Current Immune Cells News and Events

Current Immune Cells News and Events, Immune Cells News Articles.
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Myeloid immune cells in the blood tied to severe COVID-19
Individual variations in how the immune system responds to SARS-CoV-2 appear to impact the severity of disease. Researchers at Karolinska Institutet in Sweden have now been able to show that patients with severe COVID-19 have significantly elevated levels of a certain type of immune cells in their blood, called myeloid-derived suppressor cells. The study published in the Journal of Clinical Investigation may bring an increased understanding of how early immune responses impact disease severity. (2021-01-26)

Multiple sclerosis: Immune cells silence neurons by removing synapses
Damage to the brain gray matter plays an important role in the progression of multiple sclerosis. This study now shows that such damage can be caused by inflammatory reactions that lead to loss of synapses, which impairs neural activity. (2021-01-26)

New study: Malaria tricks the brain's defence system
Malaria is one of the most common causes of death in children in Africa. When the parasite builds up in the blood vessels of the brain, it develops into one of the most dangerous forms of the disease, cerebral malaria. Though it wasn't certain if the parasite was able to penetrate the brain tissue, now researchers from the University of Copenhagen have found parasites can do that and have mapped the mechanism they utilise. (2021-01-26)

Two anti-viral enzymes transform pre-leukemia stem cells into leukemia
Viral infections and space travel similarly trigger inflammation and the enzymes APOBEC3C and ADAR1; UC San Diego researchers are developing ways to inhibit them as a means to potentially lower cancer risk for both astronauts and people on Earth. (2021-01-26)

Mouse study: gabapentin prevents harmful structural changes in spinal cord
Research led by The Ohio State University Wexner Medical Center and College of Medicine found that the widely prescribed pain-relief drug gabapentin can prevent harmful structural changes in the injured spinal cords of mice, and also block cardiovascular changes and immune suppression caused by spinal cord injury. (2021-01-26)

Researchers develop virus-based treatment platform to fight pancreatic cancer
Researchers from Queen Mary University of London and Zhengzhou University have developed a powerful therapeutic platform that uses a modified virus for the treatment of pancreatic cancer. (2021-01-26)

Fine tuning first-responder immune cells may reduce TBI damage
Immediately after a traumatic brain injury and as long as one year later, there are increased levels of immune cells called ILCs in the brain promoting inflammation, which can worsen brain damage, scientists report. They also report for the first time that the cell energy sensor AMPK is a brake that can stop what becomes a chronic state of destructive inflammation driven by these ILCs, or innate lymphoid cells. (2021-01-25)

Oncotarget: Improved therapeutic efficacy of unmodified anti-tumor antibodies
The Oncotarget findings suggest that MEKi induced an increased expression of tumor-associated antigens, which in combination with anti-tumor antibodies, generated a robust adaptive anti-tumor response that was sustained by immune checkpoint inhibition therapy. (2021-01-25)

Aging-US: Growth factor beta type 1 and hypoxia-inducible factor 1 transcription complex
''The Aging-US authors report for the first time that in human breast cancer, AML and embryonic cells, HIF-1 and AP-1 upregulate the expression of TGF-β'' (2021-01-25)

Novel molecules to combat asthma and covid-related lung diseases discovered
Australian researchers have made the extraordinary discovery of two molecules - one found in a commercially available dietary supplement - that provide profound protection in experimental models of asthma and can also substantially reduce the severity of asthma attacks. The molecules also appear to have a role in treating the respiratory illness that is often fatal in people with serious COVID-19. (2021-01-25)

Immune cells found in the brain are behind the depression experienced in inflammation
Special immune cells found in the brain, microglia, play a key role in the processes that make you feel uneasy and depressed in correlation with inflammation. This is the conclusion of a study using mice carried out by researchers at Linköping University, Sweden. The results have been published in the scientific journal Immunity, and suggest that microglial cells contribute to the negative mood experienced during several neurological diseases, and maybe also depression. (2021-01-25)

Missing protein helps small cell lung cancer evade immune defenses
Small cell lung cancer (SCLC) cells are missing a surface protein that triggers an immune response, allowing them to hide from one of the body's key cancer defenses, a new study led by UT Southwestern researchers suggests. The findings, reported online today in Cancer Research, a journal of the American Association for Cancer Research, could lead to new treatments for SCLC, which has no effective therapies. (2021-01-25)

Rhesus macaques develop promising immune response to SARS-CoV-2
In a promising result for the success of vaccines against COVID-19, rhesus macaque monkeys infected with the human coronavirus SARS-CoV-2 developed protective immune responses that might be reproduced with a vaccine. (2021-01-22)

Novel target identified that could improve safety of therapy for pancreatic cancer
Researchers from Queen Mary University of London, have identified a protein that may represent a novel therapeutic target for the treatment of pancreatic cancer. Using this protein as a target, the team successfully created a CAR T cell therapy - a type of immunotherapy - that killed pancreatic cancer cells in a pre-clinical model. (2021-01-22)

Exercising muscle combats chronic inflammation on its own
Biomedical engineers at Duke University have demonstrated that human muscle has an innate ability to ward off damaging effects of chronic inflammation when exercised. The discovery was made possible through the use of lab-grown, engineered human muscle, demonstrating the potential power of the first-of-its-kind platform in such research endeavors. (2021-01-22)

Immunology - Functionality of immune cells in early life
A study by Ludwig-Maximilians-Universitaet (LMU) in Munich researchers shows that putatively immature dendritic cells found in young children are able to induce robust immune responses. The results could lead to improved vaccination protocols. (2021-01-21)

Vaccine produces long-lasting anti-tumor response in patients with melanoma
Patients treated with a vaccine tailored to mutated proteins on patients' own tumor cells, continue to have a strong immune response to the cancer four years after being vaccinated. Results demonstrate the ability of personalized cancer vaccines to provide long-term immunity against some cancers. (2021-01-21)

Important cause of preeclampsia discovered
New findings show that cholesterol crystals in the uterine wall are the villain that researchers have been looking for. These crystals cause intensified inflammation in people who become ill. (2021-01-21)

A closer look at T cells reveals big differences in mild vs. severe COVID-19 cases
A big question on people's minds these days: how long does immunity to SARS-CoV-2 last following infection? Now a research team from La Jolla Institute for Immunology (LJI), The University of Liverpool and the University of Southampton has uncovered an interesting clue. Their new study suggests that people with severe COVID-19 cases may be left with more of the protective 'memory' T cells needed to fight reinfection. (2021-01-21)

Study reveals new insights into the link between sunlight exposure and kidney damage
A new collaborative study from researchers at the Geisel School of Medicine at Dartmouth and the University of Washington and published in the Proceedings of the National Academy of Sciences (PNAS), reveals unexpected insights into how skin exposure to ultraviolet light can worsen clinical symptoms in autoimmune diseases such as lupus. (2021-01-21)

Creating a safe CAR T-Cell therapy to fight solid tumors in children
Scientists modify CAR T-Cell therapy, making it more effective and less toxic, for possible use in solid tumors such as neuroblastoma. (2021-01-21)

Sloan Kettering Institute scientists solve a 100-year-old mystery about cancer
A long-standing mystery is why fast-growing cells, like cancer cells and immune cells, rely on a seemingly inefficient form of metabolizing glucose to power their activities. In a new study, scientists at the Sloan Kettering Institute offer a compelling solution. (2021-01-21)

New combination of immunotherapies shows great promise for treating lung cancer
McMaster University researchers have established in lab settings that a novel combination of two forms of immunotherapy can be highly effective for treating lung cancer, which causes more deaths than any other form of cancer. (2021-01-21)

Stanford study reveals immune driver of brain aging
Stanford scientists have identified a key factor in mental aging and shown that it might be prevented or reversed by fixing a glitch in the immune system's frontline soldiers. (2021-01-20)

Reviving exhausted immune cells to fight cancer
Eliminating a single gene can turn exhausted cancer-fighting immune cells known as CD8+ T cells back into refreshed soldiers that can continue to battle malignant tumors, a new study led by UT Southwestern researchers suggests. The findings, published online this week in the Journal for Immunotherapy of Cancer, could offer a new way to harness the body's immune system to attack cancers. (2021-01-20)

Target of new cancer treatment valid for breast as well as blood cancers: study
Newly published research shows that a new anti-cancer drug developed at the University of Alberta, set to begin human trials this year, may work against breast cancer as well as blood cancer. (2021-01-20)

COVID-19 model reveals key role for innate immunity in controlling viral load
Since SARS-CoV-2 was identified in December 2019, researchers have worked feverishly to study the novel coronavirus. Although much knowledge has been gained, scientists still have a lot to learn about how SARS-CoV-2 interacts with the human body, and how the immune system fights it. Now, researchers reporting in ACS Pharmacology & Translational Science have developed a mathematical model of SARS-CoV-2 infection that reveals a key role for the innate immune system in controlling viral load. (2021-01-20)

The immune system mounts a lasting defense after recovery from COVID-19
The study participants continued to improve their antibodies months after initial infection, potentially due to exposure to remnants of the virus hidden in the gut. (2021-01-20)

Spike proteins of SARS-CoV-2 relatives can evolve against immune responses
Scientists have shown that two species of seasonal human coronavirus related to SARS-CoV-2 can evolve in certain proteins to escape recognition by the immune system, according to a study published today in eLife. (2021-01-19)

Fatty acid may help combat multiple sclerosis
The abnormal immune system response that causes multiple sclerosis (MS) by attacking and damaging the central nervous system can be triggered by the lack of a specific fatty acid in fat tissue, according to a new Yale study. The finding suggests that dietary change might help treat some people with the autoimmune disease. (2021-01-19)

Timing is of the essence when treating brain swelling in mice
Researchers from the National Institutes of Health have discovered Jekyll and Hyde immune cells in the brain that ultimately help with brain repair but early after injury can lead to fatal swelling, suggesting that timing may be critical when administering treatment. These dual-purpose cells, which are called myelomonocytic cells and which are carried to the brain by the blood, are just one type of brain immune cell that NIH researchers tracked, watching in real-time as the brain repaired itself after injury. (2021-01-18)

New method to assist fast-tracking of vaccines for pre-clinical tests
A new method to synthesize vaccines safely and quickly should see much faster pre-clinical testing to pursue strategies to combat novel pathogens, something the COVID pandemic has shown is necessary. (2021-01-18)

FGF23 hormone from red blood cell precursors promotes hematopoietic stem cell mobilization
A Kobe University research group have discovered that fibroblast growth factor-23 (FGF23) produced by erythroblasts (cells that are the precursors of red blood cells) promotes the movement of hematopoietic stem cells into the peripheral blood. It is hoped that this discovery will enable new strategies to be developed for harvesting hematopoietic stem cells from bone marrow transplant donors. (2021-01-18)

COVID-19 has multiple faces
Scientists from the German Center for Neurodegenerative Diseases (DZNE) and the University of Bonn have found that COVID-19 comprises at least five different variants. These differ in how the immune system responds to the infection. (2021-01-18)

A trap for nematodes
Filariae, sometimes up to 70 centimeters long nematodes, can set up residence in their host quite tenaciously and cause serious infectious diseases in the tropics. Researchers have now investigated a mechanism by which the immune system attacks the filariae. Certain immune cells, the eosinophil granulocytes, release DNA that forms a kind of web around the larvae and traps them. The researchers also identified which protein ''turns on'' the mechanism, known as the Dectin-1 receptor. (2021-01-18)

RUDN University and RLT scientists: Light, magnetic field, and ultrasound could help fight COVID-19
A team of researchers from RUDN University and RLT suggested restoring normal levels of lymphocytes in patients with COVID-19 and other viral diseases by subjecting them to the combined influence of light, magnetic field, and ultrasound. (2021-01-18)

Armouring anti-cancer T cells against immunosuppressants
New 'armoured' T cells attack cancer without being suppressed by drugs given to transplant patients to avoid organ rejection. (2021-01-18)

T cells linked to myelin implicated in MS-like disease in monkeys
Scientists have uncovered new clues implicating a type of herpes virus as the cause of a central nervous system disease in monkeys that's similar to multiple sclerosis in people. By linking two specific T cells to the loss of myelin, scientists say the new study opens the possibility of developing an antiviral therapy that could be especially useful for newly diagnosed cases of multiple sclerosis. (2021-01-15)

Overactive food quality control system triggers food allergies, Yale scientists say
In a paper published Jan. 14 in the journal Cell, four Yale immunobiologists propose an expanded explanation for the rise of food allergies -- the exaggerated activation of our food quality control system, a complex and highly evolved program designed to protect us against eating harmful foods. (2021-01-14)

Triggering tumor antiviral immune response in triple negative breast cancer
Researchers at Baylor College of Medicine have discovered how therapeutics targeting RNA splicing can activate antiviral immune pathways in triple negative breast cancers (TNBC) to trigger tumor cell death and signal the body's immune response. (2021-01-14)

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