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Current Glioma News and Events, Glioma News Articles.
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Other highlights in the June 1 JNCI
Other highlights in the June 1 JNCI include a study of cancer risk in ATM mutation carriers, the results of a trial testing UDCA for the prevention of colorectal adenoma recurrence, a description of a potential molecular target for the treatment of malignant glioma, and a study of NM23 gene expression and metastasis in a mouse model of cancer. (2005-05-31)

Variant in gene associated with telomeres predicts longer survival of deadly brain tumor
An exceptionally large study of patients with glioblastoma multiforme has found an association between a genetic variation and a doubling of survival rate - the strongest link ever established between genetic variation and outcome in this deadliest form of brain cancer, according to researchers at The University of Texas M. D. Anderson Cancer Center. (2005-04-18)

Viruses may one day help treat brain tumors
New research shows that a virus designed to kill cancer cells can significantly increase the survival of mice with an incurable human brain tumor, even in some animals with advanced disease. The study used a genetically altered herpes simplex virus that infects and reproduces only in malignant glioma cells and kills them. (2005-04-07)

New study in JAMA details trends in diagnosis, treatment of brain tumors
A two year study involving over 560 patients with the newly-diagnosed malignant brain tumors shows that patterns of care are varied and there is a need for new, detailed clinical guidelines for management of brain tumors. The study is published in the Feb. 2, 2005 issue of the Journal of the American Medical Association (JAMA), available at (2005-02-02)

Treatment for brain tumor does not always follow recommendations
An examination of how the most common type of primary brain tumor is treated found that care does not always follow established practice guidelines, according to a study in the February 2 issue of JAMA. (2005-02-01)

Brain tumor treatment can vary greatly, according to new JAMA study
Primary malignant brain tumors are not very common -- about 9,000 patients diagnosed per year -- and are associated with a poor prognosis. Treatment of these patients varies greatly among academic and community centers and can be in conflict with accepted guidelines of care, according to a new study. (2005-02-01)

Protein stops growth of brain tumor, OHSU study shows
A protein developed by scientists at Oregon Health & Science University blocks the growth of an aggressive and deadly brain tumor in laboratory rats, a new study shows. Herstatin inhibits the activation of a family of enzymes responsible for signaling inside glioblastoma cells that tells the cells to proliferate and display other malignant properties. Study co-author Gail Clinton, Ph.D., said human clinical trials for herstatin could begin as early as next year. (2005-01-27)

Columbia research lifts major hurdle to gene therapy for cancer
Researchers at Columbia University Medical Center have discovered a way to overcome one of the major hurdles in gene therapy for cancer: its tendency to kill normal cells in the process of eradicating cancer cells. (2005-01-25)

Mayo Clinic Cancer Center receives SPORE grant for brain cancer research from NCI
Mayo Clinic Cancer Center has received a Specialized Programs of Research Excellence (SPORE) grant from the National Cancer Institute (NCI) for brain cancer research. (2005-01-06)

Mouse brain tumors mimic those in human genetic disorder
A recently developed mouse model of brain tumors common in the genetic disorder neurofibromatosis 1 (NF1) successfully mimics the human condition and provides unique insight into tumor development, diagnosis and treatment, according to researchers at Washington University School of Medicine in St. Louis. (2004-12-29)

Lab study defines and blocks mechanism that lets brain tumors sidetrack immune response
Because the enzyme cyclooxygenase-2 (COX-2) has been linked to many types of cancers, manipulation of the enzyme is considered an attractive anti-cancer strategy. Researchers now describe COX-2's harmful impact on key cells that result in the immune system's tolerance of deadly brain tumor cells. By blocking the enzyme's expression in gliomas before exposure to dendritic cells, COX-2's effects may be interrupted and a more effective immune response may be launched. (2004-10-22)

Researchers define mechanism that enables stem cells to track migrating brain tumor cells
Neural stem cells, which have the ability to track deadly brain cancer cells as they migrate from a tumor to form new satellites, are potential transporters to deliver cancer-killing agents. In the May/June issue of Neoplasia, researchers identify the type of stem cells that have this capacity and describe a mechanism that turns on the tumor-tracking activity - important findings in the translation of laboratory results into therapeutic trials. (2004-05-04)

Survey reports fall in stem cell transplants for breast cancer
The use of stem cell transplantation in breast cancer treatment soared in the early and mid 1990s but the dramatic fall that begin in 1997 as clinical trials showed it appeared to be of little benefit continues, according to new European figures published in the April edition of Annals of Oncology. Editorial by US NIH specialist. (2004-03-30)

Drug may treat previously incurable brain cancer, say Stanford researchers
An old drug may have found a new role treating an incurable form of brain cancer called glioblastoma, according to preliminary research at Stanford University School of Medicine. The drug, called arsenic trioxide, increases the effectiveness of radiation therapy in mice with the disease. (2003-10-20)

In lab studies, blocking expression of gene reduces invasion of deadly brain tumor cells
Using a tool that enables molecular scientists to study the function of genes, researchers at Cedars-Sinai blocked the expression of a gene they had previously found to be involved in the development of new tumor vessels and the spread and recurrence of aggressive brain tumors called gliomas. In laboratory experiments, interrupting the expression of the gene reduced the ability of the tumor cells to spread, reinforcing the possibility that the gene may be a target for anti-tumor therapy. (2003-10-19)

Benchmark study of brain tumors points to resection over biopsy as one key to survival
Patients with gliomas, the most common type of brain tumor, have a more favorable outcome with surgical resection in a craniotomy procedure that opens the skull than patients who have only a biopsy for a tumor, according to a study led by researchers at the University of Virginia Health System. (2003-10-03)

Antigen targeted in therapy for melanoma also prompts immune response in brain tumor cells
Scientists seeking better ways to enlist the immune system in the battle against malignant brain tumors have a new target - an antigen that was previously detected in melanomas. A recent study found that the TRP-2 antigen was expressed at significant levels in glioma cells and that a strong immune response could be triggered against it. (2003-09-24)

New brain cancer treatment extends survival for more patients
Doctors have developed a new brain cancer treatment that, in a pilot study, shows promise at keeping more patients alive longer than the best current standard treatments for the disease. The treatment is a combination of two cancer-killing drugs that can be taken orally as pills, making it easier on those patients who have already undergone difficult surgery, radiation or traditional, intravenous chemotherapy. (2003-08-21)

Cedars-Sinai researchers detail events that enable brain tumors to weaken immune system
Several cell-level mechanisms appear to prevent the immune system from launching and sustaining an effective attack against gliomas, aggressive and deadly brain tumors that are now considered incurable. Researchers at Cedars-Sinai's Maxine Dunitz Neurosurgical Institute report that immune system cells produced by the thymus appear to be especially important in targeting glioma cells, but the number of those cells is reduced even before they leave the gland. (2003-07-25)

Modified adenovirus offers new approach to treating aggressive brain tumors
Researchers have created a modified adenovirus that more readily attaches to brain tumor cells, thereby infecting them and causing antitumor effects. This modified adenovirus may potentially offer a more effective approach to treating aggressive brain tumors, according to a new study in the May 7 issue of the Journal of the National Cancer Institute. (2003-05-06)

Smart virus eliminates brain cancer in animal experiments
A research team led by The University of Texas M. D. Anderson Cancer Center has tested a novel (2003-05-06)

Brain gliomas progress as function of crucial gene is lost
For the first time, researchers are characterizing the molecular processes that turn brain cancer deadly, and their work may result in a diagnostic test that can predict patient survival. (2003-04-06)

Radiation and intratumoral injection turn on immune system to attack brain tumor cells
Researchers at Cedars-Sinai's Maxine Dunitz Neurosurgical Institute are working to develop a non-surgical approach to brain cancer that combines radiation with the injection of specially cultured bone marrow cells into the tumor. The combination sets in motion a local and systemic immune response to kill surviving tumor cells. The novel approach has provided promising results in a study on rats, described in the March 3 issue of the Journal of Immunotherapy. Human trials are expected to begin this year. (2003-03-03)

Neural stem cells carry cancer-fighting protein to track and destroy brain tumor cells
Researchers at Cedars-Sinai Medical Center's Maxine Dunitz Neurosurgical Institute in Los Angeles have combined a special protein (TRAIL) that targets cancer cells with neural stem cells (NSC) to track and attack malignant brain tumor cells. With its tumor-tracking capabilities and natural cancer-killing properties, the experimental NSC-TRAIL combination may offer new hope for treating gliomas a particularly deadly type of brain tumor. (2002-12-15)

High-dose radiotherapy could reduce cognitive function for people with low-grade brain tumours
Dutch authors of a study in this week's issue of The Lancet caution against the use of high-level radiation for the treatment of low-grade brain tumours-as such treatment does not improve survival and may contribute to cognitive decline. The authors also comment that the tumour itself is the main cause of cognitive impairment, and that other factors-notably the use of antiepileptic drugs-may play a role in reducing cognitive function. (2002-10-31)

Modest survival benefit from chemotherapy for patients with glioma brain tumours
Chemotherapy in addition to radiotherapy could have a modest survival benefit for the treatment of high-grade glioma, a severe form of brain cancer, conclude authors of a study in this week's issue of THE LANCET. (2002-03-21)

Microtumor-induced vascular development
Solid tumors above a critical size become hypoxic at their core. The upregulation of the angiogenic factor VEGF under these conditions is widely thought to explain tumor vascularization and continued proliferation, but Vajkoczy and coworkers point out that some metastatic tumor cells express low levels of bio-active VEGF in a constitutive manner and appear to require VEGF signaling even at a very early stage. (2002-03-13)

Study shows promising results in using gene modification to deliver Interleukin 12 directly into resistant type of brain tumor
In an article appearing in the Dec. 28, 2001, issue of Cancer Gene Therapy, physicians and scientists at Cedars-Sinai Medical Center's Maxine Dunitz Neurosurgical Institute describe an approach that (2001-12-28)

Brain tumors and mouse models: New insight into the development of gliomas
In the latest issue of Genes & Development, a team led by Dr. Eric Holland at the Memorial Sloan-Kettering Cancer Centre in New York reports on the development of new mouse models of brain tumors. Gliomas are the most common form of primary brain tumors, with approximately 30,000 people in the USA newly diagnosed each year. Murine models offer a route to understand how different types and severities of gliomas arise, and an experimental system in which to test potential therapies. (2001-07-31)

Research detects mechanism that appears to enable deadly brain tumors to progress, develop blood supplies to fuel their growth, and invade neighboring healthy tissues
Using a technique called 'gene array' that allows them to analyze thousands of genes in one experiment, scientists at Cedars-Sinai's Maxine Dunitz Neurosurgical Institute have identified a new mechanism that may be a critical step in the development of a type of malignant brain tumor (glioblastoma multiforme or GBM) that has historically been virtually impervious to treatment. (2001-07-14)

Genetically engineered poliovirus fights brain tumors
What do you get when you cross a poliovirus with the virus that causes the common cold? An efficient mechanism for killing brain tumors, say scientists at Duke University, who have successfully used the genetically modified poliovirus to cure brain tumors in mice. (2001-05-20)

Certain occupations put people at higher risk for developing brain cancer
A statistical analysis of a certain form of brain cancer, glioma, and the occupation of the patient, shows a higher correlation between brain cancer and certain occupations. (2001-05-13)

Smoking cigarettes, cigars, pipes or using snuff or chewing tobacco does not cause brain cancer, Yale study shows
Although cigarette smoking and use of other tobacco products are considered to be the greatest single source of human exposure to certain carcinogens, they do not appear to cause brain cancer, a Yale investigation has found. (2001-05-08)

Study of dendritic cell 'vaccine' shows early promise in helping the immune system combat an extremely aggressive type of brain cancer
The existing methods of treating brain tumors have been virtually powerless against an extremely deadly type of tumor called glioblastoma multiforme (glioma). But a new type of (2001-01-30)

Blocking growth factor halts tumor advance, spread in mice
Researchers at Columbia have found that blocking the interaction of two naturally occurring molecules in tumor cells restricts the growth and spread of neoplasms in mice. The finding, published in the May 18 issue of the journal Nature, suggests a similar approach may be helpful in treating human cancers. (2000-05-16)

Mutations not the only gene defect that leads to cancer
New research shows that gene mutations are not the only kinds of defects involved in the transformation of a healthy cell into a malignant one. Scientists say that this may mean the nature of cancer is even more complicated than once thought. (2000-03-20)

Paradoxical Gene Suppresses Tumors Yet Makes Them Grow
Scientists have found a gene that has paradoxical properties -- it helps bring about tumor cell death yet is also necessary for their growth. The new study highlights an important molecular mechanism in the evolution of tumors and could lead to new anti-cancer drugs targeted to a specific gene. (1998-09-24)

University of Kentucky Neuroscientist Develops Unique Device For Treatment Of Brain Tumors
A device patented by a University of Kentucky Chandler Medical center neuroscientist has increased patient survival times in preliminary studies in treatment of malignant gliomas, the most common type of brain tumor in adults. The device delivers chemotherapy through a plastic tube that runs directly into the brain tumor. (1998-08-03)

Research Indicates Molecule Sabotage May Slow Brain Cancer
For the first time, researchers have found that a particularly lethal form of brain cancer tramples through healthy tissue with the help of a tumor-specific molecule. They hope that methods that can debilitate the molecule, brain-enriched hyaluronan binding protein (BEHAB), will slow the progression of the disease. (1998-03-25)

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