Current Hepatocytes News and Events

Current Hepatocytes News and Events, Hepatocytes News Articles.
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Study introduces mRNA-LNP as a safe therapeutic intervention for liver regeneration
When severely or chronically injured, the liver loses its ability to regenerate. A new study led by researchers at the Center for Regenerative Medicine at Boston University School of Medicine (BUSM) and Boston Medical Center (BMC) now describes a safe new potential therapeutic tool for the recovery of liver function in chronic and acute liver diseases. (2021-01-27)

Induced liver regeneration enhances CRISPR/Cas9-mediated gene repair
Use of thyroid hormone to boost hepatocyte proliferation enhanced the efficiency of CRISPR/Cas9-mediated gene correction in the mouse liver. This dietary induction of hepatocyte regeneration may be a viable clinical strategy to enhance gene repair in the liver. (2020-11-10)

When malaria parasites trick liver cells to let themselves in
A new study led by Maria Manuel Mota, group leader at Instituto de Medicina Molecular, now shows that malaria parasites secrete the protein EXP2 that is required for their entry into hepatocytes. These findings, published today in the scientific journal Nature Communications, open a new avenue for prophylactic anti-malarial strategies, since blocking or decreasing the infection of the liver can prevent the disease. (2020-11-06)

Study shows main cell type in the liver has key role in defending against some viruses
Scientists at Scripps Research have uncovered an important disease-fighting role for cells called hepatocytes, which constitute most of the liver. The discovery could potentially be harnessed to develop new medicines for viral illnesses. (2020-10-16)

Study shows proof of concept of BioIVT HEPATOPAC cultures with targeted assay to evaluate bioactivation potential and drug-induced liver injury (DILI) risk
New in vitro Bioactivation Liver Response Assay used HEPATOPAC model to demonstrate utility of in vitro transcriptomic signature-based strategy in preclinical DILI risk assessment. (2020-10-12)

Snakes reveal the origin of skin colours
The skin colour of vertebrates depends on chromatophores. A team from the University of Geneva is studying the variety of colours within the corn snake species. The research, demonstrates that the dull colour of the lavender variant of corn snake is caused by the mutation of a gene involved in forming lysosomes enough to affect every skin colour. The UNIGE study marks a step forward in our understanding of the origin of skin colours. (2020-10-05)

Pigs grow new liver in lymph nodes, study shows
Hepatocytes -- the chief functional cells of the liver - are natural regenerators, and the lymph nodes serve as a nurturing place where they can multiply. Researchers demonstrated that large animals with ailing livers can grow a new organ in their lymph nodes from their own hepatocytes. (2020-08-24)

Hepatitis B: Natural controllers shed light on immunity mechanisms
To improve our understanding of the antibody response conferring protection against HBV infection, scientists from the Institut Pasteur and Inserm, in collaboration with the Roche Innovation Center in Switzerland, produced and characterized human monoclonal antibodies specific to viral envelope antigens, referred as HBsAg, from blood memory B cells isolated from HBV vaccinees and natural controllers. (2020-08-13)

Researchers find promising therapy to fight epidemic of liver disease
In an effort to combat a growing worldwide epidemic of Nonalcoholic Fatty Liver Disease (NAFLD), scientists have discovered a new target and a new therapy that has shown promising results in preclinical mouse models, according to researchers at the University of Colorado Anschutz Medical Campus. (2020-07-08)

Scientists found out how nanoparticles kill cancer cells
Because of their unique properties, magnetic nanoparticles can be used for therapeutic diagnostics and personalized treatment of cancer diseases, as well as be an effective contrast agent for MRI examination and imaging of tumors. (2020-06-25)

First successful delivery of mitochondria to liver cells in animals
This experiment marks the first time researchers have ever successfully introduced mitochondria into specific cells in living animals. The study lays the groundwork to address a serious gap in treatment for liver diseases and may even eventually be used to treat other maladies throughout the body affected by mitochondrial malfunction or damage. (2020-06-25)

Researchers discover key player in hepatitis A virus infection
University of North Carolina School of Medicine researchers designed experiments using gene-editing tools to discover how molecules called gangliosides serve as de facto gatekeepers to allow the virus entry into liver cells and trigger disease. (2020-05-26)

Ribosome biogenesis gene DEF/UTP25 is essential for liver homeostasis and regeneration
Digestive-organ-expansion-factor (Def) is a nucleolar factor. Depletion of Def causes hypoplastic digestive organs in zebrafish. Mechanistically, Def recruits cysteine proteinase Calpain3 (Capn3) to the nucleolus to cleave target proteins including p53 and Mpp10 during organogenesis. Here researchers demonstrate that Def is also essential for liver homeostasis and regeneration in mouse, a mammalian model. Their results reveal a novel feature of nucleolus, also called the 'nucleus of a nucleus', a subcellular organelle known for ribosome biogenesis. (2020-04-28)

A potential breakthrough in obesity medicine with the help of gold nanoparticles
A team of researchers in Korea believes to have discovered a synthetic gold-based compound which may help patients with obesity. The nanoparticles were tested in both 3T3-L1 and HepG2 cell lines, which are two known candidates for studying obesity and related disease models. (2020-04-14)

CRISPR-HOT: A new tool to 'color' specific genes and cells
Researchers from the group of Hans Clevers at the Hubrecht Institute have developed a new genetic tool to label specific genes in human organoids, or mini organs. They used this new method, called CRISPR-HOT, to investigate how hepatocytes divide and how abnormal cells with too much DNA appear. By disabling the cancer gene TP53, they showed that unstructured divisions of abnormal hepatocytes were more frequent, which may contribute to cancer development. (2020-03-02)

Possible new treatment strategy for fatty liver disease
Researchers at Karolinska Institutet in Sweden have identified a molecular pathway that when silenced could restore the normal function of immune cells in people with fatty liver disease. The findings could lead to new strategies for treating the condition, which is a major health risk for people with obesity. The study is published in the scientific journal Science Translational Medicine. (2020-02-26)

Magnetic nanomaterials become an effective treatment against liver fibrosis
Fibrosis may affect different body organs. It develops as a reaction to long-time inflammation and is supposed to isolate the inflammation site from surrounding tissues. For example, chronic liver fibrosis may occur if the liver is constantly influenced by toxins, viruses, or metabolic disturbances. Liver damage is caused by the hepatocytes death, the main type of liver cells that secure the functioning of the organ. (2020-01-20)

Percentage of African ancestry affects gene expression
The percentage of African ancestry in a person's genome determines the level that certain genes are expressed, called mRNA, according to a new Northwestern Medicine study. The discovery could offer insight into the different risk of diseases as well as a different response to medications in African Americans. This is the first study to compare gene production between African Americans. Previous studies compared only black and white individuals. (2019-12-02)

CeMM PR -- Immunity -- Master regulator of liver metabolism identified during infection
Researchers at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences identified a key mechanism for how antiviral immune responses reprogram liver metabolism. Their recent study, which was published in the renowned scientific journal Immunity, investigated the communication between inflammation and liver metabolism during chronic viral infection. (2019-11-26)

Regeneration mechanism discovered in mice could provide target for drugs to combat chronic liver disease
Researchers at the University of Cambridge have uncovered a novel molecular mechanism that allows damaged adult liver cells to regenerate, paving the way for design of drugs to boost regeneration in conditions such as cirrhosis or other chronic liver diseases where regeneration is impaired. (2019-11-04)

Liver transplants could be redundant with discovery of new liver cell
Researchers at King's College London have used single cell RNA sequencing to identify a type of cell that may be able to regenerate liver tissue, treating liver failure without the need for transplants. (2019-07-26)

A human liver cell atlas
The cellular composition of the liver is incompletely understood. Researchers at the Max Planck Institute for Immunobiology and Epigenetics have created a comprehensive map of all cell types in the healthy human liver using a method named single-cell RNA sequencing. They discovered new subpopulations of liver cell types and demonstrated the usefulness of their human liver cell atlas as a resource to reveal how cells change in liver cancer. The study was published in Nature. (2019-07-10)

How hepatitis B and delta viruses establish infection of liver cells
Princeton University researchers have developed a new, scalable cell culture system that allows for detailed investigation of how host cells respond to infection with hepatitis B (HBV) and delta virus (HDV). The paper describing their findings was published online on June 18, 2019 in the journal Hepatology. (2019-06-18)

Researchers identify human protein that aids development of malaria parasite
Researchers in Japan have discovered that the Plasmodium parasites responsible for malaria rely on a human liver cell protein for their development into a form capable of infecting red blood cells and causing disease. The study, which will be published June 12 in the Journal of Experimental Medicine, suggests that targeting this human protein, known as CXCR4, could be a way to block the parasite's life cycle and prevent the development of malaria. (2019-06-12)

'Organs in a dish' pave the way for personalized medicine in gut and liver disease
One of the most exciting advancements in stem cell research has been the development of organoid systems, which are organ-like three-dimensional structures that mimic their corresponding organ in vivo. In this important review in Digestive and Liver Disease, published by Elsevier, scientists highlight some of the established and exciting novel uses for organoids or 'organs in a dish' in gastroenterology and hepatology and look towards the future in this exciting field. (2019-06-03)

How viable is your liver after you die?
In a paper to be published in a forthcoming issue of TECHNOLOGY, a group of researchers from Harvard Medical School have done a study on the viability of donated livers and its correlation with donor demographics. The results of this study could reduce the number of livers that are discarded and facilitate development of novel therapeutics and bioengineering for clinical research applications. (2019-05-13)

New progress in developing an animal model of hepatitis C
Researchers studying hepatitis C virus have introduced small mutations into mouse liver cells to make the animals more susceptible to the virus, a step toward using mice in hepatitis C vaccine research. (2019-05-10)

New BioIVT research on botanical-drug interactions published in Applied In Vitro Toxicology
This study investigates the potential for clinically-relevant botanical-drug interactions (BDIs) with Boswellia serrata (Indian Frankincense), a botanical that is used as an anti-inflammatory supplement. The popularity of products containing B. serrata extract is growing. US retail sales of B. serrata reached $14.6 million in 2017 and it continues to move up the top 40 list of best-selling herbal supplements; it is currently ranked number 19. (2019-05-02)

Cancer most frequently spreads to the liver; here's why
When cancer spreads to another organ, it most commonly moves to the liver, and now researchers at the Abramson Cancer Center of the University of Pennsylvania say they know why. (2019-03-06)

Tissue model reveals how RNA will act on the liver
MIT researchers have shown an engineered model of human liver tissue can be used to investigate nucleic acid-based therapies, such as RNA interference, before testing them in patients. (2019-03-05)

New therapeutic avenue in the fight against chronic liver disease
A recent study, affiliated with South Korea's Ulsan National Institute of Science and Technology (UNIST) has introduced a novel targeted drug delivery system in the fight against cancer. (2019-01-18)

Real-time detection of cholesterol in liver-on-chip cultures of human liver cells
In a paper to be published in the September/December 2019 issue of TECHNOLOGY, a team of researchers from the IIT, Chicago, has developed a novel microfluidic device for measuring in real-time the cholesterol secreted from liver tissue-chip containing human hepatocytes. This innovation can help researchers employing microfluidic cultures to study the effects of drugs such as statins on lowering cholesterol in real-time. (2019-01-11)

Simple method rescues stressed liver cells
Isolated human hepatocytes are essential tools in preclinical and clinical liver research, but cell quality is highly variable. Now, researchers from Uppsala University have devised a simple protocol that improves hepatocyte quality and enables cells from a wider quality spectrum to be used in standard and advanced cell culture. The findings are published in Archives of Toxicology. (2018-12-21)

Revealing the molecular mystery of human liver cells
A map of the cells in the human liver has been created by University Health Network Transplant Program and University of Toronto researchers, revealing for the first time differences between individual cells at the molecular level which can have a profound impact on their behaviour in tissue, tumours and disease. (2018-10-22)

Clay supplements in dairy cows improve immune response to aflatoxin challenge, study says
In the fight against aflatoxin, dairy producers often turn to sequestering agents such as clay to reduce transference of the toxin into milk. It's an effective tactic, but a new study from the University of Illinois shows that clay has additional benefits for overall cow health. (2018-10-11)

Study: Damaged liver cells undergo reprogramming to regenerate
New research conducted by biochemists at the University of Illinois has determined how damaged liver cells repair and restore themselves through a signal to return to an early stage of postnatal organ development. (2018-09-26)

BioIVT publishes new research on the mechanisms underlying the C-DILI assay
BioIVT, a leading provider of research models and services for drug development, today announced its research into the mechanisms involved in cholestatic drug-induced liver injury (DILI) has been published in Applied In Vitro Toxicology. DILI is one of the primary causes of drug development failures. As a result, sponsors endeavor to identify new drug candidates with a high DILI risk early in the development process. (2018-09-10)

3D liver tissue implants made from human stem cells support liver function in mice
Stem cells transformed into 3D human liver tissue show promising support of liver function when implanted into mice with a liver disease. The scientists say that in addition to being early-stage progress towards developing human liver tissue implants, it could also reduce the need for animals in research by providing a better platform to study human liver disease and test drugs in the lab. (2018-08-27)

Fatty liver disease research set to benefit from stem cell advance
Scientists have developed a lab-based system for studying the most common type of liver disease, paving the way for research into new therapies. The team at the University of Edinburgh has devised a way to probe Non-Alcoholic Fatty Liver Disease, which affects up to one in three people, using cells in a dish. (2018-05-23)

Liver fix thyself
By studying a rare liver disease called Alagille syndrome, scientists discovered the mechanism behind a form of tissue regeneration that may someday reduce the need for organ transplants. Researchers report in Nature that when disease or injury causes a shortage in one type of liver cell, the organ can instruct another type of liver cell to change identities to provide replacement supplies. The findings one day may lead to a viable treatment for human disease. (2018-05-02)

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