Current Inflammatory Response News and Events

Current Inflammatory Response News and Events, Inflammatory Response News Articles.
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New strategy blocks chronic lung disease in mice
A new study from Washington University School of Medicine in St. Louis has uncovered a previously unknown role for exosomes in inflammatory respiratory diseases. The study has implications for finding new therapies. Exosomes are tiny compartments released from cells that carry different types of cargo, including inflammatory chemicals called cytokines that can drive lung disease. (2021-02-23)

New insights on how inflammatory molecule contributes to skin and pancreatic cancers
An immune molecule called interleukin-33 can act within a cell's nucleus to stimulate abnormal growth and division, ultimately resulting in cancer. Targeting interleukin-33 in the nucleus may help prevent certain cancers. (2021-02-22)

Discovery of a mechanism by which epithelial tumours cause developmental delays
- Conducted on the fly Drosophila, the study shows that tumours caused by chromosomal instability delay entry into the adult phase. - The tumours produce the Upd3 protein (equivalent to human Interleukin-6) to block the production of developmental steroid hormones. - The work of IRB Barcelona's Growth Control and Development laboratory has been published in the journal Current Biology. (2021-02-22)

Yale neurologists identify consistent neuroinflammatory response in ICH patients
Understanding how the immune system responds to acute brain hemorrhage could open doors to identifying treatments for this devastating disease. However, up until now, there has been limited information on inflammation in the brain from human patients, especially during the first days after a hemorrhagic stroke. This led a team of researchers to partner with a large clinical trial of minimally-invasive surgery to tackle defining the human neuroinflammatory response in living patients. (2021-02-22)

Oncotarget: MEK inhibitors relevant to SARS-CoV-2 infection
The @Oncotarget authors show a drug class-effect with MEKi to stimulate NK cells, inhibit inflammatory cytokines and block host-factors for SARS-CoV-2 infection leading also to suppression of SARS-CoV-2-S pseudovirus infection of human cells (2021-02-22)

Radiological images confirm 'COVID-19 can cause the body to attack itself'
Muscle soreness and achy joints are common symptoms among COVID-19 patients. But for some people, symptoms are more severe, long lasting and even bizarre, including rheumatoid arthritis flares, autoimmune myositis or 'COVID toes.' A new Northwestern Medicine study has, for the first time, confirmed and illustrated the causes of these symptoms through radiological imaging. (2021-02-17)

How inflammatory signalling molecules contribute to carcinogenesis
A team of MedUni Vienna researchers led by Johannes A. Schmid at the Center for Physiology and Pharmacology, Institute of Vascular Biology and Thrombosis Research, has managed to identify a previously unknown molecular connection between an inflammatory signalling molecule and one of the main oncogenes. The study has been published in the leading journal 'Molecular Cancer'. (2021-02-17)

Fatty tissue accumulated in the neck linked to heart problems, study finds
Researchers from the University of Granada warn that an accumulation of fatty tissue in the neck (both the double chin and the deeper deposits, located between muscles and around the cervical vertebrae) is a predictor of central and overall adiposity, cardiometabolic risk, and a pro-inflammatory profile in sedentary young adults (2021-02-17)

New potential therapy for Crohn's disease in children
Scientists from the Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago demonstrated that a nanotherapy reduces intestinal inflammation and shrinks lesions in a rodent model of severe Crohn's disease. (2021-02-17)

Protein linked to Alzheimer's, strokes cleared from brain blood vessels
Amyloid deposits in the brain increase the risk of dementia and strokes. Researchers at Washington University School of Medicine in St. Louis have identified an antibody that clears amyloid deposits from the brain without raising the risk of brain bleeds. (2021-02-17)

Cosmetic laser may boost effectiveness of certain anti-cancer therapies
In mice treated with cancer immunotherapy, shining a cosmetic laser on a tumor boosted the therapy's effectiveness. The strategy stimulated the immune system to attack nonmutated proteins on the tumor. The findings may help investigators make cancer immunotherapy effective against currently incurable cancers. (2021-02-17)

Answer quickly to be believed
When people pause before replying to a question, even for just a few seconds, their answers are perceived to be less sincere and credible than if they had replied immediately, according to research published by the American Psychological Association. (2021-02-16)

New synthetic peptides could attenuate atherosclerosis
Atherosclerosis, a lipid-triggered chronic inflammatory disease of our arteries, is the main cause of strokes and heart attacks. An international team of researchers led by the Technical University of Munich (TUM) and the LMU University Hospital has developed novel synthetic peptides that can help to prevent atherosclerosis in vitro, that is in the test tube, as well as in animal models. (2021-02-12)

One dose of COVID-19 vaccine provokes strong immune response in those previously infected
Researchers report preliminary evidence that people previously infected with COVID-19 responded very strongly to one dose of the Pfizer vaccine, regardless of when they were infected and whether or not they had detectable antibodies against COVID-19 prior to receiving the vaccine. The response was so effective that it opens the debate as to whether one dose of the vaccine may suffice. The research also provided evidence that immune response was similar across multi-ethnic groups. (2021-02-11)

Spinal fluid of people with Alzheimer's risk gene signals inflammation
People who have a gene variant associated with an increased risk of developing Alzheimer's disease also tend to have changes in the fluid around their brain and spinal cord that are detectable years before symptoms arise, according to new research from Duke Health. (2021-02-11)

RUDN University veterinarians tested a new drug against pneumonia in calves
Respiratory tract diseases in young animals of the cattle are a big issue for world agriculture and food safety because a bacterium that causes them is resistant to most antibiotics. A team of veterinarians from RUDN University developed and tested a complex preparation called gentaminoseleferon that could help treat respiratory infection in calves. (2021-02-10)

Substance in the blood of pregnant women fights pathological immune reaction
Scientists studied the effect of trophoblastic β1-glycoprotein in the blood of pregnant women on pro-inflammatory immune cells. Thanks to trophoblastic β1-glycoprotein, a woman's body does not adversely react to the fetus and supports its normal development until birth. It turned out that trophoblastic β1-glycoproteins also suppressed the development of pro-inflammatory lymphocytes and reduced their activity. (2021-02-10)

Scientists switch on tissue repair in inflammatory bowel disease
Researchers have developed a method that instructs immune system cells to help repair damaged tissue in the intestine. The finding opens the way for more effective treatment of inflammatory bowel disease. (2021-02-08)

Some types of coronavirus steal the hosts' genes to elude their immune system
Researchers discovered this while analysing pathogens found in European hedgehogs that present the same strain of Beta-CoV responsible for both COVID-19 and MERS but without evidence of human transmissibility. It is the first time this ability is observed in coronaviruses (2021-02-08)

What happens in the mouth ... doesn't stay in the mouth
The healthy human oral microbiome consists of not just clean teeth and firm gums, but also energy-efficient bacteria living in an environment rich in blood vessels that enables the organisms' constant communication with immune-system cells and proteins. A growing body of evidence has shown that this system that seems so separate from the rest of our bodies is actually highly influential on, and influenced by, our overall health. (2021-02-08)

MSK researchers learn what's driving 'brain fog' in people with COVID-19
A unique collaboration among experts from several areas within MSK leads to findings about how inflammation appears to be driving the neurologic effects seen in some COVID-19 patients. (2021-02-08)

Novel immunotherapy approach to treat cat allergy
Researchers from the Department of Infection and Immunity of the Luxembourg Institute of Health (LIH) brought forward the potential of high doses of a specific adjuvant molecule, namely CpG oligonucleotide, in successfully modulating the immune system's allergic response to the main cat allergen Fel d 1, thereby inducing a tolerance-promoting reaction and reverting the main hallmarks of cat allergy. (2021-02-05)

Fungi in the gut prime immunity against infection
Common fungi, often present in the gut, teach the immune system how to respond to their more dangerous relatives, according to new research from scientists at Weill Cornell Medicine. Breakdowns in this process can leave people susceptible to deadly fungal infections. (2021-02-05)

Study identifies 'Achilles heel' of bacteria linked to Crohn's disease
The discovery of an ''Achilles heel'' in a type of gut bacteria that causes intestinal inflammation in patients with Crohn's disease may lead to more targeted therapies for the difficult to treat disease, according to Weill Cornell Medicine and NewYork-Presbyterian investigators. (2021-02-05)

New biomarker may predict which pancreatic cancer patients respond to CD40 immunotherapy
Inflammation in the blood could serve as a new biomarker to help identify patients with advanced pancreatic cancer who won't respond to the immune-stimulating drugs known as CD40 agonists, suggests a new study from researchers in the Abramson Cancer Center of the University of Pennsylvania published in JCI Insight. (2021-02-04)

Mast cells: Sentinels and high-speed messengers of the immune defense
A team of scientists at the Institute for Molecular and Clinical Immunology at the Otto-von-Guericke University Magdeburg unravels a crucial mechanism of cell-cell-communication during the defense against pathogens. (2021-02-04)

Study reveals how air pollution may increase the risk of cardiovascular disease
A new study has found a link between high levels of air pollution at an individual's home address and an elevated risk of developing cardiovascular disease. Air pollution exposure appears to heighten the production of inflammatory cells in the bone marrow, triggering inflammation of the arteries. (2021-02-04)

Uncovering a link between inflammation and heart disease
Patients with cardiac disease often have chronic inflammation that damages their hearts, even with no infection present. A new study published in Circulation reveals a mechanism that is activating T cells, a type of immune cell, and causing inflammation in the heart. (2021-02-04)

Duration of antibody response varies among adults naturally reinfected with RSV
Researchers at Baylor College of Medicine found that while most individuals responded to respiratory syncytial virus (RSV) natural reinfection with a typical sustained antibody response associated with protection, a few individuals surprisingly responded atypically, not being able to sustain the antibody response, which declined to levels that made the individuals susceptible to RSV reinfection. (2021-02-04)

Study shows aspirin before a diagnosis may lower colorectal cancer mortality
A new study finds that long-term aspirin use before a diagnosis of colorectal cancer (CRC) may be associated with lower CRC-specific mortality. (2021-02-02)

Surgery to heal inflamed gut may create new target for disease
A surgical procedure meant to counter ulcerative colitis, an immune disease affecting the colon, may trigger a second immune system attack, a new study shows. (2021-02-02)

Could playing host to hookworms help prevent ageing?
Parasitic worms could hold the key to living longer and free of chronic disease, according to a review article published today in the open-access eLife journal. (2021-02-02)

Study identifies noncoding RNA involved in immune response and sepsis
When the body's immune response to an infection gets out of control, the result can be sepsis, a life-threatening condition in which an overwhelming inflammatory response can lead rapidly to failure of multiple organs and death. In a new study, researchers at UC Santa Cruz have identified a long noncoding RNA (lncRNA) molecule that regulates the expression of pro-inflammatory genes in immune system cells called macrophages and affects the susceptibility of mice to septic shock. (2021-02-01)

New weapon for inflammation
Flinders University researchers have discovered a new anti-inflammatory role for well-known blood clot protein fibrinogen, which could support targeted new treatments for kidney, heart and other common diseases. The study in Redox Biology describes how fibrinogen can be protective against hypochlorite - a chemical generated by the body during inflammation - and so act as a kind of antioxidant in blood plasma. (2021-01-31)

Scientists find key function of molecule in cells crucial for regulating immunity
UNC School of Medicine scientists led by Jenny Ting, PhD, the William Kenan Distinguished Professor of Genetics, and Yisong Wan, PhD, professor of microbiology and immunology, discovered that AIM2 is important for the proper function of regulatory T cells, or Treg cells, and plays a key role in mitigating autoimmune disease. Treg cells are a seminal population of adaptive immune cells that prevents an overzealous immune response, such as those that occurs in autoimmune diseases. (2021-01-28)

'Smart' cartilage cells programmed to release drugs when stressed
Researchers at Washington University School of Medicine in St. Louis have engineered cartilage cells to release an anti-inflammatory drug in response to stresses such cells undergo when they are compressed during weight bearing and movement. (2021-01-27)

Antibiotic may improve outcomes for depression in people with low level inflammation
King's College London researchers have found evidence that minocycline, a widely used antibiotic with anti-inflammatory properties, gave greater improvement in depressive symptoms in patients with treatment resistant depression with low-grade peripheral inflammation. (2021-01-27)

Research shows people with high omega-3 index less likely to die from COVID-19
Researchers with the Fatty Acid Research Institute (FARI) and collaborators at Cedars-Sinai Medical Center in Los Angeles and in Orange County, CA, have published the first direct evidence that higher omega-3 blood levels may reduce risk for death from COVID-19 infection. The report was published in the journal Prostaglandins, Leukotrienes and Essential Fatty Acids on January 20, 2021. (2021-01-26)

Gut microbiota reveals whether drug therapies work in inflammatory bowel diseases
A study recently completed at the University of Helsinki indicates that the gut microbiota of patients suffering from inflammatory gastrointestinal disorders can be used to predict whether they will benefit from expensive therapies. The study also confirms the key role of therapies that have a beneficial effect on the gut microbiota in inflammatory bowel diseases. (2021-01-26)

Multiple sclerosis: Immune cells silence neurons by removing synapses
Damage to the brain gray matter plays an important role in the progression of multiple sclerosis. This study now shows that such damage can be caused by inflammatory reactions that lead to loss of synapses, which impairs neural activity. (2021-01-26)

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