Current Glioma News and Events | Page 2

Current Glioma News and Events, Glioma News Articles.
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How do gliomas evolve?
The Glioma Longitudinal Analysis (GLASS) Consortium characterized diffuse glioma cells both before and after therapy to characterize how they change and why this form of malignant brain cancer is so difficult to treat. The findings provide a foundation for further research and the opportunity for the clinical community to predict the effectiveness of newly developed treatments. (2019-11-20)

AI blood test can spot signs of brain tumor to speed up diagnosis
Chemical analysis of blood samples, combined with an artificial intelligence program, could speed up the diagnosis of brain tumors, according to research presented at the 2019 NCRI Cancer Conference. (2019-11-05)

A compound effective to chemotherapy-resistant cancer cells identified
A compound effective in killing chemotherapy-resistant glioblastoma-initiating cells (GICs) has been identified, raising hopes of producing drugs capable of eradicating refractory tumors with low toxicity. (2019-10-18)

Detection of tyrosine kinase inhibitors-induced COX-2 expression in bladder cancer by fluorocoxib A
Cyclooxygenase-2 is overexpressed in bladder cancer cells, making it an attractive molecular target for the detection and treatment of cancer. The effects of TKIs on bladder cancer in vivo were evaluated using the COX-2-expressing K9TCC 5Lilly xenograft mouse model and detected by fluorocoxib A. The increased COX-2 expression was detected by all tested TKIs in at least one of the tested COX-2-expressing bladder cancer cell lines in vitro. (2019-10-14)

Scientists develop new methodology to genetically modify lab mice and human cells
A team led by Cedars-Sinai has designed a rapid method to genetically alter laboratory mice and then used this method to produce personalized animal models of pediatric glioma, an aggressive type of malignant brain cancer in children. (2019-09-19)

Brain tumors form synapses with healthy neurons, Stanford-led study finds
Scientists at the Stanford University School of Medicine have shown for the first time that severe brain cancers integrate into the brain's wiring. (2019-09-18)

Precious metal flecks could be catalyst for better cancer therapies
Tiny extracts of a precious metal used widely in industry could play a vital role in new cancer therapies. (2019-09-09)

Discovered a factor that predicts long survival in brain tumor
Researchers of the Josep Carreras Leukaemia Research Institute have discovered an epigenetic lesion that allows identifying those patients affected by brain tumors that have a longer life expectancy. (2019-09-03)

New research published in cancer discovery identifies new drug target for glioblastoma
A new international study co-led by Cleveland Clinic has identified a new drug target for treating glioblastoma. This target is part of a never-before defined cellular pathway found to contribute to the spread and proliferation of a dangerous subset of cancer cells, called glioma stem cells. (2019-08-21)

Single-cell sequencing reveals glioblastoma's shape-shifting nature
Glioblastoma, a cancer that arises in the brain's supporting glial cells, is one of the worst diagnoses a child can receive. The grade IV, highly malignant tumor aggressively infiltrates healthy brain tissue, and most children die of the disease within one to two years of diagnosis, similar to adults. (2019-08-09)

Shrinking brain tumours and opening the door for targeted cancer therapies
A new drug, known as IP1867B, could be used for future treatments of brain tumours. The research team showed that IP1867B worked with existing cancer treatments boosting their effectiveness and, in some cases, restored sensitivity to some treatments. (2019-08-05)

Survivors of childhood brain tumors experience lasting cognitive and socioeconomic burdens
Survivors of childhood brain tumors who received radiotherapy and were very young at the time of diagnosis may experience cognitive and socioeconomic burdens decades after treatment, according to a study published early online in CANCER, a peer-reviewed journal of the American Cancer Society. Interventions such as cognitive therapies and educational and occupational services may be needed to mitigate such long-term effects. (2019-06-24)

Study: More aggressive treatments needed to improve 5-year survival rate for glioblastoma
Despite improvements in median and short-term survival rates for patients with glioblastoma, the most common brain tumor in adults, the percentage of patients achieving five-year survival remains low, according to new Mayo Clinic research. (2019-06-20)

Study finds macrophages' pathway to nurture PTEN-deficient glioblastoma
A common genetic deficiency empowers glioblastoma to broadcast a molecular message to the wrong type of immune cell, summoning macrophages that protect and nurture the brain tumor instead of attacking it, researchers at The University of Texas MD Anderson Cancer Center report in Cancer Cell. (2019-06-10)

Suggested benefit in PCV chemoradiotherapy for both IDH-mutant WHO-defined molecular subgroups
A recent, updated predictive analysis of the three WHO-defined molecular subgroups based on isocitrate dehydrogenase 1/2 (IDH) mutation status and 1p/19q co-deletion status represented in the high-risk treatment arms of the NRG Oncology clinical trial NRG-RTOG 9802 indicates that both IDH-mutant sub-groups (IDHmut-noncodel and IDHmut-codel) could benefit from the addition of PCV chemotherapy to radiotherapy treatment. (2019-06-03)

Immune cells determine how fast certain tumors grow
By examining brain tumors in mice, researchers at Washington University School of Medicine in St. Louis discovered that immune cells that should be defending the body against disease sometimes can be enticed into providing aid and comfort to tumor cells instead. The more immune cells a tumor can recruit to its side, the faster the tumor grows, the researchers found. (2019-06-03)

Computer-assisted diagnostic procedure enables earlier detection of brain tumor growth
A computer-assisted diagnostic procedure helps physicians detect the growth of low-grade brain tumors earlier and at smaller volumes than visual comparison alone, according to a study published May 28 in the open-access journal PLOS Medicine by Hassan Fathallah-Shaykh of the University of Alabama at Birmingham, and colleagues. However, additional clinical studies are needed to determine whether early therapeutic interventions enabled by early tumor growth detection prolong survival times and improve quality of life. (2019-05-28)

Researchers discover the Achilles' heel of an aggressive brain cancer
Researchers from the University of Helsinki, Finland, have discovered a chink in the armor of the tumor cells of glioblastoma, a lethal brain cancer. Alongside the finding, the researchers also came up with a method for attacking this vulnerability. The results gained in experiments conducted with cell cultures and a mouse model are promising. (2019-05-10)

Russian scientists developed a system for malignant brain tumors diagnosing during surgery
Scientists of the Research Medical University of Volga region and the Institute of Applied Physics, RAS have developed a system for malignant brain tumors diagnosing during surgery. The method is based on optical coherence tomography (OCT). Doctors obtained images of brain tissue that clearly show the differences between malignant and healthy cells. The method simplifies tumor removal operations and makes them more effective.The results were published in Frontiers in Oncology. (2019-05-06)

Bright spot analysis for photodynamic diagnosis of brain tumors using confocal microscopy
A Japan-based research team led by Kanazawa University have found that bright spot areas have generally lower fluorescence in brain tumors than in normal tissues in images captured by irradiation with a 405 nm wavelength laser and 544.5-619.5 nm band-pass filter. This may facilitate discrimination of glioblastoma with or without 5-aminolevulinic acid fluorescence and could be applicable to other tumors. (2019-04-11)

Shutting down deadly pediatric brain cancer at its earliest moments
Cell-by-cell genetic analyses of developing brain tissues in neonatal mice and laboratory models of brain cancer allowed scientists to discover a molecular driver of the highly aggressive, deadly, and treatment-resistant brain cancer, glioblastoma. Published in Cell Stem Cell, the findings present an opportunity to find out if new therapeutic approaches can stop glioblastoma at its earliest stages of initial formation or recurrence. (2019-04-11)

New hope for treating childhood brain cancer
Recent research has shown that a drug known as MI-2 can kill cells that cause a fatal brain cancer. But only now have scientists been able to explain how the compound works: by targeting cholesterol production in tumors. (2019-04-04)

New drug combination shows promise for common pediatric brain tumor
A new combination treatment aimed at resistant and recurrent low-grade gliomas slowed tumor growth and killed tumor cells in laboratory and mouse models. (2019-03-21)

Promising strategy to fight the most deadly brain tumor in children
A study published in Nature Communications found that an inhibitor of an enzyme called ACVR1 slows tumor growth and increases survival in an animal model of diffuse intrinsic pontine glioma (DIPG) -- the most deadly brain tumor in children. (2019-03-04)

Protein content as a marker for response to therapy in brain cancer
Brain tumors vary widely in how they respond to treatment. However, early assessment of therapy response is essential in order to choose the best possible treatment for the patient. Scientists from the German Cancer Research Center (DKFZ) have now been able to show in a study using non-invasive high-resolution 7-Tesla MRI scans that the protein content of tumors correlates with response to treatment and survival. (2019-02-28)

Study unveils a blueprint for treating a deadly brain tumor
In a study of mice and human brain tumors researchers at the University of the Michigan, Ann Arbor, searched for new treatments by exploring the reasons why some patients with gliomas live remarkably longer than others. The results suggested that certain patients' tumor cells are less aggressive and much better at repairing DNA than others but are difficult to kill with radiation. The researchers then showed that combining radiation therapy with cancer drugs designed to block DNA repair may be an effective treatment strategy. (2019-02-19)

New research findings could be key to improving outcomes for some brain cancers
Researchers from the University of Michigan Rogel Cancer Center have found that a genetic mutation seen in about half of all brain tumors produces a response that prevents radiation treatment from working. Altering that response using FDA-approved drugs restores tumors' sensitivity to radiation therapy, extending survival in mice. (2019-02-13)

Synodos does it again: Breaking barriers to solve the 'impossible' problems
Treatment for low-grade gliomas in patients living with neurofibromatosis type 1 are now one step closer thanks to recent research discoveries initiated and funded by the Children's Tumor Foundation. The Foundation's SYNODOS consortium has just recently been published in Nature Medicine, showing that immunotherapy has the potential to impact gliomas. (2018-12-27)

Artificial activation of cancer cells to destroy them
This risky method of anti-cancer therapy was suggested by scientists of Far Eastern Federal University (FEFU). Their review of mechanisms for molecular activation of stem cells of gliomas (most widely-spread brain tumors) was approved for publishing in the Frontiers in Cellular Neuroscience journal. (2018-12-26)

Some brain tumors may respond to immunotherapy, new study suggests
A new study suggests that a slow-growing brain tumor arising in patients affected by neurofibromatosis type 1 (NF1) may be vulnerable to immunotherapy, which gives the immune system a boost in fighting cancer. (2018-12-10)

New drug discovery could halt spread of brain cancer
A team of researchers at Virginia Tech may have found a solution to stopping the spread of glioblastoma with a new drug and cancer treatment method. This work is part of a five-year research grant project across multiple universities, examining the role of interstitial fluid flow in spreading glioma cells through the brain. (2018-11-19)

Cognitive decline -- radiation -- brain tumor prevented by temporarily shutting down immune response
In a new study published Nov. 13 in the journal eLife, UC San Francisco scientists report the first animal model of glioma -- the most aggressive and most common form of brain cancer in the US -- that can also be used to study the long-term effects of radiation therapy in tumor-bearing brains. Using this mouse model, the researchers showed that a drug that temporarily suppresses a key component of the brain's immune system can prevent radiation-associated cognitive decline. (2018-11-13)

Study shows potential to develop brain tumour liquid biopsies
Scientists are making strides in developing liquid biopsies for brain tumours by detecting tumour DNA in the fluid from around the brain and spine. (2018-11-06)

Fluorescent marker can help guide surgeons to remove dangerous brain tumor cells more accurately
A chemical that highlights tumor cells has been used by surgeons to help spot and safely remove brain cancer in a trial presented at the 2018 NCRI Cancer Conference. (2018-11-03)

HKUST-Beijing Tiantan Hospital scientists bring new hope to brain tumor patients
HKUST scientists in collaboration with medical staff at Beijing Tiantan Hospital undertook a groundbreaking large-scale study on secondary glioblastomas (sGBM) to search for new therapy treatments. sGBMs are an aggressive type of brain tumor, target younger patients and existing treatment method is insufficient. (2018-11-02)

A targeted approach to treating glioma
Researchers from MIT, Brigham and Women's Hospital, and Massachusetts General Hospital have developed a new way to treat low-grade glioma. They devised a test that can rapidly check for the IDH mutation during brain surgery, and if the mutation is present, they can implant microparticles that gradually release an IDH-targeted drug over several days or weeks. (2018-08-06)

Exposure to high-frequency electromagnetic fields at work not associated with brain tumors
No clear associations were found between occupational exposure to high frequency electromagnetic fields (EMF) and risk of glioma or meningioma, in one of the largest epidemiological studies performed to date and led by ISGlobal, an institution supported by 'la Caixa' Foundation. However, the findings highlight the need for further research on radiofrequency magnetic fields and tumor promotion, as well as possible interactions with other frequencies and with chemicals. (2018-07-31)

Altitude sickness drug appears to slow progression of glioblastoma
A drug used to treat altitude sickness may help patients with glioblastoma, according to a study published July 4, 2018, in the journal Science Translational Medicine. (2018-07-09)

MGMT promoter methylation associated with improved survival for patients with WHO Grade II Gliomas
Further exploration into the endpoints of the NRG Oncology/RTOG 0424 trial resulted in the discovery that MGMT promoter methylation is an independent prognostic biomarker of high-risk, low-grade glioma treated with temozolomide and radiation. This is the first study of its kind to validate the prognostic significance of MGMT promoter methylation in this patient population and treatment regimen. (2018-07-05)

A first look at interstitial fluid flow in the brain
Past research has shown a link between interstitial fluid flow and an increased invasion rate of glioblastoma cells, and biomedical researchers and electrical engineers recently developed a new method to measure and reconstruct interstitial fluid flow velocities in the brain. This method gives a first look at interstitial fluid flow dynamics in glioma models, and the technique can readily translate to clinical models already using contrast-enhanced MRI. The team describes their method in APL Bioengineering. (2018-07-03)

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