-06-08)

New research: Obese people can maintain stable weight loss
Maintaining a stable weight loss is the biggest struggle for obese individuals, yet new research from University of Copenhagen have allowed researchers new insights into the complex processes involved in obesity and especially weight loss in obesity. It is now possible to offer overweight people a clearer understanding of how to sustain weight loss. (2016-04-14)

Slow-binding inhibition of cholinesterases: Pharmacological and toxicological relevance
Researchers of Kazan Federal University describe slow-binding inhibition of cholinesterases and present their pharmacological advantages over classical reversible inhibitors (e.g. long target-residence times, resulting in prolonged efficacy with minimal unwanted side effects), slow-binding inhibitors of ChEs are promising new drugs for treatment of Alzheimer's disease, myasthenia, and neuroprotection. (2016-04-13)

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