Current Human Genome News and Events

Current Human Genome News and Events, Human Genome News Articles.
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Largest comprehensive Middle East GWAS reveals Arab genetic risk factors
A new study in Nature Communications confirms that the existing global dataset of human genomes, which overrepresent European populations, does not accurately reveal the genetic architecture of diseases affecting Arab populations in the Middle East. The Qatar Foundation-led study of genetic variants across more than 6,000 individuals in Qatar is largest of its kind and a foundation for implementing precision medicine in the Middle East. (2021-02-23)

Advanced imaging technology captures translation of the maternal genome
An international collaboration among researchers from Finland, Sweden, UK and the USA has captured ribosomes translating messenger RNA expressed from the maternally inherited mitochondrial genome. Utilising the latest advances in cryo-electron microscopy, the group discovered a novel mechanism that mitochondrial ribosomes use for the synthesis and delivery of newly made proteins to prevent premature misfolding. Disruptions to protein folding can lead to devastating human diseases. (2021-02-22)

Tweaking corn kernels with CRISPR
Corn has a highly complex genome, making it a challenge to apply genome-editing techniques to it. CSHL Professor David Jackson and postdoctoral fellow Lei Liu used CRISPR to tinker with the corn genome promoter regions and modify stem cell growth. They figured out which sections influence kernel yield, and they hope to make targeted genome-editing in corn more precise and efficient. (2021-02-22)

'Jumping genes' repeatedly form new genes over evolution
A study, 'Recurrent Evolution of Vertebrate Transcription Factors by Transposase Capture,' published Feb. 19 in Science, investigates how genetic elements called transposons, or ''jumping genes,'' are added into the mix during evolution to assemble new genes through exon shuffling. (2021-02-22)

Don't focus on genetic diversity to save our species
Scientists at the University of Adelaide have challenged the common assumption that genetic diversity of a species is a key indicator of extinction risk. Published in the journal PNAS, the scientists demonstrate that there is no simple relationship between genetic diversity and species survival. But, Dr João Teixeira and Dr Christian Huber from the University of Adelaide's School of Biological Sciences conclude, the focus shouldn't be on genetic diversity anyway, it should be on habitat protection. (2021-02-22)

Advancing understanding of hop genome to aid brewers, medical researchers
Oregon State University and U.S. Department of Agriculture researchers have significantly expanded the understanding of the hop genome, a development with important implications for the brewing industry and scientists who study the potential medical benefits of hops. (2021-02-21)

Sex that is not for reproduction
Conjugation (or mating) of ciliates is a unique phenomenon among living beings. They have sex not for reproduction or pleasure - they seek to increase genetic variation. Scientists from St Petersburg University, together with colleagues from Poland and France, have studied the mating process in five sibling species of the Paramecium aurelia complex. Their findings enabled them to describe genetic mechanisms behind this phenomenon. (2021-02-19)

First multi-whole-genome study of IBD in African Americans
In African Americans, the genetic risk landscape for inflammatory bowel disease (IBD) is very different from that of people with European ancestry, according to results of the first whole-genome study of IBD in African Americans. The authors say that future clinical research on IBD needs to take ancestry into account. (2021-02-19)

A new piece of the HIV infection puzzle explored
Researchers from the European Molecular Biology Laboratory and Heidelberg University Hospital combine high-resolution imaging to observe the infection process in cell nuclei, opening the door for new therapeutics. (2021-02-18)

Scientists identify over 140,000 virus species in the human gut
Viruses are the most numerous biological entities on the planet. Now researchers at the Wellcome Sanger Institute and EMBL's European Bioinformatics Institute (EMBL-EBI) have identified over 140,000 viral species living in the human gut, more than half of which have never been seen before. (2021-02-18)

Mutation in SARS-CoV-2 spike protein renders virus up to eight times more infectious
A mutation in the spike protein of SARS-CoV-2--one of several genetic mutations in the concerning variants that have emerged in the United Kingdom, South Africa, and Brazil -- makes the virus up to eight times more infectious in human cells than the initial virus that originated in China, according to research published in the journal eLife. (2021-02-17)

New research identifies biological causes of muscle weakness in later life
A new largescale genetic analysis has found biological mechanisms that contribute to making people more susceptible to muscle weakness in later life, finding that diseases such as osteoarthritis and diabetes may play a large role in susceptibility. (2021-02-11)

Neandertal genes alter neurodevelopment in modern human brain organoids
Building modern human brain organoids with the Neanderthal variant of a gene has provided a glimpse into the way substitutions in this gene impacted our species' evolution. (2021-02-11)

New improved dog reference genome will aid a new generation of investigation
Researchers at Uppsala University and the Swedish University of Agricultural Sciences have used new methods for DNA sequencing and annotation to build a new, and more complete, dog reference genome. This tool will serve as the foundation for a new era of research, helping scientists to better understand the link between DNA and disease, in dogs and in their human friends. The research is presented in the journal Communications Biology. (2021-02-10)

Unusual DNA folding increases the rates of mutations
DNA sequences that can fold into shapes other than the classic double helix tend to have higher mutation rates than other regions in the human genome. New research shows that the elevated mutation rate in these sequences plays a major role in determining regional variation in mutation rates across the genome. (2021-02-09)

Not a living fossil: How the Coelacanth recently evolved dozens of new genes
The research shows the dramatic effect traveling DNA can have on the creation of genes and provide a glimpse into some of the forces that shaped the genome of one of the most ancient and mysterious organisms. (2021-02-09)

Researchers develop platform to identify cancer mutations that may be responsive to drug therapies
A Cleveland Clinic-led team of researchers has developed a personalized genomic medicine platform that will help advance accelerate genomic medicine research and genome-informed drug discovery, according to new study results published recently in Genome Biology. (2021-02-08)

Genes for face shape identified
Genes that determine the shape of a person's facial profile have been discovered by a UCL-led research team. (2021-02-05)

NUI Galway demonstrate the promise of precision genomics in cancer treatment
Researchers at NUI Galway have identified genomic signatures in women developing the most common type of breast cancer that can be associated with long-term survival. The NUI Galway team analysed the genomes of breast cancer patients to look for associations with survival rates using advanced statistical techniques. (2021-02-04)

New combination therapy offers chance of healing hepatitis B
Around 260 million people, more than three percent of the global population, are chronically infected with the hepatitis B virus (HBV); in the long term, this often leads to complications such as liver cirrhosis and liver cancer. A cure is not yet possible with the available medication. Scientists at the German Center for Infection Research (DZIF) and the University Hospital Eppendorf (UKE) have now investigated a new combination therapy that has proven highly effective in their infection model. (2021-02-04)

Special Issue: Human genome at 20
In February 2001, the first drafts of the human genome were published. (2021-02-04)

Thoughts on plant genomes
The growing world population and the challenges posed by climate change make the control of these natural resources one of the most crucial issues for all humanity in the future. In this regard, genome sequence information is of fundamental importance for understanding natural diversity and evolution of living organisms as well as for the design of breeding strategies aimed to produce new varieties with suitable traits. (2021-02-03)

Epigenomic map reveals circuitry of 30,000 human disease regions
MIT researchers have published the most comprehensive map yet of noncoding DNA circuitry, helping elucidate candidate mechanisms for 30,000 disease-associated regions. (2021-02-03)

The underestimated mutation potential of retrogenes
mRNA molecules from retrogenes are reverse transcribed to DNA and incorporated into the genome. (2021-02-02)

Stem cell study illuminates the cause of a devastating inherited heart disorder
Penn Medicine scientists have uncovered the molecular causes of a congenital form of dilated cardiomyopathy (DCM)-- one of multiple congenital disorders caused by inherited mutations in a gene called LMNA. The scientists used stem cell techniques to grow human heart muscle cells containing DCM-causing mutations in LMNA. They found that these mutations severely disrupt the structural organization of DNA in the nucleus of heart muscle cells. (2021-02-01)

Glitch in genome architecture may cause B-cell malignancies
Restoring an enzyme that maintains the way chromosomes are packed inside cells may lead to new therapies for some blood cancers, according to a new study by Columbia researchers. (2021-02-01)

Constructing the first version of the Japanese reference genome
The Japanese now have their own reference genome thanks to researchers at Tohoku University who completed and released the first Japanese reference genome (JG1). (2021-01-29)

Brain 3D genome study uncovers human-specific regulatory changes during development
A team led by Prof. SU Bing from the Kunming Institute of Zoology (KIZ) of the Chinese Academy of Sciences (CAS), Prof. LI Cheng from Peking University, and Prof. ZHANG Shihua from the Academy of Mathematics and Systems Science of CAS has reported the highest resolution by far of the 3D genome of the primate brain, and demonstrated the molecular regulatory mechanisms of human brain evolution through cross-species multi-omics analysis and experimental validation. (2021-01-28)

New study unravels Darwin's 'abominable mystery' surrounding origin of flowering plants
The origin of flowering plants famously puzzled Charles Darwin, who described their sudden appearance in the fossil record from relatively recent geological times as an 'abominable mystery'. (2021-01-28)

Viral sequencing can reveal how SARS-CoV-2 spreads and evolves
The article summarizes key insights about SARS-CoV-2 that have already been gained by sequencing of its genome from individual patient samples. It also cites challenges that remain, including the collection and integration of metadata into genetic analyses and the need for the development of more efficient and scalable computational methods to apply to hundreds of thousands of genomes. (2021-01-28)

'You say tomato, I say genomics': Genome sequences for two wild tomato ancestors
A research team led by University of Tsukuba has produced genome sequences for two wild species of tomato from South America, ancestors of the cultivated tomato. The ancestral species contain thousands of genes that are not present in modern types. The novel genes will help plant breeders produce new tomatoes with features like improved disease resistance, increased tolerance for the changing climate, and improved flavor and shelf-life. (2021-01-27)

Genome-editing tool TALEN outperforms CRISPR-Cas9 in tightly packed DNA
Researchers used single-molecule imaging to compare the genome-editing tools CRISPR-Cas9 and TALEN. Their experiments revealed that TALEN is up to five times more efficient than CRISPR-Cas9 in parts of the genome, called heterochromatin, that are densely packed. Fragile X syndrome, sickle cell anemia, beta-thalassemia and other diseases are the result of genetic defects in the heterochromatin. (2021-01-27)

Humanizing yeast ORC sheds light on cancer therapy and human development
Researchers from the HKSUST and the HKU recently demonstrated that the selectivity determinant of Origin Recognition Complex for DNA binding lies in a 19-amino acid insertion helix in the Orc4 subunit, which is present in yeast but absent in human. (2021-01-27)

Researchers identify genetic dependencies in tumors that have undergone whole genome doubling
Researchers from Boston University School of Medicine (BUSM) have identified proteins that are essential for the viability of whole genome doubled tumor cells, yet non-essential to normal cells that comprise the majority of human tissue. (2021-01-27)

Genetically-modified mosquitoes key to stopping Zika virus spread
In 2016, the World Health Organization called the Zika virus epidemic a ''public health emergency of international concern'' due to the virus causing birth defects for pregnant women in addition to neurological problems. (2021-01-26)

Researchers simplify the study of gene-environment interactions
Researchers at Weill Cornell Medicine and Cornell University's Ithaca campus have developed a new computational method for studying genetic and environmental interactions and how they influence disease risk. (2021-01-26)

Oncotarget: Prognostic biomarker for patients with hepatocellular carcinoma
Reduced expression of TBX15 in tumor tissue represents a potential biomarker for predicting poor survival of patients with HCC (2021-01-25)

Meta-Apo supports cheaper, quicker microbiome functional assessment
A new algorithm called Meta-Apo, developed by researchers led by JING Gongchao of the Qingdao Institute of BioEnergy and Bioprocess Technology (QIBEBT) of the Chinese Academy of Sciences (CAS) may reduce the need for expensive, time-consuming whole-genome sequencing computations to understand how a microbiome functions. (2021-01-22)

University of Cincinnati student uses zebrafish to study spinal deformities
Oriana Zinani, a doctoral student in molecular developmental biology at the University of Cincinnati, is part of a team of researchers using zebrafish embryos to study a gene mutation that causes scoliosis, a sideways curvature of the spine that typically occurs in humans just before puberty. (2021-01-22)

UMD researcher expands plant genome editing with newly engineered variant of CRISPR-Cas9
Recently named a Web of Science 2020 Highly Cited Researcher, Yiping Qi of the University of Maryland already has a new high-profile publication in 2021 introducing SpRY, a newly engineered variant of the famed gene editing tool CRISPR-Cas9. SpRY removes the barriers of what can and can't be targeted for gene editing, making it possible for the first time to target nearly any genomic sequence in plants for potential mutation. (2021-01-22)

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