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Current Immune Cells News and Events, Immune Cells News Articles.
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Antitumoral effects of LXR activation
Tumor cells are able to avoid the attack of the immune system through several mechanisms. For instance, these can secrete factors that turn macrophages -cells in the immune system- into dual action agents that contribute to the tumor progress and will protect it from immune body defences: these become, thus, the tumor-associated macrophages (TAMs). (2021-02-12)

Sweet coating for sour bones
Scientists invent a bioactive coating to improve the function of titanium implants in osteoporotic bones. This coating, comprising a chemically-modified glycan, can sequentially turn on and off inflammation on titanium surface upon implantation. This modulation stimulates the body's immune system to promote bone healing in an effective and safe way, without addition of bone-forming genes or drugs, according to the data from a rat osteoporotic model. (2021-02-12)

Medication-based starvation of cancer cells
Immunomodulatory drugs, including the Contergan derivatives lenalidomide and pomalidomide have significantly improved the therapy of hematologic malignancies such as multiple myeloma. Researchers at the Technical University of Munich (TUM) have now further decoded the mode of action in this class of medications. At the same time, they identified new innovative targeted cancer therapies. (2021-02-12)

Gene variants increase risk of Addison's disease
Variants of nine genes increase the risk of developing Addison's disease, a rare disease in which the immune system attacks the adrenal glands. That is according to the largest genetic study to date on patients with Addison's disease. The findings help increase knowledge about what causes the disease. The study was conducted by researchers at Karolinska Institutet, Sweden, and Bergen University, Norway, and is published in the journal Nature Communications. (2021-02-11)

Cold sores: Discovery reveals how stress, illness and even sunburn trigger flareups
The finding could lead to new ways to prevent cold sores and herpes-related eye disease from reoccurring, the researchers report. (2021-02-11)

Get a load of ZIF! Better delivery of cancer immunotherapy
An antibody loaded onto a porous metal organic framework is released by the acidic environment that surrounds tumors, avoiding the adverse effects of administering the antibody alone. (2021-02-11)

Aggressive brain tumor mapped in genetic, molecular detail
A new study led by Washington University School of Medicine in St. Louis has revealed a detailed map of the genes, proteins, infiltrating cells and signaling pathways that play key roles in driving glioblastoma. The study, of 99 tumors from patients, is the largest and most detailed schematic of this deadly brain tumor. (2021-02-11)

New research identifies biological causes of muscle weakness in later life
A new largescale genetic analysis has found biological mechanisms that contribute to making people more susceptible to muscle weakness in later life, finding that diseases such as osteoarthritis and diabetes may play a large role in susceptibility. (2021-02-11)

SRC-3 is a novel regulator of human immune T regulatory cells
SRC-3, a prognostic marker for aggressive human breast and other cancers, also regulates human immune T regulatory cells (Tregs), which are involved in fighting cancer. (2021-02-11)

A new strategy to destroy cancer cells using magnetic nanoparticles and fields
The scientists analyzed how magnetic nanoparticles can be manipulated in in vitro conditions to achieve a selective antitumor effect. The method is based on the combined action of nanoparticles and permanent magnetic fields on human tumor cells. (2021-02-11)

STING activation reduces graft-versus-host disease in a mouse model
MUSC Hollings Cancer Center researcher Yongxia Wu, Ph.D., identified a new target molecule in the fight against graft-versus-host disease. (2021-02-11)

How research on chronic illnesses will improve COVID-19 treatment
A new paper in Oxford Open Immunology, published by Oxford University Press, examines prior findings in the field of neuroimmunology that suggest potential treatment strategies for patients suffering long-term symptoms from COVID-19. (2021-02-10)

Why Black men's prostate cancer may be more responsive to immunotherapy
Black men die more often of prostate cancer yet have greater survival benefits from immunotherapy treatment. A new study discovered the reason appears to be an increase of a surprising type of immune cell in the tumor. The findings could lead to immune-based precision medicine treatment for men of all races with localized aggressive and advanced prostate cancer. (2021-02-10)

Smectite promotes probiotic biofilm formation in gut for cancer immunotherapy
Orally administrating probiotics is ineffective due to the poor inhabitation of exogenous bacteria in host intestines. Chinese scientists report that smectite, a type of mineral clay and classical anti-diarrhoea drug, can promote the expansion of probiotics in the murine gut that subsequently elicits anti-tumor immune responses. Their findings suggest a novel approach to specifically enrich probiotics in the body, with high translational potential for cancer immunotherapy. (2021-02-10)

Response to cancer immunotherapy may be affected by genes we carry from birth
For all their importance as a breakthrough treatment, the cancer immunotherapies known as checkpoint inhibitors still only benefit a small minority of patients, perhaps 15 percent across different types of cancer. Moreover, doctors cannot accurately predict which of their patients will respond. (2021-02-10)

Novel protein could reverse severe muscle wasting in disease, aging and trauma
Muscle stem cells drive the tissue's growth and repair after such injuries. But growing these cells in the lab and using them to therapeutically replace damaged muscle has been frustratingly difficult. Australian researchers have discovered a factor that triggers these muscle stem cells to proliferate and heal. In a mouse model of severe muscle damage, injections of this naturally occurring protein led to the complete regeneration of muscle and the return of normal movement after severe muscle trauma. (2021-02-10)

Earliest signs of an immune response found in developing embryos
Researchers at the Centre for Genomic Regulation reveal that newly formed embryos clear dying cells to maximise their chances of survival. It is the earliest display of an innate immune response found in vertebrate animals to date. The findings may aid future efforts to understand why some embryos fail to form in the earliest stages of development, and lead to new clinical efforts in treating infertility or early miscarriages. (2021-02-10)

Scientists uncover four new facts about early SARS-CoV-2 infections
University of Minnesota Medical School researchers studied SARS-CoV-2 infections at individual cellular levels and made four major discoveries about the virus, including one that validates the effectiveness of remdesivir - an FDA-approved antiviral drug - as a form of treatment for severe COVID-19 disease. (2021-02-10)

Anti-cancer drug's mode of operation deciphered
Freiburg researchers show how the membrane protein CD20 keeps the immune system's antibody-producing cells in check. (2021-02-10)

Substance in the blood of pregnant women fights pathological immune reaction
Scientists studied the effect of trophoblastic β1-glycoprotein in the blood of pregnant women on pro-inflammatory immune cells. Thanks to trophoblastic β1-glycoprotein, a woman's body does not adversely react to the fetus and supports its normal development until birth. It turned out that trophoblastic β1-glycoproteins also suppressed the development of pro-inflammatory lymphocytes and reduced their activity. (2021-02-10)

How cells recycle the machinery that drives their motility?
Research groups at University of Helsinki and Institut Jacques Monod, Paris, discovered a new molecular mechanism that promotes cell migration. The discovery sheds light on the mechanisms that drive uncontrolled movement of cancer cells, and also revises the 'text book view' of cell migration. (2021-02-09)

Scientists switch on tissue repair in inflammatory bowel disease
Researchers have developed a method that instructs immune system cells to help repair damaged tissue in the intestine. The finding opens the way for more effective treatment of inflammatory bowel disease. (2021-02-08)

HIV: an innovative therapeutic breakthrough to optimize the immune system
Prompted by the need to improve conventional treatments for people infected with the human immunodeficiency virus (HIV-1), a team from the Institut national de la recherche scientifique (INRS) has identified a therapeutic approach to restore the effectiveness of immune cells. The study, led by doctoral student Hamza Loucif and Professor Julien van Grevenynghe, was published in the journal Autophagy. (2021-02-08)

Identification of three genes that determine the stemness of gastric tissue stem cells
Tissue stem cells can self-renew and differentiate, supplying cells necessary for tissues at various developmental stages. However, detailed analysis in vivo is difficult, so the molecular mechanisms underlying the stemness of gastric tissue stem cells have remained a mystery. Here, by using organoids that mimic tissue structure and function in vivo and GeCKO screening to inactivate arbitrary genes, Alk, Bclaf3 and Prkra have been identified as genes regulating stemness. (2021-02-08)

The genetic susceptibility of people with Down's syndrome to COVID-19
A study reveals the genetic factors that may expose or protect people with Down syndrome from SARS-CoV-2. TMPRSS2, a gene that codes for an enzyme critical for aiding the entry of SARS-CoV-2 in human cells, had 60% higher levels of expression in Down syndrome. The researchers also found higher expression levels for CXCL10, a gene that can trigger cytokine storms. The authors call to vaccinate people with Down syndrome against COVID-19 as a priority. (2021-02-08)

Some types of coronavirus steal the hosts' genes to elude their immune system
Researchers discovered this while analysing pathogens found in European hedgehogs that present the same strain of Beta-CoV responsible for both COVID-19 and MERS but without evidence of human transmissibility. It is the first time this ability is observed in coronaviruses (2021-02-08)

STINGing tumors with nanoparticles
DALLAS - Feb. 8, 2021 - A new nanoparticle-based drug can boost the body's innate immune system and make it more effective at fighting off tumors, researchers at UT Southwestern have shown. Their study, published in Nature Biomedical Engineering, is the first to successfully target the immune molecule STING with nanoparticles about one millionth the size of a soccer ball that can switch on/off immune activity in response to their physiological environment. (2021-02-08)

Immune response to insulin could identify, help treat those at risk for Type 1 Diabetes
Researchers from the Barbara Davis Center for Childhood Diabetes at the University of Colorado Anschutz Medical Campus have found that immune responses to insulin could help identify individuals most at risk for developing Type 1 diabetes. (2021-02-08)

MSK researchers learn what's driving 'brain fog' in people with COVID-19
A unique collaboration among experts from several areas within MSK leads to findings about how inflammation appears to be driving the neurologic effects seen in some COVID-19 patients. (2021-02-08)

Novel immunotherapy approach to treat cat allergy
Researchers from the Department of Infection and Immunity of the Luxembourg Institute of Health (LIH) brought forward the potential of high doses of a specific adjuvant molecule, namely CpG oligonucleotide, in successfully modulating the immune system's allergic response to the main cat allergen Fel d 1, thereby inducing a tolerance-promoting reaction and reverting the main hallmarks of cat allergy. (2021-02-05)

Study highlights risk of new SARS-CoV-2 mutations emerging during chronic infection
SARS-CoV-2 mutations similar to those in the B1.1.7 UK variant could arise in cases of chronic infection, where treatment over an extended period can provide the virus multiple opportunities to evolve, say scientists. (2021-02-05)

Fungi in the gut prime immunity against infection
Common fungi, often present in the gut, teach the immune system how to respond to their more dangerous relatives, according to new research from scientists at Weill Cornell Medicine. Breakdowns in this process can leave people susceptible to deadly fungal infections. (2021-02-05)

New biomarker may predict which pancreatic cancer patients respond to CD40 immunotherapy
Inflammation in the blood could serve as a new biomarker to help identify patients with advanced pancreatic cancer who won't respond to the immune-stimulating drugs known as CD40 agonists, suggests a new study from researchers in the Abramson Cancer Center of the University of Pennsylvania published in JCI Insight. (2021-02-04)

COVID-19 vaccine from new vaccine platform effective in mice
It is necessary to develop additional COVID-19 vaccines, as different vaccine approaches have their advantages and disadvantages and may work synergistically. Researchers at Karolinska Institutet in Sweden now report that they have developed a prototype vaccine against SARS-CoV-2 using a DNA vaccine platform that is inexpensive, stable, easy to produce, and shows a good safety profile. A study published in Scientific Reports shows that the vaccine induces potent immune responses in mice. (2021-02-04)

Mast cells: Sentinels and high-speed messengers of the immune defense
A team of scientists at the Institute for Molecular and Clinical Immunology at the Otto-von-Guericke University Magdeburg unravels a crucial mechanism of cell-cell-communication during the defense against pathogens. (2021-02-04)

New technique rapidly quantifies immune response following vaccination
A global team of researchers has developed a new strategy for fast and reliable antibody tests, which can quantify the immune response induced by vaccination and reveal the timeline and stage of pathogen infection. The team's one-step quantitative antibody tests are conducted using (blood) serum and are on a par with the gold-standard, enzyme-linked immunosorbent assay (ELISA) technique. (2021-02-04)

'Stealthy' stem cells better for treating tendon injuries in horses
Treating equine donor stem cells with a growth factor called TGF-β2 may allow them to avoid ''tripping'' the immune response in recipients, according to new research. (2021-02-04)

Uncovering a link between inflammation and heart disease
Patients with cardiac disease often have chronic inflammation that damages their hearts, even with no infection present. A new study published in Circulation reveals a mechanism that is activating T cells, a type of immune cell, and causing inflammation in the heart. (2021-02-04)

Fecal microbiota transplants help patients with advanced melanoma respond to immunotherapy
For patients with cancers that do not respond to immunotherapy drugs, adjusting the composition of microorganisms in the intestines--known as the gut microbiome--through the use of stool, or fecal, transplants may help some of these individuals respond to the immunotherapy drugs, a new study suggests. Researchers at the NCI, part of the National Institutes of Health, conducted the study in collaboration with investigators from UPMC Hillman Cancer Center at the University of Pittsburgh. (2021-02-04)

Human immune cells have natural alarm system against HIV
Researchers at Washington University School of Medicine in St. Louis have identified a potential way to eradicate the latent HIV infection that lies dormant inside infected immune cells. Studying human immune cells, the researchers showed that such cells have a natural alarm system that detects the activity of a specific HIV protein. Rather than attack the virus based on its appearance, this strategy is to attack the virus based on what it is doing -- vital activities that are required for the virus to exist. (2021-02-04)

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