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Current Hepatocytes News and Events, Hepatocytes News Articles.
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Interaction between lymph and liver cells may affect immune response
A new study on the ability of liver cells to interact with T cells (lymph cells that play a role in regulating the immune response) found that such interactions do occur and demonstrated the mechanism by which they may take place. The results may help explain the altered immune responses that occur with aging and other conditions and may be useful in developing therapies for viral hepatitis and autoimmune diseases. (2006-11-01)

Fatty acids and caveolin-1 are essential in liver regeneration
Lipids are the energy source used during liver regeneration. The research group, led by Dr. Albert Pol and with members from IDIBAPS, Universitat de Barcelona and Queensland University, unveils the essential role of the protein caveolin-1 in a fundamental process for liver cure after injury or transplant. Results also evidence the existence of cellular mechanisms by which excessive accumulation of lipids in the liver is a risk factor for the apparition of hepatic tumours. (2006-09-18)

Is liver damage down the TRAIL for a promising cancer therapy?
Although TRAIL is a protein that is considered a promising cancer therapeutic because it can kill tumor cells, controversy surrounds whether or not it affects nontumor cells. A new study now shows that TRAIL alone does not kill mouse liver cells in vitro, but it does enhance both in vitro and in vivo liver cell death induced by signaling through another liver cell protein, indicating that TRAIL-based therapeutics might cause liver damage. (2006-09-01)

Cincinnati surgeon's pediatric laparoscopic liver surgery a world first
A University of Cincinnati surgeon recently performed what is believed to be the world's first pediatric laparoscopic liver surgery, a specialized procedure for removing cancerous liver tumors without the need for a major incision. (2006-08-07)

Cycles of cell death, proliferation key to liver cancer
School of Medicine shows that liver cancer is likely caused by cycles of liver cell death and renewal. The research, appearing online the week of June 19 in advance of publication in the journal Proceedings of the National Academy of Sciences (2006-06-22)

Bile acids, receptor key in regenerating livers
Bile must have been the most important thing in medicine for the physicians of ancient Greece and Rome. Yellow bile and black bile are half of the four humors that they believed made up the body, along with blood and phlegm. In their view, restoring health required correcting imbalances in these four components. Studies by researchers from Baylor College of Medicine in a report that appears in today's issue of the journal Science suggest that they may have been on the right track. (2006-04-13)

Evolutionary conservation of a mechanism of longevity from worms to mammals
Though the study of aging in the nematode model organism C. elegans has provided much insight into this complex process, it is not yet clear whether genes involved in aging in the worm have a similar role in mammals. In a recent study, Dr. Hekimi and colleagues of McGill University (Canada) report that inactivation of the gene mclk1, the murine ortholog of the C. elegans gene clk-1, results in increased cellular fitness and prolonged lifespan in mice. (2005-10-03)

Gene therapy advance treats hemophilia in mouse models
A virus that typically infects insects could help with the development of gene therapy treatment for Hemophilia A, a condition in which even a bump on the knee can cause serious internal bleeding in people. The finding appears in the Sept. 1 issue of the journal Blood. (2005-08-22)

Tracking a killer: Observing liver invasion by malarial parasites
Tiny parasites of the Plasmodium genus causes malaria. New details of the parasites' life cycle are uncovered through the use of intravital microscopy to observe the parasites' infiltration of the liver in an article published in the open-access journal PLoS Biology. (2005-05-23)

New ways to ease liver disease
Many liver diseases are driven by immune-mediated mechanisms and therapies that can inhibit these immune-based triggers and block liver damage are needed. A study in the JCI identifies new targets in liver diseases using models of liver damage that causes hepatitis and involve T cells. Mechanisms involved in mediating IL-6 -- dependent protection -- included expression of two proteins in hepatocytes, KC and SAA2. KC and SAA2 may be of interest in developing therapies to treat immune-mediated liver disease in humans. (2005-03-03)

Embryonic stem cells treated with growth factor reverse hemophilia in mice
Embryonic stem cells treated in culture with a growth factor and then injected into the liver reverse a form of hemophilia in mice analogous to hemophilia B in humans, a study from the University of North Carolina at Chapel Hill shows. (2005-02-15)

Macrophages, not stem cells, correct liver disease by fusion
An Oregon Health & Science University study is defying a long-accepted assertion among many scientists that stem cells repair diseased tissue by transforming into other cell types in a process called plasticity. The first study from OHSU's Oregon Stem Cell Center, published in the journal Nature Medicine, found that mature macrophages derived from bone marrow stem cells, and not bone marrow stem cells themselves, are what fuse with diseased liver cells, ultimately curing a genetic liver disease. (2004-07-06)

Study may improve survival of transplanted livers
New research at the University of North Carolina at Chapel Hill School of Medicine shows that treatment with nitric oxide after storage may dramatically improve the viability of transplanted livers. (2004-05-24)

Bone marrow stem cells may one day help treat damaged livers
Research at Washington University School of Medicine in St. Louis suggests that stem cells from bone marrow or umbilical cord blood may be useful for treating people with liver damage due to cirrhosis, viral infection, trauma, chemotherapy or radiation therapy. (2003-05-14)

UNC to test new assist device for failed livers
A new bio-artificial technology about to undergo clinical tests at the University of North Carolina at Chapel Hill and several other centers nationally may help extend the lives of acute liver failure patients awaiting a donor liver and may even allow the damaged organ to heal itself completely. (2003-03-11)

U of Minnesota study: Adult bone marrow stem cells can become liver cells
Researchers at the University of Minnesota Stem Cell Institute (SCI) have demonstrated, for the first time, the ability of adult bone marrow stem cells to differentiate in vitro as hepatocytes (liver cells) with hepatocyte phenotype and function. (2002-05-15)

A new role for a versatile stem cell
Recent work has prompted a dramatic shift in thinking about cell regeneration, as researchers have come to appreciate the ability of adult stem cells to adopt the fates of many cell types, not just those in a particular tissue or a specific developmental lineage. (2002-05-15)

Insulin in heart development
Given the profound effects of insulin on energy metabolism and gene expression, it is not surprising that systemic deficiency in the insulin receptor (IR) leads to the early postnatal death of IR-deficient mice. However, a skeletal muscle-specific IR knockout (MIRKO) mice have been available for several years, and animals lacking the receptor in th pancreas or liver have been described. Belke et al. have now developed a mouse lacking the IR specifically in the heart. (2002-02-27)

Rethinking reverse cholesterol transport
The protective role of HDL, the so-called (2001-09-12)

Targeting metastatic disease with gene therapy
Because hepatocytes are constantly exposed to portal blood, the liver can be readily transduced with injected transgenes. Noting that this organ is also particularly prone to taking up metastatic colorectal tumor cells, Tada and colleagues have proposed to use gene therapy to render the liver a less hospitable environment for exogenous tumors. (2001-06-26)

Researchers discover adult stem cell that can transform itself into nearly any organ in the body
Adult stem cells that can create new liver, lung, gastrointestinal and skin cells, and possibly any other organ in the body, have been discovered in bone marrow, according to a newly-published study by a Yale researcher and collaborators. (2001-05-02)

A valuable lesson in gene therapy
A year after 18-year-old Jesse Gelsinger died after experimental gene therapy, US researchers are beginning to understand what went wrong. Their work may help to make gene therapy safer and prevent similar tragedies in the future. (2001-01-16)

Humans can regrow liver from bone marrow
Researchers have shown for the first time that the human liver can regenerate its tissue with a cell type from outside the organ -- and they present the first compelling evidence that those stem cells are human bone marrow. (2000-06-25)

Anti-cancer compound could cause serious liver damage, report University of Pittsburgh scientists
An anti-cancer compound initially slated to enter clinical trials within months could harm patients, according to a University of Pittsburgh report in the May issue of Nature Medicine. The Pittsburgh scientists found that TNF-related apoptosis inducing ligand (TRAIL) causes catastrophic damage to human liver cells. (2000-04-30)

Gene therapy useful in treating major complication of cirrhosis of the liver in animal studies
Duke University Medical Center researchers, using a modified cold virus, have delivered a nitric oxide-producing gene to key liver cells in rats, reversing the major complication of cirrhosis of the liver. (2000-03-13)

Duke study: Cold needed to preserve livers for transplant also can kill certain cells
A team of Duke University Medical Center researchers has figured out why donated livers can suffer a mysterious injury that damages their ability to perform well once transplanted. (1999-12-29)

Mature liver cells generated from bone marrow study in mice turns embryology on its head; implications are multifold
New research shows that mature liver cells are found in bone marrow turning embryology on its head. The possibilities include generating artificial livers. (1999-12-21)

Bone Marrow Gives Rise To Functioning Liver Cells, University Of Pittsburgh Scientists Discover
Bone marrow-derived cells give rise to fully functional liver cells, states a University of Pittsburgh study published May 14 in Science, yielding the first report that bone marrow- derived cells provide a lineage for cells of solid organs and suggesting that they could eventually repair or replace injured or diseased livers. (1999-05-14)

The Liver's Secret Of Regeneration
The key to the liver's amazing powers of regeneration could be stem cells migrating from bone marrow, say biologists in Pennsylvania. They hope that bone marrow stem cells could be used to grow new liver tissue for patients with cirrhosis. (1999-04-28)

University Of Pittsburgh Researchers Identify Immune System Process That Could Halt Progress Of Cirrhosis In Humans
Results of animal studies conducted at the University of Pittsburgh and being reported at Experimental Biology '99 dispel the notion that interleukin-6 causes liver fibrosis or cirrhosis and instead suggest that it is important to the liver's recovery. Patient studies will determine if IL-6 can slow liver disease progression. (1999-04-18)

First East Coast Patient Treated With Bioartificial Liver
Researchers at the University of North Carolina at Chapel Hill are the first on the East Coast to test the safety and efficacy of the bioartificial liver, HepatAssist. The patient, a 45-year-old woman from Winston-Salem, North Carolina, is the first person east of the Mississippi to receive HepatAssist therapy. (1998-07-30)

Duke Researchers Show That Anti-Cancer Agents Protect Donor Livers Awaiting Transplantation
After noticing -- almost entirely by chance -- the striking cellular similarities between the damage that occurs to donor livers awaiting transplantation and the very early stages of tumor growth, Duke University Medical Center researchers believe they have found a novel way of extending the amount of time livers can remain safely. (1997-10-31)

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