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Current Immune Cells News and Events, Immune Cells News Articles.
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Releasing molecular 'brake' kick-starts immune cell function
The immune system's ability to marshal specialized cells to fight off infection relies in part on tiny molecules called microRNAs, which act as a release for the 'brakes' that keep cells dormant until needed, according to a new study published in the journal Cell Reports. (2020-05-18)

The malaria parasite P. vivax can remain in the spleen upon expression of certain proteins
The malaria parasite Plasmodium vivax can adhere to human spleen cells through the expression of so-called variant proteins. These are the conclusions of a study led by the Barcelona Institute for Global health (ISGlobal), an institution supported by 'la Caixa' and the Germans Trias i Pujol Institute (IGTP). The results, published in Proceedings of the National Academy of Sciences, suggest that this could represent an additional challenge to eliminating the disease. (2020-05-18)

'Cells-soldiers' turned to be more resistant than 'cells-combat medics'
Researchers from Sechenov University (Russia) and University of Pittsburgh (USA) discovered that the resistance of innate immune cells, macrophages, to ferroptosis -- a type of programmed cell death -- depends on the type of their activation. It turned out that cells helping tissues to recover from inflammation were more vulnerable. The researchers identified the mechanisms underlying the cells' resistance and explained how this research would help regulate inflammation in a paper published in Nature Chemical Biology. (2020-05-16)

Viral infection: Early indicators of vaccine efficacy
Ludwig-Maximilians-Universität (LMU) in Munich researchers have shown that a specific class of immune cells in the blood induced by vaccination is an earlier indicator of vaccine efficacy than conventional tests for neutralizing antibodies. (2020-05-15)

Controlling cells with light
Photopharmacology investigates the use of light to switch the effect of drugs on and off. Now, for the first time, scientific teams from Jena, Munich, and New York have succeeded in using this method to control a component of cells that was previously considered inaccessible. (2020-05-15)

Critical window for re-infection with HIV after stem cell transplantation
So far, allogeneic stem cell transplantation for the treatment of severe blood cancers has been the only medical intervention to have cured at least three people infected with the HI virus. It is still unclear why this procedure was unable to cure other HIV-infected patients successfully. In a study with 16 HIV infected people, scientists identified a critical time window after an allogeneic stem cell transplantation, during which the donor cells could be particularly vulnerable. (2020-05-14)

Moffitt Cancer Center study suggests more could benefit from CAR T-cell therapy
Moffitt Cancer Center organized a consortium of 16 cancer treatment facilities across the US that offer Yescarta as a standard-of-care therapy for patients with relapsed/refractory large B cell lymphoma. They wanted to determine if the safety and effectiveness seen in the ZUMA-1 clinical trial were similar for patients treated with the now commercially available CAR T therapy. Their findings were published in the Journal of Clinical Oncology. (2020-05-14)

Designing vaccines from artificial proteins
EPFL scientists have developed a new computational approach to create artificial proteins, which showed promising results in vivo as functional vaccines. This approach opens the possibility to engineer safer and more effective vaccines. (2020-05-14)

Detailed analysis of immune response to SARS-CoV-2 bodes well for COVID-19 vaccine
A new study documents a robust antiviral immune response to SARS-CoV-2 in a group of 20 adults who had recovered from COVID-19. The findings show that the body's immune system is able to recognize SARS-CoV-2 in many ways, dispelling fears that the virus may elude ongoing efforts to create an effective vaccine. (2020-05-14)

How COVID-19 kills
Experts review how the SARS-Cov-2 virus can cause an immune overreaction in the form of potentially lethal cytokine storm. (2020-05-13)

Assassin cells armed with anticancer drugs kill cancer masses
POSTECH Professor Won Jong Kim's team uses immunological synapse formation of natural killer cells to treat cancer. (2020-05-13)

Uncovering how 'dark matter' regions of the genome affect inflammatory diseases
A study led by researchers at the Babraham Institute in collaboration with the Wellcome Sanger Institute has uncovered how variations in a non-protein coding 'dark matter' region of the genome could make patients susceptible to complex autoimmune and allergic diseases such as inflammatory bowel disease. Published in the leading scientific journal Nature, the research identifies a new potential therapeutic target for the treatment of inflammatory diseases. (2020-05-13)

Cancer cells deactivate their 'Velcro' to go on the attack
To form metastases, cancer cells must be able to migrate. But cancer cells are connected to each other by 'Velcro'. University of Louvain (UCLouvain) researchers have discovered that certain cancer cells manage to suppress this 'Velcro' effect so that they can migrate more easily. It's a mechanism called endocytosis. The next step? Understanding the role of this mechanism (endocytosis) in the formation of metastases, which could ultimately help fight them! (2020-05-13)

How blocking iron drives the lung immune system to control infection
Scientists at Trinity College Dublin and St James's Hospital, Dublin have discovered how the iron chelator, DFX, which functions by attaching to iron, drives the immune system to deal with tuberculosis (TB). The findings have been published in the prestigious immunity journal, Frontiers in Immunology here: https://bit.ly/3dH6eix. (2020-05-13)

Scientists generate millions of mature human cells in a mouse embryo
A team led by University at Buffalo scientists has developed a method that dramatically ramps up production of mature human cells in mouse embryos. (2020-05-13)

Yale researchers discover how HIV hides from treatment
Even after successful antiretroviral therapy, HIV can hide dormant in a tiny number of immune system cells for decades and re-emerge to threaten the life of its host. Now Yale University researchers have discovered a molecular explanation for how the virus accomplishes this insidious trick, they report May 13 in the journal Science Translational Medicine. (2020-05-13)

Molecular signatures can predict the efficacy of malaria vaccines
Molecular signatures before and after immunization can predict vaccine-induced protection, according to a study by ISGlobal, an institution supported by 'la Caixa.' The study analysed the gene expression in peripheral blood cells from individuals immunized with the first malaria vaccine (Mosquirix or RTS,S) and another experimental malaria vaccine. The results, published in Science Translational Medicine suggest that boosting the immune system before vaccination could potentially improve vaccine efficacy. (2020-05-13)

Malaria vaccine trial samples reveal immune benchmarks for achieving protection
By studying samples from two independent clinical trials of malaria vaccines, Gemma Moncunill and colleagues have linked signatures in the immune system to better vaccine protection from the disease in children and adults. (2020-05-13)

Patients improve after heart cell therapy
Four of six critically ill COVID-19 (coronavirus) patients significantly improved after receiving an experimental therapeutic designed to reduce inflammation, a major cause of death from this disease, according to a case series published by Cedars-Sinai and Capricor Therapeutics. The four patients got well enough to be discharged from the hospital. (2020-05-12)

New weapon identified in arsenal against disease
New research describes the structure and composition of supramolecular attack particles (SMAPs) and their role in killing targeted cells. Identified as having a core of cytotoxic proteins surrounded by a glycoprotein shell the SMAPs are released by killer T cells and can be left in the environment like a landmine to await and destroy infected and cancerous cells. (2020-05-12)

Platelets exacerbate immune response
Platelets not only play a key role in blood clotting, but can also significantly intensify inflammatory processes. This is shown by a new study carried out by scientists from the University of Bonn together with colleagues from Sao Paulo (Brazil). In the medium term, the results could open up new ways to treat autoimmune diseases. They have now been published in the renowned journal Cell Reports. (2020-05-12)

The challenges of developing a safe and effective COVID-19 vaccine
Researchers at Baylor College of Medicine and colleagues identify critical points to pay close attention to when designing and developing COVID-19 vaccines. (2020-05-12)

Blood cells could serve as a 'thermometer' to detect breast cancer
This study shows that patients develop alterations in a type of leukocyte at the initial stage of the disease. This discovery paves the way for the enhanced diagnosis and treatment of this type of tumor. (2020-05-12)

Malaria vaccine: Could this 'ingredient' be the secret to success?
Melbourne researchers have identified a microscopic 'ingredient' that can be added to a malaria vaccine for efficient protection against the deadly pathogen. (2020-05-12)

New HIV vaccine strategy strengthens, lengthens immunity in primates
Investigators at the Stanford University School of Medicine and several other institutions have shown that a new type of vaccination can substantially enhance and sustain protection from HIV. (2020-05-11)

Researchers ID target for colorectal cancer immunotherapy
Researchers at the Indiana University Melvin and Bren Simon Comprehensive Cancer Center have identified a target for colorectal cancer immunotherapy. (2020-05-11)

University of Toledo scientists discover new targets for preventing damage from viral infections
When the body faces stressful conditions such as high temperatures or lack of nutrients, cells produce the same large structures they make to combat virus infections. (2020-05-11)

The microbiome controls immune system fitness
Working alongside colleagues in Mainz, Bern, Hannover and Bonn, researchers from Charité -- Universitätsmedizin Berlin, the Berlin Institute of Health (BIH) and the German Rheumatism Research Center Berlin (DRFZ) were able to show how the microbiome helps to render the immune system capable of responding to pathogens. If absent, relevant mediators are not released, resulting in a failure to activate metabolic processes in certain immune cells, according to the researchers' report, published in Cell*. (2020-05-11)

How herpes simplex virus can evade the immune response to infect the brain
A research team has discovered a molecular mechanism that helps Herpes simplex virus (HSV1) evade the innate immune system and infect the brain causing a rare disease with high mortality. The study from Aarhus University, University of Oxford, and University of Gothenburg, led by first author Chiranjeevi Bodda in Søren Paludan's lab, will be published May 8 in the Journal of Experimental Medicine (JEM). (2020-05-08)

More selective elimination of leukemia stem cells and blood stem cells
Hematopoietic stem cells from a healthy donor can help patients suffering from acute leukemia. However, the side effects of therapies are often severe. A group of researchers led by the University of Zurich have now shown how human healthy and cancerous hematopoietic stem cells can be more selectively eliminated using immunotherapy instead of chemotherapy in mice. The aim is to test the new immunotherapy in humans as soon as possible. (2020-05-08)

Newly discovered cell type plays crucial role in immune response to respiratory infections
With a discovery that could rewrite the immunology textbooks, an international group of scientists, including the teams of Bart Lambrecht, Martin Guilliams, Hamida Hammad, and Charlotte Scott (all from the VIB-UGent Center for Inflammation Research) identified a new type of antigen-presenting immune cell. (2020-05-08)

Immune system discovery paves way to lengthen organ transplant survival
A new discovery in mice shows the innate immune system has 'memory,' previously thought to be a unique feature of the adaptive immune system. Blocking this memory prevented transplanted organs from being rejected, providing a way to more specific drugs that could lengthen organ transplant survival. (2020-05-08)

Researchers have found accumulation of gene mutations in chronic Graft-versus-host disease
Mutations in white blood cells can contribute to abnormal immune profile after hematopoietic stem cell transplantation. (2020-05-07)

Stem cells shown to delay their own death to aid healing
A new study shows how stem cells -- which can contribute to creating many parts of the body, not just one organ or body part -- are able to postpone their own death in order to respond to an injury that needs their attention. The study was done in planarians, which are tiny worms used as model organisms to study regeneration because of their ability to recover from any injury using stem cells. (2020-05-07)

Interleukin-12 electroporation may sensitize 'cold' melanomas to immunotherapies
Combining intratumoral electroporation of interleukin-12 (IL-12) DNA (tavokinogene telseplasmid, or TAVO) with the immune checkpoint inhibitor pembrolizumab (Keytruda) led to clinical responses in patients with immunologically quiescent advanced melanoma, according to results from a phase II trial. (2020-05-06)

Bat 'super immunity' may explain how bats carry coronaviruses -- USask study
A University of Saskatchewan (USask) research team has uncovered how bats can carry the Middle East respiratory syndrome (MERS) coronavirus without getting sick -- research that could shed light on how coronaviruses make the jump to humans and other animals. (2020-05-06)

Fighting autoimmunity and cancer: The nutritional key
Scientists at the Department of Infection and Immunity of the Luxembourg Institute of Health (LIH) revealed a novel mechanism through which the immune system controls autoimmunity and cancer. In the special focus of the researchers were regulatory T cells -- a type of white blood cells that act as a brake on the immune system. (2020-05-06)

Lymphatic vessels in mice and humans: Alike yet different
In an international collaboration, researchers from Uppsala University have mapped the lymph node lymphatic vessels in mice and humans down to the level of individual cells. The results may eventually help scientists to discover new methods for strengthening the immune system against viruses and cancer. Their work has been published in the journal Frontiers of Cardiovascular Research. (2020-05-05)

Study finds unexpected suspect in age-related macular degeneration
Scientists have identified an unexpected player in the immune reaction gone awry that causes vision loss in patients with age-related macular degeneration (AMD), according to a new study published today in eLife. (2020-05-05)

Activation of the SARS coronavirus 2 revealed
A viral spike protein mediates entry of SARS-CoV-2 into host cells and harbors an unusual activation sequence. This sequence is cleaved by the cellular enzyme furin and the cleavage is important for the infection of lung cells. These results define new starting points for therapy and vaccine research. In addition, they provide information on how coronaviruses from animals need to change in order to be able to spread in the human population. (2020-05-04)

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