Current Immune Cells News and Events

Current Immune Cells News and Events, Immune Cells News Articles.
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Researchers reveal genetic predisposition to severe COVID-19
HSE University researchers have become the first in the world to discover genetic predisposition to severe COVID-19. The results of the study were published in the journal Frontiers in Immunology. http://doi.org/10.3389/fimmu.2021.641900 (2021-02-23)

Innate immune system worsens the situation in severe COVID-19
In patients with severe COVID-19, the innate immune system overreacts. This overreaction may underlie the formation of blood clots (thrombi) and deterioration in oxygen saturation that affect the patients. This is shown in an Uppsala University study published in the journal Frontiers in Immunology. (2021-02-23)

Scientists identify potential contributor to hyper immune responses in patients with severe COVID-19
Researchers have pinpointed a helper T cell population in the lungs of patients with severe COVID-19 that may be central to the development of hyperinflammation, lung injury, and subsequent acute respiratory distress syndrome (ARDS) during disease (2021-02-23)

The unveiling of a novel mechanism of resistance to immunotherapy targeting HER2
VHIO investigators report how HER2 breast cancer cells adopt a strategy to resist clearance by redirected lymphocytes. Findings evidence that the disruption of interferon-gamma signaling confers resistance to these immunotherapies and promotes disease progression. Reported in Nature Communications, these results could help to potentiate future immune-based strategies and more precisely identify those patients who would be most likely to benefit from them. (2021-02-23)

New insights on how inflammatory molecule contributes to skin and pancreatic cancers
An immune molecule called interleukin-33 can act within a cell's nucleus to stimulate abnormal growth and division, ultimately resulting in cancer. Targeting interleukin-33 in the nucleus may help prevent certain cancers. (2021-02-22)

Absence of natural killer cell receptor associated with severe Covid-19
The course and severity of COVID-19 in individual patients is largely influenced by the interaction between the SARS-CoV-2 coronavirus and the human immune system. The NKG2C receptor communicates with an infected cell via one of its specialised surface structures, HLA-E, which results in the destruction of virus-infected cells. However, due to a genetic variation, approximately 4% of the population naturally lack the this receptor NKG2C, and in 30% of the population this receptor is only partially available. (2021-02-22)

High fructose diets could cause immune system damage
People who consume a diet high in fructose could risk damaging their immune systems. (2021-02-22)

Yale neurologists identify consistent neuroinflammatory response in ICH patients
Understanding how the immune system responds to acute brain hemorrhage could open doors to identifying treatments for this devastating disease. However, up until now, there has been limited information on inflammation in the brain from human patients, especially during the first days after a hemorrhagic stroke. This led a team of researchers to partner with a large clinical trial of minimally-invasive surgery to tackle defining the human neuroinflammatory response in living patients. (2021-02-22)

Oncotarget: MEK inhibitors relevant to SARS-CoV-2 infection
The @Oncotarget authors show a drug class-effect with MEKi to stimulate NK cells, inhibit inflammatory cytokines and block host-factors for SARS-CoV-2 infection leading also to suppression of SARS-CoV-2-S pseudovirus infection of human cells (2021-02-22)

Improving immunotherapies for blood cancers: real-time exploration in the tumor
Monoclonal antibodies are part of the therapeutic arsenal for eliminating cancer cells. Some make use of the immune system to act and belong to a class of treatment called ''immunotherapies.'' But how do these antibodies function within the tumor? And how can we hope to improve their efficacy? Using innovative in vivo imaging approaches, scientists from the Institut Pasteur and Inserm visualized in real time how anti-CD20 antibodies, used to treat B-cell lymphoma, guide the immune system to attack tumor cells. (2021-02-21)

Good cop, bad cop
Serendipitous observation leads to novel insight into how cancer-immune crosstalk can either promote or suppress tumour growth. Ultimately, this study's results may help develop novel cancer therapies as well as an assay to select patients for immunotherapy treatment. (2021-02-19)

Turbocharging the killing power of immune cells against cancer
Creating ''super soldiers'' of specific white blood cells to boost an anti-tumour response has been shown in a series of elegant experiments by Princess Margaret researchers. (2021-02-19)

3D biopsies to better understand brain tumors
Researchers at the Institut de Neurociències of the Universitat Autònoma de Barcelona (INc-UAB) obtained a highly accurate recreation of human glioblastoma's features using a novel 3D microscopy analysis. The study, published in the journal Acta Neuropathologica Communications, provides new information to help with the diagnose, by finding therapeutical targets and designing immunotherapeutical strategies. (2021-02-19)

Study reveals how a longevity gene protects brain stem cells from stress
A gene linked to unusually long lifespans in humans protects brain stem cells from the harmful effects of stress, according to a new study by Weill Cornell Medicine investigators. (2021-02-19)

Oil spill has long-term immunological effects in dolphins
A study published in Environmental Toxicology and Chemistry has found long-term impacts of the 2010 Deepwater Horizon oil spill in the northern Gulf of Mexico on bottlenose dolphins' immune function. (2021-02-18)

A new piece of the HIV infection puzzle explored
Researchers from the European Molecular Biology Laboratory and Heidelberg University Hospital combine high-resolution imaging to observe the infection process in cell nuclei, opening the door for new therapeutics. (2021-02-18)

Genetics may play role in determining immunity to COVID-19
UC San Diego researchers report that individual immune response to SARS-CoV-2 may be limited by a set of variable genes that code for cell surface proteins essential for the adaptive immune system. The finding may help explain why COVID-19 immunity varies by individual. (2021-02-18)

Neoadjuvant combination immunotherapy improves outcomes for early stage non-small cell lung cancer
The first randomized Phase II clinical trial to report on single and combined neoadjuvant immune checkpoint inhibitor therapy in stage I-III non-small cell lung cancer (NSCLC) found combination therapy produced a significant clinical benefit. (2021-02-18)

Antibody response may drive COVID-19 outcomes
Researchers at the Ragon Institute of MGH, MIT and Harvard and Massachusetts General Hospital show that levels of specific antibodies developed in the immune response may influence COVID-19 outcomes in both children and adults. (2021-02-18)

Handcuffing the culprit cancer: Immunotherapy for cold tumors with trispecific antibody
The recent discovery of ''bispecific antibodies'' has led to the development of effective immunotherapies against various cancers. Researchers have constructed a protein made up of anti-CD16, -IL-15, and -CD19 motifs, specifically designed to capture CD19-positive cancer cells and redirect them to natural killer (NK) cells. This protein also enhances the proliferation, homeostasis, activation, and survival of NK cells. This concoction has shown to induce killing of cancer cells in both cell cultures and in mouse models. (2021-02-18)

An mRNA vaccine for cancer immunotherapy
Messenger RNA (mRNA) vaccines to prevent COVID-19 have made headlines around the world recently, but scientists have also been working on mRNA vaccines to treat or prevent other diseases, including some forms of cancer. Now, researchers reporting in ACS' Nano Letters have developed a hydrogel that, when injected into mice with melanoma, slowly released RNA nanovaccines that shrank tumors and kept them from metastasizing. (2021-02-17)

Immune system protects children from severe COVID-19
Children are protected from severe COVID-19 because their innate immune system is quick to attack the virus, a new study has found. (2021-02-17)

Mimicking a chronic immune response changes the brain
Abnormal production of Inflammatory cytokines by the immune system is responsible for a host of autoimmune disorders. One important cytokine is IL-17A, which is also involved in neurological diseases. Researchers at Tsukuba University in Japan made a mouse model of chronically high IL-17A and to study its effect on the brain. They show that it leads to reduced activity and density of microglia in the brain's hippocampus, but no obvious memory deficits. (2021-02-17)

Dennis tamed the protein from hell in seven years
A research group from Aarhus University has succeeded in understanding why a very extended structure is important for an essential protein from the human immune system. The new results offer new opportunities for adjusting the activity of the immune system both up and down. Stimulation is interesting in relation to cancer treatment, while inhibition of the immune system is used in treatment of autoimmune diseases. (2021-02-17)

Cosmetic laser may boost effectiveness of certain anti-cancer therapies
In mice treated with cancer immunotherapy, shining a cosmetic laser on a tumor boosted the therapy's effectiveness. The strategy stimulated the immune system to attack nonmutated proteins on the tumor. The findings may help investigators make cancer immunotherapy effective against currently incurable cancers. (2021-02-17)

Immunosuppressive cell and cytokine response linked to bone nonunion
An abnormal suppression of the immune system linked to the onset of numerous diseases has been associated with poor functional regeneration of traumatic bone injuries. The discovery could guide a path for predicting which trauma patients may are less likely to respond to treatment. (2021-02-17)

TB study reveals potential targets to treat and control infection
Researchers at the Southwest National Primate Research Center (SNPRC) at Texas Biomedical Research Institute (Texas Biomed) may have found a new pathway to treat and control tuberculosis (TB), the disease caused by Mycobacterium tuberculosis (Mtb). Using single-cell RNA sequencing (scRNAseq), a next-generation sequencing technology, scientists were able to further define the mechanisms that lead to TB infection and latency. (2021-02-16)

How the immune system paves the way for SARS-CoV-2
The immune system actually wants to fight SARS-CoV-2 with antiviral signaling molecules. But a research team from Charité and MDC has now shown how such a signaling molecule can promote the replication of the virus. The results have been published in the journal EMBO Molecular Medicine. (2021-02-16)

Asthma may heighten flu risk and cause dangerous mutations
A subtype of asthma in adults may cause higher susceptibility to influenza and could result in dangerous flu mutations. University of Queensland-led animal studies have found that paucigranulocytic asthma (PGA) - a non-allergic form of the condition - allows the flu virus to flourish in greater numbers in sufferers. (2021-02-16)

Cancer research: Targeted elimination of leukemic stem cells
Cancer research in Bern has discovered a further mechanism to combat leukemia: a research team at Inselspital, Bern University Hospital and the University of Bern has succeeded in identifying an important signaling pathway for regulating leukemic stem cells. With this discovery, the researchers are expanding the arsenal of potentially highly effective drugs against leukemia. (2021-02-16)

Antibody-based COVID-19 treatments work best in concert with immune cells
Antibody-based drugs have been authorized for emergency use in COVID-19 patients by the Food and Drug Administration. Researchers at Washington University School of Medicine in St. Louis have discovered that the ability to interact with other elements of the immune system is an indispensable part of the effectiveness of such antibodies. The findings could help improve the design of the next generation of antibody-based COVID-19 drugs. (2021-02-16)

Combination treatment for common glioma type shows promise in mice
Gliomas are common brain tumors that comprise about one third of all cancers of the nervous system. In a study funded by the National Institutes of Health (NIH), researchers tested a novel combination treatment approach on mice with tumors with characteristics similar to human astrocytomas and found tumor regression in 60 percent of the mice treated. These encouraging results could be the first step toward developing a treatment for this type of brain cancer. (2021-02-16)

Suppressive immune cells' metabolic vulnerability may be targeted for cancer immunotherapy
A Ludwig Cancer Research study has identified a novel mechanism by which a type of cancer immunotherapy known as CTLA-4 blockade can disable suppressive immune cells to aid the destruction of certain tumors. (2021-02-16)

New immunotherapy target discovered for malignant brain tumors
Scientists say they have discovered a potential new target for immunotherapy of malignant brain tumors, which so far have resisted the ground-breaking cancer treatment based on harnessing the body's immune system. The discovery, reported in the journal CELL, emerged from laboratory experiments and has no immediate implications for treating patients. (2021-02-15)

Insight about tumor microenvironment could boost cancer immunotherapy
A paper published today in Nature shows how chemicals in the areas surrounding tumors - known as the tumor microenvironment - subvert the immune system and enable cancer to evade attack. These findings suggest that an existing drug could boost cancer immunotherapy. (2021-02-15)

Let the immune cell see the virus: Scientists discover unique way to target common virus
Scientists at Cardiff University have discovered a unique way to target a common virus that affects one in 200 newborn babies in the UK but for which there is only limited treatments available. (2021-02-15)

To improve immunotherapy, researchers look to shift immune cells' access to sugar
New research from Memorial Sloan Kettering scientists suggests that a way to improve immunotherapy is by altering immune cells' access to sugar. (2021-02-15)

Metabolic response behind reduced cancer cell growth
Researchers from Uppsala University show in a new study that inhibition of the protein EZH2 can reduce the growth of cancer cells in the blood cancer multiple myeloma. The reduction is caused by changes in the cancer cells' metabolism. These changes can be used as markers to discriminate whether a patient would respond to treatment by EZH2 inhibition. The study has been published in the journal Cell Death & Disease. (2021-02-12)

T cells depressed
In chronic infections, the immune system can become exhausted. Ludwig-Maximilians-Universitaet (LMU) in Munich researchers have looked into how this works. (2021-02-12)

New study identifies the main genetic causes of autoimmune Addison's disease
Scientists from the University of Bergen (Norway) and Karolinska Institutet (Sweden) have discovered the genes involved in autoimmune Addison's disease. (2021-02-12)

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