Current Inflammatory Diseases News and Events

Current Inflammatory Diseases News and Events, Inflammatory Diseases News Articles.
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New strategy blocks chronic lung disease in mice
A new study from Washington University School of Medicine in St. Louis has uncovered a previously unknown role for exosomes in inflammatory respiratory diseases. The study has implications for finding new therapies. Exosomes are tiny compartments released from cells that carry different types of cargo, including inflammatory chemicals called cytokines that can drive lung disease. (2021-02-23)

New insights on how inflammatory molecule contributes to skin and pancreatic cancers
An immune molecule called interleukin-33 can act within a cell's nucleus to stimulate abnormal growth and division, ultimately resulting in cancer. Targeting interleukin-33 in the nucleus may help prevent certain cancers. (2021-02-22)

Discovery of a mechanism by which epithelial tumours cause developmental delays
- Conducted on the fly Drosophila, the study shows that tumours caused by chromosomal instability delay entry into the adult phase. - The tumours produce the Upd3 protein (equivalent to human Interleukin-6) to block the production of developmental steroid hormones. - The work of IRB Barcelona's Growth Control and Development laboratory has been published in the journal Current Biology. (2021-02-22)

CHOP experts describe types of rashes associated with MIS-C
In a study published in Open Forum Infectious Diseases, researchers at Children's Hospital of Philadelphia (CHOP) describe the array of rashes seen in MIS-C patients at their hospital through late July 2020, providing photos and information that could help doctors diagnose future cases. (2021-02-22)

Oncotarget: MEK inhibitors relevant to SARS-CoV-2 infection
The @Oncotarget authors show a drug class-effect with MEKi to stimulate NK cells, inhibit inflammatory cytokines and block host-factors for SARS-CoV-2 infection leading also to suppression of SARS-CoV-2-S pseudovirus infection of human cells (2021-02-22)

First multi-whole-genome study of IBD in African Americans
In African Americans, the genetic risk landscape for inflammatory bowel disease (IBD) is very different from that of people with European ancestry, according to results of the first whole-genome study of IBD in African Americans. The authors say that future clinical research on IBD needs to take ancestry into account. (2021-02-19)

Radiological images confirm 'COVID-19 can cause the body to attack itself'
Muscle soreness and achy joints are common symptoms among COVID-19 patients. But for some people, symptoms are more severe, long lasting and even bizarre, including rheumatoid arthritis flares, autoimmune myositis or 'COVID toes.' A new Northwestern Medicine study has, for the first time, confirmed and illustrated the causes of these symptoms through radiological imaging. (2021-02-17)

How inflammatory signalling molecules contribute to carcinogenesis
A team of MedUni Vienna researchers led by Johannes A. Schmid at the Center for Physiology and Pharmacology, Institute of Vascular Biology and Thrombosis Research, has managed to identify a previously unknown molecular connection between an inflammatory signalling molecule and one of the main oncogenes. The study has been published in the leading journal 'Molecular Cancer'. (2021-02-17)

Fatty tissue accumulated in the neck linked to heart problems, study finds
Researchers from the University of Granada warn that an accumulation of fatty tissue in the neck (both the double chin and the deeper deposits, located between muscles and around the cervical vertebrae) is a predictor of central and overall adiposity, cardiometabolic risk, and a pro-inflammatory profile in sedentary young adults (2021-02-17)

New potential therapy for Crohn's disease in children
Scientists from the Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago demonstrated that a nanotherapy reduces intestinal inflammation and shrinks lesions in a rodent model of severe Crohn's disease. (2021-02-17)

New synthetic peptides could attenuate atherosclerosis
Atherosclerosis, a lipid-triggered chronic inflammatory disease of our arteries, is the main cause of strokes and heart attacks. An international team of researchers led by the Technical University of Munich (TUM) and the LMU University Hospital has developed novel synthetic peptides that can help to prevent atherosclerosis in vitro, that is in the test tube, as well as in animal models. (2021-02-12)

Spinal fluid of people with Alzheimer's risk gene signals inflammation
People who have a gene variant associated with an increased risk of developing Alzheimer's disease also tend to have changes in the fluid around their brain and spinal cord that are detectable years before symptoms arise, according to new research from Duke Health. (2021-02-11)

RUDN University veterinarians tested a new drug against pneumonia in calves
Respiratory tract diseases in young animals of the cattle are a big issue for world agriculture and food safety because a bacterium that causes them is resistant to most antibiotics. A team of veterinarians from RUDN University developed and tested a complex preparation called gentaminoseleferon that could help treat respiratory infection in calves. (2021-02-10)

Substance in the blood of pregnant women fights pathological immune reaction
Scientists studied the effect of trophoblastic β1-glycoprotein in the blood of pregnant women on pro-inflammatory immune cells. Thanks to trophoblastic β1-glycoprotein, a woman's body does not adversely react to the fetus and supports its normal development until birth. It turned out that trophoblastic β1-glycoproteins also suppressed the development of pro-inflammatory lymphocytes and reduced their activity. (2021-02-10)

Samara Polytech scientists proved the anti-cancer properties of a number of plant extracts
The composition of some extracts obtained from plant raw materials was studied at Samara Polytech, and their anticarcinogenic and antioxidant properties were assessed. (2021-02-09)

Scientists switch on tissue repair in inflammatory bowel disease
Researchers have developed a method that instructs immune system cells to help repair damaged tissue in the intestine. The finding opens the way for more effective treatment of inflammatory bowel disease. (2021-02-08)

Immune response to insulin could identify, help treat those at risk for Type 1 Diabetes
Researchers from the Barbara Davis Center for Childhood Diabetes at the University of Colorado Anschutz Medical Campus have found that immune responses to insulin could help identify individuals most at risk for developing Type 1 diabetes. (2021-02-08)

What happens in the mouth ... doesn't stay in the mouth
The healthy human oral microbiome consists of not just clean teeth and firm gums, but also energy-efficient bacteria living in an environment rich in blood vessels that enables the organisms' constant communication with immune-system cells and proteins. A growing body of evidence has shown that this system that seems so separate from the rest of our bodies is actually highly influential on, and influenced by, our overall health. (2021-02-08)

MSK researchers learn what's driving 'brain fog' in people with COVID-19
A unique collaboration among experts from several areas within MSK leads to findings about how inflammation appears to be driving the neurologic effects seen in some COVID-19 patients. (2021-02-08)

Study identifies 'Achilles heel' of bacteria linked to Crohn's disease
The discovery of an ''Achilles heel'' in a type of gut bacteria that causes intestinal inflammation in patients with Crohn's disease may lead to more targeted therapies for the difficult to treat disease, according to Weill Cornell Medicine and NewYork-Presbyterian investigators. (2021-02-05)

Mast cells: Sentinels and high-speed messengers of the immune defense
A team of scientists at the Institute for Molecular and Clinical Immunology at the Otto-von-Guericke University Magdeburg unravels a crucial mechanism of cell-cell-communication during the defense against pathogens. (2021-02-04)

Study shows aspirin before a diagnosis may lower colorectal cancer mortality
A new study finds that long-term aspirin use before a diagnosis of colorectal cancer (CRC) may be associated with lower CRC-specific mortality. (2021-02-02)

Surgery to heal inflamed gut may create new target for disease
A surgical procedure meant to counter ulcerative colitis, an immune disease affecting the colon, may trigger a second immune system attack, a new study shows. (2021-02-02)

Could playing host to hookworms help prevent ageing?
Parasitic worms could hold the key to living longer and free of chronic disease, according to a review article published today in the open-access eLife journal. (2021-02-02)

Study identifies noncoding RNA involved in immune response and sepsis
When the body's immune response to an infection gets out of control, the result can be sepsis, a life-threatening condition in which an overwhelming inflammatory response can lead rapidly to failure of multiple organs and death. In a new study, researchers at UC Santa Cruz have identified a long noncoding RNA (lncRNA) molecule that regulates the expression of pro-inflammatory genes in immune system cells called macrophages and affects the susceptibility of mice to septic shock. (2021-02-01)

New weapon for inflammation
Flinders University researchers have discovered a new anti-inflammatory role for well-known blood clot protein fibrinogen, which could support targeted new treatments for kidney, heart and other common diseases. The study in Redox Biology describes how fibrinogen can be protective against hypochlorite - a chemical generated by the body during inflammation - and so act as a kind of antioxidant in blood plasma. (2021-01-31)

Scientists find key function of molecule in cells crucial for regulating immunity
UNC School of Medicine scientists led by Jenny Ting, PhD, the William Kenan Distinguished Professor of Genetics, and Yisong Wan, PhD, professor of microbiology and immunology, discovered that AIM2 is important for the proper function of regulatory T cells, or Treg cells, and plays a key role in mitigating autoimmune disease. Treg cells are a seminal population of adaptive immune cells that prevents an overzealous immune response, such as those that occurs in autoimmune diseases. (2021-01-28)

'Smart' cartilage cells programmed to release drugs when stressed
Researchers at Washington University School of Medicine in St. Louis have engineered cartilage cells to release an anti-inflammatory drug in response to stresses such cells undergo when they are compressed during weight bearing and movement. (2021-01-27)

Gut microbiota reveals whether drug therapies work in inflammatory bowel diseases
A study recently completed at the University of Helsinki indicates that the gut microbiota of patients suffering from inflammatory gastrointestinal disorders can be used to predict whether they will benefit from expensive therapies. The study also confirms the key role of therapies that have a beneficial effect on the gut microbiota in inflammatory bowel diseases. (2021-01-26)

Multiple sclerosis: Immune cells silence neurons by removing synapses
Damage to the brain gray matter plays an important role in the progression of multiple sclerosis. This study now shows that such damage can be caused by inflammatory reactions that lead to loss of synapses, which impairs neural activity. (2021-01-26)

Immune cells found in the brain are behind the depression experienced in inflammation
Special immune cells found in the brain, microglia, play a key role in the processes that make you feel uneasy and depressed in correlation with inflammation. This is the conclusion of a study using mice carried out by researchers at Linköping University, Sweden. The results have been published in the scientific journal Immunity, and suggest that microglial cells contribute to the negative mood experienced during several neurological diseases, and maybe also depression. (2021-01-25)

Newly discovered subset of brain cells fight inflammation with instructions from the gut
A team led by researchers from Brigham and Women's Hospital, has shown that a specific astrocyte sub-population can do the opposite, instead serving a protective, anti-inflammatory function within the brain based on signals regulated by the bacteria that reside in the gut. (2021-01-25)

Exercising muscle combats chronic inflammation on its own
Biomedical engineers at Duke University have demonstrated that human muscle has an innate ability to ward off damaging effects of chronic inflammation when exercised. The discovery was made possible through the use of lab-grown, engineered human muscle, demonstrating the potential power of the first-of-its-kind platform in such research endeavors. (2021-01-22)

NSAIDs might exacerbate or suppress COVID-19 depending on timing, mouse study suggests
New research shows that non-steroidal anti-inflammatory drugs (NSAIDs) reduced both antibody and inflammatory responses to SARS-CoV-2 infection in mice. The study appears this week in the Journal of Virology, a publication of the American Society for Microbiology. (2021-01-22)

New study on the role of monocytes in sarcoidosis
The cause of the inflammatory lung disease sarcoidosis is unknown. In a new study, researchers at Karolinska Institutet in Sweden have investigated whether a type of immune cell called a monocyte could be a key player in sarcoidosis pathogenesis and explain why some patients develop more severe and chronic disease than others. The study, which is published in The European Respiratory Journal, opens new possibilities for future diagnostic and therapeutic methods. (2021-01-21)

Developmental origins of eczema and psoriasis discovered
Scientists have created a highly detailed map of skin, which reveals that cellular processes from development are re-activated in cells from patients with eczema and psoriasis inflammatory skin diseases. The study in Science offers potential new drug targets for treating these painful skin diseases and provides a new understanding of inflammatory disease. Part of the global Human Cell Atlas initiative, the research could also provide a template for regenerating healthy skin in the laboratory. (2021-01-21)

Study reveals new insights into the link between sunlight exposure and kidney damage
A new collaborative study from researchers at the Geisel School of Medicine at Dartmouth and the University of Washington and published in the Proceedings of the National Academy of Sciences (PNAS), reveals unexpected insights into how skin exposure to ultraviolet light can worsen clinical symptoms in autoimmune diseases such as lupus. (2021-01-21)

Scientists discover link between nicotine and breast cancer metastasis
Scientists at Wake Forest School of Medicine have found that nicotine promotes the spread of breast cancer cells into the lungs. (2021-01-20)

Inflammation caused by scorpion venom should be blocked immediately, study shows
In an article published in Nature Communications, Brazilian researchers show for the first time that in severe cases of scorpion envenomation it is the neuroimmune reaction triggered by the venom that leads to death. (2021-01-20)

Rush researchers demonstrate success with new therapy for COVID-19
A new therapy developed by researchers at Rush University Medical Center is showing success as a way to prevent COVID-19 symptoms in mice. (2021-01-19)

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