Current Immune Response News and Events

Current Immune Response News and Events, Immune Response News Articles.
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Innate immune system worsens the situation in severe COVID-19
In patients with severe COVID-19, the innate immune system overreacts. This overreaction may underlie the formation of blood clots (thrombi) and deterioration in oxygen saturation that affect the patients. This is shown in an Uppsala University study published in the journal Frontiers in Immunology. (2021-02-23)

Scientists identify potential contributor to hyper immune responses in patients with severe COVID-19
Researchers have pinpointed a helper T cell population in the lungs of patients with severe COVID-19 that may be central to the development of hyperinflammation, lung injury, and subsequent acute respiratory distress syndrome (ARDS) during disease (2021-02-23)

New insights on how inflammatory molecule contributes to skin and pancreatic cancers
An immune molecule called interleukin-33 can act within a cell's nucleus to stimulate abnormal growth and division, ultimately resulting in cancer. Targeting interleukin-33 in the nucleus may help prevent certain cancers. (2021-02-22)

Absence of natural killer cell receptor associated with severe Covid-19
The course and severity of COVID-19 in individual patients is largely influenced by the interaction between the SARS-CoV-2 coronavirus and the human immune system. The NKG2C receptor communicates with an infected cell via one of its specialised surface structures, HLA-E, which results in the destruction of virus-infected cells. However, due to a genetic variation, approximately 4% of the population naturally lack the this receptor NKG2C, and in 30% of the population this receptor is only partially available. (2021-02-22)

High fructose diets could cause immune system damage
People who consume a diet high in fructose could risk damaging their immune systems. (2021-02-22)

Yale neurologists identify consistent neuroinflammatory response in ICH patients
Understanding how the immune system responds to acute brain hemorrhage could open doors to identifying treatments for this devastating disease. However, up until now, there has been limited information on inflammation in the brain from human patients, especially during the first days after a hemorrhagic stroke. This led a team of researchers to partner with a large clinical trial of minimally-invasive surgery to tackle defining the human neuroinflammatory response in living patients. (2021-02-22)

Oncotarget: MEK inhibitors relevant to SARS-CoV-2 infection
The @Oncotarget authors show a drug class-effect with MEKi to stimulate NK cells, inhibit inflammatory cytokines and block host-factors for SARS-CoV-2 infection leading also to suppression of SARS-CoV-2-S pseudovirus infection of human cells (2021-02-22)

Researchers learn that pregnant women pass along protective COVID antibodies to their babies
Antibodies that guard against COVID-19 can transfer from mothers to babies while in the womb, according to a new study from Weill Cornell Medicine and NewYork-Presbyterian researchers published in the American Journal of Obstetrics and Gynecology. (2021-02-22)

Improving immunotherapies for blood cancers: real-time exploration in the tumor
Monoclonal antibodies are part of the therapeutic arsenal for eliminating cancer cells. Some make use of the immune system to act and belong to a class of treatment called ''immunotherapies.'' But how do these antibodies function within the tumor? And how can we hope to improve their efficacy? Using innovative in vivo imaging approaches, scientists from the Institut Pasteur and Inserm visualized in real time how anti-CD20 antibodies, used to treat B-cell lymphoma, guide the immune system to attack tumor cells. (2021-02-21)

Good cop, bad cop
Serendipitous observation leads to novel insight into how cancer-immune crosstalk can either promote or suppress tumour growth. Ultimately, this study's results may help develop novel cancer therapies as well as an assay to select patients for immunotherapy treatment. (2021-02-19)

Turbocharging the killing power of immune cells against cancer
Creating ''super soldiers'' of specific white blood cells to boost an anti-tumour response has been shown in a series of elegant experiments by Princess Margaret researchers. (2021-02-19)

Study reveals how a longevity gene protects brain stem cells from stress
A gene linked to unusually long lifespans in humans protects brain stem cells from the harmful effects of stress, according to a new study by Weill Cornell Medicine investigators. (2021-02-19)

Oil spill has long-term immunological effects in dolphins
A study published in Environmental Toxicology and Chemistry has found long-term impacts of the 2010 Deepwater Horizon oil spill in the northern Gulf of Mexico on bottlenose dolphins' immune function. (2021-02-18)

Genetics may play role in determining immunity to COVID-19
UC San Diego researchers report that individual immune response to SARS-CoV-2 may be limited by a set of variable genes that code for cell surface proteins essential for the adaptive immune system. The finding may help explain why COVID-19 immunity varies by individual. (2021-02-18)

Neoadjuvant combination immunotherapy improves outcomes for early stage non-small cell lung cancer
The first randomized Phase II clinical trial to report on single and combined neoadjuvant immune checkpoint inhibitor therapy in stage I-III non-small cell lung cancer (NSCLC) found combination therapy produced a significant clinical benefit. (2021-02-18)

Antibody response may drive COVID-19 outcomes
Researchers at the Ragon Institute of MGH, MIT and Harvard and Massachusetts General Hospital show that levels of specific antibodies developed in the immune response may influence COVID-19 outcomes in both children and adults. (2021-02-18)

Handcuffing the culprit cancer: Immunotherapy for cold tumors with trispecific antibody
The recent discovery of ''bispecific antibodies'' has led to the development of effective immunotherapies against various cancers. Researchers have constructed a protein made up of anti-CD16, -IL-15, and -CD19 motifs, specifically designed to capture CD19-positive cancer cells and redirect them to natural killer (NK) cells. This protein also enhances the proliferation, homeostasis, activation, and survival of NK cells. This concoction has shown to induce killing of cancer cells in both cell cultures and in mouse models. (2021-02-18)

Immune system protects children from severe COVID-19
Children are protected from severe COVID-19 because their innate immune system is quick to attack the virus, a new study has found. (2021-02-17)

Protein linked to Alzheimer's, strokes cleared from brain blood vessels
Amyloid deposits in the brain increase the risk of dementia and strokes. Researchers at Washington University School of Medicine in St. Louis have identified an antibody that clears amyloid deposits from the brain without raising the risk of brain bleeds. (2021-02-17)

Cosmetic laser may boost effectiveness of certain anti-cancer therapies
In mice treated with cancer immunotherapy, shining a cosmetic laser on a tumor boosted the therapy's effectiveness. The strategy stimulated the immune system to attack nonmutated proteins on the tumor. The findings may help investigators make cancer immunotherapy effective against currently incurable cancers. (2021-02-17)

Immunosuppressive cell and cytokine response linked to bone nonunion
An abnormal suppression of the immune system linked to the onset of numerous diseases has been associated with poor functional regeneration of traumatic bone injuries. The discovery could guide a path for predicting which trauma patients may are less likely to respond to treatment. (2021-02-17)

Answer quickly to be believed
When people pause before replying to a question, even for just a few seconds, their answers are perceived to be less sincere and credible than if they had replied immediately, according to research published by the American Psychological Association. (2021-02-16)

TB study reveals potential targets to treat and control infection
Researchers at the Southwest National Primate Research Center (SNPRC) at Texas Biomedical Research Institute (Texas Biomed) may have found a new pathway to treat and control tuberculosis (TB), the disease caused by Mycobacterium tuberculosis (Mtb). Using single-cell RNA sequencing (scRNAseq), a next-generation sequencing technology, scientists were able to further define the mechanisms that lead to TB infection and latency. (2021-02-16)

MSK physician shares kidney cancer research at annual ASCO GU Symposium
Memorial Sloan Kettering's Robert Motzer presented positive data from a phase III randomized study that assessed two different treatment combinations as first-line therapies that may benefit people with advanced kidney cancer. (2021-02-16)

How the immune system paves the way for SARS-CoV-2
The immune system actually wants to fight SARS-CoV-2 with antiviral signaling molecules. But a research team from Charité and MDC has now shown how such a signaling molecule can promote the replication of the virus. The results have been published in the journal EMBO Molecular Medicine. (2021-02-16)

Asthma may heighten flu risk and cause dangerous mutations
A subtype of asthma in adults may cause higher susceptibility to influenza and could result in dangerous flu mutations. University of Queensland-led animal studies have found that paucigranulocytic asthma (PGA) - a non-allergic form of the condition - allows the flu virus to flourish in greater numbers in sufferers. (2021-02-16)

Antibody-based COVID-19 treatments work best in concert with immune cells
Antibody-based drugs have been authorized for emergency use in COVID-19 patients by the Food and Drug Administration. Researchers at Washington University School of Medicine in St. Louis have discovered that the ability to interact with other elements of the immune system is an indispensable part of the effectiveness of such antibodies. The findings could help improve the design of the next generation of antibody-based COVID-19 drugs. (2021-02-16)

Suppressive immune cells' metabolic vulnerability may be targeted for cancer immunotherapy
A Ludwig Cancer Research study has identified a novel mechanism by which a type of cancer immunotherapy known as CTLA-4 blockade can disable suppressive immune cells to aid the destruction of certain tumors. (2021-02-16)

New immunotherapy target discovered for malignant brain tumors
Scientists say they have discovered a potential new target for immunotherapy of malignant brain tumors, which so far have resisted the ground-breaking cancer treatment based on harnessing the body's immune system. The discovery, reported in the journal CELL, emerged from laboratory experiments and has no immediate implications for treating patients. (2021-02-15)

Let the immune cell see the virus: Scientists discover unique way to target common virus
Scientists at Cardiff University have discovered a unique way to target a common virus that affects one in 200 newborn babies in the UK but for which there is only limited treatments available. (2021-02-15)

New insight into antibody-induced protective immunity to COVID-19
Researchers at the Ragon Institute of MGH, MIT and Harvard and the Brigham and Women's Hospital collaborate with SpaceX to identify humoral immune features which may track with lasting protection against SARS-CoV-2. (2021-02-15)

To improve immunotherapy, researchers look to shift immune cells' access to sugar
New research from Memorial Sloan Kettering scientists suggests that a way to improve immunotherapy is by altering immune cells' access to sugar. (2021-02-15)

Immunotherapy -- targeted drug combination improves survival in advanced kidney cancer
Patients with advanced kidney cancer, who received a targeted drug combined with a checkpoint-blocker immunotherapy agent had longer survival than patients treated with the standard targeted drug, said an investigator from Dana-Farber Cancer Institute, reporting results from a phase 3 clinical trial. (2021-02-13)

T cells depressed
In chronic infections, the immune system can become exhausted. Ludwig-Maximilians-Universitaet (LMU) in Munich researchers have looked into how this works. (2021-02-12)

New study identifies the main genetic causes of autoimmune Addison's disease
Scientists from the University of Bergen (Norway) and Karolinska Institutet (Sweden) have discovered the genes involved in autoimmune Addison's disease. (2021-02-12)

Antitumoral effects of LXR activation
Tumor cells are able to avoid the attack of the immune system through several mechanisms. For instance, these can secrete factors that turn macrophages -cells in the immune system- into dual action agents that contribute to the tumor progress and will protect it from immune body defences: these become, thus, the tumor-associated macrophages (TAMs). (2021-02-12)

Cold sores: Discovery reveals how stress, illness and even sunburn trigger flareups
The finding could lead to new ways to prevent cold sores and herpes-related eye disease from reoccurring, the researchers report. (2021-02-11)

Get a load of ZIF! Better delivery of cancer immunotherapy
An antibody loaded onto a porous metal organic framework is released by the acidic environment that surrounds tumors, avoiding the adverse effects of administering the antibody alone. (2021-02-11)

TalTech scientists developed novel immune diagnostics of multiple sclerosis
Multiple sclerosis (MS) is the most common neurological disease in young adults, affecting more than 2 million individuals worldwide, with about 1500 cases in Estonia. About 20% of MS patients experience optic neuritis (ON) as the presenting symptom, but not all ON patients develop MS. (2021-02-11)

SRC-3 is a novel regulator of human immune T regulatory cells
SRC-3, a prognostic marker for aggressive human breast and other cancers, also regulates human immune T regulatory cells (Tregs), which are involved in fighting cancer. (2021-02-11)

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