Current Glioblastoma News and Events

Current Glioblastoma News and Events, Glioblastoma News Articles.
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Targeted delivery of highly toxic anti-cancer drug to brain tumors
University of Houston biomedical researcher Sheeren Majd is reporting the development and testing of a new nano-carrier as a potential treatment to deliver highly toxic medicine to glioblastomas, the most common and aggressive form of primary brain tumors. (2021-02-23)

3D biopsies to better understand brain tumors
Researchers at the Institut de Neurociències of the Universitat Autònoma de Barcelona (INc-UAB) obtained a highly accurate recreation of human glioblastoma's features using a novel 3D microscopy analysis. The study, published in the journal Acta Neuropathologica Communications, provides new information to help with the diagnose, by finding therapeutical targets and designing immunotherapeutical strategies. (2021-02-19)

Promising new approach to stop growth of brain cancer cells
Inhibiting a key enzyme that controls a large network of proteins important in cell division and growth paves the way for a new class of drugs that could stop glioblastoma, a deadly brain cancer, from growing. (2021-02-12)

Aggressive brain tumor mapped in genetic, molecular detail
A new study led by Washington University School of Medicine in St. Louis has revealed a detailed map of the genes, proteins, infiltrating cells and signaling pathways that play key roles in driving glioblastoma. The study, of 99 tumors from patients, is the largest and most detailed schematic of this deadly brain tumor. (2021-02-11)

Researchers find parallels in spread of brain cancer in mammals, zebrafish
Virginia Tech scientists have identified a new zebrafish model that could help advance glioblastoma multiforme research. Glioblastoma is an aggressive form of primary brain tumor - fewer than one in 20 patients survive five years after diagnosis. (2021-02-11)

Brain tumor study reveals surprising gene deletion and method to overcome drug resistance
Experts at Cincinnati Children's report success at averting drug resistance in a subtype of brain tumors called glioblastomas. Importantly, the research indicates that the approach may also work in other cancers, such as melanoma, that exhibit a similar pathway of drug resistance. (2021-02-10)

Combination therapy with radiation shows promise in treating glioblastoma
In a study of mice, researchers at the UCLA Jonsson Comprehensive Cancer Center have identified a new approach that combines an anti-psychotic drug, a statin used to lower high cholesterol levels, and radiation to improve the overall survival in mice with glioblastoma (2021-02-09)

New approach emerges to better classify, treat brain tumors
A look at RNA tells us what our genes are telling our cells to do, and scientists say looking directly at the RNA of brain tumor cells appears to provide objective, efficient evidence to better classify a tumor and the most effective treatments. (2021-01-19)

Researchers link cellular transport pathway to aggressive brain cancer
Researchers at McGill University have identified a new cellular pathway that limits the growth and spread of brain tumors by controlling the recycling of cell surface receptor proteins. The study, which will be published January 14 in the Journal of Cell Biology (JCB), suggests that the pathway, which involves a protein called Rab35, is defective in many patients with glioblastoma and that restoring Rab35's activity could be a new therapeutic strategy for this deadly form of brain cancer. (2021-01-14)

Recurrent GBM brain tumors with few mutations respond best to immunotherapy
New insights from a team led by Duke's Preston Robert Tisch Brain Tumor Center provide potential answers about why immunotherapies have limited success against brain tumors. The team found that recurring glioblastoma tumors with very few mutations are far more vulnerable to immunotherapies than similar tumors with an abundance of mutations. (2021-01-13)

One in five brain cancers fueled by overactive mitochondria
A new study has found that up to 20% of aggressive brain cancers are fueled by overactive mitochondria and new drugs in development may be able to starve the cancers. (2021-01-11)

Novel RNA factors may help cancer cells thrive
Recent work by researchers at Brigham and Women's Hospital pinpoints critical changes in an enzyme known as DICER, which create a cascade of effects on this microRNAome. The team identified primary actors circ2082, a circular RNA, and RBM3, an RNA-binding protein, which form a complex with DICER to trap it in the nucleus of glioblastoma cells, therefore disrupting the cytoplasmic microRNAome. (2021-01-08)

Brain cancer linked to tissue healing
Brain tumours might arise from an injury that could not heal properly, Canadian scientists have found. The researches detected an increase in inflammation markers typical of injury response in the cells that give rise to glioblastoma, the most common and aggressive form of brain cancer, indicating the cancer cells' potential role in tissue healing. The unexpected findings open new ideas about how brain tumours develop while suggesting that anti-inflammatory medications might benefit some glioblastoma patients. (2021-01-04)

Molecular reporters expose the allies of the brain tumor
Until recently, it was unclear how and why cancer cells adapt to their environment. A team led by Gaetano Gargiulo at MDC has now developed a technology that can be used to observe the molecular processes in living cells. The researchers present their results in the journal Cancer Discovery. (2020-12-23)

Anti-diarrhoea drug drives cancer cells to cell death
In cell culture, loperamide, a drug commonly used against diarrhoea, proves effective against glioblastoma cells. A research team at Goethe University has now unravelled the drug's mechanisms of action of cell death induction and - in doing so - has shown how this compound could help attack brain tumours that otherwise are difficult to treat. (2020-12-21)

New insights into Glioblastoma invasiveness
Researchers from the NORLUX Neuro-Oncology Laboratory at the LIH Department of Oncology (DONC) explored the molecular mechanisms responsible for the ability of Glioblastoma (GBM) to infiltrate and spread to healthy brain tissue. They brought forward the novel role of protein ZFAND3 in promoting the transcription of several genes that stimulate the invasion of GBM cells in the surrounding parenchyma. The findings, which carry significant implications for the development of novel therapeutic strategies against GBM, were published in the international journal Nature Communications. (2020-12-11)

White blood cells may cause tumor cell death -- but that's not good news
White blood cells are part of many immune system responses in the human body. New research shows that a specific type of those cells may cause brain cancer tissues to die -- but that's not good news, according to researchers at Penn State College of Medicine. They said that higher amounts of this tissue death have been associated with poor survival in patients with aggressive glioblastomas, a deadly type of brain cancer that is common in adults. (2020-12-07)

Immune checkpoint inhibitor efficacy against glioblastoma may decrease with dexamethasone
Among patients with glioblastoma receiving an immune checkpoint inhibitor, those who received the corticosteroid dexamethasone at baseline for cerebral edema had significantly worse overall survival. (2020-11-25)

Revolutionary CRISPR-based genome editing system treatment destroys cancer cells
Researchers at Tel Aviv University (TAU) have demonstrated that the CRISPR/Cas9 system is very effective in treating metastatic cancers, a significant step on the way to finding a cure for cancer. The researchers developed a novel lipid nanoparticle-based delivery system that specifically targets cancer cells and destroys them by genetic manipulation. The system, called CRISPR-LNPs, carries a genetic messenger (messenger RNA), which encodes for the CRISPR enzyme Cas9 that acts as molecular scissors that cut the cells' DNA. (2020-11-18)

A therapeutic option for glioblastoma using pH-sensitive nanomicelles
A polymeric nanomicelle that effectively delivers to glioblastoma (GBM) was developed. (2020-11-12)

Glioblastoma nanomedicine crosses into brain in mice, eradicates recurring brain cancer
A new synthetic protein nanoparticle capable of slipping past the nearly impermeable blood-brain barrier in mice could deliver cancer-killing drugs directly to malignant brain tumors, new research from the University of Michigan shows. (2020-11-10)

Photon IMRT treatment group displays no significant survival difference between arms
A preliminary analysis of photon therapy treatment group 1 from the phase II NRG Oncology clinical trial NRG-BN001 indicates that there is no statistically significant overall survival (OS) or toxicity differences between dose-intensification radiation therapy (DI-RT) using intensity-modulated radiation therapy (IMRT) and standard-dose radiation therapy (SD-RT) with temozolomide treatments for patients with newly diagnosed glioblastoma (GBM). (2020-10-26)

UCalgary researchers discover new tactic to stop the growth of a deadly brain cancer
UCalgary scientists and members of the Clark H. Smith Brain Tumour Centre at the Arnie Charbonneau Cancer Institute at the Cumming School of Medicine have discovered a way to stop the growth of glioblastoma, the deadliest form of brain cancer. The finding, published in Nature Communications, provides a new tactic in the war against cancer that involves reprogramming the immune system to do what it does best - fight the tumour instead of fueling it. (2020-10-26)

New test can target and capture most lethal cells in fatal brain cancer
A laboratory test developed by a research team led by Johns Hopkins University bioengineers can accurately pinpoint, capture and analyze the deadliest cells in the most common and aggressive brain cancer in adults. (2020-10-15)

Experimental glioblastoma therapy shows curative powers in mice models
Houston Methodist researchers used a second-generation prodrug called MP-Pt(IV) to target the deadly cells of glioblastoma tumors and found mice harboring human glioblastoma tumors in their brains had greatly enhanced survival and weight gain when given the newly developed prodrug. This mitochondrial-targeted prodrug also greatly improves outcomes when coupled with standard therapies of radiation and/or chemotherapy. The study was published Oct. 8 in Molecular Cancer Therapeutics. (2020-10-08)

Molecules responsible for radio-resistant glioblastoma identified
Scientists have identified key molecules that mediate radioresistance in glioblastoma multiforme; these molecules are a potential target for the treatment of this brain cancer. (2020-09-30)

Researchers identify mechanism underlying cancer cells' immune evasion
Researchers in China have discovered how brain cancer cells increase production of a key protein that allows them to evade the body's immune system. The study, which will be published August 27 in the Journal of Experimental Medicine (JEM), suggests that targeting this cellular pathway could help treat the deadly brain cancer glioblastoma, as well as other cancers that are resistant to current forms of immunotherapy. (2020-08-27)

Blocking copper uptake in tumor cells may be clue to boosting immune system
Australian researchers have discovered that removing copper from the blood can destroy some of the deadliest cancers that are resistant to immunotherapy using models of the disease. (2020-08-18)

Extrachromosomal DNA is common in human cancer and drives poor patients outcomes
The multiplication of genes located in extrachromosomal DNA that have the potential to cause cancer drives poor patient outcomes across many cancer types, according to a Nature Genetics study published Aug. 17, 2020 by a Nature Genetics by a team of researchers including Professors Vineet Bafna and Dr.Paul Mischel of the University of California San Diego and Professor Roel Verhaak of Jackson Laboratories. (2020-08-17)

Gene targeting helps overcome the resistance of brain cancer to therapy
New insight into a gene that controls energy production in cancer stem cells could help in the search for a more effective treatment for glioblastoma. A McGill-led study published in Nature Communication reveals that suppressing the OSMR gene can improve the effectiveness of radiation therapy. (2020-08-17)

TLK protein inhibition activates the innate immune system
These proteins are a potential therapeutic target for enhancing the effect of some cancer treatments. Inhibition of TLK proteins triggers the Alternative Lengthening of Telomeres pathway, a common process in some of the most aggressive types of cancer, such as glioblastoma. The study, performed by the Genomic Instability and Cancer Laboratory at IRB Barcelona, has been published in the journal Cell Reports. (2020-08-05)

Study suggests new approach to improve radiation therapy resistance in glioblastoma
Laboratory research paves the way for a clinical trial to see if an FDA-approved drug used to prevent organ transplant rejection can work against glioblastoma, an aggressive type of brain tumor. (2020-07-30)

New drug targets for lethal brain cancer discovered
More than 200 genes with novel and known roles in glioblastoma - the most aggressive type of brain cancer - offer promising new drug targets. Researchers from the Sanger Institute and their collaborators engineered a new mouse model to show for the first time how a mutation in the well-known cancer gene, EGFR initiates glioblastoma, and works with a selection from more than 200 other genes to drive the cancer. (2020-07-29)

New study: Brain tumors may be seeded from distant site
A mouse model of glioblastoma, an aggressive type of cancer that can occur in the brain, suggests that this recalcitrant cancer originates from a pool of stem cells that can be a significant distance away from the resulting tumors. The findings of a new study, led by Children's National Hospital researchers and published July 22 in the journal Nature Communications, suggest new ways to fight this deadly disease. (2020-07-22)

MU advances chemotherapy-free treatment for cancer in animals and humans
Osteosarcoma, a common bone cancer in dogs, affects more than 10,000 dogs in the US each year. While chemotherapy is generally effective at killing some of the cancer cells, the numerous side effects can be painful and often a subset of cancer cells exist that are resistant to chemotherapy. (2020-07-17)

Reprogramming of immune cells enhances effects of radiotherapy in preclinical models of brain cancer
A Ludwig Cancer Research study has dissected how radiotherapy alters the behavior of immune cells known as macrophages found in glioblastoma (GBM) tumors and shown how these cells might be reprogrammed with an existing drug to suppress the invariable recurrence of the aggressive brain cancer (2020-07-15)

Scientists ID gene responsible for deadly glioblastoma
The discovery of the oncogene responsible for glioblastoma could be the brain cancer's Achilles' heel, one researcher says. (2020-07-14)

Unexpected associations found between drug response and cell changes in brain cancer
Therapies for treating glioblastoma brain cancer can be delivered with greater precision and existing drugs can be used in new ways. These are the conclusions from a study from Uppsala University investigating a large number of cell samples from patients with brain tumours. The researchers have characterised how changes in glioblastoma cells influence the effect of different drugs. Their findings are published in the journal Cell Reports. (2020-07-14)

New PET radiotracer proven safe and effective in imaging malignant brain tumors
A first-in-human study presented at the Society of Nuclear Medicine and Molecular Imaging 2020 Annual Meeting has demonstrated the safety, favorable pharmacokinetic and dosimetry profile of 64Cu-EBRGD, a new, relatively long-lived PET tracer, in patients with glioblastomas. The radiotracer proved to be a superior, high-contrast imaging diagnostic in patients, visualizing tumors that express low or moderate levels of αvβ3 integrin with high sensitivity. (2020-07-13)

Breakthrough with cancer vaccine
Scientists have developed a new cancer vaccine with the potential to activate the body's immune system to fight a range of cancers, including leukaemia, breast cancer, lung cancer and pancreatic cancers. (2020-07-09)

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