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Current Heart Muscle News and Events, Heart Muscle News Articles.
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Blocking protein restores strength, endurance in old mice, Stanford study finds
A single protein is a master regulator of mouse muscle function during aging, a Stanford study finds. Blocking this protein increased muscle strength and endurance in old animals. It may play a role in age-related muscle weakening in humans. (2020-12-10)

How poor oral hygiene may result in metabolic syndrome
Researchers from TMDU identified a novel mechanism by which periodontal disease may cause metabolic syndrome. By studying patients with metabolic syndrome, the researchers demonstrated high antibody titers against Porphyromonas gingivalis, the bacterium causing periodontal disease. In a mouse model, the researchers then showed that infection with this bacterium causes systemic insulin resistance and metabolic dysfunction in skeletal muscle by altering the gut microbiome. This study shows the effect periodontal disease can have on the entire body. (2020-12-08)

Grasping an object - model describes complete movement planning in the brain
Neurobiologists at the German Primate Center developed a model that for the first time can completely represent the neuronal processes from seeing to grasping an object. (2020-12-07)

Arctic ground squirrels recycle nutrients to endure deep hibernation
By studying the body chemistry of hibernating Arctic ground squirrels, researchers have found that the animals are able to recycle their body's own nutrients to survive during a long, inactive winter. A University of Alaska Fairbanks-led study monitored ground squirrels in a laboratory environment for two years, measuring the almost undetectable flow of nutrients through their hibernating bodies. Researchers found that the animals were able to convert the free nitrogen they were creating into amino acids. (2020-12-07)

Mimicking the effect of exercise with gene therapy
Gene therapy is the most effective method to be able to provide health benefits you normally gain through physical exercise. This means of ''training'' could be helpful for folks who can't exercise in the usual ways. (2020-12-04)

Researchers uncover significant reason older adults are at greater risk of heart attack
A team of surgeons has found an insufficient level of the protein Sesn2 is the reason older individuals are at greater risk of heart attack, which indicates stabilizing the protein could be the answer to maintaining a healthy heart. (2020-12-03)

Clinical trial results address concerns about pharmacogenetic testing
Researchers conducted a randomized controlled trial of pharmacogenetic testing related to cholesterol-lowering medications called statins.After one year, the cholesterol levels in the group who received their pharmacogenetic results were not higher than those in the group who did not receive their results, and they were not less likely to receive medical care meeting recommended guidelines. (2020-12-03)

Healthy muscles are a carrot on a string for healthy lungs
Scientists show effectiveness of carrot-based Japanese herbal medicine called ''Ninjin'yoeito'' in improving muscle atrophy in the hind legs of mice exposed to cigarette smoke through an increased expression of PGC-1α, positioning the medicine as a potential treatment for sarcopenia frailty-related complications with chronic obstructive pulmonary disease (COPD). Their findings were published online in the international scientific journal ''International Journal of Chronic Obstructive Pulmonary Disease'' on November 27, 2020. (2020-12-02)

Visualisation reveals how a protein 'hunkers down' to conserve energy
A visualisation made from nearly 100,000 electron microscope images has revealed the ingenious way a protein involved in muscle activity shuts itself down to conserve energy. The protein is called myosin and it is known as a molecular motor because of the way it interacts with other proteins and energy molecules to generate force and movement. It is found inside muscle fibres where it forms long myosin filaments made up of hundreds of individual myosin molecules. (2020-12-02)

AI abdominal fat measure predicts heart attack and stroke
Automated deep learning analysis of abdominal CT images produces a more precise measurement of body composition and predicts major cardiovascular events, such as heart attack and stroke, better than overall weight or body mass index (BMI), according to a study presented today at the annual meeting of the Radiological Society of North America (RSNA). (2020-12-02)

COVID-19 can impact young children's hearts
A 2-month-old infant diagnosed with COVID-19 experienced reversible myocardial injury and heart failure, similar to COVID-19 related heart issues seen in adults, according to a case published in JACC: Case Reports. The infant recovered with normal heart function and was discharged with no heart failure medications. (2020-12-02)

Molecule that regulates muscle adaptation to exercise is discovered
An article in Cell shows that the metabolite succinate is released by muscle cells during physical exercise and triggers a process of tissue remodeling that makes muscles stronger and enhances metabolic efficiency. (2020-12-01)

How thyroid function affects stress-related heart problems
Chest pain, shortness of breath, heart flutter and palpitations: these symptoms are not only characteristic of a heart attack, but can also be caused by another, as yet little researched condition. So-called Takotsubo cardiomyopathy is a rare but life-threatening disease of the heart that can occur during extreme stress events. Heart and hormone research teams in Bochum and Mannheim have now shown that there is apparently a strong link between the occurrence of Takotsubo syndrome and impaired thyroid function in patients. (2020-12-01)

Women found to be at higher risk for heart failure and heart attack death than men
Researchers found women face a 20% increased risk of developing heart failure or dying within five years after their first severe heart attack compared with men. In addition, women were more likely than men to be older and have a more complicated medical history at the time of their heart attacks. (2020-11-30)

Plant-based diet ramps up metabolism, according to new study
A plant-based diet boosts after-meal burn, leads to weight loss, and improves cardiometabolic risk factors in overweight individuals, according to a new randomized control trial published in JAMA Network Open by researchers with the Physicians Committee for Responsible Medicine. (2020-11-30)

Getting a grip on better health
Men with muscles like a young Arnold Schwarzenegger look powerful but a handshake will give away whether they're a healthy specimen - or at risk of a chronic disease or premature ageing, experts say. Medical researchers in South Australia assessed more than 600 men aged over 40 to 88 years in the Men, Androgen, Inflammation, Lifestyle, Environment, and Stress (MAILES) study to measure the link between sleep apnea and muscle mass with grip strength. (2020-11-29)

Age not just a number: Causes of joint stiffness differ between older and younger adults
As people age, joints become less flexible, causing balance problems that lower quality of life. Dr. Kosuke Hirata, Mr. Ryosuke Yamadera, and Prof. Ryota Akagi from the Shibaura Institute of Technology revealed that among younger adults, muscle but not nerve stiffness is associated with the ankle's range of motion (ROM), whereas only nerve stiffness is linked to ankle ROM among older adults. In other words, non-muscle tissue becomes more important for joint flexibility with age. (2020-11-25)

Minimal waste production is a fundamental law for animal locomotion
Is there a unifying principle underpinning animal locomotion in its rich diversity? The thermodynamic analysis shows why and how waste minimization prevails on efficiency or power maximization when it comes to free locomotion irrespective of the available mode and gaits. (2020-11-25)

Fruit flies reveal new insights into space travel's effect on the heart
Scientists at Sanford Burnham Prebys Medical Discovery Institute have shown that fruit flies that spent several weeks on the International Space Station (ISS)--about half of their lives--experienced profound structural and biochemical changes to their hearts. (2020-11-25)

The epidemiology of muscle-strengthening exercise in Europe: A 28-country comparison
A 28-country comparison of 280,605 adults reveals that just 17% of adult Europeans perform specific muscle-strengthening exercises--e.g.: squats, situps, and pushups--twice or more a week, as recommended by the WHO. (2020-11-25)

Aim to exceed weekly recommended physical activity level to offset health harms of prolonged sitting
The health harms associated with prolonged sitting can be offset by exceeding weekly recommended physical activity levels, says the World Health Organization (WHO) in new global guidelines on physical activity and sedentary behavior [1], published in a special dedicated issue of the British Journal of Sports Medicine. (2020-11-25)

How dolphins avoid "the bends"
New evidence indicates that dolphins are able to consciously slow down their heart rates when preparing to dive, and can even adjust their heart rates according to the length of their intended dive. This allows them to conserve oxygen and adjust their body to the changing pressure as they dive, therefore avoiding issues such as ''the bends''. (2020-11-24)

Scoring system improves screening for "dual" heart disease
Aortic stenosis is one of the most common heart valve defects. As well as conventional valve replacement involving open-heart surgery, a less invasive procedure has now been available for some time in the form of transcatheter aortic valve replacement (TAVR). (2020-11-24)

Treatment shows reduction in heart failure after myocardial infarction
Researchers at Baylor College of Medicine identified potential preventative therapies for heart failure after a significant heart attack. (2020-11-24)

Hypertrophic cardiomyopathy guideline encourages shared decision-making
The American Heart Association and the American College of Cardiology today released an updated guideline for managing patients with hypertrophic cardiomyopathy (HCM). The guideline encourages shared decision-making between the clinician and patient as essential when determining treatment course and updates recommendations for sudden cardiac death (SCD) risk assessment and HCM center referrals based on the latest evidence. (2020-11-20)

Adipose tissue may be the source of inflammatory factors that aggravate COVID-19
Preliminary results of patient tissue analysis show that the virus infects adipocytes and alters the quantity of signaling molecules released by these cells into the bloodstream. (2020-11-20)

Simple measurement could transform injury rehabilitation
Researchers from Edith Cowan University in Western Australia have found a simple way to analyse the effectiveness of exercise training that could one day be conducted easily at a local gym or physio. Using vertical jumps as a test activity, the researchers could predict detailed information regarding technique and muscle activation patterns just through a relatively simple analysis of forces produced against the ground during the jump. (2020-11-19)

A bypass route for the coronary vessels in the heart?
When the heart develops, some of its coronary blood vessels develop from cells lining the inner surface of the heart's ventricular chambers (endocardium). Novel findings suggest that new blood vessel growth in the heart can be stimulated with the VEGF-B growth factor from the same source after myocardial infarction to increase blood delivery to the damaged area. (2020-11-19)

A case of pediatric heart failure caused by anomalous origin of the left coronary artery from the pulmonary artery
In a new publication from Cardiovascular Innovations and Applications; DOI https://doi.org/10.15212/CVIA.2019.0585, Lei Zhang, Tiewei Lv, Xiaoyan Liu, Chuan Feng, Min Zheng, Jie Tian and Huichao Sun from the Children's Hospital of Chongqing Medical University, Chongqing, China and the Chongqing Key Laboratory of Pediatrics, Chongqing, China consider a case of pediatric heart failure caused by anomalous origin of the left coronary artery from the pulmonary artery. (2020-11-19)

Cellular pathway of genetic heart disease similar to neurodegenerative disease
Research on a genetic heart disease has uncovered a new and unexpected mechanism for heart failure. This landmark discovery found a correlation between the clumping of RNA-binding proteins long linked to neurodegenerative disease and the aggregates of protein found in the heart tissue of patients with RBM20 dilated cardiomyopathy. (2020-11-18)

New medication helps heart health in people with chronic kidney disease, Type 2 diabetes
Results of a large, international clinical trial on the novel medication finerenone indicate it reduced the rate of death, heart attack, stroke and hospitalization for heart failure among patients with chronic kidney disease and Type 2 diabetes. Finerenone helped patients with chronic conditions improve their heart health, regardless of if they had a history of cardiovascular disease. (2020-11-17)

High-dose equal to standard flu vaccine for risk of death or heart, lung hospitalization
A high-dose, trivalent influenza vaccine was no more effective than the standard-dose quadrivalent vaccine at reducing the risk of death or hospitalization for heart or lung-related causes among patients with heart disease. While overall there were few serious side effects in both vaccine groups, those who received the high-dose vaccine had more injection-related side effects such as pain, swelling and muscle aches. (2020-11-17)

Healthy sleep habits help lower risk of heart failure
Healthy sleep habits are associated with a lower risk of heart failure. Adults with the healthiest sleep patterns (morning risers, sleeping 7-8 hours a day and no frequent insomnia, snoring or excessive daytime sleepiness) experienced a 42% reduction in the risk of heart failure compared to those with unhealthy sleep patterns. (2020-11-16)

A change of heart -- new drug for HCM reduces heart mass
For the first time, a medication has impacted heart muscle thickness and function for patients with the most common inherited heart condition, hypertrophic cardiomyopathy, rather than simply addressing their symptoms. (2020-11-16)

Patients taking statins experience similar side effects from dummy pills
People taking dummy pills and statins experienced similar side effects in a new study. (2020-11-15)

Side effects often attributed to statins were the same for those taking a placebo
Study participants who reported side effects from cholesterol-lowering medications known as statins also reported the same side effects when they unknowingly took placebo pills. These side effects are real, and it appears may be mostly due to the psychological rather than the pharmacological effects of statins since symptoms were consistent when taking the placebo. (2020-11-15)

Additional heart imaging valuable for women with unexplained heart attacks
Combining diagnostic imaging methods can detect the underlying cause of heart attack in women who did not have blocked arteries. This international, diagnostic, prospective, observational study suggested that additional heart imaging is feasible and has the potential to guide medical therapy to prevent subsequent heart attacks. (2020-11-14)

A diet rich in ultra-processed fats and sugars increases the possibility of muscle pain
A research team from the Universitat Rovira i Virgili (Tarragona - Spain) has observed that following a diet rich in fats and sugars from ultra-processed foods (such as sweet rolls and pastries) for a six-week period increases the number of inflammatory molecules in the organism, which increases the excitability of the muscle nerves. This is known as musculoskeletal neurotransmission. (2020-11-13)

New medicine reduced risk for heart failure emergencies, hospital visits
Results from a large, Phase 3, global, cardiovascular outcomes study indicate a new medication may reduce the risk for heart failure-related events or cardiovascular deaths in people with chronic heart failure. (2020-11-13)

Intravenous iron reduced rehospitalization risk in people with heart failure
Iron deficiency is present in about 50% of people with chronic heart failure. Patients with heart failure who also have iron-deficiency are more likely to have poor outcomes. Intravenous iron replacement with ferric carboxymaltose reduced the risk of heart failure hospitalizations in patients with iron deficiency after an episode of acute heart failure. (2020-11-13)

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