Current Glucose News and Events

Current Glucose News and Events, Glucose News Articles.
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Give the heart a ketone? It may be beneficial
There is growing evidence that ketone bodies may be beneficial to heart disease patients regardless of the method of delivery used to increase ketone delivery to the heart. A Journal of the American College of Cardiology review paper examines emerging evidence regarding ketone bodies' effects on the heart and the potential for ketone therapy as a cardiovascular intervention in heart disease patients. (2021-02-23)

An efficient method for separating O-18 from O-16, essential for use in cancer treatment
Positron Emission Tomography (PET) plays a major role in the early detection of various types of cancer. A research group led by Specially Appointed Professor Katsumi Kaneko of the Research Initiative for Supra-Materials (RISM), Shinshu University have discovered a method to separate oxygen-18 from oxygen-16, an essential isotope for PET diagnosis, at high speed and high efficiency. The results of this research were recently published online in the journal Nature Communications. (2021-02-18)

Association of maternal cardiovascular health during pregnancy with later health of offspring in adolescence
The observational study examined associations between maternal cardiovascular health during pregnancy (as measured by body mass index, blood pressure, total cholesterol level, glucose level and smoking) with the later cardiovascular health of their offspring at ages 10 to 14 years old (as measured by body mass index, blood pressure, total cholesterol level and glucose level). (2021-02-16)

Mother's heart health in pregnancy impacts child's heart health in adolescence
A mother's heart health while she is pregnant may have a significant impact on her child's cardiovascular health in early adolescence (ages 10 to 14), according to a new study. It is the first study to examine the implications of a mother's cardiovascular health during pregnancy for offspring health in the longer term. (2021-02-16)

Suppressive immune cells' metabolic vulnerability may be targeted for cancer immunotherapy
A Ludwig Cancer Research study has identified a novel mechanism by which a type of cancer immunotherapy known as CTLA-4 blockade can disable suppressive immune cells to aid the destruction of certain tumors. (2021-02-16)

New skin patch brings us closer to wearable, all-in-one health monitor
Engineers at the University of California San Diego have developed a soft, stretchy skin patch that can be worn on the neck to continuously track blood pressure and heart rate while measuring the wearer's levels of glucose as well as lactate, alcohol or caffeine. It is the first wearable device that monitors cardiovascular signals and multiple biochemical levels in the human body at the same time. (2021-02-15)

Dopamine is key to the mystery of metabolic dysfunction in psychiatric patients
Antipsychotic drugs not only block dopamine signaling in the brain but also in the pancreas, leading to uncontrolled production of blood glucose-regulating hormones, obesity and diabetes. (2021-02-15)

To improve immunotherapy, researchers look to shift immune cells' access to sugar
New research from Memorial Sloan Kettering scientists suggests that a way to improve immunotherapy is by altering immune cells' access to sugar. (2021-02-15)

Study: Diabetes complications in young children target the brain
Brain volume, verbal IQ, and overall IQ are lower in children with Type 1 diabetes (T1D) than in children without diabetes, according to a new longitudinal study published in Diabetes Care, a journal of the American Diabetes Association. The nearly eight-year study compared brain scans of young children who have T1D with those of non-diabetic children to assess the extent to which glycemic exposure may adversely affect the developing brain. (2021-02-10)

New targets for the development of a drug treatment for obesity and type 2 diabetes
The GIP receptor in the central nervous system plays a crucial role in the regulation of body weight and food intake. This is shown by a recent study by Helmholtz Zentrum München, ETH Zurich and the German Center for Diabetes Research (DZD). The study, which has now been published in 'Cell Metabolism', identifies new targets for the development of a drug treatment for obesity and type 2 diabetes. (2021-02-10)

Use of goldenseal may compromise glucose control in diabetics on metformin
Diabetic patients taking the natural product goldenseal while taking the prescription drug metformin may be unwittingly sabotaging their efforts to maintain healthy blood glucose levels. Metformin--the world's most-prescribed oral glucose-lowering medication--was included in a cocktail of selected drugs given to participants in a clinical study led by scientists at Washington State University. The study found that after six days of taking goldenseal, participants had about 25 percent less metformin in their bodies. (2021-02-08)

Type 2 diabetes: drugs initially increase glucose production
Although SGLT-2 inhibitors are central to the treatment of diabetes, their exact mode of action was hitherto unknown. A study shows that there is a direct correlation between the elimination of glucose via the kidneys and new glucose production in the liver. (2021-02-08)

"Prediabetes" diagnosis less useful in older patients
Older adults who are classified as having ''prediabetes'' due to moderately elevated measures of blood sugar usually don't go on to develop full-blown diabetes. (2021-02-08)

Beyond secretion of insulin,the novel function of β cell in regulating glucose homeostasis
In a new study published in Journal of Extracellular Vesicles, Chen-Yu Zhang's group and Antonio Vidal-Puig's group at University of Cambridge report that pancreatic β cells secrete miR-29 family members (miR-29a, miR-29b and miR-29c) in response to high levels of free fatty acids (FFAs). These β cell-derived miR-29s are delivered to the liver, promoting insulin resistance and enhancing hepatic glucose output. (2021-02-07)

Nickel phosphide nanoparticle catalyst is the full package
Osaka University researchers prepared a nickel phosphide nanoparticle catalyst on a hydrotalcite support (nano-Ni2P/HT) that showed high activity and selectivity in the hydrogenation of D-glucose to D-sorbitol. The catalyst was air-stable, reusable, and effective in water and at 25°C or 1 bar hydrogen gas pressure. Its mild operating conditions will contribute to the low-cost, green, and sustainable production of D-sorbitol for food, cosmetics, and pharmaceutical industries. (2021-02-04)

Researchers discover mechanism to overcome drug-resistance in leukemia
In a new study led by Yale Cancer Center, researchers have discovered a novel metabolic gatekeeper mechanism for leukemia. This mechanism depends on a molecule called PON2, which could lead to a new treatment for the disease. The findings were published online today in the Proceedings of the National Academy of Sciences. (2021-02-01)

Even machines need their greens
Image that products could be strengthened with the same living materials that provide nutrients to strengthen trees. Professor Qiming Wang's research lab is one of the first to infuse 3-D printer ink with living material. The material has potential for greater strength, to be flexible and self-heal. (2021-01-27)

Hybrid closed-loop insulin therapy improves glycemic control
Hybrid closed-loop insulin therapy improved glycemic control in adolescents and young adults with type 1 diabetes. These outcomes, derived from the International Diabetes Closed-Loop (iDCL) (2021-01-26)

Pancreatic β cell-derived exosomal miR-29 family enhances hepatic glucose output
In a new study published in Journal of Extracellular Vesicles, Chen-Yu Zhang's group at Nanjing University, School of Life Sciences, and Antonio Vidal-Puig's group at University of Cambridge report that pancreatic β cells secrete miR-29 family members (miR-29s) via exosomes in response to high levels of free fatty acids (FFAs). Theses β cell-derived exosomal miR-29s regulate glucose homeostasis through their manipulations on glucose output in liver. (2021-01-22)

Sloan Kettering Institute scientists solve a 100-year-old mystery about cancer
A long-standing mystery is why fast-growing cells, like cancer cells and immune cells, rely on a seemingly inefficient form of metabolizing glucose to power their activities. In a new study, scientists at the Sloan Kettering Institute offer a compelling solution. (2021-01-21)

NIH study compares low-fat, plant-based diet to low-carb, animal-based diet
People on a low-fat, plant-based diet ate fewer daily calories but had higher insulin and blood glucose levels, compared to when they ate a low-carbohydrate, animal-based diet, according to a small but highly controlled study at the National Institutes of Health. Led by researchers at the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the study compared the effects of the two diets on calorie intake, hormone levels, body weight, and more. (2021-01-19)

Moffitt researchers identify how cancer cells adapt to survive harsh tumor microenvironments
To better understand the conditions that select for the Warburg Effect and the mechanisms where cells can express this metabolic adaptation, Moffitt researchers subjected nonmalignant cells to the harsh tumor microenvironment that is present during early carcinogenesis, known as ductal carcinoma in situ. In a new research article published in the Proceedings of the National Academy of Sciences, the Moffitt team shows that these conditions select for cells to express a Warburg Effect. (2021-01-19)

Better diet and glucose uptake in the brain lead to longer life in fruit flies
Researchers from Tokyo Metropolitan University have discovered that fruit flies with genetic modifications to enhance glucose uptake have significantly longer lifespans. Looking at the brain cells of aging flies, they found that better glucose uptake compensates for age-related deterioration in motor functions, and led to longer life. The effect was more pronounced when coupled with dietary restrictions. This suggests healthier eating plus improved glucose uptake in the brain might lead to enhanced lifespans. (2021-01-16)

ADA lowers target HbA1C levels for children with type-1 diabetes
In early 2020, upon recommendation by leading endocrinologists, American Diabetes Association lowered the target hemoglobin A1C guidelines for children with type 1 diabetes. Their goal in recommending stricter glucose control was to ensure children with type 1 diabetes have better immediate and long-term health outcomes with fewer health complications and reduced mortality rates. In this ''Perspective'' article they discuss the evidence and rationale behind this new recommendation. (2021-01-14)

Same difference: predicting divergent paths of genetically identical cells
DALLAS - Jan. 11, 2021 - A set of biomarkers not traditionally associated with cell fate can accurately predict how genetically identical cells behave differently under stress, according to a UT Southwestern study. The findings, published by Cell Reports as a Dec. 1 cover story, could eventually lead to more predictable responses to pharmaceutical treatments. (2021-01-11)

Surrey unveils breakthrough manufacturing process of ultra-thin sensor for smart contact lenses
Smart contact lenses could soon become mainstream thanks to a new manufacturing process that has allowed the University of Surrey to develop a multifunctional ultra-thin sensor layer. (2021-01-06)

Research shows a few beneficial organisms could play key role in treating type 2 diabetes
Researchers have found that a few organisms in the gut microbiome play a key role in type 2 diabetes, opening the door to possible probiotic treatments for a serious metabolic disease affecting roughly one in 10 Americans. (2021-01-04)

Study of 50,000 people finds brown fat may protect against numerous chronic diseases
By far the largest of its kind in humans, the study confirms and expands the health benefits of brown fat suggested by previous research. (2021-01-04)

Common diabetes drug may trigger rare complications for COVID-19 patients
An uptick in a particular type of DKA called euDKA at Brigham and Women's Hospital during the COVID-19 pandemic has led researchers to hypothesize that diabetes patients on glucose-lowering drugs may be at increased risk for euDKA when they contract COVID-19. The observational case series was published in The American Association of Clinical Endocrinologists Clinical Case Reports. (2020-12-24)

New research highlights the importance of the thymus in successful pregnancies
How the immune system adapts to pregnancies has puzzled scientists for decades. Now, findings from an international group of researchers, led by researchers at Karolinska Institutet in Sweden, reveal important changes that occur in the thymus to prevent miscarriages and gestational diabetes. The results are published in the journal Nature. (2020-12-23)

New research highlights the importance of a forgotten organ in ensuring healthy pregnancies
An international research team led by UBC has uncovered for the first time the importance of a small gland tucked behind the sternum that works to prevent miscarriage and diabetes in pregnant women. (2020-12-23)

The thymus as key to healthy pregnancies
How the immune system adapts to pregnancy has puzzled researchers for decades. An international team of researchers, including scientists from IMBA (Institute of Molecular Biotechnology) of the Austrian Academy of Sciences has now discovered that important changes in the thymus occur in order to prevent miscarriages and gestational diabetes. The results are published in the journal Nature. (2020-12-23)

New drug combination could improve glucose and weight control in diabetes
Scientists have shown that adding an experimental cancer drug to a widely used diabetes treatment improves blood glucose control and weight loss in mice, according to a study published today in eLife. (2020-12-22)

New discovery opens novel pathway for high-titer production of drop-in biofuels
Using an unusual, light-dependent enzyme and a newly discovered enzymatic mechanism, researchers from Aarhus University and Massachusetts Institute of Technology have enabled the biological synthesis of high-yield industry relevant production of climate neutral drop-in fuels from biowaste. The study along with the new discovery has been published in Nature Communications. (2020-12-17)

CAN risk in diabetes reduced with intensive control of blood glucose and blood pressure
Cardiovascular autonomic neuropathy (CAN), a frequent but underdiagnosed complication of diabetes that can be life-threatening. Researchers found that intensive glycemic control reduced CAN risk by 17%, while intensive blood pressure control reduced risks by 22%. (2020-12-16)

Proteins enable crop-infecting fungi to 'smell' food
New UC Riverside research shows the same proteins that enable human senses such as smell also allow certain fungi to sense something they can eat. (2020-12-15)

Different forms of sugar impact hunger-suppressing hormones in young adults
Drinks with sucrose compared to glucose may cause young adults to produce lower levels of appetite-regulating hormones, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism. (2020-12-10)

Hydrogels with fine-toothed molecular combs may make enduring glucose-monitoring implants
In a new study, published online in the journal American Chemical Society (ACS) Applied Polymer Materials, scientists at Texas A&M University reported they have designed a hydrogel membrane that may be used to house optical glucose sensing materials, toward building a biosensor for monitoring sugar levels in diabetics. (2020-12-09)

How poor oral hygiene may result in metabolic syndrome
Researchers from TMDU identified a novel mechanism by which periodontal disease may cause metabolic syndrome. By studying patients with metabolic syndrome, the researchers demonstrated high antibody titers against Porphyromonas gingivalis, the bacterium causing periodontal disease. In a mouse model, the researchers then showed that infection with this bacterium causes systemic insulin resistance and metabolic dysfunction in skeletal muscle by altering the gut microbiome. This study shows the effect periodontal disease can have on the entire body. (2020-12-08)

Researchers use genomics to identify diabetic retinopathy factors
In the paper, ''Integration of genomics and transcriptomics predicts diabetic retinopathy susceptibility genes,'' published in eLife, researchers identified genes that respond differently in response to high glucose in individuals with and without diabetic retinopathy. (2020-12-07)

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