Current Inflammation News and Events

Current Inflammation News and Events, Inflammation News Articles.
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Medicine-carriers made from human cells can cure lung infections
Scientists used human white blood cell membranes to carry two drugs, an antibiotic and an anti-inflammatory, directly to infected lungs in mice. The nano-sized drug delivery method successfully treated both the bacterial growth and inflammation in the mice's lungs. The study shows a potential new strategy for treating infectious diseases, including COVID-19. (2020-12-03)

Liver cirrhosis: Disease progression
Patients with liver cirrhosis display a wide range of clinical symptoms. A prospective study conducted by MedUni Vienna has now shown that blood levels of biomarkers for systemic inflammation increase over the various stages of the disease and can predict the development of complications, even in previously asymptomatic patients. (2020-11-30)

Getting a grip on better health
Men with muscles like a young Arnold Schwarzenegger look powerful but a handshake will give away whether they're a healthy specimen - or at risk of a chronic disease or premature ageing, experts say. Medical researchers in South Australia assessed more than 600 men aged over 40 to 88 years in the Men, Androgen, Inflammation, Lifestyle, Environment, and Stress (MAILES) study to measure the link between sleep apnea and muscle mass with grip strength. (2020-11-29)

New breakthrough in the treatment of rheumatoid arthritis
People with Rheumatoid Arthritis (RA) could soon benefit from a new drug treatment, otilimab, that not only suppresses inflammation but also significantly reduces patient reported pain scores. (2020-11-25)

Animal-free method predicts nanoparticle toxicity for safer industrial materials
Researchers at Helmholtz Zentrum München together with scientists across Europe developed a novel animal-free method to predict the toxic effect of nanoparticles to the human lung. The method aims to enable the safety-by-design development of safer industrial materials. (2020-11-24)

COVID's collateral damage: Germicidal lamps may damage corneas
In a paper published in the journal of Ocular Immunology and Inflammation, physicians from the Bascom Palmer Eye Institute at the University of Miami Miller School of Medicine reported that several patients using germicidal lamps in an attempt to sanitize against the coronavirus, developed painful inflammation of the cornea, a condition called photokeratitis. These consumer-available ultraviolet (UV) emitting devices were being usedin an attempt toeliminate coronavirusfrom homes and offices. (2020-11-24)

Targeting calcium overload could improve stroke outcomes, research suggests
Excessive calcium contributes to harmful inflammation in ischemic stroke, and targeting it may provide doctors with a new way to improve patient outcomes. (2020-11-23)

Gut-brain axis influences multiple sclerosis
A Basel-led international research team has discovered a connection between the intestinal flora and sites of inflammation in the central nervous system in multiple sclerosis. A specific class of immune cell plays a central role in this newly identified gut-brain axis. The discovery could pave the way for new treatments for MS that target the intestinal flora. (2020-11-20)

Potential new target to combat inflammatory diseases
An international team of researchers have uncovered a drug-like compound that blocks a crucial inflammatory pathway, potentially paving the way for a new treatment for a host of diseases - including COVID-19. WEHI's Associate Professor Seth Masters and his research team discovered the compound could prevent up-regulation of CD14, a key inflammatory protein. The discovery was recently published in EBioMedicine. (2020-11-19)

Study pinpoints target for managing inflammation, promoting tissue repair
Drugs that can manage the activity of a protein called BCAP could help the body repair IBD-related tissue damage caused by inflammation, according to experts at Cincinnati Children's. (2020-11-16)

Study: Respiratory failure in COVID-19 usually not driven by cytokine storm
A study by researchers at Washington University School of Medicine in St. Louis and St. Jude Children's Research Hospital in Memphis showed that, contrary to expectation, most people with severe COVID-19 do not suffer from unbridled inflammation. The findings suggest that anti-inflammatory therapies may not be helpful for most COVID-19 patients. (2020-11-13)

Scientists pinpoint two new potential therapeutic targets for rheumatoid arthritis
A collaborative team of scientists has pinpointed two new potential therapeutic targets for rheumatoid arthritis - a painful inflammatory disease that affects an estimated 350 million people worldwide. (2020-11-12)

New study points to a better way to ward off asthma triggers
Every day, ten Americans die from asthma. While quick-acting inhalers and medications can reduce inflammation during an asthma attack, people with asthma have few tools to prevent the next attack from coming. Now researchers at La Jolla Institute for Immunology (LJI) have discovered that blocking two immune molecules at the same time is key to preventing asthma attacks in a mouse model. (2020-11-11)

The natural artistry of disease: a wintry landscape in the eye
Researchers from Tokyo Medical and Dental University (TMDU) report a case of frosted branch angiitis in a woman presenting years after being treated for leukemia-lymphoma with allogeneic human stem cell transplant. The relevance of this ocular finding is discussed and its value as an early warning sign of immune activation following therapeutic immunological interventions is highlighted. (2020-11-09)

RUDN University biologist found sex differences in inflammatory reactions in rat pups
A biologist from RUDN University studied the development of the immune response in prepubertal male and female animals. According to her, the severity and mortality of infectious and inflammatory diseases at this age depend not on the sex hormones, but mainly on the chromosome set or karyotype. (2020-11-09)

Methotrexate improves function in people with knee OA after 3 months
A new study presented at ACR Convergence, the American College of Rheumatology's annual meeting, shows that after three months of treatment with oral methotrexate, adults with primary knee osteoarthritis (OA) with inflammation had significant improvements in physical function and inflammation, a sign that this inexpensive, generic pill may be an important intervention for knee OA. (2020-11-06)

The ebb and flow of brain ventricles
Enlarged ventricles in the brains of people with multiple sclerosis were previously considered a sign of tissue loss. But a team at the MDC and ECRC demonstrated that this expansion often recedes. A study published in JCI Insight now shows that the process observed in mice is transferable to humans. (2020-11-05)

Rapid changes in biomarker of inflammation may be a key predictor of COVID-19 outcomes
Brigham and Women's Hospital researchers analyzed patients' levels of inflammation, known to be associated with severity of illness, by looking at C-reactive protein (CRP) trends in 100 COVID-19 patients admitted to the hospital. They found that a rapid rise in CRP levels during the first 48-to-72 hours of hospitalization was predictive of subsequent respiratory deterioration and intubation, while steadier CRP levels were observed in patients whose condition remained stable. (2020-11-05)

COVID-19 lung damage caused by persistence of 'abnormal cells'
Investigations of deceased COVID-19 patients have shed light on possible lung damage caused by the virus. (2020-11-03)

Avoiding inflammatory foods can lower heart disease, stroke risk
Diets high in red and processed meat, refined grains and sugary beverages, which have been associated with increased inflammation in the body, can increase subsequent risk of heart disease and stroke compared to diets filled with anti-inflammatory foods according to a study published today in the Journal of the American College of Cardiology. A separate JACC study assessed the positive effects eating walnuts, an anti-inflammatory food, had on decreasing inflammation and heart disease risk. (2020-11-02)

New cause of COVID-19 blood clots identified
A new study reveals that COVID-19 triggers production of antibodies circulating through the blood, causing clots in people hospitalized with the disease. (2020-11-02)

Cancer treatment could be replicated for COVID-19
Beta-blockers could potentially be used to treat COVID-19, according to a new international study by Italian and Australian scientists. (2020-11-02)

New cause of inflammation in people with HIV identified
A new study led by researchers at Boston Medical Center examined what factors could be contributing to this inflammation, and they identified the inability to control HIV RNA production from existing HIV DNA as a potential key driver of inflammation. (2020-10-30)

Eating less suppresses liver cancer due to fatty liver
Liver cancer from too much fat accumulation in the liver has been increasing in many countries including Japan. In order to change this unfortunate state of affairs, it is important to improve the prognosis of non-alcoholic fatty liver disease. Fatty liver is often improved through eating less, getting more exercise, and reducing body weight. The research group posed the question, ''Can eating less also suppress liver cancer caused by fatty liver?'' (2020-10-29)

Taking the itch out of cancer immunotherapy
Researchers from the University of Tsukuba have determined that PD-1 expression on CD8 T cells is the biological pathway that leads to psoriasis-like dermatitis, an unfavorable side effect of cancer immunotherapy with PD-1 inhibitors. This finding offers hope that blocking this pathway can prevent or reduce the undesirable side effect and help cancer patients continue their treatment with improved quality-of-life. (2020-10-26)

New insights into a potential target for autoimmune disease
With insights into a molecular pathway that regulates the activity of Tregs, a type of T cell involved in immunosuppression, research by the University of Pennsylvania's George Hajishengallis and colleagues opens up possibly new avenues for treating inflammatory and autoimmune diseases. (2020-10-26)

Plant compound reduces cognitive deficits in mouse model of Down syndrome
The plant compound apigenin improved the cognitive and memory deficits usually seen in a mouse model of Down syndrome, according to a study by researchers at the National Institutes of Health and other institutions. Apigenin is found in chamomile flowers, parsley, celery, peppermint and citrus fruits. The findings raise the possibility that a treatment to lessen the cognitive deficits seen in Down syndrome could one day be offered to pregnant women whose fetuses have been diagnosed with Down syndrome through prenatal testing. (2020-10-23)

Tryptophan's role in celiac pathway in mice points to treatment strategies
New studies in mice show how an inability to metabolize tryptophan may be related to celiac disease, according to Bruno Lamas and colleagues. (2020-10-21)

More turkey dinners for people with celiac disease?
An international team of researchers led by McMaster University has found that tryptophan, an amino acid present in high amounts in turkey, along with some probiotics, may help them heal and respond better to a gluten-free diet (2020-10-21)

Anti-inflammatory therapy shows promise in slowing progression of multiple sclerosis
Intranasal administration of an anti-inflammatory drug helped reduce disease progression in a preclinical model of multiple sclerosis, according to recent research out of the University of Alberta. (2020-10-20)

New study highlights links between inflammation and Parkinson's disease
An international collaboration involving researchers from the Luxembourg Centre for Systems Biology (LCSB) at the University of Luxembourg established an association between inflammation and specific genetic mutations in Parkinson's patients. The study, recently published in the scientific journal Brain, highlights two biomarkers that could be used to assess Parkinson's disease state and progression. The results also suggest that targeting the immune system with anti-inflammatory medication holds the potential to influence the disease course, at least in a subset of patients. (2020-10-14)

Maltreatment tied to higher inflammation in girls
New research by a University of Georgia scientist reveals that girls who are maltreated show higher levels of inflammation at an early age than boys who are maltreated or children who have not experienced abuse. (2020-10-14)

Bacterial toxin with healing effect
A bacterial toxin promoting tissue healing has been discovered by an international research team led by scientists from University of Jena (Germany). The compound α-Hemolysine found in Staphylococcus aureus does not just damage cells, but also stimulates tissue regeneration. (2020-10-13)

Stopping lethal lung damage from the flu with a natural human protein
The raging lung inflammation that can contribute to death from the flu can be stopped in its tracks by a drug derived from a naturally occurring human protein, a new animal study suggests. (2020-10-12)

Light stimulation makes bones heavier
Tokyo Medical and Dental University (TMDU) researchers showed that laser ablation of bone inhibits expression of the osteogenesis inhibitor protein sclerostin without causing inflammation, unlike the conventional bur-drilling technique. Further investigations confirmed that this beneficial bio-stimulation works by inducing mechanical stress. These findings help advance research into the treatment of osteoporosis as well as specific enhancement of bone regrowth in orthopedic and dental surgery. (2020-10-08)

Severe COVID-19 infection linked to overactive immune cells
Samples from the lungs of patients show a runaway immune system reaction could be one mechanism behind severe COVID-19 cases. (2020-10-08)

'Danger molecule' associated with being obese, female and black in younger adults
A 'danger molecule' is higher in the blood of younger black adults than whites, females than males and increases with weight and age, researchers report in the first large, longitudinal study associating circulating HMGB1 levels with obesity, inflammation promoters and early indicators of cardiovascular risk in humans. (2020-10-08)

New efficacies of Ganoderma lucidum: Treatment of skin conditions like atopic dermatitis
Ganoderma lucidum, known as Yeongji mushroom in Korea, has long been used medicinally in China, Japan and Korea. Ganoderic acid, an active ingredient found in the mushroom, is known for its excellence in enhancing the immune function of cells. The Korean research team determined the conditions for enhancing the anti-inflammatory, anti-diabetic, and antioxidant effects of Ganoderma lucidum and confirmed its marketability as an anti-inflammatory agent for the skin. (2020-10-07)

Taking the STING out of MND
Melbourne researchers are working towards a potential treatment to slow the progression of motor neuron disease (MND). The research team have uncovered how inflammation in MND is triggered. Pinpointing the molecules involved in this pathway could be a first step towards a new treatment for MND. (2020-10-07)

Forsyth researchers demonstrate how changing the stem cell response to inflammation may reverse periodontal disease
In new research published recently in the journal Frontiers in Immunology, Forsyth Institute scientists have discovered that a specific type of molecule may stimulate stem cells to regenerate, reversing the inflammation caused by periodontal disease. (2020-10-02)

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