Current Insulin News and Events

Current Insulin News and Events, Insulin News Articles.
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Study shows new treatment pathway to prevent and treat endometrial cancer recurrence
In a new study led by Yale Cancer Center, researchers demonstrate sex hormones and insulin growth factors are associated with recurrence risk of endometrial cancer. (2021-02-23)

Artificial pancreas system upgraded with AI algorithm
POSTECH professor Sung-Min Park's research team is developing a fully automated glucose management system that goes beyond the limits. (2021-02-22)

New data on COVID-19 patients with diabetes show that one in five die within
Updated results from the CORONADO study, analysing the outcomes of patients with diabetes admitted to hospital with COVID-19, shows that one in five patients die within 28 days while around half are discharged. The study is published in Diabetologia (the journal of the European Association for the Study of Diabetes [EASD]). (2021-02-17)

Dopamine is key to the mystery of metabolic dysfunction in psychiatric patients
Antipsychotic drugs not only block dopamine signaling in the brain but also in the pancreas, leading to uncontrolled production of blood glucose-regulating hormones, obesity and diabetes. (2021-02-15)

New discovery could pave the way for improved treatments for diabetes
Monash University researchers have uncovered the barrier to β-cell (beta cell) regeneration that could pave the way for improved treatments for diabetes and diseases that involve organ and tissue damage. (2021-02-12)

Immune response to insulin could identify, help treat those at risk for Type 1 Diabetes
Researchers from the Barbara Davis Center for Childhood Diabetes at the University of Colorado Anschutz Medical Campus have found that immune responses to insulin could help identify individuals most at risk for developing Type 1 diabetes. (2021-02-08)

Beyond secretion of insulin,the novel function of β cell in regulating glucose homeostasis
In a new study published in Journal of Extracellular Vesicles, Chen-Yu Zhang's group and Antonio Vidal-Puig's group at University of Cambridge report that pancreatic β cells secrete miR-29 family members (miR-29a, miR-29b and miR-29c) in response to high levels of free fatty acids (FFAs). These β cell-derived miR-29s are delivered to the liver, promoting insulin resistance and enhancing hepatic glucose output. (2021-02-07)

Aging-US: Sulforaphane promotes C. elegans longevity and healthspan
'The results in this Aging-US research output, indicate that sulforaphane prolongs the lifespan and healthspan of C. elegans through insulin/IGF-1 signaling.' (2021-02-03)

Insulin can be stored out of refrigeration in hot settings!
Patients with diabetes must keep a supply of insulin which must respect the cold chain. However not every household has a refrigerator. This forces people living with diabetes to go to hospital on a daily basis. MSF and UNIGE test insulin storage at temperatures ranging from 25°C to 37°C. The findings demonstrate that the stability of insulin stored under these conditions is the same as that of cold-stored insulin, with no impact on efficacy. (2021-02-03)

Aging-US: A pro-diabetogenic mtDNA polymorphism in mitochondrial-derived peptide
'The m.1382A>C polymorphism is associated with susceptibility to T2D in men, possibly interacting with exercise, and contributing to the risk of T2D in sedentary males by reducing the activity of MOTS-c.' (2021-02-02)

'Weak' and 'strong' cells bonding boosts body's diabetes fight
Scientists have broadened our understanding of how 'weak' cells bond with their more mature cellular counterparts to boost the body's production of insulin, improving our knowledge of the processes leading to type 2 diabetes - a significant global health problem. (2021-01-29)

Social media study reveals diabetics' fear of disrupted insulin supplies because of Brexit
Diabetics living in the UK worry about disruption to insulin supplies as a result of Brexit, new research shows. (2021-01-27)

Scientists discover a new promising target for diabetes treatment
Researchers have discovered a novel and druggable insulin inhibitory receptor, named inceptor. The blocking of inceptor function leads to an increased sensitisation of the insulin signaling pathway in pancreatic beta cells. This might allow protection and regeneration of beta cells for diabetes remission. (2021-01-27)

Hybrid closed-loop insulin therapy improves glycemic control
Hybrid closed-loop insulin therapy improved glycemic control in adolescents and young adults with type 1 diabetes. These outcomes, derived from the International Diabetes Closed-Loop (iDCL) (2021-01-26)

When -- not what -- obese mice ate reduced breast cancer risk
University of California San Diego School of Medicine and Moores Cancer Center researchers report that intermittent fasting reduced breast cancer risk in obese mice. (2021-01-25)

Pancreatic β cell-derived exosomal miR-29 family enhances hepatic glucose output
In a new study published in Journal of Extracellular Vesicles, Chen-Yu Zhang's group at Nanjing University, School of Life Sciences, and Antonio Vidal-Puig's group at University of Cambridge report that pancreatic β cells secrete miR-29 family members (miR-29s) via exosomes in response to high levels of free fatty acids (FFAs). Theses β cell-derived exosomal miR-29s regulate glucose homeostasis through their manipulations on glucose output in liver. (2021-01-22)

NIH study compares low-fat, plant-based diet to low-carb, animal-based diet
People on a low-fat, plant-based diet ate fewer daily calories but had higher insulin and blood glucose levels, compared to when they ate a low-carbohydrate, animal-based diet, according to a small but highly controlled study at the National Institutes of Health. Led by researchers at the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the study compared the effects of the two diets on calorie intake, hormone levels, body weight, and more. (2021-01-19)

ADA lowers target HbA1C levels for children with type-1 diabetes
In early 2020, upon recommendation by leading endocrinologists, American Diabetes Association lowered the target hemoglobin A1C guidelines for children with type 1 diabetes. Their goal in recommending stricter glucose control was to ensure children with type 1 diabetes have better immediate and long-term health outcomes with fewer health complications and reduced mortality rates. In this ''Perspective'' article they discuss the evidence and rationale behind this new recommendation. (2021-01-14)

High insulin levels during childhood a risk for mental health problems in adulthood, study suggests
Researchers have shown that the link between physical and mental illness is closer than previously thought. Certain changes in physical health, which are detectable in childhood, are linked with the development of mental illness in adulthood. (2021-01-13)

Endocrine Society recommends government negotiation and other policies to lower out-of-pocket costs
The Endocrine Society is calling on policymakers to include government negotiation as part of an overall strategy to reduce insulin prices in its updated position statement published today in The Journal of Clinical Endocrinology & Metabolism. (2021-01-12)

NTU Singapore develops oral insulin nanoparticles that could be an alternative to jabs
NTU Singapore scientists have developed insulin nanoparticles that may become an alternative to insulin injections for diabetics. Delivering insulin orally would be preferable over insulin jabs because it causes less pain, but remains challenging because insulin gets degraded in the gut before it can reach the bloodstream to regulate blood glucose. To overcome this challenge, the scientists designed a nanoparticle loaded with insulin at the core, then coated with alternating layers of insulin and chitosan. (2021-01-11)

In liver, a stressed cell can be bad news for its neighbors
When a stressed liver cell starts communicating with its neighbors, it can send stress signals to neighboring cells, causing significant problems that can lead to fatty liver disease and metabolic disease. (2020-12-18)

Different forms of sugar impact hunger-suppressing hormones in young adults
Drinks with sucrose compared to glucose may cause young adults to produce lower levels of appetite-regulating hormones, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism. (2020-12-10)

Targeting T cell protein could prevent type 1 diabetes, study suggests
Researchers at the University of Utah School of Medicine have identified a new therapeutic target to treat patients with type 1 diabetes. The study, which will be published December 9 in the Journal of Experimental Medicine (JEM), reveals that inhibiting a protein called OCA-B protects mice from type 1 diabetes by limiting the activity of immune cells that would otherwise destroy the pancreas' insulin-producing β cells. (2020-12-09)

Study connects diabetes, air pollution to interstitial lung disease
People with pre-diabetes or diabetes who live in ozone-polluted areas may have an increased risk for an irreversible disease with a high mortality rate. These findings are especially important today in the midst of the COVID-19 pandemic, where there is a heightened concern for the convergence of health effects from air pollution and SARS-CoV-2 in susceptible populations. (2020-12-09)

How poor oral hygiene may result in metabolic syndrome
Researchers from TMDU identified a novel mechanism by which periodontal disease may cause metabolic syndrome. By studying patients with metabolic syndrome, the researchers demonstrated high antibody titers against Porphyromonas gingivalis, the bacterium causing periodontal disease. In a mouse model, the researchers then showed that infection with this bacterium causes systemic insulin resistance and metabolic dysfunction in skeletal muscle by altering the gut microbiome. This study shows the effect periodontal disease can have on the entire body. (2020-12-08)

Findings about cilia on cells of the vessel wall may be relevant for diabetes treatment
A new study from Karolinska Institutet and the Helmholtz Diabetes Research Center shows that primary cilia, hair-like protrusions on endothelial cells inside vessels, play an important role in the blood supply and delivery of glucose to the insulin-producing beta cells in the pancreatic islets. The findings are published in eLife and may be relevant for transplantation therapies in diabetes, as formation of functional blood vessels is important for the treatment to be successful. (2020-12-04)

Blackcurrants are favorable for glucose metabolism
Blackcurrants have a beneficial effect on post-meal glucose response, and the required portion size is much smaller than previously thought, a new study from the University of Eastern Finland shows. (2020-12-03)

Better diabetes treatment: New insulin molecule can self-regulate blood sugar
Researchers from the University of Copenhagen and biotech firm Gubra have developed a new insulin molecule that will make blood sugar regulation both easier and safer for those with type 1 diabetes. (2020-12-03)

'Artificial Pancreas Dashboard' to standardize hybrid closed-loop reporting
A standardized ''Artificial Pancreas (AP) Dashboard'' should provide easy to use single-page hybrid closed-loop system (HCL) reporting for insulin requiring patients with diabetes. The AP Dashboard will help standardize HCL reporting similar to standardized CGM reporting and an electrocardiogram (EKG) and will be likely to help improve glycemic control and reduce hypoglycemia. (2020-12-01)

Protein commonly screened for in pregnancy is linked to gestational diabetes
Laboratory research and analysis of epidemiological data by Silvia Corvera, MD, and Tiffany Moore Simas, MD, MPH, MEd, and colleagues show that low levels of a protein commonly seen in screening tests for chromosomal disorders during the first trimester of pregnancy is associated with adipose tissue remodeling, glucose resistance and gestational diabetes mellitus in pregnant women. (2020-11-30)

Plant-based diet ramps up metabolism, according to new study
A plant-based diet boosts after-meal burn, leads to weight loss, and improves cardiometabolic risk factors in overweight individuals, according to a new randomized control trial published in JAMA Network Open by researchers with the Physicians Committee for Responsible Medicine. (2020-11-30)

Signaling switch in pancreatic β-cells determines anti-diabetic drug effectiveness
An international research group headed by Professor SEINO Susumu (Kobe University Graduate School of Medicine) has clarified the action mechanism of widely utilized incretin-based drugs in the treatment of diabetes. These findings are important for illuminating the mechanism behind diabetes and will hopefully provide a basis for new treatments. (2020-11-25)

Study: gut hormones' regulation of fat production abnormal in obesity, fatty liver disease
Gut hormones play an important role in regulating fat production in the body. One key hormone, released a few hours after eating, turns off fat production by regulating gene expression in the liver, but this regulation is abnormal in obesity, researchers at the University of Illinois Urbana-Champaign found in a new study. (2020-11-24)

Mediterranean diet tied to 30 percent risk reduction for diabetes in Women's Health Study
In a paper published in JAMA Network Open, Brigham investigators report that women who adhered to a more Mediterranean-like diet had a 30 percent lower rate of type 2 diabetes than women who did not. The team examined several biomarkers to look for biological explanations for these results, finding key mechanisms including insulin resistance, body mass index, lipoprotein metabolism and inflammation. (2020-11-19)

Incretin hormone levels linked to arteriosclerosis
Diabetes is currently treated using incretin hormones to reduce the risk of cardiovascular disease and other medical issues that the illness can trigger. Now researchers from Lund University in Sweden have noted new links between these hormones and arteriosclerosis, and believe their discovery could be significant for treatment of diabetes in the future. The study is published in Diabetes Care. (2020-11-19)

The gut microbiota forms a molecule that can contribute to diabetes progression
It is the bacterial changes in the gut that increase the levels of imidazole propionate, the molecule that makes the body's cells resistant to insulin in type 2 diabetes. This result emerges from a European study, MetaCardis. (2020-11-18)

Potential therapeutic strategy for obesity
Together with researchers from Poland, Germany, Australia and Austria, a team of MedUni Vienna scientists has now discovered the signalling pathways responsible for the development of a valuable type of adipose tissue macrophage (ATM) in obesity, which prevents lipotoxicity. (2020-11-17)

New Fred Hutch-led trial shows no benefits of dairy foods for blood sugar regulation
Results from a new trial published by a team led by researchers at Fred Hutchinson Cancer Research Center suggests lower dairy intake may be beneficial for people with metabolic syndrome. (2020-11-16)

In mice, cadmium exposure during pregnancy linked to obesity in female offspring
In a mouse study aimed at modeling human exposure to the toxic metal cadmium, researchers found that female offspring of mice exposed to cadmium during pregnancy became obese in adulthood, developed fatty livers and could not process glucose normally. Male offspring were not affected in the same way. The study also sheds light on how cadmium exposure could affect mitochondrial function and developmental signaling pathways in the liver. (2020-11-12)

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