Current Insulin Resistance News and Events

Current Insulin Resistance News and Events, Insulin Resistance News Articles.
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Study shows new treatment pathway to prevent and treat endometrial cancer recurrence
In a new study led by Yale Cancer Center, researchers demonstrate sex hormones and insulin growth factors are associated with recurrence risk of endometrial cancer. (2021-02-23)

Targeted delivery of highly toxic anti-cancer drug to brain tumors
University of Houston biomedical researcher Sheeren Majd is reporting the development and testing of a new nano-carrier as a potential treatment to deliver highly toxic medicine to glioblastomas, the most common and aggressive form of primary brain tumors. (2021-02-23)

Hormone helps prevent muscle loss in mice on high fat diets, USC study finds
A new study suggests that a hormone known to prevent weight gain and normalize metabolism can also help maintain healthy muscles in mice. The findings present new possibilities for treating muscle-wasting conditions associated with age, obesity or cancer, according to scientists from the University of Southern California Leonard Davis School of Gerontology. (2021-02-22)

Artificial pancreas system upgraded with AI algorithm
POSTECH professor Sung-Min Park's research team is developing a fully automated glucose management system that goes beyond the limits. (2021-02-22)

Metabolic mutations help bacteria resist drug treatment
MIT researchers have identified a new class of mutations that help bacteria develop antibiotic resistance. In a study of E. coli, they discovered that mutations to genes involved in metabolism can help bacteria to evade the toxic effects of several different antibiotics. (2021-02-18)

SuperAger brains resist protein tangles that lead to Alzheimer's
A new study showed cognitive SuperAgers have resistance to the development of fibrous tangles in a brain region related to memory and which are known to be markers of Alzheimer's disease. Their resistance appears to help protect their memory. (2021-02-17)

New data on COVID-19 patients with diabetes show that one in five die within
Updated results from the CORONADO study, analysing the outcomes of patients with diabetes admitted to hospital with COVID-19, shows that one in five patients die within 28 days while around half are discharged. The study is published in Diabetologia (the journal of the European Association for the Study of Diabetes [EASD]). (2021-02-17)

Hospital wastewater favors multi-resistant bacteria
Scientists from the University of Gothenburg, Sweden presents evidence that hospital wastewater, containing elevated levels of antibiotics, rapidly kills antibiotic-sensitive bacteria, while multi-resistant bacteria continue to grow. Hospital sewers may therefore provide conditions that promote the evolution of new forms of antibiotic resistance. (2021-02-16)

Researchers solve riddle of plant immune system
How do plants build resilience? An international research team led by the University of Göttingen studied the molecular mechanisms of the plant immune system. They were able to show a connection between a relatively unknown gene and resistance to pathogens. The results of the study were published in the journal The Plant Cell. (2021-02-16)

Nursing home staff responses to pandemic reveal resilience, shortcomings: Concordia study
Writing in the Journal of Comparative Policy Analysis: Research and Practice, PhD student Daniel Dickson, his supervisor Patrik Marier, professor of political science, and co-author Robert Henry Cox of the University of South Carolina perform a comparative analysis of nursing home workers' experiences. In it, they look at Quebec (including those at government-run CHSLDs), British Columbia, Washington State and Ohio by reviewing 336 articles in six newspapers published between late-February and mid-June 2020. (2021-02-16)

Moffitt uses mathematical modeling to identify factors that determine adaptive therapy success
In a new article featured on this month's cover of Cancer Research, Moffitt Cancer Center researchers, in collaboration with Oxford University, report results from their study using mathematical modeling to show that cell turnover impacts drug resistance and is an important factor that governs the success of adaptive therapy. (2021-02-15)

Dopamine is key to the mystery of metabolic dysfunction in psychiatric patients
Antipsychotic drugs not only block dopamine signaling in the brain but also in the pancreas, leading to uncontrolled production of blood glucose-regulating hormones, obesity and diabetes. (2021-02-15)

Exercise now proven to have mental health benefits for prostate cancer
New Edith Cowan University (ECU) research has found that exercise not only has physical benefits for men with prostate cancer, it also helps reduce symptoms of depression and anxiety. (2021-02-15)

New discovery could pave the way for improved treatments for diabetes
Monash University researchers have uncovered the barrier to β-cell (beta cell) regeneration that could pave the way for improved treatments for diabetes and diseases that involve organ and tissue damage. (2021-02-12)

New weapon against resistant bacteria
Researchers have developed a new antibiotic that can help in the fight against resistant bacteria, and they hope it will reach the patients. (2021-02-10)

Brain tumor study reveals surprising gene deletion and method to overcome drug resistance
Experts at Cincinnati Children's report success at averting drug resistance in a subtype of brain tumors called glioblastomas. Importantly, the research indicates that the approach may also work in other cancers, such as melanoma, that exhibit a similar pathway of drug resistance. (2021-02-10)

Immune response to insulin could identify, help treat those at risk for Type 1 Diabetes
Researchers from the Barbara Davis Center for Childhood Diabetes at the University of Colorado Anschutz Medical Campus have found that immune responses to insulin could help identify individuals most at risk for developing Type 1 diabetes. (2021-02-08)

Beyond secretion of insulin,the novel function of β cell in regulating glucose homeostasis
In a new study published in Journal of Extracellular Vesicles, Chen-Yu Zhang's group and Antonio Vidal-Puig's group at University of Cambridge report that pancreatic β cells secrete miR-29 family members (miR-29a, miR-29b and miR-29c) in response to high levels of free fatty acids (FFAs). These β cell-derived miR-29s are delivered to the liver, promoting insulin resistance and enhancing hepatic glucose output. (2021-02-07)

CDDEP's report 'The State of the World's Antibiotics' highlights the growing threat of AMR
Researchers at CDDEP have released, The State of the World's Antibiotics in 2021, which presents extensive data on global antimicrobial use and resistance as well as drivers and correlates of antimicrobial resistance, based on CDDEP's extensive research and data collection through ResistanceMap (www.resistancemap.org), a global repository that has been widely used by researchers, policymakers, and the media. (2021-02-03)

Intensity not paramount for physical training during cancer therapy
People receiving treatment for cancer are known to feel better with physical training. But does it make any difference how vigorously they exercise? A new study by researchers at Uppsala University shows that whether the training is intensive or rather less strenuous, its effect is roughly the same. The results are published in the journal Scandinavian Journal of Medicine and Science in Sports. (2021-02-03)

Aging-US: Sulforaphane promotes C. elegans longevity and healthspan
'The results in this Aging-US research output, indicate that sulforaphane prolongs the lifespan and healthspan of C. elegans through insulin/IGF-1 signaling.' (2021-02-03)

Insulin can be stored out of refrigeration in hot settings!
Patients with diabetes must keep a supply of insulin which must respect the cold chain. However not every household has a refrigerator. This forces people living with diabetes to go to hospital on a daily basis. MSF and UNIGE test insulin storage at temperatures ranging from 25°C to 37°C. The findings demonstrate that the stability of insulin stored under these conditions is the same as that of cold-stored insulin, with no impact on efficacy. (2021-02-03)

Body and mind: hormones in the brain may explain how exercise improves metabolism
A mitochondrial hormone expressed by cells deep in the brain appears to play a role in improving metabolism and fighting off obesity, according to a new study in mice. (2021-02-02)

Toward safer steroids: Scientists devise method for improving safety of drug used to treat COVID-19, autoimmune disorders and more
Scripps Research scientists bring together multiple technologies to engineer potentially safer glucocorticoids, drugs used to treat COVID-19 and other conditions. (2021-02-02)

Aging-US: A pro-diabetogenic mtDNA polymorphism in mitochondrial-derived peptide
'The m.1382A>C polymorphism is associated with susceptibility to T2D in men, possibly interacting with exercise, and contributing to the risk of T2D in sedentary males by reducing the activity of MOTS-c.' (2021-02-02)

'Weak' and 'strong' cells bonding boosts body's diabetes fight
Scientists have broadened our understanding of how 'weak' cells bond with their more mature cellular counterparts to boost the body's production of insulin, improving our knowledge of the processes leading to type 2 diabetes - a significant global health problem. (2021-01-29)

Novel therapy-resistance mechanism promoting the growth of breast cancer brain metastasis
SORLA is a protein trafficking receptor that has been mainly studied in neurons, but it also plays a role in cancer cells. Professor Johanna Ivaska's research group at Turku Bioscience observed that SORLA functionally contributes to the most reported therapy-resistant mechanism by which the cell-surface receptor HER3 counteracts HER2 targeting therapy in HER2-positive cancers. Removing SORLA from cancer cells sensitized anti-HER2 resistant breast cancer brain metastasis to targeted therapy. (2021-01-29)

How is human behavior impacting wildlife movement?
For species to survive in the wild, maintaining connectivity between populations is critical. Without 'wildlife corridors', groups of animals are isolated and may die out. In assessing wildlife connectivity, many aspects of the landscape are measured, but the impact of human behaviour has largely been overlooked. Now, an international team led by the University of Göttingen and Humboldt University Berlin, introduce the concept of 'anthropogenic resistance'. Their perspective article was published in the journal One Earth. (2021-01-29)

Social media study reveals diabetics' fear of disrupted insulin supplies because of Brexit
Diabetics living in the UK worry about disruption to insulin supplies as a result of Brexit, new research shows. (2021-01-27)

Scientists discover a new promising target for diabetes treatment
Researchers have discovered a novel and druggable insulin inhibitory receptor, named inceptor. The blocking of inceptor function leads to an increased sensitisation of the insulin signaling pathway in pancreatic beta cells. This might allow protection and regeneration of beta cells for diabetes remission. (2021-01-27)

Hybrid closed-loop insulin therapy improves glycemic control
Hybrid closed-loop insulin therapy improved glycemic control in adolescents and young adults with type 1 diabetes. These outcomes, derived from the International Diabetes Closed-Loop (iDCL) (2021-01-26)

In preclinical models, antiviral better inhibits COVID-19 than Remdesivir; further studies warranted
Working in preclinical models, researchers report that plitidepsin, a drug with limited clinical approval for the treatment of multiple myeloma, is more potent against SARS-CoV-2 than remdesivir, an antiviral that received FDA emergency use authorization for the treatment of COVID-19 in 2020. (2021-01-25)

When -- not what -- obese mice ate reduced breast cancer risk
University of California San Diego School of Medicine and Moores Cancer Center researchers report that intermittent fasting reduced breast cancer risk in obese mice. (2021-01-25)

Pancreatic β cell-derived exosomal miR-29 family enhances hepatic glucose output
In a new study published in Journal of Extracellular Vesicles, Chen-Yu Zhang's group at Nanjing University, School of Life Sciences, and Antonio Vidal-Puig's group at University of Cambridge report that pancreatic β cells secrete miR-29 family members (miR-29s) via exosomes in response to high levels of free fatty acids (FFAs). Theses β cell-derived exosomal miR-29s regulate glucose homeostasis through their manipulations on glucose output in liver. (2021-01-22)

Antibiotic resistance may spread even more easily than expected
Pathogenic bacteria in humans are developing resistance to antibiotics much faster than expected. Now, computational research at Chalmers University of Technology, Sweden, shows that one reason could be significant genetic transfer between bacteria in our ecosystems and to humans. This work has also led to new tools for resistance researchers. (2021-01-21)

Mitochondrial mutation increases the risk of diabetes in Japanese men
A new study of Type 2 diabetes (T2D) in Japanese populations has uncovered a previously uncharacterized genetic variant that puts male carriers at greater risk for the disease, as well as the mechanism by which it does so. The impact of the variant was most pronounced in sedentary men; those with the variant had a 65% greater rate of T2D than sedentary men without it. (2021-01-21)

Diabetes powerfully associated with premature coronary heart disease in women
To understand what factors put younger individuals at higher risk of premature coronary heart disease, researchers from Brigham and Women's Hospital and the Mayo Clinic analyzed more than 50 risk factors in 28,024 women who participated in the decades-long Women's Health Study. Notably, women under 55 with type-2 diabetes had a tenfold greater risk of having CHD over the next two decades, with lipoprotein insulin resistance proving to be a strong, predictive biomarker as well. (2021-01-20)

NIH study compares low-fat, plant-based diet to low-carb, animal-based diet
People on a low-fat, plant-based diet ate fewer daily calories but had higher insulin and blood glucose levels, compared to when they ate a low-carbohydrate, animal-based diet, according to a small but highly controlled study at the National Institutes of Health. Led by researchers at the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the study compared the effects of the two diets on calorie intake, hormone levels, body weight, and more. (2021-01-19)

ADA lowers target HbA1C levels for children with type-1 diabetes
In early 2020, upon recommendation by leading endocrinologists, American Diabetes Association lowered the target hemoglobin A1C guidelines for children with type 1 diabetes. Their goal in recommending stricter glucose control was to ensure children with type 1 diabetes have better immediate and long-term health outcomes with fewer health complications and reduced mortality rates. In this ''Perspective'' article they discuss the evidence and rationale behind this new recommendation. (2021-01-14)

High insulin levels during childhood a risk for mental health problems in adulthood, study suggests
Researchers have shown that the link between physical and mental illness is closer than previously thought. Certain changes in physical health, which are detectable in childhood, are linked with the development of mental illness in adulthood. (2021-01-13)

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